Pub Date : 2023-02-04DOI: 10.11648/j.plm.20230701.11
Gudisa Bereda
: A common neurological condition known as epilepsy is characterized by recurrent bouts of uncontrollable body movements that affect only a portion of the body (partial) or the full body (generalized), occasionally accompanied by loss of consciousness and control over bowel or bladder function. Uncontrolled seizures are linked to medical and psychological illness, dependent behavior, a low quality of life, and a higher risk of untimely death. Epilepsy affects people of all ages, ethnicities, sexes, levels of education, socioeconomic status, and social classes worldwide. The prodrome phase is a pre-epileptic feeling or experience that might start hours, days, or even weeks in advance of the actual seizure. The most prevalent prodromal phase symptoms include difficulties maintaining focus, tension, exhaustion, sleep disruptions, behavioral changes (differently smelling, tasting, having ringing in the ears, feeling queasy, etc.), restlessness, and others. The ictal phase defined as spans the interval between the start of a seizure and its conclusion. The phrase "interictal" refers to a phase that occurs between seizures or headaches. "Postictal" refers to the period following a seizure. The duration of postictalphase varies from minutes to hours depending on the type of seizure, the frequency and intensity of seizures, and the length of the seizure.
{"title":"Seizures Are the Main Sign of Epilepsy: Stages of Seizures","authors":"Gudisa Bereda","doi":"10.11648/j.plm.20230701.11","DOIUrl":"https://doi.org/10.11648/j.plm.20230701.11","url":null,"abstract":": A common neurological condition known as epilepsy is characterized by recurrent bouts of uncontrollable body movements that affect only a portion of the body (partial) or the full body (generalized), occasionally accompanied by loss of consciousness and control over bowel or bladder function. Uncontrolled seizures are linked to medical and psychological illness, dependent behavior, a low quality of life, and a higher risk of untimely death. Epilepsy affects people of all ages, ethnicities, sexes, levels of education, socioeconomic status, and social classes worldwide. The prodrome phase is a pre-epileptic feeling or experience that might start hours, days, or even weeks in advance of the actual seizure. The most prevalent prodromal phase symptoms include difficulties maintaining focus, tension, exhaustion, sleep disruptions, behavioral changes (differently smelling, tasting, having ringing in the ears, feeling queasy, etc.), restlessness, and others. The ictal phase defined as spans the interval between the start of a seizure and its conclusion. The phrase \"interictal\" refers to a phase that occurs between seizures or headaches. \"Postictal\" refers to the period following a seizure. The duration of postictalphase varies from minutes to hours depending on the type of seizure, the frequency and intensity of seizures, and the length of the seizure.","PeriodicalId":88950,"journal":{"name":"Pathology and laboratory medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72869218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Alchami, Zafar Iqbal, Carl Niclas Björkhammer, Mohammed Saeed, R. Ramakrishnan, C. Clelland, F. Ahmad, A. Charles
{"title":"Whole Slide Imaging Integration with Lab Information Systems, a Study of the Requirements, Processes and Procedures Enabling a Reporting-Based Workflow","authors":"F. Alchami, Zafar Iqbal, Carl Niclas Björkhammer, Mohammed Saeed, R. Ramakrishnan, C. Clelland, F. Ahmad, A. Charles","doi":"10.2147/plmi.s388981","DOIUrl":"https://doi.org/10.2147/plmi.s388981","url":null,"abstract":"","PeriodicalId":88950,"journal":{"name":"Pathology and laboratory medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43323972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bizunesh Dires Fenta, Tesfalem Israel Korga, Tuji Dinka Bikila, Abraham Kassahun Tadele, Berhanu Lijalem Yigezu, Mikiyas Gosa Negash
: Primary intraosseous meningioma is a rare tumor arising commonly from the calvarial bone. Here, we report a case of primary intraosseous meningioma which presented as a Bifrontal skull mass in a 30-year-old woman who presented with a progressive forehead enlargement and headache of 3 years duration. Brain CT shows hyperostosis of the frontal bone and microscopy shows intertrabecular syncytial proliferation of oval to spindle cells at the area forming whorl. Even though it is rare, PIM is the most common subtype of extradural meningioma.
