The open pediatric medicine journal最新文献_第3页

Clinical course of steroid sensitive nephrotic syndrome in children: outcome and outlook 儿童类固醇敏感性肾病综合征的临床过程:结局和前景

The open pediatric medicine journal

Pub Date : 2011-10-14 DOI: 10.2174/1874309901105010018

S. Fomina, T. Pavlenko, E. Englund, I. Bagdasarova

Introduction: The aim of our study was to investigate the relative efficiency and adverse effects of various treatments of steroid sensitive nephrotic syndrome (SSNS) in children, and to determine factors associated with relapse risk in these patients. Materials and Method: We retrospectively studied the data from 690 SSNS children treated in referral center over 25 years. The analyzed treatment protocols were: Prednisolone (PRED, eight weeks in a dose 1.5-2.0 mg/kg, then it tapering and given for 9-12 months), Chlorambucil (CHL, cumulative dose 28.5-30 mg/kg), Cyclophosphamide intravenously (CYC I.V., cumulative dose of 30-36 mg/kg, then supporting dose of CHL, cumulative dose of 20-25 mg/kg) and intramuscular (CYC I.M., cumulative dose of 120-150 mg/kg). The alkylating agents were used after remission induction by PRED and under its protection. Results: Cumulative relapse-free survival was 81.9%, 69.0% and 64.5% after 12, 36 and 60 months, respectively. In multivariate analyses, relapse risk was associated with age of treatment (<6 years), and both PRED and CYC I.V. The only predictive factor for early relapse was PRED, unlike two and more relapses group where PRED and CYC I.V. as well as age from 3 to 6 years was highly prognostic. The high probability of sustained remission in combination with relatively mild adverse effects was observed for PRED used at first episode and CHL used at relapse. Conclusion: To summarize, our protocols characterized by the prolonged PRED and CHL demonstrated promising results and should be considered as an efficient alternative strategy in SSNS management.

本研究的目的是探讨儿童类固醇敏感性肾病综合征(SSNS)的各种治疗方法的相对疗效和不良反应，并确定这些患者复发风险的相关因素。材料和方法:我们回顾性研究了25年来在转诊中心治疗的690名SSNS儿童的资料。所分析的治疗方案为:泼尼松龙(PRED, 8周，剂量1.5 ~ 2.0 mg/kg，然后逐渐减量，连续给药9 ~ 12个月)、氯苯(CHL，累积剂量28.5 ~ 30 mg/kg)、环磷酰胺静脉注射(CYC静脉注射，累积剂量30 ~ 36 mg/kg，然后给药CHL，累积剂量20 ~ 25 mg/kg)和肌注(CYC静脉注射，累积剂量120 ~ 150 mg/kg)。经PRED诱导缓解后，在其保护下使用烷基化剂。结果:12个月、36个月和60个月的累积无复发生存率分别为81.9%、69.0%和64.5%。在多变量分析中，复发风险与治疗年龄(<6岁)、PRED和CYC静脉注射均相关。早期复发的唯一预测因素是PRED，不像两次或两次以上复发组，PRED和CYC静脉注射以及3至6岁的年龄是高度预后因素。在首次发作时使用PRED，在复发时使用CHL，观察到持续缓解的可能性很高，副作用相对轻微。结论:总之，我们的方案以延长PRED和CHL为特征，显示出良好的效果，应被视为SSNS管理的有效替代策略。

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引用次数: 5

Self Determination and Health Behaviors in Children with Cystic Fibrosis 囊性纤维化儿童的自我决定与健康行为

The open pediatric medicine journal

Pub Date : 2011-06-17 DOI: 10.2174/1874309901105010001

P. Bingham, M. Meyer

Purpose: We interviewed pediatric patients with cystic fibrosis (CF) to plan an intervention that would support adherence to respiratory therapies while also promoting self-determination. Interviews were structured so as to assess our hypothesis that patients experience less self-determination in the context of their health care compared to other activities. Methods: We conducted a qualitative interview study to characterize CF patients' sense of competence, autonomy, and relatedness in the areas of health care behaviors, recreational activities, and other activities of daily life. Interviews were performed with seventeen, 8 to 16 year old children and adolescents with CF. Results: Although subjects described similar levels of competency in the practice of healthcare activities compared to other daily activities, most reported relatively lower levels of autonomy and relatedness when discussing respiratory therapies compared to other daily activities. Conclusion: Failure to meet patients' needs for autonomy and relatedness may represent potential barriers to treatment adherence in these adolescent and pre-adolescent subjects with CF. Our CF patients relate to recreational activities as supporting their competence and relatedness.

