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Enabling energy-efficient manufacturing of pharmaceutical solid oral dosage forms via integrated techno-economic analysis and advanced process modeling 通过集成的技术经济分析和先进的工艺建模实现药物固体口服剂型的高效生产
Pub Date : 2022-07-04 DOI: 10.1002/amp2.10136
Chaitanya Sampat, Lalith Kotamarthy, Pooja Bhalode, Yingjie Chen, Ashley Dan, Sania Parvani, Zeal Dholakia, Ravendra Singh, Benjamin J. Glasser, Marianthi Ierapetritou, Rohit Ramachandran

The global pharmaceutical industry is a trillion-dollar market. However, the pharmaceutical sector often lags in manufacturing innovation and automation which limits its potential to maximize energy efficiency. The integration of techno-economic analysis (TEA) with advanced process models as part of an overarching smart manufacturing platform, can help industries create business models, which can be adapted for manufacturing to reduce energy consumption and operating costs while ensuring product quality which can further enable a more sustainable process operation. In this study, a rational design of experiment on three unit-operations (wet granulation, drying, and milling) was performed on a batch (case 1) and continuous (case 2) pharmaceutical process to obtain experimental data. Process models for predicting product quality and energy efficiency of each of the three-unit operations were developed. The experimental data were used to validate the models and good agreement was observed. The energy consumption of each unit operation was calculated using statistical models relating the power consumption and the process parameters. The developed process models and energy models were further integrated into a TEA framework, which quantified the energy and monetary cost of manufacturing for both batch and continuous manufacturing cases. With this integrated framework, energy costs savings of ~33% was obtained in the continuous manufacturing process (case 2) over the batch process (case 1).

全球制药行业是一个万亿美元的市场。然而,制药行业在制造创新和自动化方面往往落后,这限制了其最大限度地提高能源效率的潜力。作为总体智能制造平台的一部分,技术经济分析(TEA)与先进流程模型的集成可以帮助行业创建商业模型,这些模型可以适应制造业,以降低能耗和运营成本,同时确保产品质量,从而进一步实现更可持续的流程运营。本研究对间歇式(案例1)和连续式(案例2)制药工艺进行了三个单元操作(湿制粒、干燥和制粉)的合理实验设计,获得实验数据。开发了用于预测产品质量和三个单元操作中每个单元的能源效率的过程模型。用实验数据对模型进行了验证,得到了较好的一致性。利用功率消耗与工艺参数相关的统计模型计算了各单元操作的能耗。开发的过程模型和能源模型进一步集成到TEA框架中,该框架量化了批量和连续制造情况下的制造能源和货币成本。有了这个集成的框架,在连续生产过程(案例2)中,与批量生产过程(案例1)相比,节省了约33%的能源成本。
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引用次数: 7
When is “Net Zero net zero?” 什么时候是“净零”?
Pub Date : 2022-06-23 DOI: 10.1002/amp2.10135
Matthew J. Realff
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引用次数: 1
Experimental validation of multiphysics model simulations of the thermal response of a cement clinker rotary kiln at laboratory scale 实验室规模下水泥熟料回转窑热响应多物理模型模拟的实验验证
Pub Date : 2022-06-19 DOI: 10.1002/amp2.10134
Juan David Tabares, William M. McGinley, Thad L. Druffel, Bhagyashri Aditya Bhagwat

An increasing demand for buildings, transportation systems and civil infrastructure development has driven expansion of cement consumption world-wide, producing a significant increase in related global energy demand. With approximately 7% of the world-wide industrial energy consumption (10.7 exajoules [EJ]), the cement industry is the third most energy intensive industrial processes and a key component for concrete, the most consumed composite material in the global construction industry. In cement manufacturing, the cement kiln accounts for most of the energy consumption in the production process. As the heart of a cement plant, the cement kiln is where the kiln feed primarily containing calcium oxide (CaO), silica (SiO2), alumina (Al2O3), and iron (Fe2O3) are thermally and chemically transformed into clinker minerals. The presented work developed a multiphysics model, designed and built a laboratory-scale rotary cement clinker kiln, and produced cement clinker at laboratory-scale. The model was developed to study the interaction between the various thermal, fluid dynamic and chemical interactions involved in the sintering process used to form Portland cement clinker in an effort to reduce energy use. The analytical model was validated through experimental testing using a unique laboratory-scale rotary cement kiln developed during the investigation. Also demonstrated was the feasibility of producing clinker at laboratory scale. This modeling and lab scale tests were designed to better understand the clinker sintering process so that operational and quality decisions can be made to optimize energy consumption without compromising cement clinker quality. The computational fluid dynamics modeling was developed in COMSOL Multiphysics 6.0. The characteristics of the combustion fluid flow, concentration of species, temperature and heat transfer were studied for a turbulent flow of methane (CH4) gas and oxygen (O2). Theory suggests that heat transfer impacts the cement production process but the multiphysics model more accurately describes the convection, conduction, and radiant heat transfer in the kilning process and thus allows for a better understanding of the energy exchange driving the chemical reactions that produce Portland cement. Clinker minerals were formed because of appropriate burning conditions implemented during experimental model validation.