{"title":"Primary Intraosseous Meningioma: Bifrontal Skull Mass","authors":"Bizunesh Dires Fenta, Tesfalem Israel Korga, Tuji Dinka Bikila, Abraham Kassahun Tadele, Berhanu Lijalem Yigezu, Mikiyas Gosa Negash","doi":"10.2147/plmi.s388172","DOIUrl":"https://doi.org/10.2147/plmi.s388172","url":null,"abstract":": Primary intraosseous meningioma is a rare tumor arising commonly from the calvarial bone. Here, we report a case of primary intraosseous meningioma which presented as a Bifrontal skull mass in a 30-year-old woman who presented with a progressive forehead enlargement and headache of 3 years duration. Brain CT shows hyperostosis of the frontal bone and microscopy shows intertrabecular syncytial proliferation of oval to spindle cells at the area forming whorl. Even though it is rare, PIM is the most common subtype of extradural meningioma.","PeriodicalId":88950,"journal":{"name":"Pathology and laboratory medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47946622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: The elderly and those with underlying chronic diseases (i.e., comorbidities) such as pulmonary, cardiovascular, metabolic, and renal diseases, increase their susceptibility to sepsis, including COVID-19. The SARS-CoV-2 virus damages pulmonary cells, causing acute respiratory distress syndrome (ARDS) and hypoxia. It further damages endothelial cells, altering clotting mechanisums causing intravascular hemolysis, microvascular thrombosis, and micro-embolization, contributing to the risk of death. Approximately 75% of the immune system functions of humans depend on vitamin D and the availability of sufficient amounts of vitamin D metabolites [vitamin D and 25(OH)D] concentrations to enter immune cells from the bloodstream. Such concentrations are achievable through sun exposure, targeted food fortification programs, and adequate daily or weekly vitamin D supplements. That would allow for generating 1,25(OH) 2 D (non-hormonal form of calcitriol) intracellularly in peripheral target cells like immune cells. This enables immune cells’ physiological functions, including intracrine/autocrine and paracrine signaling processes. This initiates and maintains robust immune functions, such as forming antibodies and antimicrobial peptides, suppressing inflammation, and increasing the expression of anti-inflammatory and antioxidant genes, thus, strengthening immune functions. The opposite occurs in hypovitaminosis D, increasing vulnerability to infections and dying from it. Therefore, governments should make the population sufficient with immunoceuticals—micronutrients, especially vitamin D, and other micronutrients: the most cost-effective intervention to keep the population healthy. The cost of such interventions are minuscule compared to the expenses related to increased hospitalizations and premature deaths. Supposed such a program was implemented in mid-2020 as the author proposed, we estimated that 50% of hospitalizations (and the associated healthcare costs) and a third of deaths from COVID could have been prevented. Described herein are cost-effective strategies using vitamin D to achieve and sustain serum D 3 and 25(OH)D concentrations crucial for maintaining a robust immune system, improving general health, minimizing disease severities and deaths, and reducing healthcare costs.
