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CANCER PREDICTION IN INFLAMMATORY BOWEL DISEASE PATIENTS BY USING MACHINE LEARNING ALGORITHMS 利用机器学习算法预测炎症性肠病患者的癌症
IF 0.9 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2023-05-05 DOI: 10.4015/s1016237223500114
F. Moayedi, J. Karimi, Seyed Ebrahim Dashti
Colon cancer is one of the most common spread cancers in the world, which leads to total death of 10%. Prediction of onset of cancer, and the cause of its development in these patients can be of an enormous help and relief to those affected, as they can get back their “normal” life. Data mining and machine learning are important intelligent tools for classification, prediction and hidden relation extraction between patient information. We collected data from Shahid Faghihi Hospital in Shiraz. Features collected are as follows: Gender, age, duration of cancer before surgery, number of times the patients used bathroom, taking anti-inflammatory drug prednisolone, duration of drug use and dosage, kind of surgery and number of times consulted and retreatment of surgery, incontinence, etc. After pre-processing and data cleaning stages, effective features were extracted, and also occurrence of cancer predicts by using different classification algorithms. Then association rule mining algorithms like Apriori were used for obtaining any internal hidden relation between entries. Approaching them with different algorithms and assessing them with support vector machine was with highest prediction accuracy (84%). Due to unbalanced dataset, we chose cost sensitive support vector machine. In another aspect, after applying Apriori algorithm, the conditions of non-inflammation were extracted based on dataset features. Some significant outcomes are in what follows. If surgery treatment or diagnosed was less than 5 years, the possibility of developing colon cancer is lower. Also, as the duration of disease increases, the possibility of reoperation increases, as confirmed by the interiors. Since this issue with these features was raised for the first time in this paper at the suggestion of internists, early detection of cancer and also the extraction of effective laws can be of help to the medical community. In future, to get higher accuracy, the improvement of the dataset in terms of number of samples and colonoscopy image features is considered.
结肠癌是世界上最常见的扩散性癌症之一,导致总死亡率为10%。预测癌症的发病及其发展的原因对这些患者来说是一个巨大的帮助和缓解,因为他们可以恢复“正常”的生活。数据挖掘和机器学习是对患者信息进行分类、预测和隐藏关系提取的重要智能工具。我们从设拉子的Shahid Faghihi医院收集数据。收集的特征包括:性别、年龄、术前癌变持续时间、患者上厕所次数、是否服用消炎药强的松龙、用药持续时间及剂量、手术种类及会诊次数、手术再治疗、尿失禁等。经过预处理和数据清洗阶段,提取出有效特征,并通过不同的分类算法预测癌症的发生。然后使用Apriori等关联规则挖掘算法获取条目之间的任何内部隐藏关系。用不同的算法逼近它们并用支持向量机对它们进行评估,预测准确率最高(84%)。由于数据集不平衡,我们选择了代价敏感支持向量机。另一方面,在应用Apriori算法后,根据数据集特征提取非炎症条件。以下是一些重要的结果。如果手术治疗或确诊时间少于5年,患结肠癌的可能性较低。此外,正如内部证实的那样,随着疾病持续时间的增加,再次手术的可能性也在增加。由于本文是在内科医生的建议下第一次提出具有这些特点的问题,因此早期发现癌症并提取有效规律对医学界是有帮助的。未来,为了获得更高的准确性,将考虑在样本数量和结肠镜图像特征方面对数据集进行改进。
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引用次数: 0
EoG COMMUNICATION SIGNAL FOR SLEEP LEVEL DETECTION 为睡眠水平检测的EoG通信信号
IF 0.9 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2023-05-05 DOI: 10.4015/s1016237223500102
Nabil K. Al Shamaa, R. A. Fayadh, M. Wali
The detection of sleep is important because it contributes to most road accidents especially high levels of deep sleep while driving. Sleep detection is based on electrooculogram (EoG) signal as sleep causes various changes to this signal. Drivers travelling for long hours, especially those working under transportation field are more likely to sleep in the middle of their journey. In order to avoid this situation, drivers are aided with a system which is capable of monitoring the drivers’ condition depending on communication between the driving simulator and the subject EoG signal as many sleep detection devices are dependent upon eye behavior and movement in addition to pupil size and eye closure for certain periods. Therefore, to solve the problem of detecting sleep while driving, this work extracted different features from the EoG signal precisely from its frequency range (0–25[Formula: see text]Hz) and (25–37.5[Formula: see text]Hz) by discrete wavelet transform technique. In this research, 15 subjects have been set in a driving environment for more than 1[Formula: see text]h for collecting the sleep EoG signal data by low power sensors. The EoG signal is recorded using Cobra3 Data acquisition set and few features (minimum, maximum, mean, standard deviation (SD), mode, energy, median and variance) are extracted using discrete wavelet transform. These features have been used to classify three classes (sleep 0, sleep 0, sleep 1) using support vector machine (SVM). This classifier depends upon the fusion of the above features to get an accuracy of 78% for high-level sleep detection based on db4 wavelet.
