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Feature Exploration using Local Frequency Distributions in Computed Tomography Data 利用计算机断层扫描数据的局部频率分布进行特征探索
Pub Date : 2020-01-01 DOI: 10.2312/vcbm.20201166
M. Falk, P. Ljung, C. Lundström, A. Ynnerman, I. Hotz
Frequency distributions (FD) are an important instrument when analyzing and investigating scientific data. In volumetric visualization, for example, frequency distributions visualized as histograms, often assist the user in the process of designing transfer function (TF) primitives. Yet a single point in the distribution can correspond to multiple features in the data, particularly in low-dimensional TFs that dominate time-critical domains such as health care. In this paper, we propose contributions to the area of medical volume data exploration, in particular Computed Tomography (CT) data, based on the decomposition of local frequency distributions (LFD). By considering the local neighborhood utilizing LFDs we can incorporate a measure for neighborhood similarity to differentiate features thereby enhancing the classification abilities of existing methods. This also allows us to link the attribute space of the histogram with the spatial properties of the data to improve the user experience and simplify the exploration step. We propose three approaches for data exploration which we illustrate with several visualization cases highlighting distinct features that are not identifiable when considering only the global frequency distribution. We demonstrate the power of the method on selected datasets. CCS Concepts • Human-centered computing → Scientific visualization; Visualization techniques; • Applied computing → Life and medical sciences;
频率分布(FD)是分析和调查科学数据的重要工具。例如,在体积可视化中,以直方图形式显示的频率分布通常有助于用户设计传递函数(TF)原语。然而,分布中的一个点可以对应于数据中的多个特征,特别是在低维tf中,它主导着时间关键领域,如医疗保健。在本文中,我们提出了基于局部频率分布(LFD)分解的医学体数据探索领域的贡献,特别是计算机断层扫描(CT)数据。通过利用lfd考虑局部邻域,我们可以结合邻域相似性度量来区分特征,从而提高现有方法的分类能力。这也允许我们将直方图的属性空间与数据的空间属性联系起来,以改善用户体验,简化探索步骤。我们提出了三种数据探索方法,我们用几个可视化案例来说明,这些案例突出了仅考虑全局频率分布时无法识别的不同特征。我们在选定的数据集上展示了该方法的强大功能。•以人为本的计算→科学可视化;可视化技术;•应用计算→生命和医学科学;
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引用次数: 0
Analyzing Protein Similarity by Clustering Molecular Surface Maps 聚类分子表面图分析蛋白质相似性
Pub Date : 2020-01-01 DOI: 10.2312/vcbm.20201177
Karsten Schatz, Florian Friess, M. Schäfer, T. Ertl, M. Krone
Many biochemical and biomedical applications like protein engineering or drug design are concerned with finding functionally similar proteins, however, this remains to be a challenging task. We present a new imaged-based approach for identifying and visually comparing proteins with similar function that builds on the hierarchical clustering of Molecular Surface Maps. Such maps are two-dimensional representations of complex molecular surfaces and can be used to visualize the topology and different physico-chemical properties of proteins. Our method is based on the idea that visually similar maps also imply a similarity in the function of the mapped proteins. To determine map similarity we compute descriptive feature vectors using image moments, color moments, or a Convolutional Neural Network and use them for a hierarchical clustering of the maps. We show that image similarity as found by our clustering corresponds to functional similarity of mapped proteins by comparing our results to the BRENDA database, which provides a hierarchical function-based annotation of enzymes. We also compare our results to the TM-score, which is a similarity value for pairs of arbitrary proteins. Our visualization prototype supports the entire workflow from map generation, similarity computing to clustering and can be used to interactively explore and analyze the results. CCS Concepts • Human-centered computing → Dendrograms; Scientific visualization; • Applied computing → Bioinformatics; © 2020 The Author(s) Eurographics Proceedings © 2020 The Eurographics Association. DOI: 10.2312/vcbm.20201177 https://diglib.eg.org https://www.eg.org K. Schatz, F. Frieß, M. Schäfer, T. Ertl, and M. Krone / Analyzing Protein Similarity by Clustering Molecular Surface Maps