目的:我们采访了患有囊性纤维化(CF)的儿科患者，以计划一项干预措施，该干预措施将支持坚持呼吸治疗，同时也促进自决。访谈的结构是为了评估我们的假设，即与其他活动相比，患者在医疗保健方面的自决权较少。方法:采用质性访谈法研究CF患者在保健行为、娱乐活动和其他日常生活活动方面的能力感、自主性和相关性。访谈对象为17、8至16岁患有CF的儿童和青少年。结果:尽管受试者在保健活动实践中描述的能力水平与其他日常活动相似，但与其他日常活动相比，大多数受试者在讨论呼吸治疗时报告的自主性和相关性水平相对较低。结论:未能满足患者对自主性和相关性的需求可能是这些青少年和青春期前CF患者坚持治疗的潜在障碍。我们的CF患者认为娱乐活动支持他们的能力和相关性。

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引用次数: 4

Lessons Learned from Using Health Literacy Strategies in a Pilot Communication Skills Program 在沟通技巧试点项目中使用卫生素养战略的经验教训

The open pediatric medicine journal

Pub Date : 2010-12-28 DOI: 10.2174/1874309901004010026

R. Connelly, T. Turner, X. Tran, A. Giardino

Introduction: Limited health literacy results in poorer health outcomes, however, effective communication can facilitate understanding. Communication skills programs could incorporate strategies to address communication gaps caused by poor health literacy. Objectives: 1) to describe the effects of a pilot educational intervention on providers' knowledge and reported use of health literacy strategies; 2) to describe participants' reasons to participate and their opinions regarding the educational intervention's delivery and content. Methodology: We conducted a quasi-experimental study design with a questionnaire before, immediately after, one and three months after the intervention. Semi-structured interviews conducted one year after the intervention explored participants' opinions and experiences with the intervention and strategies. Results: Of 329 physicians invited, only 13 (3.9%) participated. Participants' mean knowledge score increased from 59.2% to 80% (p<0.001) but was lower at three months (63.3, p<0.005). Reported awareness of health literacy issues increased from 23.1% to 92.3% (p<0.001) and remained high at three months. Using simple language, limiting amount of information and checking for understanding were strategies reportedly still used at three months. Information presented was new for participants and increased their awareness of communication problems. Health literacy strategies were reportedly simple to use. Conclusions: Our program increased participants' awareness of health literacy issues and self-reported use of health literacy strategies for communication up to three months after the intervention. Future research areas should include replication with a larger sample size, objective measurement of strategies utilized by providers, and measuring patients' opinions about these strategies.

导读:有限的健康素养导致较差的健康结果，然而，有效的沟通可以促进理解。沟通技巧项目可以纳入解决卫生知识贫乏造成的沟通差距的战略。目标:1)描述试点教育干预对提供者的知识和报告使用卫生素养战略的影响;2)描述参与者参与的原因以及他们对教育干预的方式和内容的意见。方法:我们采用准实验研究设计，在干预前、干预后、干预后1个月和干预后3个月分别进行问卷调查。干预一年后进行的半结构化访谈探讨了参与者对干预和策略的看法和经验。结果:329名受邀医师中，仅有13名(3.9%)参与。参与者的平均知识得分从59.2%上升到80% (p<0.001)，但在三个月时下降(63.3,p<0.005)。报告的健康素养问题意识从23.1%增加到92.3% (p<0.001)，并在三个月时保持较高水平。据报道，使用简单的语言、限制信息量和检查理解能力是三个月大时仍然使用的策略。所提供的资料对与会者来说是新的，提高了他们对沟通问题的认识。据报告，卫生知识普及战略易于使用。结论:我们的项目提高了参与者对健康素养问题的认识，并在干预后三个月自我报告使用健康素养策略进行沟通。未来的研究领域应该包括更大样本量的复制、对提供者使用的策略的客观测量以及对患者对这些策略的意见的测量。

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引用次数: 4

Diet vs Sugar-Sweetened Soda Preferences and Attitudes in a Sample of Adolescents~!2010-03-19~!2010-06-07~!2010-08-06~! 青少年饮食与含糖汽水偏好及态度的比较研究2010-03-19 2010-06-07 2010-08-06

