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Tri-fold process integration leveraging high- and low-temperature plasmas: From biomass to fertilizers with local energy and for local use 利用高温和低温等离子体的三重工艺集成:从生物质到当地能源和当地使用的肥料
Pub Date : 2021-03-14 DOI: 10.1002/amp2.10081
Mohammad M. Sarafraz, Nam N. Tran, Hung Nguyen, Laurent Fulcheri, Rachel Burton, Peter Wadewitz, Gregory Butler, Lawrence Kirton, Volker Hessel

In the present study, a series of thermochemical equilibrium modeling was conducted to assess the thermodynamic potential of biomass conversion to ammonia using thermal and nonthermal plasma at small- and large-scale production. The system was designed and evaluated for five different locations in Australia including the Northern Territory, South Australia, Western Australia, and New South Wales using local biomass feedstock. The equilibrium modeling showed that the pathway of biomass to biomethane using an anaerobic digestion reactor, biomethane to hydrogen using a thermal plasma reactor, followed by conversion of hydrogen to ammonia via a nonthermal plasma reactor is a plausible route, by which the exergy efficiency of the process can be as high as ~60%. It is identified that the thermal plasma reactor required two distinct zones at 3000°C < T < 4000°C and 1500°C < T < 2500°C. The first zone aims at converting electric energy into very high temperature thermal flow while the second one enables to split methane molecules into solid carbon and hydrogen. The new ammonia process is also assessed from the viewpoint of the current industrial transformation, being accelerated by the post-COVID economy, which moves toward local, resilient, integrated and self-sufficient production under the umbrella of an emerging fractal economy. With respect to local production, the developed process is designed for a quick response to farm use and on-time production in view of the demands of modern ICT-sensor based precision agriculture. The proposed process was found to be flexible (“resilient”) against production scale, geographical location, price and type of feedstock, and source of renewable energy. The system was found to be flexible against different feedstock such as spent grape marc, mustard seed, bagasse, piggery and poultry. The system can be self-sustained up to ~80% at T = 3500°C; with the thermal plasma reactor-zone 2 producing the electricity requirements for the nonthermal plasma via a steam turbine power block. Finally, the system it is investigated to which degree the system is adaptable to local production, self-sufficient, and circulatory.

在本研究中,进行了一系列热化学平衡建模,以评估在小型和大型生产中使用热等离子体和非热等离子体将生物质转化为氨的热力学潜力。该系统针对澳大利亚的五个不同地点进行了设计和评估,包括北领地、南澳大利亚、西澳大利亚,和新南威尔士州使用当地生物质原料。平衡模型表明,使用厌氧消化反应器将生物质转化为生物甲烷气,使用热等离子体反应器将生物甲烷气转化为氢气,然后通过非热等离子反应器将氢气转化为氨的途径是可行的,通过该方法,该过程的火用效率可以高达~60%。已经确定,热等离子体反应器在3000°C时需要两个不同的区域 <; T <; 4000°C和1500°C <; T <; 2500°C第一个区域旨在将电能转化为非常高温的热流,而第二个区域则能够将甲烷分子分解为固体碳和氢气。新的氨工艺也从当前工业转型的角度进行了评估,新冠疫情后的经济加速了这一转型,新兴分形经济保护伞下的综合自给生产。就本地生产而言,鉴于现代基于ICT传感器的精准农业的需求,所开发的工艺是为快速响应农场使用和准时生产而设计的,地理位置、原料的价格和类型以及可再生能源。该系统对不同的原料(如废葡萄渣、芥子、甘蔗渣、养猪场和家禽)具有灵活性。在T=3500°C时,该系统可自我维持约80%;热等离子体反应器2区通过蒸汽轮机功率块产生非热等离子体的电力需求。最后,对该系统进行了研究,研究了该系统在多大程度上适应本地生产、自给自足和循环
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引用次数: 12
A metamodeling approach for the simulation of energy and media demand for the brewing industry 酿造工业能源和媒体需求模拟的元建模方法
Pub Date : 2021-03-12 DOI: 10.1002/amp2.10080
Raik M. Bär, Tobias Voigt

Due to economic, social and technical trends, as well as rising energy costs, the food and beverage industry is challenged to work energy-efficiently. Small and medium-sized enterprises in particular lack of both time and knowledge to identify and implement suitable energy efficiency measures. With the help of simulation, decision-makers can pursue numerous approaches and make well-founded decisions. A metamodel based on four modeling pillars (physical-, process-, article/recipe-, and production plan model) for an entire production system concerning the forecast of energy and media consumption is presented. The metamodel is implemented in a user-friendly modeling tool, which enables a simple hybrid modeling without prequalification of the user. Subsequently, a standardized data exchange file, as basis for a simulation model, is generated. For validation, various use cases were modeled and the tool was validated using a systematic test. In addition, two simulation studies were performed to show that the presented approach provides the opportunity to create a holistic model in terms of forecasting energy and media consumption.