许多生物化学和生物医学应用,如蛋白质工程或药物设计,都涉及到寻找功能相似的蛋白质,然而,这仍然是一项具有挑战性的任务。我们提出了一种新的基于图像的方法来识别和视觉比较具有相似功能的蛋白质,该方法建立在分子表面图的分层聚类上。这种图谱是复杂分子表面的二维表示,可用于可视化蛋白质的拓扑结构和不同的物理化学性质。我们的方法是基于这样的想法,即视觉上相似的地图也意味着在绘制的蛋白质的功能上相似。为了确定地图的相似性,我们使用图像矩、颜色矩或卷积神经网络计算描述性特征向量,并将它们用于地图的分层聚类。通过将我们的结果与BRENDA数据库进行比较,我们发现通过聚类发现的图像相似性与映射蛋白质的功能相似性相对应,该数据库提供了基于分层功能的酶注释。我们还将我们的结果与tm分数进行了比较,tm分数是任意蛋白质对的相似性值。我们的可视化原型支持从地图生成、相似性计算到聚类的整个工作流程,并可用于交互式地探索和分析结果。•以人为中心的计算→树形图;科学可视化;•应用计算→生物信息学;©2020 The Author(s) Eurographics Proceedings©2020 The Eurographics Association。DOI: 10.2312 / vcbm。20201177 https://diglib.eg.org https://www.eg.org K. Schatz, F. Frieß, M. Schäfer, T. Ertl, M. Krone /聚类分子表面图分析蛋白质相似性
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引用次数: 1
VRIDAA: Virtual Reality Platform for Training and Planning Implantations of Occluder Devices in Left Atrial Appendages VRIDAA:用于训练和规划左心房附件闭塞装置植入的虚拟现实平台
Pub Date : 2020-01-01 DOI: 10.2312/vcbm.20201168
E. Medina, Ainhoa M. Aguado, Jordi Mill, X. Freixa, D. Arzamendi, C. Yagüe, O. Camara
Personalized anatomical information of the heart is usually obtained from the visual analysis of patient-specific medical images with standard multiplanar reconstruction (MPR) of 2D orthogonal slices, volume rendering and surface mesh views. Commonly, medical data is visualized in 2D flat screens, thus hampering the understanding of 3D complex anatomical details, including incorrect depth/scaling perception, which is critical for some cardiac interventions such as medical device implantations. Virtual reality (VR) is becoming a valid complementary technology overcoming some of the limitations of conventional visualization techniques and allowing an enhanced and fully interactive exploration of human anatomy. In this work, we present VRIDAA, a VR-based platform for the visualization of patient-specific cardiac geometries and the virtual implantation of left atrial appendage occluder (LAAO) devices. It includes different visualization and interaction modes to jointly inspect 3D LA geometries and different LAAO devices, MPR 2D imaging slices, several landmarks and morphological parameters relevant to LAAO, among other functionalities. The platform was designed and tested by two interventional cardiologists and LAAO researchers, obtaining very positive user feedback about its potential, highlighting VRIDAA as a source of motivation for trainees and its usefulness to better understand the required surgical approach before the intervention. CCS Concepts • Human-centered computing → Information visualization; • Applied computing → Interactive learning environments; Health care information systems;
个性化的心脏解剖信息通常是通过对患者特异性医学图像进行视觉分析,采用二维正交切片、体绘制和表面网格视图的标准多平面重建(MPR)。通常,医疗数据是在2D平面屏幕上可视化的,因此阻碍了对3D复杂解剖细节的理解,包括不正确的深度/缩放感知,这对于一些心脏干预措施(如医疗设备植入)至关重要。虚拟现实(VR)正在成为一种有效的补充技术,克服了传统可视化技术的一些局限性,并允许对人体解剖进行增强和完全互动的探索。在这项工作中,我们提出了VRIDAA,一个基于vr的平台,用于可视化患者特定心脏几何形状和左心房附件闭塞器(LAAO)装置的虚拟植入。它包括不同的可视化和交互模式,以联合检查3D LA几何形状和不同的LAAO设备,MPR 2D成像切片,与LAAO相关的几个地标和形态学参数等功能。该平台由两位介入心脏病专家和LAAO研究人员设计和测试,获得了非常积极的用户反馈,强调了VRIDAA作为学员的动力来源,以及它在干预前更好地了解所需手术方法的实用性。•以人为本的计算→信息可视化;•应用计算→交互式学习环境;卫生保健信息系统;
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引用次数: 7
GLANCE: Visual Analytics for Monitoring Glaucoma Progression GLANCE:用于监测青光眼进展的可视化分析
Pub Date : 2020-01-01 DOI: 10.2312/vcbm.20201175
Astrid van den Brandt, Mark Christopher, L. Zangwill, Jasmin Rezapour, C. Bowd, Sally L. Baxter, D. Welsbie, A. Camp, S. Moghimi, Jiun L. Do, R. Weinreb, Chris C. P. Snijders, M. A. Westenberg
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引用次数: 4
VirtualDSA++: Automated Segmentation, Vessel Labeling, Occlusion Detection and Graph Search on CT-Angiography Data virtualdsa++: ct血管造影数据的自动分割,血管标记,闭塞检测和图形搜索