对建筑、运输系统和民用基础设施发展的需求不断增加,推动了世界范围内水泥消费的扩大,导致相关的全球能源需求大幅增加。水泥工业约占全球工业能耗的7%(10.7焦耳[EJ]),是第三大能源密集型工业过程,也是混凝土的关键组成部分,混凝土是全球建筑行业中消耗最多的复合材料。在水泥生产过程中,水泥窑的能耗占生产过程能耗的绝大部分。作为水泥厂的心脏,水泥窑是主要含有氧化钙(CaO)、二氧化硅(SiO2)、氧化铝(Al2O3)和铁(Fe2O3)的窑料通过热和化学方式转化为熟料矿物的地方。本文建立了一个多物理场模型,设计并建造了一个实验室规模的旋转水泥熟料窑,并在实验室规模上生产水泥熟料。该模型旨在研究硅酸盐水泥熟料烧结过程中各种热、流体动力学和化学相互作用之间的相互作用,以减少能源消耗。分析模型通过实验测试验证了在调查期间开发的一个独特的实验室规模的水泥回转窑。还论证了在实验室规模上生产熟料的可行性。该模型和实验室规模的测试旨在更好地了解熟料烧结过程,以便在不影响水泥熟料质量的情况下做出操作和质量决策,以优化能源消耗。计算流体动力学建模在COMSOL Multiphysics 6.0中进行。研究了甲烷(CH4)气体与氧气(O2)紊流的燃烧流体流动、物质浓度、温度和传热特性。理论表明,传热影响水泥生产过程,但多物理场模型更准确地描述了对流、传导和辐射传热在烧制过程中,从而允许更好地理解能量交换驱动的化学反应,生产波特兰水泥。在实验模型验证过程中,采用适当的燃烧条件形成熟料矿物。
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引用次数: 0
Getting to net zero through extended producer responsibility 通过扩大生产者责任实现净零
Pub Date : 2022-06-18 DOI: 10.1002/amp2.10132
P. Hugh Helferty

The application of Extended Producer Responsibility, including for greenhouse gases, to manufacturing broadly would go a long way toward enabling society to meet its net zero goals. Within the oil and gas industry, this could be achieved by phasing-in a Carbon Takeback Obligation. American leadership in applying Extended Producer Responsibility to include greenhouse gases could both reduce U.S. emissions and help drive other countries to do so.

扩大生产者责任(Extended Producer Responsibility),包括对温室气体的责任,广泛应用于制造业,将大大有助于社会实现其净零目标。在石油和天然气行业,这可以通过分阶段实施碳回收义务来实现。美国在将扩大生产者责任纳入温室气体排放方面的领导作用,既可以减少美国的排放,也有助于推动其他国家这样做。
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引用次数: 1
An integral monitoring concept for data-driven detection and localization of incipient leakages by fusion of process and environment data 通过过程和环境数据的融合实现数据驱动的早期泄漏检测和定位的整体监测概念
Pub Date : 2022-06-17 DOI: 10.1002/amp2.10133
Kristian Kasten, Caroline Charlotte Zhu, Joachim Birk, Steven X. Ding

The risk of leakages in process industry is environmentally critical and potentially hazardous. Many technologies and schemes for process monitoring are theoretically developed and applied in an industrial context. Nevertheless, most approaches still focus on individual monitoring of a process and its environment. The major challenge is the lack of a priori knowledge about the leakage. This paper introduces a new approach combining monitoring of the environment and its embedded process. The application on an industrial use-case in a real plant environment illustrates the success of this combined monitoring approach as well as a decision support to localize an incipient leakage.