由于经济、社会和技术的发展趋势,以及不断上升的能源成本,食品和饮料行业面临着节能工作的挑战。中小型企业尤其缺乏时间和知识来确定和实施适当的能源效率措施。在模拟的帮助下,决策者可以采用多种方法并做出有充分根据的决策。提出了一种基于物理模型、过程模型、产品/配方模型和生产计划模型的元模型,用于预测整个生产系统的能源和介质消耗。该元模型是在一个用户友好的建模工具中实现的,该工具支持简单的混合建模,而无需对用户进行预认证。随后,生成一个标准化的数据交换文件,作为仿真模型的基础。为了验证,对各种用例进行了建模,并使用系统测试验证了该工具。此外,进行了两项模拟研究,以表明所提出的方法提供了在预测能源和媒体消耗方面创建整体模型的机会。
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引用次数: 2
Solvent extraction process design using deep reinforcement learning 使用深度强化学习的溶剂提取工艺设计
Pub Date : 2021-03-08 DOI: 10.1002/amp2.10079
Siby Jose Plathottam, Blake Richey, Gregory Curry, Joe Cresko, Chukwunwike O. Iloeje

Many chemical manufacturing and separations processes like solvent extraction comprise hierarchically complex configurations of functional process units. With increasing complexity, strategies that rely on heuristics become less reliable for design optimization. In this study, we explore deep reinforcement learning for mapping the space of feasible designs to find an optimization strategy that can match or exceed the performance of conventional optimization. To this end, we implement a highly configurable learning environment for the solvent design process to which we can couple state-of-the-art deep reinforcement learning agents. We evaluate the trained agents against the heuristic optimization for the solvent process design tasked to optimize recovery efficiency and product purity. Results demonstrated the agent successfully learned the strategy for predicting comparably optimal solvent extraction process designs for varying combinations of feed compositions.

许多化学制造和分离过程,如溶剂提取,包括功能过程单元的层次结构复杂。随着复杂性的增加,依赖启发式的策略在设计优化方面变得不那么可靠。在这项研究中,我们探索了用于映射可行设计空间的深度强化学习,以找到一种可以匹配或超过传统优化性能的优化策略。为此,我们为溶剂设计过程实现了一个高度可配置的学习环境,我们可以将最先进的深度强化学习代理与之耦合。我们针对溶剂工艺设计的启发式优化来评估经过训练的试剂,该溶剂工艺设计旨在优化回收效率和产品纯度。结果表明,该试剂成功地学习了预测不同原料成分组合的相对最佳溶剂萃取工艺设计的策略。
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引用次数: 5
Sustainable production and the role of digital twins–Basic reflections and perspectives 可持续生产与数字双胞胎的作用——基本思考和展望
Pub Date : 2021-02-18 DOI: 10.1002/amp2.10078
Robert Miehe, Lara Waltersmann, Alexander Sauer, Thomas Bauernhansl

Sustainable production is essential for the future of the global economy. Despite the publication of its baseline vision over 30 years ago and the resulting diversity of interpretations and subdisciplines in engineering and social sciences, the progress of the approach in industrial practice remains marginal. This is mainly due to the fact that the discipline has not yet succeeded to realize the magnitude of the rethinking necessary of its very own perception as a whole. Existing definitions of sustainable production presented to date are thus only partly consistently derived from the baseline concept. Meanwhile, digitalization provides an increasing number of technologies that offer a new perspective on sustainable production. This especially applies to the concept of digital twins. Recent studies, thus, address their role in the context of sustainable production by analyzing its contribution to existing sustainability related methods as well as technical challenges on a microeconomic level (bottom-up approach). Although these approaches provide concrete requirements for technical deployment, it is highly questionable how they will contribute to sustainable production as a whole. In this paper, we choose a top-down approach to discuss the role of digital twins in the context of sustainable production. Based on fundamental reflections on the baseline concept of sustainability, we advocate a reorientation of production within the framework of planetary boundaries. Thereupon, we discuss the role of digital twins and digital threads and provide a number of requirements that future R&D needs to address for a future sustainability-oriented data-driven monitoring and regulation of production.

