Background: The need to replace new drug structures for the treatment of resistant strains has become essential. Streptococcus mutans is one of the most important factors in causing tooth decay. Glucan binding protein-C (Gbp-C) is a crucial mobileular floor protein that is worried in biofilm formation, and 1, 3, 4-oxadiazoles are new antibacterial structures. Accordingly, this study focused on assessing in vitro and in silico activity of our previously synthesized compounds of 1, 3, 4-oxadiazole against S. mutans. Methods: To this end, our previously synthesized derivatives were re-synthesized and prepared, and then antibacterial susceptibility tests were used for inhibition zone, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) test values. The molecular docking method was also applied to confirm the effect of compounds in interaction with the Gbp-C of S. mutans. Results: All compounds showed different effects against the bacterial sample. Among these, the most effective ones were related to naphthalene (4d), fluorophenyl (4e), and dimethoxyphenyl (4h) derivatives against S. mutans, respectively. Other compounds also had antibacterial properties but to a lesser extent. In the molecular part, compounds 4d and 4h had the highest affinity to inhibit the GbpC-protein. compound 4d with amino acids ASP and GLN established 402 and 391 hydrogen bonds, respectively, and compound 4h with amino acids SER, GLU, THR, and TRP established 347, 360, 449, and 451 hydrogen bonds, respectively. Conclusions: In general, 1, 3, 4-oxadiazoles containing naphthalene and dimethoxy phenyl functional groups in high concentrations can be good alternatives to the existing drugs for eliminating caries-causing tooth mutants that have drug resistance. It seems that more inhibitory effects can be observed on clinical specimens by adding different purposeful groups and increasing the destructive power of oxadiazole-based compounds.
背景:需要更换新的药物结构，以治疗耐药菌株已成为必不可少的。变形链球菌是导致蛀牙的最重要因素之一。葡聚糖结合蛋白- c (Gbp-C)是生物膜形成过程中重要的活动底蛋白，1,3,4 -恶二唑是新型抗菌结构。因此，本研究的重点是评估我们之前合成的1,3,4 -恶二唑对变形链球菌的体外和体内活性。方法:对先前合成的衍生物进行重新合成和制备，并采用抑菌区、最小抑菌浓度(MIC)和最小杀菌浓度(MBC)试验值进行抗菌药敏试验。分子对接法也证实了化合物与变形链球菌Gbp-C相互作用的效果。结果:各化合物对细菌样品均有不同的抑菌效果。其中萘(4d)、氟苯基(4e)和二甲氧基(4h)衍生物对变形链球菌的抑制作用最强。其他化合物也有抗菌性能，但程度较低。在分子部分，化合物4d和4h对gbpc -蛋白的抑制作用最强。化合物4d与氨基酸ASP、GLN分别建立402、391个氢键，化合物4h与氨基酸SER、GLU、THR、TRP分别建立347、360、449、451个氢键。结论:一般情况下，含有高浓度萘和二甲氧基苯基官能团的1,3,4 -恶二唑可作为现有药物的良好替代品，用于消除具有耐药性的致龋牙齿突变体。似乎通过添加不同目的基团和增加恶二唑类化合物的破坏力，可以在临床标本上观察到更多的抑制作用。
{"title":"In Vitro and In Silico Evaluation of Biological Properties of Some 1, 3, 4-Oxadiazole Derivatives Against Streptococcus mutans and Their Interaction With Gbp-C by Molecular Docking","authors":"B. Omidi, Yasin SarveAhrabi","doi":"10.34172/ajdr.2021.27","DOIUrl":"https://doi.org/10.34172/ajdr.2021.27","url":null,"abstract":"Background: The need to replace new drug structures for the treatment of resistant strains has become essential. Streptococcus mutans is one of the most important factors in causing tooth decay. Glucan binding protein-C (Gbp-C) is a crucial mobileular floor protein that is worried in biofilm formation, and 1, 3, 4-oxadiazoles are new antibacterial structures. Accordingly, this study focused on assessing in vitro and in silico activity of our previously synthesized compounds of 1, 3, 4-oxadiazole against S. mutans. Methods: To this end, our previously synthesized derivatives were re-synthesized and prepared, and then antibacterial susceptibility tests were used for inhibition zone, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) test values. The molecular docking method was also applied to confirm the effect of compounds in interaction with the Gbp-C of S. mutans. Results: All compounds showed different effects against the bacterial sample. Among these, the most effective ones were related to naphthalene (4d), fluorophenyl (4e), and dimethoxyphenyl (4h) derivatives against S. mutans, respectively. Other compounds also had antibacterial properties but to a lesser extent. In the molecular part, compounds 4d and 4h had the highest affinity to inhibit the GbpC-protein. compound 4d with amino acids ASP and GLN established 402 and 391 hydrogen bonds, respectively, and compound 4h with amino acids SER, GLU, THR, and TRP established 347, 360, 449, and 451 hydrogen bonds, respectively. Conclusions: In general, 1, 3, 4-oxadiazoles containing naphthalene and dimethoxy phenyl functional groups in high concentrations can be good alternatives to the existing drugs for eliminating caries-causing tooth mutants that have drug resistance. It seems that more inhibitory effects can be observed on clinical specimens by adding different purposeful groups and increasing the destructive power of oxadiazole-based compounds.","PeriodicalId":8679,"journal":{"name":"Avicenna Journal of Dental Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87027056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farzaneh Pakdel, R. Attaran, Sevda Movafagh, Z. Aghazadeh
