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Study on Income Effect of Nutrient Intake Structure of Migrant Workers: The Case of China 农民工营养摄入结构的收入效应研究——以中国为例
Pub Date : 2020-08-31 DOI: 10.31033/ijemr.10.4.27
Zhiwei He, Kang Yu
This paper empirically analyzes the income effect of the nutrient intake structure of migrant workers based on the 2014 survey data on the employment and food demand of urban migrant workers in China. The results showed that after controlling for factors such as labor intensity, height and weight, the monthly average income significantly increased the calorie intake of migrant workers, and the income elasticity was 0.052. From the perspective of nutrient intake structure, the average monthly income had no significant effect on the carbohydrate intake of migrant workers, but significantly increased the fat and protein intake of migrant workers, and the income elasticity was 0.222 and 0.075, respectively. Nutrition has not linear relationship between demand and income. The effect of average income on caloric intake of migrant workers in low income group, middle income group and high income group decreases with the increase of income group, until it has no significant effect on high income group, and heat demand income elasticity of low-income as well as middle-income group of migrant workers was 0.182 and 0.092, respectively.
本文基于2014年中国城镇农民工就业与食物需求调查数据,实证分析了农民工营养摄入结构的收入效应。结果表明,在控制劳动强度、身高、体重等因素后,月平均收入显著增加了农民工的热量摄入,收入弹性为0.052。从营养摄入结构来看,月平均收入对农民工碳水化合物摄入量无显著影响,但显著增加了农民工脂肪和蛋白质摄入量,收入弹性分别为0.222和0.075。营养需求与收入之间不存在线性关系。平均收入对低收入群体、中等收入群体和高收入群体农民工热量摄入的影响随着收入群体的增加而减小,直至对高收入群体无显著影响,低收入群体和中等收入群体农民工热需求收入弹性分别为0.182和0.092。
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引用次数: 0
Was the United States Prepared to Confront Covid-19? According to Scientists, It Depends 美国准备好应对Covid-19了吗?根据科学家的说法,这要看情况
Pub Date : 2020-07-04 DOI: 10.2139/ssrn.3643531
Mattia Caldarulo
Six months after the first coronavirus case was identified in the United States, the virus continues to circulate across the country To what extent was the US
在美国发现首例冠状病毒病例六个月后,该病毒继续在全国范围内传播
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引用次数: 0
Construction of an Assistant Forecast System for Breast Cancer Oncotype Dx Recurrence Risk by Machine Learning 基于机器学习的乳腺癌Oncotype Dx复发风险辅助预测系统构建
Pub Date : 2020-07-03 DOI: 10.2139/ssrn.3642585
X. Kong, Lin Zhang, Quanda Zhang, Jiun Choong, Sicong Ma, X. Qin, Z. Qi, Ran Cheng, Yi Fang, Z. Ge, Yu Jiang, Jing Wang
Background: TAILORx data confirm that using a 21-gene expression assay known as Oncotype DX (ODX; Genomic Health, Redwood City, CA) to assess the risk of early-stage breast cancer recurrence can spare women unnecessary chemotherapy. However, high up-front costs (list price, $4175) could dissuade usage. Also, from a technical perspective, this test cannot be widely used in developing countries, especially in relatively poor areas. Methods: By analyzing the Surveillance, Epidemiology, and End-Results (SEER) database, Logistic Regression models were firstly used to identified significant variables that might be associated with breast cancer patients’ ODX recurrence scores (RS) and risk levels. Secondly, by adopting a series of machine leaning (ML) technologies, including random forest (RF), gradient boosting decision tree (GBDT), and XGBoost, we developed an assistant forecast system for the ODX recurrence risks [low-to-intermediate-risk (RS=2~25) and high-risk (RS=26~100)] based on individual’s sociodemographic information and clinicopathological information. This developed system was then validated in an independent validation data set via a training-test split method on the original data set. Findings: We identified 111,635 patients with breast cancer, among which, 86617 patients (77.59%) were not beyond 50 years old. There were 23,514 patients (21.1%) whose ODX RSs were within the low risk of recurrence group, 71,439 patients (64.0%) were at intermediate-risk level, and 16,682 patients (14.9%) were at high-risk level. Via the multinomial ordinal logit regression, the variables closely associated with the ODX recurrence scores included age, sex, race, tumor primary site, histopathological grade, tumor size, pathology, PR status, HER2 status, (all P<0.05). Through our developed assistant forecast system, as long as a breast cancer patient’s precise sociodemographic and clinicopathological information was input, the computer would be able to automatically forecast the patient’s ODX recurrence risk level with an accuracy probability. According to the validation results, the best overall accuracy of this forecast system was 87.02% (Ordered Logistic Regression), with 99.06% specificity (Ordered Logistic Regression), and 86.0% sensitivity (RF). Interpretation: Our developed assistant forecast system based on sociodemographic and clinicopathological data provided clinicians an alternative tool to estimate breast cancer patients’ ODX recurrence risk level, which could be used to help assist in making an adjuvant treatment decision. In the future, this tool is widely worthwhile to be retrospectively validated in clinical practice and applied in actual clinical scenarios.