{"title":"Overcoming Infections Including COVID-19, by Maintaining Circulating 25(OH)D Concentrations Above 50 ng/mL","authors":"S. Wimalawansa","doi":"10.2147/plmi.s373617","DOIUrl":"https://doi.org/10.2147/plmi.s373617","url":null,"abstract":": The elderly and those with underlying chronic diseases (i.e., comorbidities) such as pulmonary, cardiovascular, metabolic, and renal diseases, increase their susceptibility to sepsis, including COVID-19. The SARS-CoV-2 virus damages pulmonary cells, causing acute respiratory distress syndrome (ARDS) and hypoxia. It further damages endothelial cells, altering clotting mechanisums causing intravascular hemolysis, microvascular thrombosis, and micro-embolization, contributing to the risk of death. Approximately 75% of the immune system functions of humans depend on vitamin D and the availability of sufficient amounts of vitamin D metabolites [vitamin D and 25(OH)D] concentrations to enter immune cells from the bloodstream. Such concentrations are achievable through sun exposure, targeted food fortification programs, and adequate daily or weekly vitamin D supplements. That would allow for generating 1,25(OH) 2 D (non-hormonal form of calcitriol) intracellularly in peripheral target cells like immune cells. This enables immune cells’ physiological functions, including intracrine/autocrine and paracrine signaling processes. This initiates and maintains robust immune functions, such as forming antibodies and antimicrobial peptides, suppressing inflammation, and increasing the expression of anti-inflammatory and antioxidant genes, thus, strengthening immune functions. The opposite occurs in hypovitaminosis D, increasing vulnerability to infections and dying from it. Therefore, governments should make the population sufficient with immunoceuticals—micronutrients, especially vitamin D, and other micronutrients: the most cost-effective intervention to keep the population healthy. The cost of such interventions are minuscule compared to the expenses related to increased hospitalizations and premature deaths. Supposed such a program was implemented in mid-2020 as the author proposed, we estimated that 50% of hospitalizations (and the associated healthcare costs) and a third of deaths from COVID could have been prevented. Described herein are cost-effective strategies using vitamin D to achieve and sustain serum D 3 and 25(OH)D concentrations crucial for maintaining a robust immune system, improving general health, minimizing disease severities and deaths, and reducing healthcare costs.","PeriodicalId":88950,"journal":{"name":"Pathology and laboratory medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48240066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abraham Kassahun Tadele, Tesfalem Israel Korga, Abebe Melis Nisiro, Selamawit Abebe Ayele
: Hydatid cyst of the breast is a very rare disease that predominantly affects endemic regions. Breast hydatid cysts can occur alone or as a component of widespread hydatidosis. Histopathology is the best diagnostic method for hydatid cysts of the breast, but fine needle aspiration cytology can be utilized in preoperative diagnosis. Here we report, a case of a female patient who was diagnosed with Hydatid cyst of the breast Postoperatively in Wolaita Sodo University teaching hospital, southern Ethiopia. Preoperatively the patient was diagnosed with tuberculous mastitis and she took the full course of Anti Tuberculous treatment. After completing the treatment there was no improvement. The cyst was removed surgically and histopathology confirmed the disease to be Hydatid cyst of the breast.
{"title":"Rare Case Report on Hydatid Cyst of Breast","authors":"Abraham Kassahun Tadele, Tesfalem Israel Korga, Abebe Melis Nisiro, Selamawit Abebe Ayele","doi":"10.2147/plmi.s380081","DOIUrl":"https://doi.org/10.2147/plmi.s380081","url":null,"abstract":": Hydatid cyst of the breast is a very rare disease that predominantly affects endemic regions. Breast hydatid cysts can occur alone or as a component of widespread hydatidosis. Histopathology is the best diagnostic method for hydatid cysts of the breast, but fine needle aspiration cytology can be utilized in preoperative diagnosis. Here we report, a case of a female patient who was diagnosed with Hydatid cyst of the breast Postoperatively in Wolaita Sodo University teaching hospital, southern Ethiopia. Preoperatively the patient was diagnosed with tuberculous mastitis and she took the full course of Anti Tuberculous treatment. After completing the treatment there was no improvement. The cyst was removed surgically and histopathology confirmed the disease to be Hydatid cyst of the breast.","PeriodicalId":88950,"journal":{"name":"Pathology and laboratory medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46324599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samuel Sahile Kebede, A. Yalew, T. Yesuf, Getachew Mesfin Bambo, Tadesse Duguma, Berhanu Woldu