Background: The exact mechanism of the formation of salivary gland stones is unknown. Elucidating pathophysiology of the formation of salivary stones might prevent both their formation and the need for implementing invasive surgical procedures. Therefore, this study aimed to evaluate the effects exerted by some etiological factors on the formation of salivary gland stones. Methods: In this case–control study, the records of 80 patients with sialolithiasis were studied as a census from April 2011 to June 2019. These patients were referred to the Oral Medicine and the ENT departments of Tabriz University of Medical Sciences. The control group consisted of the same number of the patients with no sialolithiasis. Two groups were compared in terms of stone size, smoking, gallstones, and renal stones. Chi-squared, independent t-test, and Mann-Whitney U test were adopted to examine the quantitative variables. The data were analyzed using SPSS 17. Statistical significance was set at P<0.05. Results: Overall, 96.2% of sialoliths were found in the submandibular gland, of which 78.8% were single. Moreover, 32.5% of the patients with a history of sialolithiasis were smokers, whereas this frequency was 23.8% in the control group. In the case and control groups, 2.5% and 5% of the patients had a history of renal stones, respectively. Only one patient who had undergone a surgical procedure to remove salivary gland stones had a history of gallstones, while none of the patients in the control group had a history of gallstones. Conclusions: The results showed that the formation of salivary gland stones was not associated with smoking, history of renal stones, and gallstones. Furthermore, it was found that the numbers and sizes of salivary stones were not affected by smoking.
{"title":"Evaluation of the Relation of Smoking, Gallstones, and Renal Stones With Sialolithiasis in Patients Referred to Oral Medicine and ENT Department of Tabriz University of Medical Sciences","authors":"Farzaneh Pakdel, R. Attaran, Sevda Movafagh, Z. Aghazadeh","doi":"10.34172/ajdr.2021.24","DOIUrl":"https://doi.org/10.34172/ajdr.2021.24","url":null,"abstract":"Background: The exact mechanism of the formation of salivary gland stones is unknown. Elucidating pathophysiology of the formation of salivary stones might prevent both their formation and the need for implementing invasive surgical procedures. Therefore, this study aimed to evaluate the effects exerted by some etiological factors on the formation of salivary gland stones. Methods: In this case–control study, the records of 80 patients with sialolithiasis were studied as a census from April 2011 to June 2019. These patients were referred to the Oral Medicine and the ENT departments of Tabriz University of Medical Sciences. The control group consisted of the same number of the patients with no sialolithiasis. Two groups were compared in terms of stone size, smoking, gallstones, and renal stones. Chi-squared, independent t-test, and Mann-Whitney U test were adopted to examine the quantitative variables. The data were analyzed using SPSS 17. Statistical significance was set at P<0.05. Results: Overall, 96.2% of sialoliths were found in the submandibular gland, of which 78.8% were single. Moreover, 32.5% of the patients with a history of sialolithiasis were smokers, whereas this frequency was 23.8% in the control group. In the case and control groups, 2.5% and 5% of the patients had a history of renal stones, respectively. Only one patient who had undergone a surgical procedure to remove salivary gland stones had a history of gallstones, while none of the patients in the control group had a history of gallstones. Conclusions: The results showed that the formation of salivary gland stones was not associated with smoking, history of renal stones, and gallstones. Furthermore, it was found that the numbers and sizes of salivary stones were not affected by smoking.","PeriodicalId":8679,"journal":{"name":"Avicenna Journal of Dental Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72646311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Khamverdi, E. Yarmohammadi, B. Tolaminejad, Anahita Barghilashgari
Background: Extending the lifespan and improving the physical properties of dental burs as the most extensivly used instruments have been the subject of several studies. One of the proposed methods is using surface coatings for the burs. Since the dental instruments are reused, they require sterilization. One of the possible causes of the damage to dental burs is autoclaving process. This study aimed to investigate sterilization (autoclave) effect on wear of diamond coated tungsten-carbide burs with different thicknesses. Methods: In this in vitro study, 40 tungsten-carbide dental burs (IQ DENT, Poznan, Poland) were selected, out of which 20 burs were coated with 1.5-μm-like diamond particles, and 20 burs were coated with 3.5-μm by PVD method using Swin Plasma Coating Machine. Then, the burs were randomly divided into four groups (n=10) as follow: G1: 1.5 μm thickness coated burs