背景:TAILORx数据证实,使用21个基因表达试验Oncotype DX (ODX;基因组健康,红木城,CA)评估早期乳腺癌复发的风险可以避免妇女不必要的化疗。然而,高昂的前期成本(标价4175美元)可能会阻碍用户使用。此外,从技术角度来看,这种测试不能在发展中国家广泛使用,特别是在相对贫穷的地区。方法:通过对SEER (Surveillance, Epidemiology, and End-Results)数据库的分析,首先采用Logistic回归模型识别可能与乳腺癌患者ODX复发评分(RS)和风险水平相关的显著变量。其次,采用随机森林(random forest, RF)、梯度增强决策树(gradient boosting decision tree, GBDT)、XGBoost等一系列机器学习(ML)技术,基于个体的社会人口统计学信息和临床病理信息,开发了ODX复发风险[低至中危(RS=2~25)和高危(RS=26~100)]的辅助预测系统。然后,通过原始数据集上的训练-测试分割方法,在独立的验证数据集中对该开发系统进行了验证。结果:共发现111635例乳腺癌患者,其中年龄不超过50岁的患者86617例(77.59%)。ODX RSs低危复发组23514例(21.1%),中危复发组71439例(64.0%),高危复发组16682例(14.9%)。经多项有序logit回归分析,与ODX复发评分密切相关的变量包括年龄、性别、种族、肿瘤原发部位、组织病理分级、肿瘤大小、病理、PR状态、HER2状态等(均P<0.05)。通过我们开发的辅助预测系统,只要输入乳腺癌患者精确的社会人口学和临床病理信息,计算机就能自动预测患者的ODX复发风险水平,并具有准确的概率。验证结果表明,该预测系统的最佳总体准确率为87.02%(有序Logistic回归),特异度为99.06%(有序Logistic回归),敏感性为86.0% (RF)。解释:我们开发的基于社会人口学和临床病理数据的辅助预测系统为临床医生提供了一种评估乳腺癌患者ODX复发风险水平的替代工具,可用于帮助制定辅助治疗决策。在未来,该工具值得在临床实践中进行回顾性验证,并在实际临床场景中应用。
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引用次数: 1
Approach of Image Processing in Diagnosis and Medication of Fungal Infections in Pet Animals 图像处理在宠物真菌感染诊断和治疗中的应用
Pub Date : 2020-07-01 DOI: 10.2139/ssrn.3673124
Aarti Chugh, P. Makkar, S. Aggarwal, Shriya Sharma, Yashwant Kumar Singh
The focus of this paper is to design and develop the Artificial Intelligence and Machine Learning based system which detects the fungal infection on a pet animal (especially Dog and Cat), and provide the treatment for it. It also provides the causes, Symptoms, Prevention for it. The proposed system integrates on Machine Learning algorithm trained on disease dataset, it first detects the species of pet animal by capturing the image of fungal infection of pet by using camera or by uploading the image in the system from the file explorer, and then provide the diagnosis about the fungal disease and its medication and treatment also. Although our system will verify the scan image for determining the diseases in canine. Diagnosing the Fungal Infection on pet animal quickly and accurately has the economic effectiveness.