睡眠检测很重要,因为它会导致大多数交通事故,尤其是开车时深度睡眠。睡眠检测是基于眼电图(EoG)信号,因为睡眠会引起该信号的各种变化。长时间开车的司机,尤其是在运输工地工作的司机,更有可能在旅途中睡觉。为了避免这种情况,驾驶员配备了一个系统,该系统能够根据驾驶模拟器和受试者EoG信号之间的通信来监控驾驶员的状态,因为许多睡眠检测设备除了瞳孔大小和特定时期的闭眼之外,还依赖于眼睛的行为和运动。因此,为了解决驾驶时睡眠的检测问题,本工作采用离散小波变换技术,从eeg信号的频率范围(0-25[公式:见文]Hz)和(25-37.5[公式:见文]Hz)精确提取不同特征。本研究将15名受试者置于1个以上的驾驶环境中[公式:见文]h,通过低功耗传感器采集睡眠眼动信号数据。使用Cobra3数据采集集记录EoG信号,并使用离散小波变换提取少量特征(最小值、最大值、平均值、标准差(SD)、模态、能量、中位数和方差)。使用支持向量机(SVM)将这些特征分类为三类(睡眠0,睡眠0,睡眠1)。该分类器基于以上特征的融合,得到了基于db4小波的高水平睡眠检测的78%的准确率。
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引用次数: 0
DUAL-SCALE CNN ARCHITECTURE FOR COVID-19 DETECTION FROM LUNG CT IMAGES 基于双尺度CNN架构的肺部ct图像COVID-19检测
IF 0.9 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2023-05-05 DOI: 10.4015/s1016237223500126
Alka Singh, V. Gopi, Anju Thomas, Omkar Singh
Coronavirus Disease 2019 (COVID-19) is a terrible illness affecting the respiratory systems of animals and humans. By 2020, this sickness had become a pandemic, affecting millions worldwide. Prevention of the spread of the virus by conducting fast tests for many suspects has become difficult. Recently, many deep learning-based methods have been developed to automatically detect COVID-19 infection from lung Computed Tomography (CT) images of the chest. This paper proposes a novel dual-scale Convolutional Neural Network (CNN) architecture to detect COVID-19 from CT images. The network consists of two different convolutional blocks. Each path is similarly constructed with multi-scale feature extraction layers. The primary path consists of six convolutional layers. The extracted features from multipath networks are flattened with the help of dropout, and these relevant features are concatenated. The sigmoid function is used as the classifier to identify whether the input image is diseased. The proposed network obtained an accuracy of 99.19%, with an Area Under the Curve (AUC) value of 0.99. The proposed network has a lower computational cost than the existing methods regarding learnable parameters, the number of FLOPS, and memory requirements. The proposed CNN model inherits the benefits of densely linked paths and residuals by utilizing effective feature reuse methods. According to our experiments, the proposed approach outperforms previous algorithms and achieves state-of-the-art results.