The open pediatric medicine journal

Pub Date : 2010-08-09 DOI: 10.2174/1874309901004010023

Nathaniel Etheridge Frank-White, E. Frank

North American adolescents' consumption of sodas is of concern in the face of the obesity epidemic. We wished to determine if their perceptions about sugared and diet sodas were reflected in their blinded preferences. Our n=194, with an average age of 15.2 years, and a response rate of 97%. Among respondents, 3% stated that they strongly preferred diet soda, 3% somewhat preferred diet soda, 37% strongly preferred sugar-sweetened soda, 27% somewhat preferred sugar-sweetened soda, and 30% had no preference between diet and sugar-sweetened soda. The average rating for sugar-sweetened soda was 5.9 vs 5.1 vs diet sodas. The r2 was 0.034 (p=0.73) between actual sugar content and taste rating. Public health campaigns that wish to convert adolescents from sugar-sweetened to diet sodas would do well to lessen adolescents' concerns about health risks of diet sodas, and manufacturers might consider that adolescents seek tastes in soda beyond merely sugar consumption.

面对肥胖的流行，北美青少年对苏打水的消费引起了人们的关注。我们希望确定他们对含糖苏打水和无糖苏打水的看法是否反映在他们的盲目偏好中。我们的n=194，平均年龄15.2岁，有效率为97%。在受访者中，3%的人表示他们非常喜欢无糖苏打水，3%的人比较喜欢无糖苏打水，37%的人非常喜欢含糖苏打水，27%的人比较喜欢含糖苏打水，30%的人对无糖苏打水和含糖苏打水没有偏好。含糖苏打水的平均评分是5.9比5.1比无糖苏打水。实际含糖量与口感评分之间的r2为0.034 (p=0.73)。希望将青少年从含糖苏打水转变为无糖苏打水的公共卫生运动将很好地减轻青少年对无糖苏打水健康风险的担忧，制造商可能会考虑青少年在苏打水中寻求的不仅仅是糖的口味。

引用次数: 2

Results of an Observational Study of Child Care Centers in Pennsylvania: Varying Approaches to Health and Safety 宾夕法尼亚州儿童护理中心的观察性研究结果:不同的健康和安全方法

The open pediatric medicine journal

Pub Date : 2010-07-21 DOI: 10.2174/1874309901004010014

F. Nadel, S. Aronson, A. Giardino, H. Rivers, Amy Requa, K. Shaw

Objective: Exploring several health and safety practices in child care centers (CCCs) in Pennsylvania (PA). Design and Methods: A prospective observational study of a convenience sample of CCCs was done. On-site evaluations included direct observation of hand washing behaviors, infant sleep position, playground equipment safety, and an assessment of safety policies. Results: Evaluations were done at 134 sites. The director's median time in her current position was 2.5 years; 32% of the providers worked at the site less than one year. Sixteen (12%) sites had consulted a doctor on health policy development. Of 114 food preparation or consumption observations, 88 (77%) of the adults and 100 (92%) of the children washed their hands; and, of 181 diapering or toileting observations, 78 (83%) of the adults and 103 (95%) of the children washed their hands. Staff placed 67% of infants on their backs for sleep. Safe playground surfacing was observed surrounding 10 (21%) indoor and 52 (57%) outdoor equipment areas. Overall, suburban, non-profit, parent funded centers performed better than urban, for profit, state funded centers—except for sleep positioning when the opposite association was observed.

目的:探讨宾夕法尼亚州托儿中心(CCCs)的几种健康和安全措施。设计和方法:对CCCs的方便样本进行前瞻性观察研究。现场评估包括直接观察洗手行为、婴儿睡眠姿势、游乐场设备安全性和安全政策评估。结果:在134个地点进行了评价。该董事在当前职位上的平均工作时间为2.5年;32%的供应商在现场工作不到一年。16个(12%)站点就卫生政策制定咨询了医生。在114项食物准备或消费观察中，88名成人(77%)和100名儿童(92%)洗手;在181个换尿布或如厕的观察中，78个(83%)成年人和103个(95%)儿童洗手。工作人员让67%的婴儿仰卧睡觉。在10个(21%)室内设备区和52个(57%)室外设备区周围观察到安全的游乐场路面。总的来说，郊区的、非营利的、父母资助的中心比城市的、营利的、国家资助的中心表现得更好——除了睡眠姿势，相反的关联被观察到。