Background: Hereditary spherocytosis is a type of hemolytic anemia characterized by a clinically heterogeneous, genetically defined red blood cell membrane abnormality that results in hemolytic crisis. The inheritance of HS is autosomal dominant in 80% of affected individuals and recessive genes or sporadic type in the remaining 20%. Objective: The main aim of this study was to determine the magnitude of immune hereditary spherocytosis among human immunodeficiency virus-infected adults at the University of Gondar comprehensive specialized hospital in northwest Ethiopia from March to April 2021. Methods: An institution-based cross-sectional study was conducted on 358 human immunodeficiency virus-infected adults selected by systematic random sampling at the University of Gondar comprehensive specialized hospital from March to April 2021. Data for socio-demographic data were collected by structured pretested questionnaire. Five ml of venous blood was drawn from each participant and analyzed by Unicel DHX 800 hematology analyzer, and blood film examination and antihuman globulin test were performed to exclude immune hemolytic anemia. Data was entered into Epidata version 4.6 and analyzed by STATA version 14. Descriptive statistics were computed and drawn in charts and graphs. Results: The prevalence of hereditary spherocytosis was 2 of 358 participants. Both individuals who developed hereditary spherocytosis were females and in the age group of 22 to 35. The overall prevalence of anemia was 91 (25.42%). Of those anemic study population 3 (3.29%), 28 (30.77%), and 60 (65.93%), respectively, had severe, moderate, and mild anemia. Conclusion and Recommendation: Hereditary spherocytosis is a less frequent condition in human immunodeficiency virus-infected adults. In these patients, early detection and treatment are necessary at the familial level by using a test algorithm.
{"title":"The Magnitude of Hereditary Spherocytosis Among Human Immunodeficiency Virus-Infected Adults Attending University of Gondar Comprehensive Specialized Hospital Northwest Ethiopia 2021 GC, Cross-Sectional Study Design","authors":"Samuel Sahile Kebede, A. Yalew, T. Yesuf, Getachew Mesfin Bambo, Tadesse Duguma, Berhanu Woldu","doi":"10.2147/plmi.s366451","DOIUrl":"https://doi.org/10.2147/plmi.s366451","url":null,"abstract":"Background: Hereditary spherocytosis is a type of hemolytic anemia characterized by a clinically heterogeneous, genetically defined red blood cell membrane abnormality that results in hemolytic crisis. The inheritance of HS is autosomal dominant in 80% of affected individuals and recessive genes or sporadic type in the remaining 20%. Objective: The main aim of this study was to determine the magnitude of immune hereditary spherocytosis among human immunodeficiency virus-infected adults at the University of Gondar comprehensive specialized hospital in northwest Ethiopia from March to April 2021. Methods: An institution-based cross-sectional study was conducted on 358 human immunodeficiency virus-infected adults selected by systematic random sampling at the University of Gondar comprehensive specialized hospital from March to April 2021. Data for socio-demographic data were collected by structured pretested questionnaire. Five ml of venous blood was drawn from each participant and analyzed by Unicel DHX 800 hematology analyzer, and blood film examination and antihuman globulin test were performed to exclude immune hemolytic anemia. Data was entered into Epidata version 4.6 and analyzed by STATA version 14. Descriptive statistics were computed and drawn in charts and graphs. Results: The prevalence of hereditary spherocytosis was 2 of 358 participants. Both individuals who developed hereditary spherocytosis were females and in the age group of 22 to 35. The overall prevalence of anemia was 91 (25.42%). Of those anemic study population 3 (3.29%), 28 (30.77%), and 60 (65.93%), respectively, had severe, moderate, and mild anemia. Conclusion and Recommendation: Hereditary spherocytosis is a less frequent condition in human immunodeficiency virus-infected adults. In these patients, early detection and treatment are necessary at the familial level by using a test algorithm.","PeriodicalId":88950,"journal":{"name":"Pathology and laboratory medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43364855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phenotypic Analyses of Blood Culture Contaminants in COVID-19 Intensive Care Unit Using Hierarchical Clustering During the Pandemic First Wave in Surabaya","authors":"Daniel Edbert, N. Mertaniasih, P. Endraswari","doi":"10.2147/plmi.s356299","DOIUrl":"https://doi.org/10.2147/plmi.s356299","url":null,"abstract":"","PeriodicalId":88950,"journal":{"name":"Pathology and laboratory medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45704686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edosa Kifle Tola, Y. T. Dabi, Gemechu Tiruneh Dano