2019冠状病毒病(COVID-19)是一种影响动物和人类呼吸系统的可怕疾病。到2020年,这种疾病已成为一种流行病,影响着全世界数百万人。通过对许多嫌疑人进行快速检测来防止病毒传播已经变得困难。最近,许多基于深度学习的方法已经被开发出来,可以从肺部计算机断层扫描(CT)图像中自动检测COVID-19感染。本文提出了一种新的双尺度卷积神经网络(CNN)架构,用于CT图像的COVID-19检测。该网络由两个不同的卷积块组成。每条路径都类似地由多尺度特征提取层构建。主路径由六个卷积层组成。利用dropout技术对多路径网络提取的特征进行平面化处理,并将相关特征进行串联。使用sigmoid函数作为分类器来识别输入图像是否患病。该网络的准确率为99.19%,曲线下面积(AUC)值为0.99。该网络在可学习参数、FLOPS个数和内存需求方面比现有方法具有更低的计算成本。本文提出的CNN模型通过利用有效的特征重用方法继承了密集链接路径和残差的优点。根据我们的实验,所提出的方法优于以前的算法,并取得了最先进的结果。
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引用次数: 0
EFFECTIVENESS OF LEARNING RATE IN DEMENTIA SEVERITY PREDICTION USING VGG16 学习率在vgg16预测痴呆严重程度中的有效性
Q4 ENGINEERING, BIOMEDICAL Pub Date : 2023-05-04 DOI: 10.4015/s1016237223500060
Farhad Abedinzadeh Torghabeh, Yeganeh Modaresnia, Mohammad Mahdi khalilzadeh
Alzheimer’s disease (AD) is the leading worldwide cause of dementia. It is a common brain disorder that significantly impacts daily life and slowly progresses from moderate to severe. Due to inaccuracy, lack of sensitivity, and imprecision, existing classification techniques are not yet a standard clinical approach. This paper proposes utilizing the Convolutional Neural Network (CNN) architecture to classify AD based on MRI images. Our primary objective is to use the capabilities of pre-trained CNNs to classify and predict dementia severity and to serve as an effective decision support system for physicians in predicting the severity of AD based on the degree of dementia. The standard Kaggle dataset is used to train and evaluate the classification model of dementia. Synthetic Minority Oversampling Technique (SMOTE) tackles the primary problem with the dataset, which is a disparity across classes. VGGNet16 with ReduceLROnPlateau is fine-tuned and assessed using testing data consisting of four stages of dementia and achieves an overall accuracy of 98.61% and a specificity of 99% for a multiclass classification, which is superior to current approaches. By selecting appropriate Initial Learning Rate (ILR) and scheduling it during the training phase, the proposed method has the benefit of causing the model to converge on local optimums with better performance.
阿尔茨海默病(AD)是全球痴呆症的主要原因。这是一种常见的脑部疾病,严重影响日常生活,从中度到重度进展缓慢。由于不准确、缺乏敏感性和不精确,现有的分类技术尚未成为标准的临床方法。本文提出利用卷积神经网络(CNN)架构对基于MRI图像的AD进行分类。我们的主要目标是利用预训练cnn的能力来分类和预测痴呆症的严重程度,并作为一个有效的决策支持系统,帮助医生根据痴呆症的程度来预测AD的严重程度。使用标准的Kaggle数据集来训练和评估痴呆症的分类模型。合成少数派过采样技术(SMOTE)解决了数据集的主要问题,即不同类别之间的差异。使用ReduceLROnPlateau的VGGNet16使用由痴呆四个阶段组成的测试数据进行微调和评估,总体准确率为98.61%,多类别分类特异性为99%,优于目前的方法。通过选择合适的初始学习率(ILR)并在训练阶段调度,该方法可以使模型收敛到局部最优并具有更好的性能。
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引用次数: 0
HYBRID AI MODEL FOR THE DETECTION OF RHEUMATOID ARTHRITIS FROM HAND RADIOGRAPHS 用于手部x线片类风湿关节炎检测的混合ai模型
IF 0.9 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2023-04-28 DOI: 10.4015/s1016237223500096
R. Ahalya, U. Snekhalatha, Palani Thanaraj Krishnan
The study aims to develop a computerized hybrid model using artificial intelligence (AI) for the detection of rheumatoid arthritis (RA) from hand radiographs. The objectives of the study include (i) segmentation of proximal interphalangeal (PIP), and metacarpophalangeal (MCP) joints using the deep learning (DL) method, and features are extracted using handcrafted feature extraction technique (ii) classification of RA and non-RA participants is performed using machine learning (ML) techniques. In the proposed study, the hand radiographs are resized to [Formula: see text] pixels and pre-processed using the various image processing techniques such as sharpening, median filtering, and adaptive histogram equalization. The segmentation of the finger joints is carried out using the U-Net model, and the segmented binary image is converted to gray scale image using the subtraction method. The features are extracted using the Harris feature extractor, and classification of the proposed work is performed using Random Forest and Adaboost ML classifiers. The study included 50 RA patients and 50 normal subjects for the evaluation of RA. Data augmentation is performed to increase the number of images for U-Net segmentation technique. For the classification of RA and healthy subjects, the Random Forest classifier obtained an accuracy of 91.25% whereas the Adaboost classifier had an accuracy of 90%. Thus, the hybrid model using a Random Forest classifier can be used as an effective system for the diagnosis of RA.