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引用次数: 6

Tobacco Smoke Exposure and Somatic Mutation in Newborns 烟草烟雾暴露与新生儿的体细胞突变

The open pediatric medicine journal

Pub Date : 2010-06-24 DOI: 10.2174/1874309901004010010

S. G. Grant

Maternal exposure to tobacco smoke is known to have deleterious effects on the developing fetus, but it has only recently been shown that there may be life-long consequences due to genotoxic damage. Analysis of newborn cord bloods with the GPA somatic mutation assay demonstrates a significant effect of maternal active smoking and suggests that similar mutational induction occurs in mothers who experience only secondary exposure to environmental tobacco smoke (ETS). Moreover, in both cases, mutational induction occurs by the same molecular mechanism, likely chromosome missegregation, resulting in an effective loss of one parental chromosome 4 and duplication of the other. These data also suggest that quitting smoking during pregnancy without actively avoiding secondary ETS exposure is not effective at protecting the unborn child from the genotoxic effects of tobacco smoke.

众所周知，母亲接触烟草烟雾会对发育中的胎儿产生有害影响，但直到最近才有证据表明，由于基因毒性损害，可能会产生终生后果。对新生儿脐带血的GPA体细胞突变分析表明，母亲主动吸烟对新生儿脐带血有显著影响，并表明在仅二次暴露于环境烟草烟雾(ETS)的母亲中也会发生类似的突变诱导。此外，在这两种情况下，突变诱导是通过相同的分子机制发生的，可能是染色体错分离，导致亲本4号染色体的有效丢失和另一条染色体的复制。这些数据还表明，在怀孕期间戒烟而不积极避免继发性ETS暴露并不能有效保护未出生的孩子免受烟草烟雾的遗传毒性影响。

引用次数: 7

Cognitive Functioning and Academic Performance in Elementary School Children with Anxious/Depressed and Withdrawn Symptoms. 焦虑/抑郁及退缩症状小学生的认知功能与学业表现

The open pediatric medicine journal

Pub Date : 2010-04-14 DOI: 10.2174/1874309901004010001

Shannon M Lundy, Graciela E Silva, Kristine L Kaemingk, James L Goodwin, Stuart F Quan

RATIONALE: Few studies have evaluated the relationship between depressive symptomatology and neuropsychological performance in children without symptomatic depression. OBJECTIVES: This study determined the relationship between anxious/depressed and withdrawn symptoms and performance on cognitive and academic achievement measures. METHODS: 335 Caucasian and Hispanic children aged 6 to 11 years who participated in the Tucson Children's Assessment of Sleep Apnea (TuCASA) study were administered a comprehensive neuropsychological battery measuring cognitive functioning and academic achievement. Their parents completed the Child Behavior Checklist (CBCL). Correlations between performance on the cognitive and academic achievement measures and two Internalizing scales from the CBCL were calculated. Comparisons were made between a "Clinical" referral group (using a T-score of ≥ 60 from the CBCL scales) and a "Normal" group, as well as between Caucasians and Hispanics. RESULTS: No differences were found between those participants with increased anxious/depressed or withdrawn symptoms on the CBCL and those without increased symptoms with respect to age, gender, ethnicity, or parental education level. However, significant negative correlations were found between these symptoms and general intellectual function, language, visual construction skills, attention, processing speed, executive functioning abilities, aspects of learning and memory, psychomotor speed and coordination, and basic academic skills. CONCLUSIONS: These findings support the hypothesis that depressive symptomatology negatively impacts performance on cognitive and academic achievement measures in school-aged children and these findings are not affected by ethnicity. The findings also reinforce the concept that the presence of anxious/depressed or withdrawn symptoms needs to be considered when evaluating poor neuropsychological performance in children.

基本原理:很少有研究评估无抑郁症状儿童的抑郁症状学和神经心理表现之间的关系。目的:本研究确定焦虑/抑郁和退缩症状与认知和学业成绩测试成绩之间的关系。方法:参加图森儿童睡眠呼吸暂停评估(TuCASA)研究的335名6至11岁的白人和西班牙裔儿童接受了全面的神经心理测试，测量认知功能和学业成绩。他们的父母完成了儿童行为检查表(CBCL)。计算了认知和学业成就测量和CBCL的两个内化量表之间的相关性。比较“临床”转诊组(使用CBCL量表t评分≥60)和“正常”组，以及高加索人和西班牙人之间的差异。结果:CBCL上焦虑/抑郁或退缩症状加重的受试者与无症状加重的受试者在年龄、性别、种族或父母教育水平方面没有差异。然而，这些症状与一般智力功能、语言、视觉构建技能、注意力、处理速度、执行功能能力、学习和记忆方面、精神运动速度和协调以及基本学术技能之间存在显著的负相关。结论:这些发现支持了抑郁症状对学龄儿童认知和学业成绩有负面影响的假设，这些发现不受种族的影响。研究结果还强化了这样一个概念，即在评估儿童不良的神经心理学表现时，需要考虑焦虑/抑郁或退缩症状的存在。