without sterilization; G2: 3.5 μm thickness coated burs without sterilization; G3: 1.5 μm coated with sterilization; and G4: 3.5μm thickness coated burs with sterilization. Their weights were measured before wear test.Wear test was performed and then they were re-weighted. Data were analyzed using SPSS software (version 21) as well as Two-way ANOVA and Tukey HSD supplementary tests (α=0.05). Results: Mean and standard deviation of the burs weights without sterilization in the control groups were 7.31±2.63 and 7.96±1.61 mg, respectively; and mean and standard deviation of the burs weights in the sterilization groups were 7.06±0.98 and 7.12±1.11 mg, respectively. The study results showed that "sterilization application" and "thickness of coated layer" were the main factors and their intraction had no statistically significant difference (P=0.589). Conclusions: The sterilization process had no effect on wear of diamond coated tungsten-carbide burs with different thicknesses.
{"title":"Effect of Sterilization (Autoclave) on Wear of Tungsten-Carbide Burs Coated With Diamond Particles With Different Thicknesses","authors":"Z. Khamverdi, E. Yarmohammadi, B. Tolaminejad, Anahita Barghilashgari","doi":"10.34172/ajdr.2021.23","DOIUrl":"https://doi.org/10.34172/ajdr.2021.23","url":null,"abstract":"Background: Extending the lifespan and improving the physical properties of dental burs as the most extensivly used instruments have been the subject of several studies. One of the proposed methods is using surface coatings for the burs. Since the dental instruments are reused, they require sterilization. One of the possible causes of the damage to dental burs is autoclaving process. This study aimed to investigate sterilization (autoclave) effect on wear of diamond coated tungsten-carbide burs with different thicknesses. Methods: In this in vitro study, 40 tungsten-carbide dental burs (IQ DENT, Poznan, Poland) were selected, out of which 20 burs were coated with 1.5-μm-like diamond particles, and 20 burs were coated with 3.5-μm by PVD method using Swin Plasma Coating Machine. Then, the burs were randomly divided into four groups (n=10) as follow: G1: 1.5 μm thickness coated burs without sterilization; G2: 3.5 μm thickness coated burs without sterilization; G3: 1.5 μm coated with sterilization; and G4: 3.5μm thickness coated burs with sterilization. Their weights were measured before wear test.Wear test was performed and then they were re-weighted. Data were analyzed using SPSS software (version 21) as well as Two-way ANOVA and Tukey HSD supplementary tests (α=0.05). Results: Mean and standard deviation of the burs weights without sterilization in the control groups were 7.31±2.63 and 7.96±1.61 mg, respectively; and mean and standard deviation of the burs weights in the sterilization groups were 7.06±0.98 and 7.12±1.11 mg, respectively. The study results showed that \"sterilization application\" and \"thickness of coated layer\" were the main factors and their intraction had no statistically significant difference (P=0.589). Conclusions: The sterilization process had no effect on wear of diamond coated tungsten-carbide burs with different thicknesses.","PeriodicalId":8679,"journal":{"name":"Avicenna Journal of Dental Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90424174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Govahi, H. Ajami, V. Khalili, Ayda Paydar, Gooya Kabir
Background: Latent third molar extraction is the most common surgery in dentistry. Common complications of this surgery include pain, swelling, and trismus. To control these side effects, several drugs have been developed and evaluated in various studies. However, the present study is the first one to compare the effects of ibuprofen and ketorolac on pain, swelling, and trismus after molar surgery. Methods: This study was a split-mouth clinical trial. To conduct the trial, 20 candidates were selected from among patients referring to Surgery Department of the Dentistry School at Yazd Shahid Sadoughi University of Medical Sciences for mandibular third molar removal surgery. The patients were divided into two groups after the surgery: one group received ibuprofen, and the other one received ketorolac. Pain, swelling, and trismus were evaluated prior to the surgical procedure, 24 hours later, and one week after the surgery. Data were analyzed by SPSS software version 22 by using Wilcoxon statistical tests and paired t test. Results: Ibuprofen and ketorolac had similar effects on pain relief (P value>0.05). Studying the two groups produced similar results regarding improvement in mouth opening (P value>0.05). Improvement pace of the postoperative swelling was significantly faster in the group receiving ketorolac compared to the one receiving ibuprofen (P value <0.05). Conclusions: It was concluded that ibuprofen and ketorolac had positive and almost similar effects on pain control, edema, and trismus after molar surgery. However, ketorolac was more effective in controlling edema after surgery.