过程工业中的泄漏风险对环境至关重要,具有潜在的危害。许多过程监控的技术和方案都是从理论上发展起来的,并在工业环境中得到了应用。然而,大多数方法仍然侧重于对过程及其环境的单独监视。主要的挑战是缺乏关于泄漏的先验知识。本文介绍了一种将环境监测与嵌入式过程相结合的新方法。在一个真实工厂环境中的工业用例上的应用说明了这种组合监测方法的成功,以及对早期泄漏进行定位的决策支持。
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引用次数: 0
Techno-economic, environmental, and social measurement of clean energy technology supply chains 清洁能源技术供应链的技术经济、环境和社会衡量
Pub Date : 2022-06-11 DOI: 10.1002/amp2.10131
Jill A. Engel-Cox, Hope M. Wikoff, Samantha B. Reese

In addition to the criteria of reliability and cost, clean energy technologies, such as wind, solar, and batteries, need to strive to a higher standard of environmental and societal benefit along their entire supply chain. This means additional performance metrics for these technologies should be considered, such as embodied energy, embodied carbon, recycled content and recyclability, environmental impact of material sourcing, impact on land and ecosystems, materials recovery at end of life, and production through quality nonexploitive jobs with community benefit. Many commercial and emerging energy technologies have not yet been explicitly evaluated based on these environmental and social performance metrics, which presents multiple opportunities for researchers and analysts. In this paper, we review the importance and current limitations of techno-economic and life-cycle assessment models for research design and manufacturing decisions. We explore emerging manufacturing modeling options that could improve environmental and social performance and how they could be used to help guide research. Even with the deployment of low-carbon energy-generation technologies, the future of a successful clean energy transition requires collaboration between researchers, advanced manufacturers, independent standards and tracking organizations, local communities, and national governments, to ensure the financial, environmental, and social sustainability of the entire supply and manufacturing process of energy technologies.

除了可靠性和成本标准外,风能、太阳能和电池等清洁能源技术还需要在整个供应链中努力实现更高标准的环境和社会效益。这意味着应该考虑这些技术的额外性能指标,如内含能量、内含碳、可回收含量和可回收性、材料来源对环境的影响、对土地和生态系统的影响、寿命结束时的材料回收,以及通过具有社区效益的高质量非消耗性工作进行生产。许多商业和新兴能源技术尚未根据这些环境和社会绩效指标进行明确评估,这为研究人员和分析师提供了多种机会。在本文中,我们回顾了技术经济和生命周期评估模型在研究设计和制造决策中的重要性和当前的局限性。我们探索了可以改善环境和社会绩效的新兴制造建模选项,以及如何利用它们来帮助指导研究。即使部署了低碳能源发电技术,清洁能源成功转型的未来也需要研究人员、先进制造商、独立标准和跟踪组织、地方社区和国家政府之间的合作,以确保财政、环境、,以及能源技术的整个供应和制造过程的社会可持续性。
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引用次数: 0
Smart connected worker edge platform for smart manufacturing: Part 2—Implementation and on-site deployment case study 面向智能制造的智能互联工人边缘平台:第2部分:实施和现场部署案例研究
Pub Date : 2022-05-22 DOI: 10.1002/amp2.10130
Richard P. Donovan, Yoon G. Kim, Anthony Manzo, Yutian Ren, Shijie Bian, Tongzi Wu, Shweta Purawat, Henry Helvajian, Marilee Wheaton, Bingbing Li, Guann-Pyng Li

In this paper, we describe specific deployments of the Smart Connected Worker (SCW) Edge Platform for Smart Manufacturing through implementation of four instructive real-world use cases that illustrate the role of people in a Smart Manufacturing paradigm through which affordable, scalable, accessible, and portable (ASAP) information technology (IT) acquires and contextualizes data into information for transmission to operation technologies (OT). For case one, the platform captures the relationships between energy consumption and human workflows for improved energy productivity while workers interact with machines during semiconductor manufacturing. The platform utilizes human cognition to identify anomalous machine behavior for root cause analysis of system faults via neural network (NN) that recognize alarm postures of workers with cameras. For case two, a smart assembly line is demonstrated for state monitoring and fault detection. Machine learning (ML) models are used to recognize system states and identify fault scenarios with human intervention. For case three, the platform monitors human–machine interactions to classify manufacturing machine states for proper operations and energy productivity. Internal energy states of individual or collections of manufacturing equipment are determined via NN based algorithms that disaggregate signals associated with smart metering typically deployed at manufacturing facilities. These methods predict the real time energy profile of each machine from the total energy profile of a manufacturing site. For case four, a software defined sensor system built with scientific workflow engines is demonstrated for contextualizing data from laser surface refraction for characterization, and diagnostics in the processing of additively manufactured titanium alloy.