该研究旨在利用人工智能(AI)开发一种计算机化混合模型,用于从手部x光片中检测类风湿性关节炎(RA)。该研究的目标包括(i)使用深度学习(DL)方法对近端指间关节(PIP)和掌指关节(MCP)关节进行分割,并使用手工特征提取技术提取特征(ii)使用机器学习(ML)技术对RA和非RA参与者进行分类。在本研究中,手部x光片被调整为像素,并使用锐化、中值滤波和自适应直方图均衡化等各种图像处理技术进行预处理。使用U-Net模型对手指关节进行分割,并使用减法将分割后的二值图像转换为灰度图像。使用Harris特征提取器提取特征,并使用Random Forest和Adaboost ML分类器对所提出的工作进行分类。本研究选取50例RA患者和50例正常受试者进行RA评价。数据增强是为了增加U-Net分割技术的图像数量。对于RA和健康受试者的分类,Random Forest分类器的准确率为91.25%,而Adaboost分类器的准确率为90%。因此,使用随机森林分类器的混合模型可以作为RA诊断的有效系统。
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引用次数: 0
A NEW COMPUTER-AIDED DIAGNOSIS OF PRECISE MALARIA PARASITE DETECTION IN MICROSCOPIC IMAGES USING A DECISION TREE MODEL WITH SELECTIVE OPTIMAL FEATURES 一种利用具有选择性最优特征的决策树模型在显微镜图像中精确检测疟疾寄生虫的计算机辅助诊断新方法
IF 0.9 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2023-04-27 DOI: 10.4015/s1016237223500047
Thanakorn Phumkuea, Phurich Nilvisut, T. Wongsirichot, Kasikrit Damkliang
Malaria is a life-threatening mosquito-borne disease. Recently, the number of malaria cases has increased worldwide, threatening vulnerable populations. Malaria is responsible for a high rate of morbidity and mortality in people all around the world. Each year, many people, die from this disease, according to the World Health Organization (WHO). Thick and thin blood smears are used to determine parasite habitation and computer-aided diagnosis (CADx) techniques using machine learning (ML) are being used to assist. CADx reduces traditional diagnosis time, lessens socio-economic impact, and improves quality of life. This study develops a simplified model with selective features to reduce processing power and further shorten diagnostic time, which is important to resource-constrained areas. To improve overall classification results, we use a decision tree (DT)-based approach with image pre-processing called optimal features to identify optimal features. Various feature selection and extraction techniques are used, including information gain (IG). Our proposed model is compared to a benchmark state-of-art classification model. For an unseen dataset, our proposed model achieves accuracy, precision, recall, F-score, and processing time of 0.956, 0.949, 0.964, 0.956, and 9.877 s, respectively. Furthermore, our proposed model’s training time is less than those of the state-of-the-art classification model, while the performance metrics are comparable.