{"title":"The Effect of Oral Ketorolac Compared to Ibuprofen on Edema, Trismus, and Pain After Mandibular Third Molar Surgery","authors":"M. Govahi, H. Ajami, V. Khalili, Ayda Paydar, Gooya Kabir","doi":"10.34172/ajdr.2021.25","DOIUrl":"https://doi.org/10.34172/ajdr.2021.25","url":null,"abstract":"Background: Latent third molar extraction is the most common surgery in dentistry. Common complications of this surgery include pain, swelling, and trismus. To control these side effects, several drugs have been developed and evaluated in various studies. However, the present study is the first one to compare the effects of ibuprofen and ketorolac on pain, swelling, and trismus after molar surgery. Methods: This study was a split-mouth clinical trial. To conduct the trial, 20 candidates were selected from among patients referring to Surgery Department of the Dentistry School at Yazd Shahid Sadoughi University of Medical Sciences for mandibular third molar removal surgery. The patients were divided into two groups after the surgery: one group received ibuprofen, and the other one received ketorolac. Pain, swelling, and trismus were evaluated prior to the surgical procedure, 24 hours later, and one week after the surgery. Data were analyzed by SPSS software version 22 by using Wilcoxon statistical tests and paired t test. Results: Ibuprofen and ketorolac had similar effects on pain relief (P value>0.05). Studying the two groups produced similar results regarding improvement in mouth opening (P value>0.05). Improvement pace of the postoperative swelling was significantly faster in the group receiving ketorolac compared to the one receiving ibuprofen (P value <0.05). Conclusions: It was concluded that ibuprofen and ketorolac had positive and almost similar effects on pain control, edema, and trismus after molar surgery. However, ketorolac was more effective in controlling edema after surgery.","PeriodicalId":8679,"journal":{"name":"Avicenna Journal of Dental Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87168370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The present study aimed to survey the influence of two different bleaching techniques on changes of color, translucency, and whiteness of the four CAD/CAM materials. Methods: The monolithic blocks of Vita Suprinity, Vita Enamic, IPS e.max CAD, and Katana Zirconia were sectioned to discs with thickness of 2 mm (n=30 / each group). Samples from each type of ceramic were assigned to three subgroups: 1) the 40% hydrogen peroxide for 20 minutes; 2) the 16% carbamide peroxide for three hours/day for 2 weeks; and 3) the control. Then CIELab coordinates of each sample were evaluated before and after the intervention by a spectrophotometer. Final color change (ΔE), Whiteness (ΔWI D), and Translucency Parameter (ΔTP) were calculated. Two-way ANOVA test was adopted to analyze the data (α=0.05). Results: Type of ceramic, bleaching subgroups, and interaction between them had a statistically significant influence on mean values of ΔE, ΔWID. The influence of bleaching subgroup on the mean value of ΔTP was also significant (P<0.001). Conclusions: Carbamide peroxide 16% for three hours/day and for two weeks caused the most considerable changes in final color, whiteness, and translucency of the all tested CAD/CAM materials. Maximum color change and whiteness were detected in the Vita Enamic, which were clinically unacceptable.