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引用次数: 71

Neurobiological and Psychological Mechanisms Explaining How Hatred isProgrammed into the Minds of Children 神经生物学和心理学机制解释了仇恨是如何被编入儿童的思想的

The open pediatric medicine journal

Pub Date : 2010-01-04 DOI: 10.2174/1874309900903010058

G. Katzman

An understanding of the mechanisms involving the programming of hatred into the minds of children has evolved. Indoctrination of children with storylines that are often fabrications is common. The animosities engendered by these stories are fueled by anger frequently associated with mental or physical maltreatment of children in authoritarian societies. Studies indicate that the dominant premotor areas of the brain are important for moral decision making and cognitive control. Eliminating destructive indoctrination, prevention of child abuse and inculcating children with values that promote peaceful human relations have the potential for eliminating the development of hatred and the associated acting out of violent behaviors.

对将仇恨植入儿童思想的机制的理解已经有所发展。给孩子灌输虚构的故事情节是很常见的。这些故事引发的敌意，往往与专制社会中儿童遭受精神或身体虐待有关。研究表明，大脑的主要运动前区域对道德决策和认知控制很重要。消除破坏性的思想灌输、防止虐待儿童和向儿童灌输促进和平人际关系的价值观，有可能消除仇恨的发展和相关的暴力行为。

引用次数: 4

Temporal Variation of Ljungan Virus Antibody Levels in Relation to Islet Autoantibodies and Possible Correlation to Childhood Type 1 Diabetes Ljungan病毒抗体水平与胰岛自身抗体的时间变化及其与儿童1型糖尿病的可能相关性

The open pediatric medicine journal

Pub Date : 2010-01-04 DOI: 10.2174/1874309900903010061

Anna-Lena Nilsson, E. Lagerquist, K. Lynch, Å. Lernmark, O. Rolandsson

Viral infection may trigger islet autoimmunity, type 1diabetes (T1D), or both. Fluctuating population density of bank voles as a putative reservoir of Ljungan virus has been claimed to be associated with variations in T1D incidence rate (IR). We tested the hypothesis that Ljungan virus antibodies reflecting prior exposure(s) to the virus may be associated with islet autoimmunity, childhood diabetes or both. Incident, 0-18y, T1D patients (n = 63) were studied along with age and sample time matched controls (n = 126). The younger children (< 9 years) tended to have a higher incidence rate during winter (IR = 67.6, 95%CI 41.9-103.5) compared to summer (IR = 33.6, 95%CI 15.3-63.9) months. The proportion of children with high level antibodies against Ljungan virus (LVAb) were both younger compared to the rest of the children (p < 0.002) and correlated with half yearly T1D IR (r = 0.78, p = 0.005). High level LVAb fluctuating with season and correlating with T1D IR indicates that past exposure to Ljungan virus may be associated with T1D.

病毒感染可能引发胰岛自身免疫，1型糖尿病(T1D)，或两者兼而有之。河岸田鼠作为假定的永安病毒储存库，其种群密度的波动与T1D发病率(IR)的变化有关。我们检验了一种假设，即反映先前暴露于该病毒的Ljungan病毒抗体可能与胰岛自身免疫、儿童糖尿病或两者兼而有之。0-18岁T1D患者(n = 63)与年龄和样本时间匹配的对照组(n = 126)一起进行研究。年龄较小的儿童(< 9岁)在冬季(IR = 67.6, 95%CI 41.9-103.5)的发病率高于夏季(IR = 33.6, 95%CI 15.3-63.9)。携带高水平Ljungan病毒抗体(Ljungan virus, LVAb)的儿童比例比其他儿童更年轻(p < 0.002)，且与半年T1D IR相关(r = 0.78, p = 0.005)。高水平LVAb随季节波动并与T1D IR相关，表明过去接触过Ljungan病毒可能与T1D有关。