疟疾是一种威胁生命的蚊媒疾病。最近,全世界疟疾病例数有所增加,威胁到脆弱人群。疟疾在世界各地造成了很高的发病率和死亡率。根据世界卫生组织(WHO)的数据,每年都有许多人死于这种疾病。厚血涂片和薄血涂片被用来确定寄生虫的栖息地,使用机器学习(ML)的计算机辅助诊断(CADx)技术被用来辅助。CADx减少了传统的诊断时间,减少了社会经济影响,并提高了生活质量。本研究开发了一个具有选择性特征的简化模型,以降低处理能力并进一步缩短诊断时间,这对资源受限地区具有重要意义。为了提高整体分类结果,我们使用基于决策树(DT)的方法和称为最优特征的图像预处理来识别最优特征。使用了各种特征选择和提取技术,包括信息增益(IG)。我们提出的模型与最先进的基准分类模型进行了比较。对于未见过的数据集,我们提出的模型的准确率、精密度、召回率、f分数和处理时间分别为0.956、0.949、0.964、0.956和9.877 s。此外,我们提出的模型的训练时间少于最先进的分类模型,而性能指标是可比的。
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引用次数: 0
DETECTION AND CLASSIFICATION OF COVID-19 CASES FROM OTHER CARDIOVASCULAR CLASSES FROM ELECTROCARDIOGRAPHY SIGNALS USING DEEP LEARNING AND ResNet NETWORK 利用深度学习和ResNet网络从心电图信号中检测和分类其他心血管类型的COVID-19病例
IF 0.9 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2023-04-27 DOI: 10.4015/s1016237223500059
Shokufeh Akbari, Faraz Edadi Ebrahimi, Mehdi Rajabioun
Nowadays, the world confronts a highly infectious pandemic called coronavirus (COVID-19) and over 4 million people worldwide have now died from this illness. So, early detection of COVID-19 outbreak and distinguishing it from other diseases with the same physical symptoms can give enough time for treatment with true positive results and prevent coma or death. For early recognition of COVID-19, several methods for each modality are proposed. Although there are some modalities for COVID-19 detection, electrocardiography (ECG) is one of the fastest, the most accessible, the cheapest and the safest one. This paper proposed a new method for classifying COVID-19 patients from other cardiovascular disease by ECG signals. In the proposed method, Resnet50v2 which is a kind of convolutional neural network, is used for classification. In this paper because of image format of data, first data with image format are applied to the network and then for comparison, ECG images are changed to signal format and classification is done. These two strategies are used for COVID-19 classification from other cardiac abnormalities with different filter sizes and the results of strategies are compared with each other and other methods in this field. As it can be concluded from the results, signal-based data give better accuracy than image classification at best performance and it is better to change the image format to signals for classification. The second result can be found by comparing with other methods in this field, the proposed method of this paper gives better performance with high accuracy in COVID-19 classification.
如今,世界面临着一种传染性很强的大流行病,即冠状病毒(COVID-19),全球已有400多万人死于这种疾病。因此,早期发现COVID-19疫情并将其与具有相同身体症状的其他疾病区分开来,可以为获得真正阳性结果的治疗提供足够的时间,防止昏迷或死亡。为了早期识别COVID-19,每种模式都提出了几种方法。虽然有一些检测COVID-19的方法,但心电图(ECG)是最快、最容易获得、最便宜和最安全的方法之一。本文提出了一种利用心电信号将COVID-19患者与其他心血管疾病进行分类的新方法。在该方法中,使用一种卷积神经网络Resnet50v2进行分类。本文针对数据的图像格式,首先将具有图像格式的数据应用到网络中,然后进行比较,将心电图像转换为信号格式并进行分类。将这两种策略用于其他心脏异常的COVID-19分类,采用不同的过滤尺寸,并将两种策略的结果与该领域的其他方法进行比较。从结果可以看出,在最佳性能下,基于信号的数据比图像分类的准确率更高,最好将图像格式改为信号进行分类。对比该领域的其他方法可以发现,本文提出的方法在COVID-19分类中具有更好的性能和较高的准确率。
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引用次数: 0
INVESTIGATIONS ON OSTEOPOROTIC FRACTURE RISK ASSESSMENT AMONG SOUTH INDIAN WOMEN 南印度妇女骨质疏松性骨折风险评估调查
IF 0.9 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2023-04-01 DOI: 10.4015/s101623722250051x
K. Dhandapani, P. Vinupritha, D. Parimala, E. J. Eucharista
Background: Osteoporosis results in an increased risk of fracture among aging women. A strong connection exists for bone health with tooth loss, menopause, diet, BMI and hysterectomy. Purpose: To study the impact of heel BMD with age, BMI, menopausal status, hysterectomy and tooth loss among people living in Chennai metropolitan neighborhood. Materials and Methods: The study involved ([Formula: see text], age: [Formula: see text] years) women, which included women with normal BMD ([Formula: see text] = 35, age: [Formula: see text] years), Osteopenia ([Formula: see text], age: [Formula: see text] years) and Osteoporosis ([Formula: see text], age: [Formula: see text] years). All the participants underwent BMD assessment at their right heel using an Ultrasound densitometer system (Model: CM-200, Manufacturer: FURUNO ELECTRIC CO. LTD., Japan). The subjects were classified into various subgroups based on BMD, age, Menopausal status, hysterectomy and tooth loss. Results: The mean age of women attaining menopause and those undergoing hysterectomy are [Formula: see text] years and [Formula: see text] years, respectively. The decrease of heel BMD was very prominent among women having more than two tooth extracted, menopause and hysterectomy. It was found that approximately 90% of the studied population were suffering from either osteopenia or osteoporosis in their post-menopausal period. Conclusion: Women aged above 50 years are at greater risk of osteoporosis due to post-menopausal phase, high probability of undergoing hysterectomy and tooth loss. Therefore, women should ensure sufficient consumption of calcium rich diet in their entire life cycle to ensure a healthy livelihood.