Pub Date : 2020-01-01 DOI: 10.2312/vcbm.20201181
Florian Thamm, Markus Jürgens, H. Ditt, A. Maier
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引用次数: 6
Visual Analysis of Multivariate Intensive Care Surveillance Data 多变量重症监护监测数据的可视化分析
Pub Date : 2020-01-01 DOI: 10.2312/vcbm.20201174
N. Brich, C. Schulz, Jörg Peter, Wilfried Klingert, M. Schenk, D. Weiskopf, M. Krone
We present an approach for visual analysis of high-dimensional measurement data with varying sampling rates in the context of an experimental post-surgery study performed on a porcine surrogate model. The study aimed at identifying parameters suitable for diagnosing and prognosticating the volume state—a crucial and difficult task in intensive care medicine. In intensive care, most assessments not only depend on a single measurement but a plethora of mixed measurements over time. Even for trained experts, efficient and accurate analysis of such multivariate time-dependent data remains a challenging task. We present a linked-view post hoc visual analysis application that reduces data complexity by combining projection-based time curves for overview with small multiples for details on demand. Our approach supports not only the analysis of individual patients but also the analysis of ensembles by adapting existing techniques using non-parametric statistics. We evaluated the effectiveness and acceptance of our application through expert feedback with domain scientists from the surgical department using real-world data: the results show that our approach allows for detailed analysis of changes in patient state while also summarizing the temporal development of the overall condition. Furthermore, the medical experts believe that our method can be transferred from medical research to the clinical context, for example, to identify the early onset of a sepsis. CCS Concepts • Applied computing → Health care information systems; • Mathematics of computing → Time series analysis; Dimensionality reduction; • Human-centered computing → Information visualization; © 2020 The Author(s) Eurographics Proceedings © 2020 The Eurographics Association. DOI: 10.2312/vcbm.20201174 https://diglib.eg.org https://www.eg.org N. Brich et al. / Visual Analysis of Multivariate Intensive Care Surveillance Data
我们提出了一种在猪代孕模型上进行的实验性术后研究背景下,以不同采样率对高维测量数据进行视觉分析的方法。该研究旨在确定适合诊断和预测体积状态的参数,这是重症监护医学中至关重要和困难的任务。在重症监护中,大多数评估不仅依赖于单一的测量,而且随着时间的推移,还依赖于过多的混合测量。即使对于训练有素的专家来说,有效和准确地分析这种多变量时间相关数据仍然是一项具有挑战性的任务。我们提出了一个链接视图的事后可视化分析应用程序,通过将基于投影的时间曲线与小倍数的需求细节相结合,降低了数据的复杂性。我们的方法不仅支持个体患者的分析,而且通过使用非参数统计调整现有技术来支持整体分析。我们通过与外科领域科学家使用真实数据的专家反馈来评估我们的应用程序的有效性和接受度:结果表明,我们的方法允许详细分析患者状态的变化,同时也总结了整体状况的时间发展。此外,医学专家认为,我们的方法可以从医学研究转移到临床环境中,例如,识别败血症的早期发作。•应用计算→医疗保健信息系统;•计算数学→时间序列分析;降维;•以人为本→信息可视化;©2020 The Author(s) Eurographics Proceedings©2020 The Eurographics Association。DOI: 10.2312 / vcbm。20201174 https://diglib.eg.org https://www.eg.org N. Brich et al. /重症监护监测数据的可视化分析
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引用次数: 3
Robustness Evaluation of CFD Simulations to Mesh Deformation 网格变形CFD仿真的鲁棒性评价
Pub Date : 2019-01-01 DOI: 10.2312/vcbm.20191244
Alexander Scheid-Rehder, K. Lawonn, M. Meuschke
CFD simulations are an increasingly important method for the non-invasive analysis of risk factors for aneurysm rupture. Their robustness, however, has to be examined more thoroughly before clinical use is possible. We present a novel framework that enables robustness evaluation of CFD simulation according to mesh deformation on patient-specific blood vessel geometry. Our tool offers a guided workflow to generate, run, and visualize OpenFOAM simulations, which significantly decreases the usual overhead of CFD simulations with OpenFOAM. Besides, the deformation of the original geometry allows the user to evaluate the robustness of the simulation without the need to repeat expensive operations of the data pre-processing phase. We assessed the robustness of CFD simulations by applying our framework to several aneurysm data sets. CCS Concepts • Human-centered computing → Scientific visualization;