引用次数: 8

A Study on Herpes Simplex Encephalitis in 18 Children, Including 3 Relapses 18例儿童单纯疱疹脑炎复发3例分析

The open pediatric medicine journal

Pub Date : 2009-07-09 DOI: 10.2174/1874309900903010048

M. Salih, H. E. Khashab, H. Hassan, A. Kentab, Sara S. Al Subaei, R. M. Zeidan, M. Al-Nasser, S. Othman

Background: Herpes Simplex Virus (HSV) is the most common cause of acute sporadic focal encephalitis. Early Diagnosis is, therefore, crucial for predicting outcome. Improved laboratory technology and improved neuroimaging accessibility have enhanced our ability to diagnose this condition. Aims: To assess the reliability of different investigative tools in diagnosing and subsequent management of herpes simplex encephalitis (HSE); as well as the impact of infection and its relapse on the outcome of a cohort of 18 children evaluated during a period of 13 years. Methods: This combined prospective and retrospective study describes the clinical, laboratory, electroencephalographic and diagnostic imaging studies; and outcome in a cohort of 18 children with HSE over a period of 13 years. It also details the clinical and diagnostic features of 3 patients who relapsed. Results: The commonest initial presenting symptoms and signs were fever (100%), seizures (72%) irritability (50%) and weakness/hemiparesis (39%). Cerebrospinal fluid (CSF) pleocytosis was found in 62%, red blood cells (RBCs) >10x10 6 /L in 81% and raised proteins (>0.59g/L) in 52%. Examination for herpes simplex virus (HSV) by polymerase chain reaction (PCR) was positive in 50% (6/12). Electroencephalographic changes were universally abnormal (17/17; 100%) and periodic lateralization discharges (PLEDS) were seen in 35% (6/17). During the acute stage (days 1-8 from symptom onset), magnetic resonance imaging (MRI) revealed abnormalities in 91% (10/11), cranial computed tomography (CT) in 50% (5/10) and single photon emission computed tomography (SPECT), within 3days from onset of symptoms) had significant association with poor outcome (P = 0.002). Initial negative PCR results may become positive on subsequent CSF specimen. Conclusion: Diagnosis of HSE requires combined clinical, laboratory, electroencephalographic and neuroimaging studies. Negative results of PCR do not exclude the infection and should not interrupt the treatment. Early diagnosis and initiation of treatment minimize the devastating effect of HSE. Full course treatment with acyclovir for 21 days is also crucial for prognosis and prevention of subsequent relapse.

背景:单纯疱疹病毒(HSV)是急性散发性局灶性脑炎最常见的病因。因此，早期诊断对于预测预后至关重要。改进的实验室技术和改进的神经成像可及性提高了我们诊断这种疾病的能力。目的:评估不同调查工具在单纯疱疹病毒性脑炎(HSE)诊断和后续治疗中的可靠性;以及感染及其复发对一组18名儿童在13年期间的结果的影响。方法:前瞻性和回顾性相结合的研究描述了临床、实验室、脑电图和诊断成像研究;对18名患有HSE的儿童进行了为期13年的研究。本文还详细介绍了3例复发患者的临床和诊断特点。结果:最常见的首发症状和体征为发热(100%)、癫痫发作(72%)、烦躁(50%)和虚弱/偏瘫(39%)。脑脊液(CSF)增多62%，红细胞(rbc) > 10x10.6 /L 81%，蛋白升高(>0.59g/L) 52%。聚合酶链反应(PCR)检测单纯疱疹病毒(HSV)阳性率为50%(6/12)。脑电图改变普遍异常(17/17;100%)和周期性侧化放电(PLEDS)占35%(6/17)。在急性期(症状出现后1-8天)，磁共振成像(MRI)异常率为91%(10/11)，颅脑CT (CT)异常率为50%(5/10)，单光子发射计算机断层扫描(SPECT)在症状出现后3天内与预后不良有显著相关(P = 0.002)。最初的阴性PCR结果可能在随后的CSF标本上变为阳性。结论:诊断HSE需要临床、实验室、脑电图和神经影像学综合检查。PCR阴性结果不能排除感染，不应中断治疗。早期诊断和开始治疗可以最大限度地减少HSE的破坏性影响。用阿昔洛韦进行21天的全程治疗对于预后和预防随后的复发也至关重要。

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引用次数: 10