可持续生产对全球经济的未来至关重要。尽管其基线愿景在30多年前就已发表,工程和社会科学的解释和子学科也随之多样化,但该方法在工业实践中的进展仍然很缓慢。这主要是因为该学科尚未成功地意识到对其自身整体感知进行必要反思的重要性。因此,迄今为止提出的可持续生产的现有定义仅在一定程度上与基线概念相一致。与此同时,数字化提供了越来越多的技术,为可持续生产提供了新的视角。这尤其适用于数字双胞胎的概念。因此,最近的研究通过分析其对现有可持续性相关方法的贡献以及微观经济层面的技术挑战(自下而上的方法),探讨了它们在可持续生产中的作用。尽管这些方法为技术部署提供了具体要求,但它们将如何促进整个可持续生产,这是非常值得怀疑的。在本文中,我们选择了一种自上而下的方法来讨论数字双胞胎在可持续生产中的作用。基于对可持续性基线概念的基本思考,我们主张在行星边界的框架内重新调整生产方向。因此,我们讨论了数字双胞胎和数字线程的作用,并提供了未来研发需要解决的一些要求,以实现未来以可持续性为导向的数据驱动的生产监控和监管。
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引用次数: 15
Rapid pressure swing adsorption for small scale ammonia separation: A proof-of-concept 用于小型氨分离的快速变压吸附:概念验证
Pub Date : 2021-02-16 DOI: 10.1002/amp2.10077
Bosong Lin, I-Min Hsieh, Mahdi Malmali

In a typical Haber-Bosch process, a gas stream containing 15–20 mol% ammonia is obtained from the reactor effluent, and ammonia is then partially separated in a phase-changing condensation unit. When operating at lower pressure for distributed manufacturing, the single-pass conversion drops to less than 10 mol%, which makes the condensation more cost-intensive. A small adsorber is proposed for concentrating ammonia through rapid pressure swing adsorption (RPSA) that fits the small-scale processing. A mathematical model is developed to evaluate the feasibility of the RPSA process for ammonia separation with high recovery. The ideal adsorbed solution theory, based on the Freundlich single-component isotherm model, is proposed to predict binary isotherms for various commercially available adsorbents. The performance of the RPSA-assisted adsorber is then studied at different process conditions for concentrating ammonia. The effect of various operating variables such as exhaust flow rate, cycle time, and feed pressure, is investigated. The proposed numerical model shows that nearly pure ammonia can be continuously produced at optimized conditions, with more than 95% recovery. This low-pressure RPSA-assisted adsorber can be used to design modular ammonia devices for distributed manufacturing. Our proposed technology can be further extended to concentrate other dilute gas mixtures, such as carbon dioxide.

在典型的Haber Bosch工艺中,含有15–20 从反应器流出物中获得mol%的氨,然后在相变冷凝单元中部分分离氨。当在分布式制造的较低压力下操作时,单程转化率降至低于10 mol%,这使得冷凝更加成本密集。提出了一种适用于小规模工艺的小型吸附器,用于通过快速变压吸附(RPSA)浓缩氨。建立了一个数学模型来评估RPSA工艺用于高回收率氨分离的可行性。基于Freundlich单组分等温线模型,提出了理想吸附溶液理论,用于预测各种市售吸附剂的二元等温线。然后研究了RPSA辅助吸附器在不同氨浓缩工艺条件下的性能。研究了排气流量、循环时间和进料压力等各种操作变量的影响。所提出的数值模型表明,在优化的条件下,可以连续生产几乎纯的氨,回收率超过95%。这种低压RPSA辅助吸附器可用于设计用于分布式制造的模块化氨装置。我们提出的技术可以进一步扩展到浓缩其他稀释气体混合物,如二氧化碳。
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引用次数: 4
Computational fluid dynamics simulation of the roll-to-roll coating process for the production of thin film composite membranes including validation 薄膜复合膜生产中卷对卷涂覆过程的计算流体动力学模拟,包括验证
Pub Date : 2021-02-02 DOI: 10.1002/amp2.10076
Florian Brennecke, Juliana Clodt, Jan Pohlmann, Clarissa Abetz, Torsten Brinkmann, Volker Abetz

