首页 > 最新文献

Ernst Schering Foundation symposium proceedings最新文献

英文 中文
In vitro and in vivo characterization of a novel nonsteroidal, species-specific progesterone receptor modulator, PRA-910. 一种新型非甾体、物种特异性黄体酮受体调节剂PRA-910的体外和体内表征。
Z Zhang, S G Lundeen, O Slayden, Y Zhu, J Cohen, T J Berrodin, J Bretz, S Chippari, J Wrobel, P Zhang, A Fensome, R C Winneker, M R Yudt

The progesterone receptor (PR) is an important regulator of female reproduction. Consequently, PR modulators have found numerous pharmaceutical utilities in women's reproductive health. In the process of identifying more receptor-specific and tissue-selective PR modulators, we discovered a novel nonsteroidal, 6-aryl benzoxazinone compound, PRA-910, that displays unique in vitro and in vivo activities. In a PR/PRE reporter assay in COS-7 cells, PRA-910 shows potent PR antagonist activity with an IC50 value of approximately 20 nM. In the alkaline phosphatase assay in the human breast cancer cell line T47D, PRA-910 is a partial progesterone antagonist at low concentrations and is also an effective PR agonist at higher concentrations (EC50 value of approximately 700 nM). PRA-910 binds to the human PR with high affinity (Kd = 4 nM) and was previously shown to exhibit greater than 100-fold selectivity for the PR versus other steroid receptors. In the adult ovariectomized rat, PRA-910 is a potent PR antagonist. It inhibits progesterone-induced uterine decidual response with an ED50 value of 0.4 mg/kg, p.o., and reverses progesterone suppression of estradiol-induced complement C3 expression with potency similar to RU-486. In the nonhuman primate, however, PRA-910 is a PR agonist. The effect on endometrial histology strongly resembles that of progesterone. This unique compound also suppresses estradiol-induced epithelial cell proliferation and both estrogen and progesterone receptor expression in the uterine endometrium as a PR agonist would. In summary, PRA-910 is a structurally and biologically novel selective PR modulator with either PR agonist or antagonist activity, depending on context, concentration, and species.