{"title":"Effect of Different Bleaching Methods on Optical Behaviors of CAD/CAM Ceramics","authors":"S. Nikanjam, S. Abbasi, S. Khazaei","doi":"10.34172/ajdr.2021.22","DOIUrl":"https://doi.org/10.34172/ajdr.2021.22","url":null,"abstract":"Background: The present study aimed to survey the influence of two different bleaching techniques on changes of color, translucency, and whiteness of the four CAD/CAM materials. Methods: The monolithic blocks of Vita Suprinity, Vita Enamic, IPS e.max CAD, and Katana Zirconia were sectioned to discs with thickness of 2 mm (n=30 / each group). Samples from each type of ceramic were assigned to three subgroups: 1) the 40% hydrogen peroxide for 20 minutes; 2) the 16% carbamide peroxide for three hours/day for 2 weeks; and 3) the control. Then CIELab coordinates of each sample were evaluated before and after the intervention by a spectrophotometer. Final color change (ΔE), Whiteness (ΔWI D), and Translucency Parameter (ΔTP) were calculated. Two-way ANOVA test was adopted to analyze the data (α=0.05). Results: Type of ceramic, bleaching subgroups, and interaction between them had a statistically significant influence on mean values of ΔE, ΔWID. The influence of bleaching subgroup on the mean value of ΔTP was also significant (P<0.001). Conclusions: Carbamide peroxide 16% for three hours/day and for two weeks caused the most considerable changes in final color, whiteness, and translucency of the all tested CAD/CAM materials. Maximum color change and whiteness were detected in the Vita Enamic, which were clinically unacceptable.","PeriodicalId":8679,"journal":{"name":"Avicenna Journal of Dental Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79991686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Many patients refer to their load implants while there is no attached gingiva in the area of prosthetic implants – unlike the attached gingivae found with natural teeth. The important role played by gingiva in comforting the patient and preventing gingival inflammation has not been fully appreciated yet. This study aimed to evaluate the association between the attached gingival height with gingival inflammation and patients’ comfort. Methods: This retrospective cohort study was conducted to examine 80 implants (Dio uf) placed in 63 patients. At least two months had passed since the patients had had implant crown. The patients were divided into three groups: attached gingiva, gingival up to 2 mm, and at least 2 mm of attached gingiva. Indices such as bleeding on probing (BOP), the amount of plaque, gingival index and patient comfort during brushing and chewing were evaluated. Statistical data were analyzed using the Kolmogorov– Smirnov test, Levene’s test and independent t-test. Results: By increasing the height of attached gingiva, decreases were observed in probing depth (P value=0.004), BOP (P value=0.001), the degree of plaque index (P value=0.006), and gingival index (P value=0.003); and this association was statistically quite significant. By increasing the attached gingiva height, furthermore, the patients felt less discomfort when brushing and chewing; however, the findings were not statistically significant in terms of patients’ comfort during chewing (P value=0.364). Conclusions: Increasing the height of attached gingiva reduced the symptoms of gingival inflammation, but increased patients’ comfort when chewing and brushing.
{"title":"Evaluating the Effect of Attached Gingiva Height on Pre-implant Tissue","authors":"M. Bidgoli, Maryam Pourjebreil","doi":"10.34172/ajdr.2021.26","DOIUrl":"https://doi.org/10.34172/ajdr.2021.26","url":null,"abstract":"Background: Many patients refer to their load implants while there is no attached gingiva in the area of prosthetic implants – unlike the attached gingivae found with natural teeth. The important role played by gingiva in comforting the patient and preventing gingival inflammation has not been fully appreciated yet. This study aimed to evaluate the association between the attached gingival height with gingival inflammation and patients’ comfort. Methods: This retrospective cohort study was conducted to examine 80 implants (Dio uf) placed in 63 patients. At least two months had passed since the patients had had implant crown. The patients were divided into three groups: attached gingiva, gingival up to 2 mm, and at least 2 mm of attached gingiva. Indices such as bleeding on probing (BOP), the amount of plaque, gingival index and patient comfort during brushing and chewing were evaluated. Statistical data were analyzed using the Kolmogorov– Smirnov test, Levene’s test and independent t-test. Results: By increasing the height of attached gingiva, decreases were observed in probing depth (P value=0.004), BOP (P value=0.001), the degree of plaque index (P value=0.006), and gingival index (P value=0.003); and this association was statistically quite significant. By increasing the attached gingiva height, furthermore, the patients felt less discomfort when brushing and chewing; however, the findings were not statistically significant in terms of patients’ comfort during chewing (P value=0.364). Conclusions: Increasing the height of attached gingiva reduced the symptoms of gingival inflammation, but increased patients’ comfort when chewing and brushing.","PeriodicalId":8679,"journal":{"name":"Avicenna Journal of Dental Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91471350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arezoo Khabazian, A. Forouzanfar, Hossein Parsaee, S. Soltani