On the way toward a carbon-neutral economy, a rise in the demand for separation technologies can be expected. This holds especially for membranes, which are energy efficient and thus very promising technologies. However, this challenges membrane researchers to consider the sustainability and scalability of their membrane fabrication processes. At our institute, we employ a roll-to-roll coating process for the production of thin film composite membranes. This procedure is relatively easy to scale up and can be adapted for different polymers/solvents and thus applications. To increase the production efficiency and optimize the process for any polymer of interest, it is necessary to develop a solid understanding of the physics of this production system. Therefore, we would like to present a numerical model based on computational fluid dynamics that can predict the film thickness of a polydimethylsiloxane-based polymer coated in a roll-to-roll setup. In the future, this model should improve the production efficiency and fine-tuning of process parameters. We verify the numerical procedure with a mesh refinement study and validate the predicted film thicknesses with experimental results for different roll speeds and polymer concentrations. The predicted variability of the thickness is assessed by a design of experiments study and compares relatively well to the measured variations of the coated membrane thickness.

在迈向碳中和的经济的道路上,对分离技术的需求有望上升。这一点尤其适用于膜,因为膜是节能的,因此是非常有前景的技术。然而,这挑战了膜研究人员考虑其膜制造工艺的可持续性和可扩展性。在我们的研究所,我们采用辊对辊涂布工艺生产薄膜复合膜。该程序相对容易扩大规模,并可适用于不同的聚合物/溶剂,从而适用于各种应用。为了提高生产效率并优化任何感兴趣的聚合物的工艺,有必要对该生产系统的物理特性有深入的了解。因此,我们希望提出一个基于计算流体动力学的数值模型,该模型可以预测在辊对辊设置中涂覆的聚二甲基硅氧烷基聚合物的膜厚度。未来,该模型应能提高生产效率和工艺参数的微调。我们用网格细化研究验证了数值程序,并用不同辊速和聚合物浓度的实验结果验证了预测的膜厚度。通过实验研究的设计来评估厚度的预测变异性,并将其与涂膜厚度的测量变异性进行比较。
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引用次数: 1
Industry 4.0 digital transformation conference: Has the pandemic accelerated digital transformation? 工业4.0数字化转型大会:疫情是否加速了数字化转型?
Pub Date : 2020-12-30 DOI: 10.1002/amp2.10075
Michael Rinker, Chaitanya Khare, Sachin Padhye, Katie Fayman

AIChE's Advanced Manufacturing and Processing Society held its second annual “Industry 4.0 Digital Transformation Conference” on December 8. The premise of this year's virtual conference was to focus on how COVID-19 has disrupted manufacturing operations and supply chains across the US and globally. This conference explored the role of digital transformation and how that impacted manufacturing during the early days of the pandemic, how manufacturers reacted, and what the future may hold for manufacturing and continued digitalization. These topics were underpinned by a key note talk from 3 M on manufacturing of personal protective equipment (PPE) and a presentation by Sandoz, a Novartis company and how they have embraced the digital transformation in pharmaceutical development. There were two panel sessions that addressed questions about how digital transformation was accelerated during the onset of the pandemic and what the future will hold for ongoing digital transformation. Finally, a digital transformation roadmap discussion and short workshop were held to complete the conference.

A summary of each session follows.

Dr. Cristina Thomas's introduction of 3 M told us about a striking feature of innovation: “Curiosity is just the beginning.” As a major global company, 3 M has sales in nearly every country on the planet. They have recent sales of approximately $32 billion, employ over 96 000 people and have over 120 000 patents. 3-M has four business groups: Safety and Industrial, Transportation and Electronics, Healthcare, and Consumer. Those groups have been working together to address challenges resulting from the pandemic. While most people heard about the challenges of ramping up production for N95 respirators, 3 M also ramped up production of other solutions in response to COVID-19, for example, sanitizers and disinfectants.

One important aspect that 3 M works on is biopharmaceutical filtration. 3 M works with public-private manufacturing institutes like Manufacturing USA's RAPID. The current situation put biopharmaceutical filtration at the center for using the surface modification technology of membranes into speeding up the development of vaccines as well as therapies.

Digital platforms that are in use at 3-M include: Computer vision, Data science, Electronic systems, Modeling & Simulation, Advanced robotics, Sensors, and Software solutions. These digital capabilities augment material science and domain expertise.