背景:骨质疏松导致老年妇女骨折风险增加。骨质健康与牙齿脱落、更年期、饮食、身体质量指数和子宫切除密切相关。目的:研究金奈城区居民足跟骨密度与年龄、BMI、绝经状况、子宫切除和牙齿脱落的关系。材料与方法:本研究涉及([公式:见文],年龄:[公式:见文]年)女性,其中包括骨密度正常的女性([公式:见文]= 35岁,年龄:[公式:见文]年)、骨质疏松([公式:见文]年)和骨质疏松([公式:见文]年,年龄:[公式:见文]年)。所有参与者使用超声密度计系统(型号:CM-200,制造商:FURUNO ELECTRIC CO. LTD, Japan)对右脚跟进行骨密度评估。研究对象根据骨密度、年龄、绝经状态、子宫切除和牙齿脱落情况被分为不同的亚组。结果:绝经妇女和子宫切除术妇女的平均年龄分别为[公式:见文]年和[公式:见文]年。在拔牙两颗以上、绝经和子宫切除的女性中,足跟骨密度的下降尤为明显。研究发现,大约90%的被研究人群在绝经后出现骨质减少或骨质疏松症。结论:50岁以上妇女绝经后、子宫切除和牙齿脱落的可能性较大,骨质疏松的发生风险较大。因此,女性在整个生命周期中都应确保摄入足够的富钙饮食,以确保健康的生活。
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引用次数: 0
AN OPTICAL APPROACH FOR BLOODLESS, IN-VITRO AND NON-INVASIVE GLUCOSE MONITORING 一种无血、体外、无创血糖监测的光学方法
IF 0.9 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2023-03-14 DOI: 10.4015/s1016237223500023
M. S. Fathimal, S. P. A. Kirubha, A. Jeya Prabha, S. Jothiraj
Diabetes mellitus (DM) indicates elevated glucose concentration in blood. In type 1 diabetes, the pancreas produces inadequate insulin whereas in type 2 diabetes, the body is incapable to utilize the insulin present. Insulin is required to transport glucose into the cells. The insulin resistance by the cells causes the glucose level in the blood to increase. At present, the clinical methods available to diagnose DM are invasive. The diagnosis of DM is done by either pricking the fingertip or drawing blood from the vein followed by the quantification of blood glucose in terms of [Formula: see text]. Continuous monitoring is limited as skin is punctured or venous blood is extracted. Spectroscopic analysis of hair, nail, saliva and urine possess the potential to differentiate the hyperglycaemic from the healthy subjects facilitating non-intrusive diagnosis of diabetes. The variation in the incident wavelength following the interaction with the sample is measured by a spectrometer. Based on the energy of the excitation source, the molecular structures present in the sample will either vibrate or absorb and emit photons that produce a spectrum. The samples were collected from both the groups of subjects and pre-processed prior to further examination. The samples were then characterized using the Fourier-transform infrared (FTIR) spectroscopy. The spectral output was pre-processed, filtered and analyzed so as to discriminate between the diabetic and healthy subjects. Although the spectral band of nail and hair samples appears to be identical, a difference in the amplitude was observed between both diabetic and normal subjects at 1450, 1520, 1632, 2925 cm[Formula: see text]. The area under curve (AUC) in the range of 3600 to 3100 cm-1 is a prominent marker in the discrimination. The peak wavelength and AUC were utilized as a biomarker to discriminate the diabetic and normal individuals.