孕激素受体(PR)是女性生殖的重要调节因子。因此,PR调节剂在妇女生殖健康方面发现了许多医药用途。在鉴定更多受体特异性和组织选择性PR调节剂的过程中,我们发现了一种新的非甾体,6-芳基苯并杂嗪酮化合物PRA-910,它在体外和体内都具有独特的活性。在COS-7细胞的PR/PRE报告细胞实验中,PRA-910显示出有效的PR拮抗剂活性,IC50值约为20 nM。在人乳腺癌细胞系T47D的碱性磷酸酶试验中,PRA-910在低浓度下是部分黄体酮拮抗剂,在高浓度下也是有效的PR激动剂(EC50值约为700 nM)。PRA-910与人类PR具有高亲和力(Kd = 4 nM),并且先前显示对PR的选择性比其他类固醇受体高100倍。在切除卵巢的成年大鼠中,PRA-910是一种有效的PR拮抗剂。抑制黄体酮诱导的子宫蜕膜反应,ED50值为0.4 mg/kg, p.o,逆转黄体酮对雌二醇诱导的补体C3表达的抑制作用,其效价与RU-486相似。然而,在非人灵长类动物中,PRA-910是一种PR激动剂。对子宫内膜组织学的影响与黄体酮非常相似。这种独特的化合物还可以抑制雌二醇诱导的上皮细胞增殖以及子宫内膜中雌激素和孕激素受体的表达,就像PR激动剂一样。总之,PRA-910是一种结构和生物学上新颖的选择性PR调节剂,根据环境、浓度和物种的不同,具有PR激动剂或拮抗剂活性。
{"title":"In vitro and in vivo characterization of a novel nonsteroidal, species-specific progesterone receptor modulator, PRA-910.","authors":"Z Zhang,&nbsp;S G Lundeen,&nbsp;O Slayden,&nbsp;Y Zhu,&nbsp;J Cohen,&nbsp;T J Berrodin,&nbsp;J Bretz,&nbsp;S Chippari,&nbsp;J Wrobel,&nbsp;P Zhang,&nbsp;A Fensome,&nbsp;R C Winneker,&nbsp;M R Yudt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The progesterone receptor (PR) is an important regulator of female reproduction. Consequently, PR modulators have found numerous pharmaceutical utilities in women's reproductive health. In the process of identifying more receptor-specific and tissue-selective PR modulators, we discovered a novel nonsteroidal, 6-aryl benzoxazinone compound, PRA-910, that displays unique in vitro and in vivo activities. In a PR/PRE reporter assay in COS-7 cells, PRA-910 shows potent PR antagonist activity with an IC50 value of approximately 20 nM. In the alkaline phosphatase assay in the human breast cancer cell line T47D, PRA-910 is a partial progesterone antagonist at low concentrations and is also an effective PR agonist at higher concentrations (EC50 value of approximately 700 nM). PRA-910 binds to the human PR with high affinity (Kd = 4 nM) and was previously shown to exhibit greater than 100-fold selectivity for the PR versus other steroid receptors. In the adult ovariectomized rat, PRA-910 is a potent PR antagonist. It inhibits progesterone-induced uterine decidual response with an ED50 value of 0.4 mg/kg, p.o., and reverses progesterone suppression of estradiol-induced complement C3 expression with potency similar to RU-486. In the nonhuman primate, however, PRA-910 is a PR agonist. The effect on endometrial histology strongly resembles that of progesterone. This unique compound also suppresses estradiol-induced epithelial cell proliferation and both estrogen and progesterone receptor expression in the uterine endometrium as a PR agonist would. In summary, PRA-910 is a structurally and biologically novel selective PR modulator with either PR agonist or antagonist activity, depending on context, concentration, and species.</p>","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 1","pages":"171-97"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27487552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organocatalytic syntheses of bioactive natural products. 生物活性天然产物的有机催化合成。
Pub Date : 2007-01-01 DOI: 10.1007/2789_2007_066
M. Christmann
{"title":"Organocatalytic syntheses of bioactive natural products.","authors":"M. Christmann","doi":"10.1007/2789_2007_066","DOIUrl":"https://doi.org/10.1007/2789_2007_066","url":null,"abstract":"","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":"92 1","pages":"125-39"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85682404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Solving the IRAK-4 enigma: application of kinase-dead knock-in mice. 解决IRAK-4之谜:激酶死亡敲入小鼠的应用。
Pub Date : 2007-01-01 DOI: 10.1007/2789_2007_071
M. Koziczak-Holbro, C. Joyce, A. Glück, B. Kinzel, M. Müller, H. Gram
{"title":"Solving the IRAK-4 enigma: application of kinase-dead knock-in mice.","authors":"M. Koziczak-Holbro, C. Joyce, A. Glück, B. Kinzel, M. Müller, H. Gram","doi":"10.1007/2789_2007_071","DOIUrl":"https://doi.org/10.1007/2789_2007_071","url":null,"abstract":"","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":"114 1","pages":"63-82"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78654291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Steroid receptor coactivator 2: an essential coregulator of progestin-induced uterine and mammary morphogenesis. 类固醇受体共激活因子2:黄体酮诱导的子宫和乳腺形态发生的重要共调节因子。
Pub Date : 2007-01-01 DOI: 10.1007/2789_2007_057
A Mukherjee, P Amato, D Craig-Allred, F J DeMayo, B W O'Malley, J P Lydon

The importance of the progesterone receptor (PR) in transducing the progestin signal is firmly established in female reproductive and mammary gland biology; however, the coregulators preferentially recruited by PR in these systems have yet to be comprehensively investigated. Using an innovative genetic approach, which ablates gene function specifically in murine cell-lineages that express PR, steroid receptor coactivator 2 (SRC-2, also known as TIF-2 or GRIP-1) was shown to exert potent coregulator properties in progestin-dependent responses in the uterus and mammary gland. Uterine cells positive for PR (but devoid of SRC-2) led to an early block in embryo implantation, a phenotype not shared by knockouts for SRC-1 or SRC-3. In the case of the mammary gland, progestin-dependent branching morphogenesis and alveologenesis failed to occur in the absence of SRC-2, thereby establishing a critical coactivator role for SRC-2 in cellular proliferative programs initiated by progestins in this tissue. Importantly, the recent detection of SRC-2 in both human endometrium and breast suggests that this coregulator may provide a new clinical target for the future management of female reproductive health and/or breast cancer.