The corporate research systems laboratory has five strategic platforms: Internet of Things (IOT), Edge Computing, Artificial Intelligence (AI), Modeling & Simulation, Visualization & Perception, and Data.

Dr. Vijay Rajamini of 3 M provided additional discussion regarding their PPE manufacturing response. There has been a tremendous surge for digital solutions to respiratory PPE challenges during the pandemic. Visualization as well as sharing of knowledge transfer of data and anal

例如,我们现在有虚拟会议/通信,这一事实允许对制造和加工设施中的“伙伴系统”进行修改,这样一个人可以带着头盔摄像头进入该区域,而他们的远程“伙伴”仍然可以虚拟地在那里,以便工厂可以运行。其他数字解决方案允许对建筑暖通空调系统的气流和过滤控制进行修改,以应对新的安全挑战。小组讨论了有关供应链中断的问题,以及本地/区域解决方案是否能减轻这些中断。许多公司迅速开始了供应链的多样化,以减轻获得所需材料的挑战。许多公司致力于增加库存,因为他们发现“准时制”的交付风险正在上升。制造商从了解COVID-19疫情可能发生的地方以及是否会对工人(对于局部疫情)或交付产生影响的角度,仔细考虑了制造和供应商的本地化。有人提出了关于大流行期间数据共享的问题。虽然制造商和供应商之间的数据共享无疑具有很高的价值,但供应商一直担心,为了保持竞争优势,他们的数据不会与另一个供应商共享。数据安全是一个持续的挑战,需要持续关注。该小组还讨论了与许多制造商,特别是中小型制造商加速数字化转型相关的劳动力和技能问题。对于具有制造和操作专业知识但不一定具有信息技术(IT)技能的工人来说,显然存在技能差距,反之亦然。诺华旗下山德士公司产品开发主管Subodh Deshmukh谈到了大流行如何加速药物开发。有人指出,虽然地塞米松和瑞德韦等现有药物正在重新用于治疗COVID-19,但正在利用人工智能方法开发其他药物,以针对潜在的COVID-19治疗方法。这推动了药物开发的前沿。会上还介绍了新药开发的细节,以及如何在整个行业中利用数字化转型。诺华致力于利用数据和数字技术重新构想药物开发。数字化转型正在影响他们业务的各个方面。它不仅涉及研发,还涉及扰乱市场、影响供应链、制造和人员实践,最重要的是文化变革。诺华已经开始了这一旅程,因此他们有一个很好的基线来利用COVID-19。该公司希望利用人类生物学知识和计算能力来寻找更好的药物。通过这种数字化方法,有三个重点领域:创新、运营和参与。十多年前,美国政府发起了一项倡议,后来被称为“美国制造网络”。美国制造业协会由16家公私机构组成,1家由美国商务部赞助,6家由能源部赞助,9家由国防部赞助。这些协会是会员制组织,汇集了近2000个组织,代表了各种规模的制造商、学术界、技术提供商、初创企业、政府实体等。每个研究所都专注于特定的先进制造技术领域,但都朝着同一个高水平目标努力:通过制造创新、教育和合作来确保美国的未来。工业4.0数字化转型会议召集了三位美国制造业代表,分别是来自MxD的Kym Wehrle、RAPID的Ignasi Palou-Rivera和CESMII的Jim Davis,并请他们预测2019冠状病毒病危机后制造业的未来走向。小组成员一致认为,供应链可见性将是未来几年制造业的关键资产,但在这一领域仍有大量工作要做。一些行业,特别是包装消费品和制药公司,在疫情期间需求急剧上升;其他行业,如航空航天和国防,与新冠疫情前的需求保持一致。然而,由于供应链中断,每个行业都面临着满足其生产需求的挑战。