本文的重点是设计和开发基于人工智能和机器学习的宠物动物(特别是狗和猫)真菌感染检测系统,并提供治疗。它还提供了它的原因,症状和预防。该系统结合基于疾病数据集训练的机器学习算法,首先通过摄像头捕捉宠物真菌感染的图像,或者通过文件资源管理器上传宠物真菌感染的图像到系统中,对宠物动物的种类进行检测,然后提供真菌疾病的诊断和药物治疗。虽然我们的系统将验证扫描图像,以确定犬的疾病。快速准确地诊断宠物真菌感染具有经济效益。
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引用次数: 0
Artificial Satisfaction - The Brother of Artificial Intelligence 人工满足——人工智能的兄弟
Pub Date : 2020-06-08 DOI: 10.34257/gjcstdvol20is1pg29
Satish Gajawada, H. Mustafa
John McCarthy (September 4, 1927 – October 24,2011) was an American computer scientist and cognitive scientist. The term “Artificial Intelligence” was coined by him(Wikipedia, 2020). Satish Gajawada (March 12, 1988 – Present) is an Indian Independent Inventor and Scientist. He coined the term “Artificial Satisfaction” in this article (Gajawada, S., and Hassan Mustafa, 2019a). A new field titled “Artificial Satisfaction” is introduced in this article. “Artificial Satisfaction” will be referred to as “The Brother of Artificial Intelligence” after the publication of this article. A new algorithm titled “Artificial Satisfaction Algorithm (ASA)” is designed and implemented in this work. For the sake of simplicity, Particle Swarm Optimization (PSO) Algorithm is modified with Artificial Satisfaction Concepts to create the“Artificial Satisfaction Algorithm (ASA).” PSO and AS Aalgorithms are applied on five benchmark functions. A comparision is made between the results obtained. The focus of this paper is more on defining and introducing “Artificial Satisfaction Field” to the rest of the world rather than on implementing complex algorithms from scratch.
约翰·麦卡锡(John McCarthy, 1927年9月4日- 2011年10月24日),美国计算机科学家和认知科学家。“人工智能”一词是由他创造的(维基百科,2020)。萨蒂什·加贾瓦达(1988年3月12日-至今),印度独立发明家和科学家。他在这篇文章中创造了“人工满足”一词(Gajawada, S.和Hassan Mustafa, 2019a)。本文介绍了一个名为“人工满足”的新领域。本文发表后,“人工满足”将被称为“人工智能的兄弟”。本文设计并实现了一种新的算法“人工满足算法(Artificial Satisfaction algorithm, ASA)”。为简单起见,将粒子群优化算法(Particle Swarm Optimization, PSO)加入人工满意(Artificial Satisfaction)概念,形成“人工满意算法(Artificial Satisfaction Algorithm, ASA)”。在5个基准函数上分别应用了PSO和AS算法。对得到的结果进行了比较。本文的重点是定义和介绍“人工满足场”,而不是从头开始实现复杂的算法。
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引用次数: 2
Raman Spectroscopy is Sensitive to Biochemical Changes Related to Various Cartilage Injuries 拉曼光谱对各种软骨损伤相关的生化变化敏感
Pub Date : 2020-06-04 DOI: 10.2139/ssrn.3606831
R. Shaikh, E. Nippolainen, V. Virtanen, J. Torniainen, L. Rieppo, S. Saarakkala, I. Afara, J. Töyräs
In recent years, Raman spectroscopy has evolved as a promising in vivo tool in various biomedical applications. It has also shown potential for scoring the lesion severity of joint cartilage, which could be useful in determining the best treatment strategy during cartilage arthroscopic repair surgery. However, the effect of different cartilage injury types on Raman spectra is unknown. The study aims to show the potential of Raman spectroscopy to detect different cartilage injury types that mimic physiologically relevant damages. Different types of injuries were induced using established mechanical and enzymatic approaches. The mechanical damage—was induced through surface abrasion (ABR) (n = 12) or impact loading (IMP) (n = 12). Enzymatic damage—was induced using three different treatments: 30 minutes trypsin digestion (T-30)(n = 12), 90 minutes collagenase digestion (C-90)(n = 12), and 24 hours collagenase digestion (C-24)(n = 12). Raman spectra were obtained from all the specimens, and partial least squares discriminant analysis (PLS-DA) was applied to distinguish cartilage injury types from their respective controls. The PLS-DA cross-validation accuracies were higher for C-24 (88%) and IMP (79%) than for C-90 (67%), T-30 (63%), and ABR (58%) groups. This study indicates that Raman spectroscopy, combined with multivariate analysis, can identify different cartilage injury types.
