Pub Date : 2025-12-24DOI: 10.1016/j.bpj.2025.12.032
Alexandra A. Yakusheva, Andrei D. Megalinskii, Catherine Bourdon, Anita Eckly, Alexey M. Shibeko, Fazoil I. Ataullakhanov, Dmitry Y. Nechipurenko, Pierre H. Mangin, Mikhail A. Panteleev
{"title":"Transient build-up of a mural thrombus promotes intrathrombus coagulation reactions","authors":"Alexandra A. Yakusheva, Andrei D. Megalinskii, Catherine Bourdon, Anita Eckly, Alexey M. Shibeko, Fazoil I. Ataullakhanov, Dmitry Y. Nechipurenko, Pierre H. Mangin, Mikhail A. Panteleev","doi":"10.1016/j.bpj.2025.12.032","DOIUrl":"https://doi.org/10.1016/j.bpj.2025.12.032","url":null,"abstract":"","PeriodicalId":8922,"journal":{"name":"Biophysical journal","volume":"11 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145823745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.bpj.2025.12.028
Stefanie D. Pritzl, Jan Lipfert
{"title":"Protein force spectroscopy using magnetic tweezers: slow and steady wins the race?","authors":"Stefanie D. Pritzl, Jan Lipfert","doi":"10.1016/j.bpj.2025.12.028","DOIUrl":"https://doi.org/10.1016/j.bpj.2025.12.028","url":null,"abstract":"","PeriodicalId":8922,"journal":{"name":"Biophysical journal","volume":"9 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-23DOI: 10.1016/j.bpj.2025.12.024
Ramon Mendoza Uriarte, Benoît Roux
{"title":"Conductance of a potassium channel in the limit of zero membrane potential","authors":"Ramon Mendoza Uriarte, Benoît Roux","doi":"10.1016/j.bpj.2025.12.024","DOIUrl":"https://doi.org/10.1016/j.bpj.2025.12.024","url":null,"abstract":"","PeriodicalId":8922,"journal":{"name":"Biophysical journal","volume":"26 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-22DOI: 10.1016/j.bpj.2025.12.023
Anil K Dasanna,Marianne Papagrigorakes,Michael Lanzer,Ulrich S Schwarz,Gerhard Gompper,Dmitry A Fedosov
Margination is a physical phenomenon that describes the migration of cells and particles toward vessel walls in blood flow, and thus, serves as a necessary pre-condition for the adhesion of particles suspended in blood plasma to the endothelium. In the context of malaria, adhesion of infected red blood cells (iRBCs) to the endothelium is essential for the disease progression, as iRBCs have to evade the removal from the blood circulation in the spleen. Some malaria strains lead to the formation of rosettes, multicellular structures composed of one iRBC surrounded by several adhered healthy RBCs (hRBCs). We employ mesoscopic hydrodynamics simulations and microfluidic experiments to investigate the margination of rosettes in blood flow at various flow rates, volume fractions of hRBCs, and binding strengths between iRBCs and hRBCs. Surprisingly, rosette margination is significantly weaker than that of single iRBCs, suggesting their limited adhesion potential in blood flow. The main reason for poor margination of rosettes is the deformability and dynamics of rosette clusters formed by several hRBCs around one iRBCs. Simulation predictions are confirmed by microfluidic experiments. Our results suggest that the main function of rosette formation is not to enhance cytoadhesion to the endothelium, but to keep the iRBCs in the blood flow, at least along straight vessel segments.