利用数字解决方案来提高整个供应链的可见性和透明度,将有助于制造商在未来避免类似的挑战。我们的专家之间也多次提到数据共享。毫无疑问,数据共享将成为未来制造业的主要内容。 目前看来,很多制造商似乎还在努力掌握数据的收集,确保他们在运营中收集的数据是“正确的”。在此基础上,制造商需要将数据转换为上下文和可用的格式,以便提供更有洞察力的分析。最后,小组成员相信,制造业的未来——从设计到生产,再到供应链管理——将会越来越数字化和自动化。从劳动力的角度来看,必须注意的是,自动化和数字化不一定会导致失业,而是将资源重新分配到对工人更安全的角色上。最终,制造业的态度发生了变化。在新冠肺炎之前,许多制造商将先进制造技术视为一种选择。现在,他们似乎开始把先进的制造技术视为一种主食,往好了说,这将提高他们的效率和竞争力,往坏了说,这将使他们在下一次危机中得以生存。来自Infosys的Ravi Kumar、Sachin Padhye、Saibal Samaddar和Shatam Bhattacharyya主持了一个关于流程工业数字化转型路线图的研讨会。Ravi Kumar博士通过对工业4.0的看法拉开了研讨会的序幕。他强调了信息技术(IT)和操作技术(OT)的整合,其中网络系统与物理系统更紧密地结合在一起。这种数字化转型发生在整个价值链上,垂直从供应链到制造再到企业资源规划系统,横向从供应商到制造商再到客户。网络物理系统、设备传感器、无缝互操作性、先进自动化和控制、大数据和分析技术的进步正在推动这一转型。这种转变将IT、OT和工程技术(ET)结合起来。印孚瑟斯在2015年对美国、欧洲和亚太地区的制造商进行了调查,以评估他们在工业4.0之旅中的地位。只有15%的受访者制定了与工业4.0相关的战略。所有受访者都希望采用工业4.0来开发互联产品和服务,并提高效率。2017年,重点是提高制造业的生产率绩效管理,重点是质量管理。可持续性和能源效率是2018年的重点关注领域。2019年和2020年的重点转向使用远程技术进行协助、指导、数字孪生、自动化和低触摸或无触摸。COVID-19加速了这一转变。这使得整个价值链的利润率和效率提高了8%至40%。世界经济论坛在其报告中引用了几个例子来概述这些成果。成立于德国科学与工程院的Acatech和印孚瑟斯开发了一个模型来衡量工业4.0的成熟度。这个模型有六个成熟度级别。前两个层次是计算机化和连接,是工业3.0的一部分。就成熟度而言,其他四个级别是可见性(仪表板)、透明度(什么、为什么、如何)、可预测性(将发生什么)和适应性(自我纠正机制)。资源、信息系统、组织结构和文化支持成熟度模型。生物制药等其他行业也有类似的成熟度衡量标准。总之,制造商正在利用工业4.0,这将导致未来的工厂,其中IT-OT集成是从工厂生成数据以提高收入和底线的基础。Saibal Samaddar概述了开始和继续工业4.0之旅的设计思维(DT)过程。DT是一种解决问题的方法,关注从车间到高管层的最终用户。它应用以人为中心的设计,以迭代的方式解决问题。DT依靠跨职能团队通过列出挑战来定义“共情”阶段的问题。这些挑战被分组,“我们该如何做”的问题被要求构思解决方案。对解决方案进行测试和原型化,并进行缩放或重新访问。总之,与工业4.0路线图相关的最大挑战是评估投资回报率(ROI),创建适合采用的文化,以及保持势头。Ravi Kumar博士为解决这些挑战提供了一些见解,包括为绿地和棕地方案设计流程,利用变更管理,从小做起,扩大规模。Chaitanya Khare:写作-原稿。Sachin Padhye:写作——原稿。凯蒂·费曼:写作——原稿。
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引用次数: 5
The scaling economics of small unit operations 小单位操作的规模经济
Pub Date : 2020-12-13 DOI: 10.1002/amp2.10074
Robert S. Weber, Jalal A. Askander, John A. Barclay