CFD模拟在动脉瘤破裂危险因素的无创分析中越来越重要。然而,在临床应用之前,必须对其稳健性进行更彻底的检查。我们提出了一种新的框架,可以根据患者特定血管几何形状的网格变形来评估CFD模拟的鲁棒性。我们的工具提供了一个指导工作流来生成、运行和可视化OpenFOAM模拟,这大大降低了使用OpenFOAM进行CFD模拟的通常开销。此外,原始几何形状的变形允许用户评估模拟的鲁棒性,而无需重复昂贵的数据预处理阶段的操作。我们通过将我们的框架应用于几个动脉瘤数据集来评估CFD模拟的稳健性。•以人为本的计算→科学可视化;
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引用次数: 1
Layer-Aware iOCT Volume Rendering for Retinal Surgery 视网膜手术的分层感知iOCT体积绘制
Pub Date : 2019-01-01 DOI: 10.2312/vcbm.20191239
J. Weiss, U. Eck, M. A. Nasseri, M. Maier, A. Eslami, N. Navab
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引用次数: 6
Evolutionary Pathlines for Blood Flow Exploration in Cerebral Aneurysms 脑动脉瘤血流探测的进化途径
Pub Date : 2019-01-01 DOI: 10.2312/vcbm.20191250
B. Behrendt, W. Engelke, P. Berg, O. Beuing, B. Preim, I. Hotz, S. Saalfeld
Blood flow simulations play an important role for the understanding of vascular diseases, such as aneurysms. However, analysis of the resulting flow patterns, especially comparisons across patient groups, are challenging. Typically, the hemodynamic analysis relies on trial and error inspection of the flow data based on pathline visualizations and surface renderings. Visualizing too many pathlines at once may obstruct interesting features, e.g., embedded vortices, whereas with too little pathlines, particularities such as flow characteristics in aneurysm blebs might be missed. While filtering and clustering techniques support this task, they require the pre-computation of pathlines densely sampled in the space-time domain. Not only does this become prohibitively expensive for large patient groups, but the results often suffer from undersampling artifacts. In this work, we propose the usage of evolutionary algorithms to reduce the overhead of computing pathlines that do not contribute to the analysis, while simultaneously reducing the undersampling artifacts. Integrated in an interactive framework, it efficiently supports the evaluation of hemodynamics for clinical research and treatment planning in case of cerebral aneurysms. The specification of general optimization criteria for entire patient groups allows the blood flow data to be batch-processed. We present clinical cases to demonstrate the benefits of our approach especially in presence of aneurysm blebs. Furthermore, we conducted an evaluation with four expert neuroradiologists. As a result, we report advantages of our method for treatment planning to underpin its clinical potential. CCS Concepts • Human-centered computing → Scientific visualization;
血流模拟对了解血管疾病(如动脉瘤)起着重要作用。然而,对结果流模式的分析,特别是跨患者组的比较,是具有挑战性的。通常,血流动力学分析依赖于基于路径可视化和表面渲染的流量数据的试错检查。一次可视化太多的路径可能会阻碍有趣的特征,例如嵌入的漩涡,而太少的路径可能会错过动脉瘤泡中的流动特征。虽然滤波和聚类技术支持这一任务,但它们需要预先计算在时空域中密集采样的路径。这不仅对大的患者群体来说变得非常昂贵,而且结果经常受到采样不足的影响。在这项工作中,我们建议使用进化算法来减少对分析没有贡献的计算路径的开销,同时减少欠采样工件。集成在一个交互式框架中,它有效地支持脑动脉瘤的临床研究和治疗计划的血流动力学评估。对整个患者组的通用优化标准的规范允许批量处理血流数据。我们提出临床病例,以证明我们的方法的好处,特别是在存在动脉瘤泡。此外,我们与四位神经放射专家进行了评估。因此,我们报告了我们的治疗计划方法的优势,以巩固其临床潜力。•以人为本的计算→科学可视化;
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引用次数: 1
A Visual Environment for Hypothesis Formation and Reasoning in Studies with fMRI and Multivariate Clinical Data 功能磁共振成像和多变量临床数据研究中假设形成和推理的视觉环境
Pub Date : 2019-01-01 DOI: 10.2312/vcbm.20191232
Daniel Jönsson, Albin Bergström, C. Forsell, Rozalyn Simon, M. Engström, A. Ynnerman, I. Hotz
We present an interactive visual environment for linked analysis of brain imaging and clinical measurements. The environment is developed in an iterative participatory design process involving neur ...
我们提出了一个交互式的视觉环境,用于脑成像和临床测量的关联分析。环境是在一个迭代的参与式设计过程中开发的,其中包括……
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引用次数: 9
期刊
Eurographics Workshop on Visual Computing for Biomedicine
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