在女性生殖和乳腺生物学中,孕激素受体(PR)在孕激素信号转导中的重要性已经确立;然而,PR在这些系统中优先招募的共调节因子尚未得到全面的研究。利用一种创新的遗传方法,在表达PR的小鼠细胞系中特异性地消除基因功能,类固醇受体共激活因子2 (SRC-2,也称为TIF-2或GRIP-1)在子宫和乳腺的孕激素依赖性反应中发挥了有效的共调节特性。PR阳性的子宫细胞(但缺乏SRC-2)导致胚胎着床早期阻滞,这是SRC-1或SRC-3基因敲除所没有的表型。以乳腺为例,在缺乏SRC-2的情况下,孕激素依赖性分支形态形成和肺泡形成无法发生,从而确立了SRC-2在该组织中由孕激素启动的细胞增殖程序中的关键协同激活因子作用。重要的是,最近在人类子宫内膜和乳房中检测到SRC-2表明,这种共调节因子可能为未来女性生殖健康和/或乳腺癌的管理提供新的临床靶点。
{"title":"Steroid receptor coactivator 2: an essential coregulator of progestin-induced uterine and mammary morphogenesis.","authors":"A Mukherjee,&nbsp;P Amato,&nbsp;D Craig-Allred,&nbsp;F J DeMayo,&nbsp;B W O'Malley,&nbsp;J P Lydon","doi":"10.1007/2789_2007_057","DOIUrl":"https://doi.org/10.1007/2789_2007_057","url":null,"abstract":"<p><p>The importance of the progesterone receptor (PR) in transducing the progestin signal is firmly established in female reproductive and mammary gland biology; however, the coregulators preferentially recruited by PR in these systems have yet to be comprehensively investigated. Using an innovative genetic approach, which ablates gene function specifically in murine cell-lineages that express PR, steroid receptor coactivator 2 (SRC-2, also known as TIF-2 or GRIP-1) was shown to exert potent coregulator properties in progestin-dependent responses in the uterus and mammary gland. Uterine cells positive for PR (but devoid of SRC-2) led to an early block in embryo implantation, a phenotype not shared by knockouts for SRC-1 or SRC-3. In the case of the mammary gland, progestin-dependent branching morphogenesis and alveologenesis failed to occur in the absence of SRC-2, thereby establishing a critical coactivator role for SRC-2 in cellular proliferative programs initiated by progestins in this tissue. Importantly, the recent detection of SRC-2 in both human endometrium and breast suggests that this coregulator may provide a new clinical target for the future management of female reproductive health and/or breast cancer.</p>","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 1","pages":"55-76"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2007_057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27487610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Controlling the selectivity and stability of proteins by new strategies in directed evolution: the case of organocatalytic enzymes. 定向进化中的新策略控制蛋白质的选择性和稳定性:以有机催化酶为例。
M T Reetz

The directed evolution of functional enzymes as catalysts in organic reactions has emerged as a powerful method of protein engineering. This includes the directed evolution of enantioselective enzymes as pioneered by the author. In recent years the challenges in this new area of asymmetric catalysis has shifted to solving the problem of probing protein sequence space more efficiently than before. Iterative saturation mutagenesis (ISM) is one way of addressing this crucial question. This chapter reviews the concept of ISM and its application in controlling the enantioselectivity and thermostability of enzymes, specifically those that have an organocatalytic mechanism. Illustrative examples include the directed evolution of lipases, Baeyer-Villigerases and epoxide hydrolases.

功能酶作为有机反应催化剂的定向进化已成为蛋白质工程的一种有力方法。这包括作者开创的对映体选择性酶的定向进化。近年来,不对称催化这一新领域的挑战已经转移到解决比以前更有效地探测蛋白质序列空间的问题。迭代饱和诱变(ISM)是解决这一关键问题的一种方法。本章综述了ISM的概念及其在控制酶对映体选择性和热稳定性方面的应用,特别是那些具有有机催化机制的酶。说明性的例子包括脂肪酶、baeyer - villigerase和环氧化物水解酶的定向进化。
{"title":"Controlling the selectivity and stability of proteins by new strategies in directed evolution: the case of organocatalytic enzymes.","authors":"M T Reetz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The directed evolution of functional enzymes as catalysts in organic reactions has emerged as a powerful method of protein engineering. This includes the directed evolution of enantioselective enzymes as pioneered by the author. In recent years the challenges in this new area of asymmetric catalysis has shifted to solving the problem of probing protein sequence space more efficiently than before. Iterative saturation mutagenesis (ISM) is one way of addressing this crucial question. This chapter reviews the concept of ISM and its application in controlling the enantioselectivity and thermostability of enzymes, specifically those that have an organocatalytic mechanism. Illustrative examples include the directed evolution of lipases, Baeyer-Villigerases and epoxide hydrolases.</p>","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 2","pages":"321-40"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27547544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organocatalytic syntheses of bioactive natural products. 生物活性天然产物的有机催化合成。
M Christmann

The current scope and limitations of organocatalytic reactions and the consequences for the strategic planning of natural product syntheses are discussed. Examples from our group include the total synthesis of UCS1025A and lepidopteran sex pheromones.