{"title":"Rosette margination in blood flow during malaria pathogenesis.","authors":"Anil K Dasanna,Marianne Papagrigorakes,Michael Lanzer,Ulrich S Schwarz,Gerhard Gompper,Dmitry A Fedosov","doi":"10.1016/j.bpj.2025.12.023","DOIUrl":"https://doi.org/10.1016/j.bpj.2025.12.023","url":null,"abstract":"Margination is a physical phenomenon that describes the migration of cells and particles toward vessel walls in blood flow, and thus, serves as a necessary pre-condition for the adhesion of particles suspended in blood plasma to the endothelium. In the context of malaria, adhesion of infected red blood cells (iRBCs) to the endothelium is essential for the disease progression, as iRBCs have to evade the removal from the blood circulation in the spleen. Some malaria strains lead to the formation of rosettes, multicellular structures composed of one iRBC surrounded by several adhered healthy RBCs (hRBCs). We employ mesoscopic hydrodynamics simulations and microfluidic experiments to investigate the margination of rosettes in blood flow at various flow rates, volume fractions of hRBCs, and binding strengths between iRBCs and hRBCs. Surprisingly, rosette margination is significantly weaker than that of single iRBCs, suggesting their limited adhesion potential in blood flow. The main reason for poor margination of rosettes is the deformability and dynamics of rosette clusters formed by several hRBCs around one iRBCs. Simulation predictions are confirmed by microfluidic experiments. Our results suggest that the main function of rosette formation is not to enhance cytoadhesion to the endothelium, but to keep the iRBCs in the blood flow, at least along straight vessel segments.","PeriodicalId":8922,"journal":{"name":"Biophysical journal","volume":"66 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.bpj.2025.12.014
Enamul Mojumdar, Andreas Sonesson, Quoc Dat Pham, Daniel Topgaard, Emma Sparr
{"title":"Molecular Dynamics in the Stratum Corneum of Plantar Heels in Atopic Dermatitis Patients","authors":"Enamul Mojumdar, Andreas Sonesson, Quoc Dat Pham, Daniel Topgaard, Emma Sparr","doi":"10.1016/j.bpj.2025.12.014","DOIUrl":"https://doi.org/10.1016/j.bpj.2025.12.014","url":null,"abstract":"","PeriodicalId":8922,"journal":{"name":"Biophysical journal","volume":"35 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of Glycine and Its Methyl-Derivatives on Conformational Stability and Dynamics of Cytochrome c","authors":"Sanjeev Kumar, Sureshan Muthusamy, Saraboji Kadhirvel, Kiranjot Kaur, Vijayakumar Rajendran, Rajesh Kumar","doi":"10.1016/j.bpj.2025.12.020","DOIUrl":"https://doi.org/10.1016/j.bpj.2025.12.020","url":null,"abstract":"","PeriodicalId":8922,"journal":{"name":"Biophysical journal","volume":"17 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.bpj.2025.12.022
Dong-hun Lee, Daniel A. Hammer
{"title":"1Measuring the Traction Forces 1of Upstream-Migrating Hematopoietic-like KG1a Cells Under Shear Flow","authors":"Dong-hun Lee, Daniel A. Hammer","doi":"10.1016/j.bpj.2025.12.022","DOIUrl":"https://doi.org/10.1016/j.bpj.2025.12.022","url":null,"abstract":"","PeriodicalId":8922,"journal":{"name":"Biophysical journal","volume":"16 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.bpj.2025.12.019
Phillip Kohl, Chaeyeon Song, Bretton Fletcher, Peter J. Chung, Rebecca L. Best, Herbert P. Miller, Leslie Wilson, Myung Chul Choi, Youli Li, Stuart C. Feinstein, Cyrus R. Safinya
{"title":"A model of the microtubule cytoskeleton of the axon-initial-segment in mixtures of tubulin, tau, and GTP","authors":"Phillip Kohl, Chaeyeon Song, Bretton Fletcher, Peter J. Chung, Rebecca L. Best, Herbert P. Miller, Leslie Wilson, Myung Chul Choi, Youli Li, Stuart C. Feinstein, Cyrus R. Safinya","doi":"10.1016/j.bpj.2025.12.019","DOIUrl":"https://doi.org/10.1016/j.bpj.2025.12.019","url":null,"abstract":"","PeriodicalId":8922,"journal":{"name":"Biophysical journal","volume":"17 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.bpj.2025.11.018
Luis Perez, Xue Wen Ng, Michael Mohs, David W. Piston, Shankar Mukherji
{"title":"Mitochondrial position responds to glucose stimulation in a model of the pancreatic beta cell","authors":"Luis Perez, Xue Wen Ng, Michael Mohs, David W. Piston, Shankar Mukherji","doi":"10.1016/j.bpj.2025.11.018","DOIUrl":"https://doi.org/10.1016/j.bpj.2025.11.018","url":null,"abstract":"","PeriodicalId":8922,"journal":{"name":"Biophysical journal","volume":"17 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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