We present a correlation that represents the capital costs of the components of even very small modular facilities. Conversion of distributed feedstocks (eg, associated natural gas, biomass, and carbonaceous wastes) could provide a small fraction of the liquid fuels now used for transportation in the U.S. (~6%), or nearly half of the chemical products now made from petroleum. However, those resources tend to be available at small geographically distributed sites, and they are difficult or expensive to transport to a distant processing center. Modular, and likely intensified, processes that can be numbered up promise to enable utilizing such distributed resources. Early stage economics evaluation of those processes requires cost estimates for the components, which are likely smaller in scale than can be accommodated by the 0.6 power law typically used in chemical engineering.

我们提出了一个相关性,它代表了即使是非常小的模块化设施的组件的资本成本。分布式原料(如伴生天然气、生物质和含碳废物)的转化可以提供美国目前用于运输的液体燃料的一小部分(约6%),或者现在由石油制成的化学产品的近一半。然而,这些资源往往在地理上分散的小站点上可用,并且很难或昂贵地将它们运输到远程处理中心。模块化的,可能是强化的,可以编号的过程保证能够利用这种分布式资源。这些过程的早期经济评估需要对组件进行成本估算,这些组件的规模可能比化学工程中通常使用的0.6次方律所能容纳的要小。
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引用次数: 1
Conceptual design of chemical devices 化学装置的概念设计
Pub Date : 2020-11-11 DOI: 10.1002/amp2.10073
Elliot Ngou-Tin Ho, Ka Yip Fung, Christianto Wibowo, Xiang Zhang, Ka Ming Ng

Chemical devices are chemical products that transform a feed stream into an outlet stream with the desired attributes by performing reaction, fluid flow, heating, cooling, and/or separations. They resemble small chemical plants and can be described by device flowsheets, similar to the process flowsheets of chemical plants. This article proposes a generic design framework for chemical devices. It shares some steps with Douglas' hierarchical design procedure for chemical processes but has its own distinguishing features such as capturing of consumer preferences, formulation of an engineering statement, and the use of unconventional processing techniques in device manufacturing. Two examples, domestic dehumidifier and air purifier, are discussed to illustrate the design framework. A new dehumidifier design was found using this framework.

化学装置是通过进行反应、流体流动、加热、冷却和/或分离将进料流转化为具有所需属性的出口流的化学产品。它们类似于小型化工厂,可以用装置流程图来描述,类似于化工厂的工艺流程图。本文提出了一个通用的化学装置设计框架。它与道格拉斯的化学工艺分级设计程序有一些共同的步骤,但有自己的显著特点,如捕捉消费者偏好、制定工程声明,以及在设备制造中使用非常规加工技术。以国产除湿机和空气净化器为例,阐述了其设计框架。一种新的除湿器设计是使用这个框架。
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引用次数: 0
AIChE PD2M Advanced Process Control workshop-moving APC forward in the pharmaceutical industry AIChE PD2M先进过程控制研讨会推动APC在制药行业的发展
Pub Date : 2020-11-03 DOI: 10.1002/amp2.10071
Jun Huang, Thomas O'Connor, Kaschif Ahmed, Sharmista Chatterjee, Chris Garvin, Krishna Ghosh, Marianthi Ierapetritou, Malcolm Jeffers, David Lauri Pla, Sau L. Lee, David Lovett, Olav Lyngberg, John Mack, Eoin McManus, Saly Romero-Torres, Cenk Undey, Venkat Venkatasubramanian, Martin Warman

This whitepaper summarizes the outcome of the first Advanced Process Control (APC) workshop in the pharmaceutical industry, presented by AIChE PD2M, and held in Washington DC, Sep 30 to Oct 01, 2019. Approximately 50 attendees from regulatory agencies, industry and academia had an opportunity to share perspectives and best practices on the business, technical and regulatory aspects of APC for both small and large molecule drug manufacturing. The event consisted of keynote talks, case studies and panel discussions, filled with lively interactions that focused on: (a) Business drivers for APC in pharma; (b) Alignment on the definitions of key terminology; (c) Clarification of roles and relationships of APC with regards to popular initiatives such as Quality by Design (QbD), Process Analytical Technology (PAT), Real Time Release testing (RTRt), Continued Process Verification (CPV), continuous manufacturing and digital manufacturing; (d) APC manufacturing implementation considerations; (e) Quality system and regulatory considerations for APC implementation; (f) APC opportunities in modular manufacturing, process intensification, integrated continuous manufacturing. (g) standards, training, and collaboration.

本白皮书总结了由AIChE PD2M于2019年9月30日至10月1日在华盛顿特区举办的制药行业第一届先进过程控制(APC)研讨会的成果。来自监管机构、行业和学术界的约50名与会者有机会分享APC在小分子和大分子药物制造的商业、技术和监管方面的观点和最佳实践。该活动包括主题演讲、案例研究和小组讨论,充满了生动的互动,重点是:(a)制药APC的商业驱动因素;(b) 关键术语定义的一致性;(c) 澄清APC在设计质量(QbD)、工艺分析技术(PAT)、实时发布测试(RTRt)、持续工艺验证(CPV)、连续制造和数字化制造等流行举措方面的作用和关系;(d) APC制造实施注意事项;(e) APC实施的质量体系和监管考虑;(f) APC在模块化制造、工艺强化、集成连续制造方面的机会。(g) 标准、培训和协作。
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引用次数: 3
期刊
Journal of advanced manufacturing and processing
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