Background: Hyperglycemia in diabetic patients can affect the success of many dental treatments. Thus, many dental procedures are contraindicated in patients with uncontrolled diabetes mellitus (DM) due to the consequent delay in wound healing. This study aimed to assess the effect of a long-term control of blood sugar on tissue healing after implant placement. Methods: This cohort study evaluated 20 patients aged 50-60, referring to the School of Dentistry, Mashhad University of Medical Sciences for implant placement. All patients underwent blood sugar test and were divided into two groups of diabetic and non-diabetic patients regarding their HbA1c level. Bone loss, bleeding on probing (BOP), and pocket probing depth (PPD) of patients were measured 1 and 6 months after the implant placement. Data were analyzed using independent t test and chi-square test. Results: Blood sugar control had no significant effect on bone loss, BOP and PPD one and six month(s) after implant placement (P>0.05). Although PPD significantly increased in both groups over time (P=0.016 in the healthy group and P=0.007 in the diabetic group), the difference between the two groups was not significant (P>0.05). Conclusion: According to the results from this study, blood sugar control examined in the age range of our study had no significant effect on tissue healing one and six month(s) after the implant placement. However, further studies are required to explore this subject more thoroughly.
{"title":"Evaluation of Soft and Hard Tissue Condition After Dental Implant Surgery in Diabetic and Non-diabetic Patients (6 Months Follow up)","authors":"Arezoo Khabazian, A. Forouzanfar, Hossein Parsaee, S. Soltani","doi":"10.34172/ajdr.2021.18","DOIUrl":"https://doi.org/10.34172/ajdr.2021.18","url":null,"abstract":"Background: Hyperglycemia in diabetic patients can affect the success of many dental treatments. Thus, many dental procedures are contraindicated in patients with uncontrolled diabetes mellitus (DM) due to the consequent delay in wound healing. This study aimed to assess the effect of a long-term control of blood sugar on tissue healing after implant placement. Methods: This cohort study evaluated 20 patients aged 50-60, referring to the School of Dentistry, Mashhad University of Medical Sciences for implant placement. All patients underwent blood sugar test and were divided into two groups of diabetic and non-diabetic patients regarding their HbA1c level. Bone loss, bleeding on probing (BOP), and pocket probing depth (PPD) of patients were measured 1 and 6 months after the implant placement. Data were analyzed using independent t test and chi-square test. Results: Blood sugar control had no significant effect on bone loss, BOP and PPD one and six month(s) after implant placement (P>0.05). Although PPD significantly increased in both groups over time (P=0.016 in the healthy group and P=0.007 in the diabetic group), the difference between the two groups was not significant (P>0.05). Conclusion: According to the results from this study, blood sugar control examined in the age range of our study had no significant effect on tissue healing one and six month(s) after the implant placement. However, further studies are required to explore this subject more thoroughly.","PeriodicalId":8679,"journal":{"name":"Avicenna Journal of Dental Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74963916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Shishehian, F. Amiri, A. Izadi, S. Abbasi, M. Farhadian, Armaqan Shahbazi
Background: Luting cement provides the connection between crowns and tooth structure. The sensitivity, solubility, and decomposition stages of the cement after the hardening stage are still subjects of relative controversy. These characteristics could lead to a poor connection between the braces and the teeth, increased probability of decay, and decalcification. The present study aimed to evaluate the adsorption and solubility of 4 types of glass ionomer cement. Methods: Four luting cements were examined. A total of 10 specimens were prepared for each material following the manufacturer’s instructions, and the sorption and solubility were measured in accordance with the ISO 4049’s. Specimens were immersed in artificial saliva for 30 days, and were evaluated for sorption and solubility by first weighting them before incubation (W1), then immersing them in artificial saliva, dehydrating them in an oven for 24 hours, and weighing them again (W2 and W3, respectively). The data were analyzed using SPSS software version 21. One-way analysis of variance (ANOVA) followed by Tukey post hoc test was used to examine the differences among groups (α = 0.05). Results: As for the both sorption and solubility, there was a significant interaction between the sorption and solubility of all materials (P<0.001). The sorption values in artificial saliva were highest for glass ionomer cement Riva Luting followed by GC Fuji 1 and Cavex, whereas the least value was observed for Meron (P<0.000). As for solubility, it was significantly higher in Cavex followed by GC Fuji1 and Meron, but it was significantly lower in Riva Luting. Conclusions: It was determined that the weight changes of glass ionomer cements significantly varied among all the materials. Riva Luting followed by GC Fuji 1 had the highest water sorption, and the solubility was significantly higher in Cavex followed by GC Fuji1. Meron improved both water sorption and solubility properties among all glass ionomer cements.