在本文中,我们通过实施四个指导性的现实世界用例,描述了智能制造的智能互联工作者(SCW)边缘平台的具体部署,这些用例说明了人在智能制造范式中的作用,通过这种范式,可负担、可扩展、可访问和便携式(ASAP)信息技术(IT)获取数据并将数据上下文化为信息,以便传输到操作技术(OT)。例如,在半导体制造过程中,当工人与机器交互时,该平台捕获能源消耗与人类工作流程之间的关系,以提高能源生产率。该平台利用人类认知来识别异常机器行为,通过神经网络(NN)对系统故障进行根本原因分析,神经网络可以识别带有摄像头的工作人员的报警姿势。对于案例二,演示了用于状态监控和故障检测的智能装配线。机器学习(ML)模型用于识别系统状态,并通过人为干预识别故障场景。对于案例三,平台监控人机交互,对制造机器状态进行分类,以实现正确的操作和能源生产率。单个或集合的制造设备的内部能量状态是通过基于神经网络的算法确定的,该算法分解了与智能计量相关的信号,这些信号通常部署在制造设施中。这些方法从制造现场的总能量分布预测每台机器的实时能量分布。在案例四中,演示了一个由科学工作流引擎构建的软件定义传感器系统,用于将激光表面折射的数据上下文化,以便在增材制造钛合金的加工过程中进行表征和诊断。
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引用次数: 2
Smart connected worker edge platform for smart manufacturing: Part 1—Architecture and platform design 面向智能制造的智能互联工人边缘平台:第1部分:架构和平台设计
Pub Date : 2022-05-22 DOI: 10.1002/amp2.10129
Yoon G. Kim, Richard P. Donovan, Yutian Ren, Shijie Bian, Tongzi Wu, Shweta Purawat, Anthony J. Manzo, Ilkay Altintas, Bingbing Li, Guann-Pyng Li

The challenge of sustainably producing goods and services for healthy living on a healthy planet requires simultaneous consideration of economic, societal, and environmental dimensions in manufacturing. Enabling technology for data driven manufacturing paradigms like Smart Manufacturing (a.k.a. Industry 4.0) serve as the technological backbone from which sustainable approaches to manufacturing can be implemented. Unfortunately, these technologies are typically associated with broader and deeper factory automation that is often too expensive and complex for the small and medium sized manufacturers (SMMs) that comprise the majority of manufacturing business in the USA and for whom their most valuable asset are the people whose jobs automation while replace. This paper describes an edge intelligent platform to integrate internet-of-things technologies with computing hardware, software, computational workflows for machine learning, and data ingestion, enabling SMMs to transition into smart manufacturing paradigms by leveraging the intelligence of their people. The platform leverages consumer grade electronics and sensors (affordable and portable), customized software with open source software packages (accessible), and existing communication network infrastructures (scalable). The software systems are implemented via Kubernetes orchestration of Docker containerization to ensure scalability and programmability. The platform is adaptive via computational workflow engines that produce information from data by processing with low-cost edge computing devices while efficiently accessing resources of cloud servers as needed. The proposed edge platform connects workers to technological resources that provide computational intelligence (i.e., silicon-based sensing and computation for data collection and contextualization) to enable decision making at the edge of advanced manufacturing.

为了在一个健康的地球上实现健康生活,可持续地生产商品和服务,这一挑战要求在制造业中同时考虑经济、社会和环境方面的因素。智能制造(又称工业4.0)等数据驱动制造范式的使能技术是实施可持续制造方法的技术支柱。不幸的是,这些技术通常与更广泛和更深层次的工厂自动化相关联,对于中小型制造商(smm)来说,这通常过于昂贵和复杂,而中小型制造商(smm)构成了美国制造业的大部分,对他们来说,他们最有价值的资产是自动化正在取代的工作人员。本文描述了一个边缘智能平台,将物联网技术与计算硬件、软件、用于机器学习的计算工作流程和数据摄取集成在一起,使中小企业能够通过利用员工的智慧过渡到智能制造范式。该平台利用了消费级电子产品和传感器(可负担且便携)、带有开源软件包的定制软件(可访问)以及现有的通信网络基础设施(可扩展)。软件系统通过Docker容器化的Kubernetes编排实现,以确保可扩展性和可编程性。该平台通过计算工作流引擎进行自适应,该引擎通过低成本边缘计算设备处理数据产生信息,同时根据需要有效访问云服务器的资源。提议的边缘平台将工人连接到提供计算智能的技术资源(即用于数据收集和情境化的基于硅的传感和计算),以实现先进制造边缘的决策。
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引用次数: 0
First principles of smart manufacturing 智能制造的第一原则
Pub Date : 2022-05-13 DOI: 10.1002/amp2.10123
Conrad Leiva