糖尿病(DM)是指血液中葡萄糖浓度升高。在1型糖尿病中,胰腺产生的胰岛素不足,而在2型糖尿病中,身体无法利用现有的胰岛素。将葡萄糖运送到细胞中需要胰岛素。细胞的胰岛素抵抗导致血液中的葡萄糖水平升高。目前,临床诊断糖尿病的方法是侵入性的。糖尿病的诊断是通过刺破指尖或从静脉抽血,然后根据[公式:见文]对血糖进行量化。由于皮肤被刺穿或抽取静脉血,持续监测受到限制。毛发、指甲、唾液和尿液的光谱分析有可能将高血糖患者与健康受试者区分开来,从而促进糖尿病的非侵入性诊断。用光谱仪测量与样品相互作用后入射波长的变化。基于激发源的能量,存在于样品中的分子结构要么振动,要么吸收并发射产生光谱的光子。从两组受试者中收集样本,并在进一步检查之前进行预处理。然后用傅里叶变换红外光谱(FTIR)对样品进行了表征。对光谱输出进行预处理、滤波和分析,以区分糖尿病和健康受试者。虽然指甲和头发样本的光谱波段看起来是相同的,但在糖尿病患者和正常受试者之间,在1450、1520、1632、2925厘米处观察到振幅的差异[公式:见文本]。3600 ~ 3100 cm-1范围内的曲线下面积(AUC)是判别的显著标志。利用峰值波长和AUC作为区分糖尿病和正常人的生物标志物。
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引用次数: 0
AUTOMATIC 2D AND 3D SEGMENTATION OF GLIOBLASTOMA BRAIN TUMOR 脑胶质母细胞瘤的自动二维和三维分割
IF 0.9 Q4 ENGINEERING, BIOMEDICAL Pub Date : 2023-03-14 DOI: 10.4015/s1016237222500557
J. G. Precious, S. P. A. Kirubha, R. Premkumar, I. K. Evangeline
The brain tumor is the most common destructive and deadly disease. In general, various imaging modalities such as CT, MRI and PET are used to evaluate the brain tumor. Magnetic resonance imaging (MRI) is a prominent diagnostic method for evaluating these tumors. Gliomas, due to their malignant nature and rapid development, are the most common and aggressive form of brain tumors. In the clinical routine, the method of identifying tumor borders from healthy cells is still a difficult task. Manual segmentation takes time, so we use a deep convolutional neural network to improve efficiency. We present a combined DNN architecture using U-net and MobilenetV2. It exploits both local characteristics and more global contextual characteristics from the 2D MRI FLAIR images. The proposed network has encoder and decoder architecture. The performance metrices such as dice loss, dice coefficient, accuracy and IOU have been calculated. Automated segmentation of 3D MRI is essential for the identification, assessment, and treatment of brain tumors although there is significant interest in machine-learning algorithms for computerized segmentation of brain tumors. The goal of this work is to perform 3D volumetric segmentation using BraTumIA. It is a widely available software application used to separate tumor characteristics on 3D brain MR volumes. BraTumIA has lately been used in a number of clinical trials. In this work, we have segmented 2D slices and 3D volumes of MRI brain tumor images.
脑肿瘤是最常见的破坏性和致命性疾病。通常,各种成像方式如CT、MRI和PET用于评估脑肿瘤。磁共振成像(MRI)是评估这些肿瘤的主要诊断方法。胶质瘤由于其恶性性质和快速发展,是最常见和最具侵袭性的脑肿瘤。在临床常规中,从健康细胞中识别肿瘤边界的方法仍然是一项困难的任务。人工分割需要时间,因此我们使用深度卷积神经网络来提高效率。我们提出了一个使用U-net和MobilenetV2的组合DNN架构。它利用了二维MRI FLAIR图像的局部特征和更多的全局背景特征。该网络具有编码器和解码器结构。计算了骰子损耗、骰子系数、精度、欠条等性能指标。3D MRI的自动分割对于脑肿瘤的识别、评估和治疗至关重要,尽管机器学习算法对脑肿瘤的计算机分割有很大的兴趣。这项工作的目标是使用BraTumIA进行3D体分割。它是一种广泛使用的软件应用程序,用于分离3D脑MR体积上的肿瘤特征。最近,BraTumIA被用于许多临床试验。在这项工作中,我们对MRI脑肿瘤图像的二维切片和三维体积进行了分割。
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Biomedical Engineering: Applications, Basis and Communications
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