{"title":"Comparison of Sorption and Solubility Behavior of Four Different Types of Glass Ionomer Luting Cements in Artificial Saliva","authors":"A. Shishehian, F. Amiri, A. Izadi, S. Abbasi, M. Farhadian, Armaqan Shahbazi","doi":"10.34172/ajdr.2021.19","DOIUrl":"https://doi.org/10.34172/ajdr.2021.19","url":null,"abstract":"Background: Luting cement provides the connection between crowns and tooth structure. The sensitivity, solubility, and decomposition stages of the cement after the hardening stage are still subjects of relative controversy. These characteristics could lead to a poor connection between the braces and the teeth, increased probability of decay, and decalcification. The present study aimed to evaluate the adsorption and solubility of 4 types of glass ionomer cement. Methods: Four luting cements were examined. A total of 10 specimens were prepared for each material following the manufacturer’s instructions, and the sorption and solubility were measured in accordance with the ISO 4049’s. Specimens were immersed in artificial saliva for 30 days, and were evaluated for sorption and solubility by first weighting them before incubation (W1), then immersing them in artificial saliva, dehydrating them in an oven for 24 hours, and weighing them again (W2 and W3, respectively). The data were analyzed using SPSS software version 21. One-way analysis of variance (ANOVA) followed by Tukey post hoc test was used to examine the differences among groups (α = 0.05). Results: As for the both sorption and solubility, there was a significant interaction between the sorption and solubility of all materials (P<0.001). The sorption values in artificial saliva were highest for glass ionomer cement Riva Luting followed by GC Fuji 1 and Cavex, whereas the least value was observed for Meron (P<0.000). As for solubility, it was significantly higher in Cavex followed by GC Fuji1 and Meron, but it was significantly lower in Riva Luting. Conclusions: It was determined that the weight changes of glass ionomer cements significantly varied among all the materials. Riva Luting followed by GC Fuji 1 had the highest water sorption, and the solubility was significantly higher in Cavex followed by GC Fuji1. Meron improved both water sorption and solubility properties among all glass ionomer cements.","PeriodicalId":8679,"journal":{"name":"Avicenna Journal of Dental Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85588484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Systemic lupus erythematosus is a systemic autoimmune disease that involves multi organs. Genetic, endocrine, immunological, and environmental factors influence the loss of immunological tolerance against self-antigens leading to the formation of pathogenic autoantibodies that cause tissue damage through multiple mechanisms. The gingival overgrowth can be caused by three factors: noninflammatory, hyperplastic reaction to the medication; chronic inflammatory hyperplasia; or a combined enlargement due to chronic inflammation and drug-induced hyperplasia. Drug-Induced Gingival Overgrowth is associated with the use of three major classes of drugs, namely anticonvulsants, calcium channel blockers, and immunosuppressants. Due to recent indications for these drugs, their use continues to grow.