{"title":"Assessment of Types and Frequency of Errors in Diagnostic Laboratories Among Selected Hospitals in East Wollega Zone, Oromia, Ethiopia","authors":"Edosa Kifle Tola, Y. T. Dabi, Gemechu Tiruneh Dano","doi":"10.2147/plmi.s351851","DOIUrl":"https://doi.org/10.2147/plmi.s351851","url":null,"abstract":"","PeriodicalId":88950,"journal":{"name":"Pathology and laboratory medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49220966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.11648/j.plm.20220601.11
Uzma Naz Shaikh, Muhammad Ali Ghoto, A. Dayo, Mudassar Iqbal Arain, R. Parveen
{"title":"Propylthiouracil: An Intriguing Connection Among the Propylthiouracil, Hypothyroidism, and Obesity","authors":"Uzma Naz Shaikh, Muhammad Ali Ghoto, A. Dayo, Mudassar Iqbal Arain, R. Parveen","doi":"10.11648/j.plm.20220601.11","DOIUrl":"https://doi.org/10.11648/j.plm.20220601.11","url":null,"abstract":"","PeriodicalId":88950,"journal":{"name":"Pathology and laboratory medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85241607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.11648/j.plm.20220601.12
K. Pavel
: The author's aim in this article is to describe a common exanthematic disease typical of adolescence, pityriasis rosea Gibert, in the light of new findings. Another aim is to draw attention to an overlooked fact about the difficulty and inconsistency of therapy with the recommended course of action. The author uses his own experience from his many years of dermatological practice and adds facts from current literature sources on the disease. The meaning of the disease name is explained and the historical implications of the disease name are clarified. The current view of its probable viral etiopathogenesis and its similarity to another exanthematous skin disease, exanthema subitum, are described. The prodromal stage of the disease and the clinical picture of the skin findings with characteristic seeding of lesions resembling "Christmas tree branches" are described. The author's clinical pictures of the findings in individual patients with this disease are included. The possible relationship with COVID-19 is noted. The differential diagnosis is discussed, including the similarity to secondary syphilis, and the uncharacteristic histopathological picture of the disease is described. Finally, treatment options are discussed, with the caveat that the very common use of topical corticosteroids is not very effective and rather non-corticoid external therapy is recommended. The author draws attention to the possible alteration of the psychological state of predominantly adolescent patients due to the frequent long persistence of cutaneous, and therefore visible, symptoms.
{"title":"Pityriasis Rosea Gibert - Disease History and New Findings","authors":"K. Pavel","doi":"10.11648/j.plm.20220601.12","DOIUrl":"https://doi.org/10.11648/j.plm.20220601.12","url":null,"abstract":": The author's aim in this article is to describe a common exanthematic disease typical of adolescence, pityriasis rosea Gibert, in the light of new findings. Another aim is to draw attention to an overlooked fact about the difficulty and inconsistency of therapy with the recommended course of action. The author uses his own experience from his many years of dermatological practice and adds facts from current literature sources on the disease. The meaning of the disease name is explained and the historical implications of the disease name are clarified. The current view of its probable viral etiopathogenesis and its similarity to another exanthematous skin disease, exanthema subitum, are described. The prodromal stage of the disease and the clinical picture of the skin findings with characteristic seeding of lesions resembling \"Christmas tree branches\" are described. The author's clinical pictures of the findings in individual patients with this disease are included. The possible relationship with COVID-19 is noted. The differential diagnosis is discussed, including the similarity to secondary syphilis, and the uncharacteristic histopathological picture of the disease is described. Finally, treatment options are discussed, with the caveat that the very common use of topical corticosteroids is not very effective and rather non-corticoid external therapy is recommended. The author draws attention to the possible alteration of the psychological state of predominantly adolescent patients due to the frequent long persistence of cutaneous, and therefore visible, symptoms.","PeriodicalId":88950,"journal":{"name":"Pathology and laboratory medicine international","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88350880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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