讨论了目前有机催化反应的范围和局限性以及对天然产物合成战略规划的影响。我们小组的例子包括UCS1025A和鳞翅目性信息素的全合成。
{"title":"Organocatalytic syntheses of bioactive natural products.","authors":"M Christmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The current scope and limitations of organocatalytic reactions and the consequences for the strategic planning of natural product syntheses are discussed. Examples from our group include the total synthesis of UCS1025A and lepidopteran sex pheromones.</p>","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 2","pages":"125-39"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27548211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oncogenes meet metabolism. From deregulated genes to a broader understanding of tumour physiology. Preface. 致癌基因满足新陈代谢。从解除管制的基因到对肿瘤生理学更广泛的理解。前言。
Björn Riefke, Dominik Mumberg, Guido Kroemer, Hector Keun, Kirstin Petersen, Thomas Steger-Hartmann
{"title":"Oncogenes meet metabolism. From deregulated genes to a broader understanding of tumour physiology. Preface.","authors":"Björn Riefke,&nbsp;Dominik Mumberg,&nbsp;Guido Kroemer,&nbsp;Hector Keun,&nbsp;Kirstin Petersen,&nbsp;Thomas Steger-Hartmann","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 4","pages":"V-VII"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27690205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human metabolic phenotyping and metabolome wide association studies. 人类代谢表型与代谢组广泛关联研究。
Pub Date : 2007-01-01 DOI: 10.1007/2789_2008_096
E Holmes, J K Nicholson

Metabolic phenotyping in large-scale population studies can yield crucial information regarding the impact and interaction of genetic and environmental factors with regard to the prevalence and risk of chronic diseases. Spectroscopic technologies such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) can be used to generate multi-parameter profiles of biological samples and together with automated sample delivery and mathematical modelling systems, can be used as a high throughput screening tool. The adaptation of these metabolic profiling tools from pre-clinical studies in animal models to population studies in man is explored and an overview of the current and future roles of metabolic phenotyping is described, including the idea of "Metabolome Wide Association Screening" focussing on key disease areas such as cardiovascular disease and metabolic syndrome, cancers and neurodegeneration.

大规模人群研究中的代谢表型可以提供关于遗传和环境因素对慢性病患病率和风险的影响和相互作用的关键信息。核磁共振(NMR)光谱和质谱(MS)等光谱技术可用于生成生物样品的多参数剖面,并与自动样品输送和数学建模系统一起,可作为高通量筛选工具。这些代谢分析工具从动物模型的临床前研究到人类群体研究的适应性进行了探索,并概述了代谢表型的当前和未来作用,包括“代谢组全关联筛选”的想法,重点关注心血管疾病和代谢综合征、癌症和神经变性等关键疾病领域。
{"title":"Human metabolic phenotyping and metabolome wide association studies.","authors":"E Holmes,&nbsp;J K Nicholson","doi":"10.1007/2789_2008_096","DOIUrl":"https://doi.org/10.1007/2789_2008_096","url":null,"abstract":"<p><p>Metabolic phenotyping in large-scale population studies can yield crucial information regarding the impact and interaction of genetic and environmental factors with regard to the prevalence and risk of chronic diseases. Spectroscopic technologies such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) can be used to generate multi-parameter profiles of biological samples and together with automated sample delivery and mathematical modelling systems, can be used as a high throughput screening tool. The adaptation of these metabolic profiling tools from pre-clinical studies in animal models to population studies in man is explored and an overview of the current and future roles of metabolic phenotyping is described, including the idea of \"Metabolome Wide Association Screening\" focussing on key disease areas such as cardiovascular disease and metabolic syndrome, cancers and neurodegeneration.</p>","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 4","pages":"227-49"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2008_096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27691255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Sensing, presenting, and regulating PAMPs. 感知、呈现和调节PAMPs。
Pub Date : 2007-01-01 DOI: 10.1007/2789_2007_072
J. D. de Diego, G. Gerold, A. Zychlinsky
{"title":"Sensing, presenting, and regulating PAMPs.","authors":"J. D. de Diego, G. Gerold, A. Zychlinsky","doi":"10.1007/2789_2007_072","DOIUrl":"https://doi.org/10.1007/2789_2007_072","url":null,"abstract":"","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":"30 1","pages":"83-95"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75874939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Recoverable, soluble polymer-supported organic catalysts. 可回收、可溶聚合物负载的有机催化剂。
Pub Date : 2007-01-01 DOI: 10.1007/2789_2007_067
M. Benaglia
{"title":"Recoverable, soluble polymer-supported organic catalysts.","authors":"M. Benaglia","doi":"10.1007/2789_2007_067","DOIUrl":"https://doi.org/10.1007/2789_2007_067","url":null,"abstract":"","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":"145 1","pages":"299-319"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79944521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Ernst Schering Foundation symposium proceedings
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1