{"title":"Drug-Induced Gingival Overgrowth in an 8-Year-Old Girl: A Case Report","authors":"P. Torkzaban, A. Talaie","doi":"10.34172/ajdr.2021.21","DOIUrl":"https://doi.org/10.34172/ajdr.2021.21","url":null,"abstract":"Systemic lupus erythematosus is a systemic autoimmune disease that involves multi organs. Genetic, endocrine, immunological, and environmental factors influence the loss of immunological tolerance against self-antigens leading to the formation of pathogenic autoantibodies that cause tissue damage through multiple mechanisms. The gingival overgrowth can be caused by three factors: noninflammatory, hyperplastic reaction to the medication; chronic inflammatory hyperplasia; or a combined enlargement due to chronic inflammation and drug-induced hyperplasia. Drug-Induced Gingival Overgrowth is associated with the use of three major classes of drugs, namely anticonvulsants, calcium channel blockers, and immunosuppressants. Due to recent indications for these drugs, their use continues to grow.","PeriodicalId":8679,"journal":{"name":"Avicenna Journal of Dental Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73985241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Omid Amiri Nasab, Mohammad Bahaodini, A. Mohammadbeigi, H. Naderifar
Background: Changes in oral health like tooth loss can have a profound effect on the patients’ quality of life. The condition of relative or complete toothlessness exerts negative effects on chewing, speech, and appearance of the individual. The high capability of dental implants in restoring the beauty and oral function of the patients has led to their widespread usage. This study aimed to compare the quality of life of the toothless patients before and after treatment with implant. Methods: In the present study, 50 patients afflicted with complete or relative toothlessness were examined. Before completing the questionnaires, all participants were asked to complete and sign the consent form of the questionnaire from Oral Impacts on Daily Performance) OIDP). The questionnaires were completed before receiving the implant coating, and a month after the delivery of the patients’ prosthesis. Finally, the data were analyzed using SPSS statistical software, ANOVA, Mann-Whitney, and McNemar. Results: In this study, 50 patients with the mean age of 46.84±11.87 years were investigated. As for the gender and marital status of the participants, 50% (25 patients) were male and 84% (42 ones) were married. According to the data obtained from the OIDP questionnaire, the most significant changes were detected in eating, smiling, laughing and showing teeth without discomfort and speaking clearly, respectively. Moreover, a significant difference was found between the total score of oral effect on daily activities and some levels included in disruption questionnaire on daily activities such as eating, speaking clearly, going out, sleeping, relaxation, smiling, enjoying communication with others, job-related activities, as well as emotional conditions (Irritability); however, no significant difference was found between cases of cleaning teeth and light physical activity. Conclusions: According to the data from OIDP questionnaire and the study results, implant had favorable effects on the quality of life of the patients. However, long-term studies and follow-ups are necessary to determine other possible favorable effects of implant treatment.
{"title":"Comparing the Incidence of Disruption in Daily Activities and Quality of Life Score Associated With Oral Health in Patients With Implant Candidates Before and After Treatment","authors":"Omid Amiri Nasab, Mohammad Bahaodini, A. Mohammadbeigi, H. Naderifar","doi":"10.34172/ajdr.2021.20","DOIUrl":"https://doi.org/10.34172/ajdr.2021.20","url":null,"abstract":"Background: Changes in oral health like tooth loss can have a profound effect on the patients’ quality of life. The condition of relative or complete toothlessness exerts negative effects on chewing, speech, and appearance of the individual. The high capability of dental implants in restoring the beauty and oral function of the patients has led to their widespread usage. This study aimed to compare the quality of life of the toothless patients before and after treatment with implant. Methods: In the present study, 50 patients afflicted with complete or relative toothlessness were examined. Before completing the questionnaires, all participants were asked to complete and sign the consent form of the questionnaire from Oral Impacts on Daily Performance) OIDP). The questionnaires were completed before receiving the implant coating, and a month after the delivery of the patients’ prosthesis. Finally, the data were analyzed using SPSS statistical software, ANOVA, Mann-Whitney, and McNemar. Results: In this study, 50 patients with the mean age of 46.84±11.87 years were investigated. As for the gender and marital status of the participants, 50% (25 patients) were male and 84% (42 ones) were married. According to the data obtained from the OIDP questionnaire, the most significant changes were detected in eating, smiling, laughing and showing teeth without discomfort and speaking clearly, respectively. Moreover, a significant difference was found between the total score of oral effect on daily activities and some levels included in disruption questionnaire on daily activities such as eating, speaking clearly, going out, sleeping, relaxation, smiling, enjoying communication with others, job-related activities, as well as emotional conditions (Irritability); however, no significant difference was found between cases of cleaning teeth and light physical activity. Conclusions: According to the data from OIDP questionnaire and the study results, implant had favorable effects on the quality of life of the patients. However, long-term studies and follow-ups are necessary to determine other possible favorable effects of implant treatment.","PeriodicalId":8679,"journal":{"name":"Avicenna Journal of Dental Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85589533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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