The democratizing of innovation and technology happens when tools and expertise are made affordable and accessible at scale to most manufacturers. To realize the democratization of smart manufacturing innovation, it is not only necessary to democratize the technology, but also necessary to provide wide access to the knowledge required to implement the strategies and leverage the solutions and insights in a more digitally enabled manufacturing ecosystem. We are at a point in the journey where it is time to converge on a concrete set of guiding principles and a framework that organizes expectations and requirements for the implementation of smart manufacturing. This paper summarizes the practices that define smart manufacturing as developed by the industry leaders, early adopters, and expert practitioners working in the ecosystem at CESMII, the smart manufacturing institute. In smart manufacturing, organizations, people, and technology work in synergy via processes and technology-based solutions that follow these seven First Principles: Flat & real-time, open & interoperable, proactive & semi-autonomous, sustainable & energy efficient, secure, scalable, orchestrated & resilient. All the design principles must be considered to fully realize the vision for smart manufacturing. This paper will further explain how the seven principles work collectively to achieve new levels of connectivity, intelligence, and automation in the manufacturing ecosystem.

当工具和专业知识对大多数制造商来说都是负担得起的,并且可以大规模使用时,创新和技术的民主化就会发生。为了实现智能制造创新的民主化,不仅需要实现技术的民主化,还需要提供实施战略所需的广泛知识,并在更加数字化的制造生态系统中利用解决方案和见解。我们正处在这样一个阶段,是时候集中制定一套具体的指导原则和框架,组织实施智能制造的期望和要求。本文总结了定义智能制造的实践,这些实践是由行业领导者、早期采用者和在智能制造研究所CESMII的生态系统中工作的专家从业者开发的。在智能制造中,组织、人员和技术通过遵循以下七个首要原则的流程和基于技术的解决方案协同工作:实时、开放;可互操作的、主动的&;半自主、可持续的& &;节能,安全,可扩展,精心策划& &;有弹性。为了充分实现智能制造的愿景,必须考虑所有的设计原则。本文将进一步解释这七项原则如何共同发挥作用,以实现制造业生态系统中连接、智能和自动化的新水平。
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引用次数: 3
Process prediction and detection of faults using probabilistic bidirectional recurrent neural networks on real plant data 基于真实工厂数据的概率双向递归神经网络过程预测和故障检测
Pub Date : 2022-05-09 DOI: 10.1002/amp2.10124
Lucky E. Yerimah, Sambit Ghosh, Yajun Wang, Yanan Cao, Jesus Flores-Cerrillo, B. Wayne Bequette

Attaining Industry 4.0 for manufacturing operations requires advanced monitoring systems and real-time data analytics of plant data, among other topics. We propose a probabilistic bidirectional recurrent network (PBRN) for industrial process monitoring for the early detection of faults. The model is based on a gated recurrent unit (GRU) neural network that allows the model to retain long-term dependencies between sensor data along a time horizon, hence learning the dynamic behavior of the process. To reduce the false-positive detection rate of the model, we compel the model to learn from a highly noisy sensor reading while outputting noise-free sensor outputs. The performance of the proposed model is compared with other data-driven statistical process monitoring schemes using real plant data from an industrial air separations unit (ASU) containing noisy sensor readings. We show that the model can learn from noisy data without reducing its performance. Using two different fault cases, we demonstrate the model's ability to carry out early fault detection with average false-positive rates of 2.9% and 4.9% for both fault cases. The missed detection rates are 0.1% and 0.2%, respectively.

实现制造业运营的工业4.0需要先进的监控系统和工厂数据的实时数据分析等主题。提出了一种用于工业过程监测的概率双向循环网络(PBRN),用于故障的早期检测。该模型基于门控循环单元(GRU)神经网络,该网络允许模型沿时间范围保留传感器数据之间的长期依赖关系,从而学习过程的动态行为。为了降低模型的假阳性检测率,我们迫使模型从高噪声的传感器读数中学习,同时输出无噪声的传感器输出。采用含噪声传感器读数的工业空气分离装置(ASU)的真实工厂数据,将所提出模型的性能与其他数据驱动的统计过程监测方案进行了比较。我们证明了该模型可以在不降低其性能的情况下从噪声数据中学习。使用两种不同的故障案例,我们证明了该模型进行早期故障检测的能力,两种故障案例的平均假阳性率分别为2.9%和4.9%。漏检率分别为0.1%和0.2%。
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引用次数: 4
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Journal of advanced manufacturing and processing
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