近年来,拉曼光谱已经发展成为一种有前途的体内工具,在各种生物医学应用。它还显示了对关节软骨损伤严重程度评分的潜力,这可能有助于确定软骨关节镜修复手术期间的最佳治疗策略。然而,不同软骨损伤类型对拉曼光谱的影响尚不清楚。该研究旨在展示拉曼光谱的潜力,以检测不同的软骨损伤类型,模拟生理相关损伤。采用已建立的机械和酶的方法诱导不同类型的损伤。机械损伤是通过表面磨损(ABR) (n = 12)或冲击载荷(IMP) (n = 12)引起的。采用三种不同的处理方法诱导酶损伤:30分钟胰蛋白酶消化(T-30)(n = 12), 90分钟胶原酶消化(C-90)(n = 12)和24小时胶原酶消化(C-24)(n = 12)。从所有标本中获得拉曼光谱,并应用偏最小二乘判别分析(PLS-DA)区分软骨损伤类型与各自的对照。C-24(88%)和IMP(79%)的PLS-DA交叉验证准确性高于C-90(67%)、T-30(63%)和ABR(58%)组。本研究表明,结合多变量分析,拉曼光谱可以识别不同的软骨损伤类型。
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引用次数: 9
System Engineering and Overshoot Damping for Epidemics Such As COVID-19 COVID-19等流行病的系统工程与超调阻尼
Pub Date : 2020-05-01 DOI: 10.2139/ssrn.3590869
Robert L. Shuler, Theodore Koukouvitis, Dyske Suematsu
Like the trajectory of a rocket whose landing point is unpredictable unless it is steered, an epidemic takes a trajectory highly dependent on human behavior. To control the threat of a pandemic, a city or region must also be viewed as a system with certain capacities and constraints. The goal of this paper is to contribute the perspective of a systems engineer to the effort to fight pandemics. The availability of low latency case data and effectiveness of social distancing suggest sufficient control authority is for successful smoothing and targeting almost any desired level of low or high cases and immunity. We examine multi-step and intermittent-with-feedback partial unlock of social distancing for rapidly-spreading moderate-mortality epidemics and pandemics similar to COVID-19. Optimized scenarios reduce total cases and therefore deaths typically 8% and up to 30% by controlling overshoot as groups cross the herd immunity threshold, or lower thresholds to manage medical resources and provide economic relief. We analyze overshoot and provide guidance on how to damp it. An SIR model is used to evaluate scenarios that are intended to function over a wide variety of parameters. The end result is not a case trajectory prediction, but a prediction of which strategies produce near-optimal results over a wide range of epidemiological and social parameters.
就像火箭的轨迹一样,除非有人操纵,否则它的着陆点是不可预测的,流行病的轨迹高度依赖于人类的行为。为了控制大流行的威胁,还必须将一个城市或地区视为具有一定能力和制约因素的系统。本文的目标是为抗击流行病的努力提供一个系统工程师的视角。低潜伏期病例数据的可用性和社会距离的有效性表明,有足够的控制权力可以成功地平滑和瞄准几乎任何期望的低或高病例和免疫水平。我们研究了快速传播的中等死亡率流行病和类似于COVID-19的流行病的多步骤和间歇性反馈部分解除社会距离的方法。优化方案通过控制群体越过群体免疫阈值或更低阈值以管理医疗资源和提供经济救济时的超调,将总病例减少8%,因此死亡率最高可达30%。我们分析超调并提供如何抑制超调的指导。SIR模型用于评估旨在在各种参数上运行的场景。最终结果不是病例轨迹预测,而是预测哪种策略在广泛的流行病学和社会参数范围内产生接近最佳的结果。
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引用次数: 0
Production of an Alkaline Protease From Nocardiopsis Alba Om-4, a Haloalkaliphilic Actinobacteria in Solid-State Fermentation Using Agricultural Waste Products 利用农业废弃物固态发酵嗜盐嗜碱放线菌白无心菌Om-4生产碱性蛋白酶
Pub Date : 2020-04-12 DOI: 10.2139/ssrn.3586506
F. Thakrar, D. Goswami, Satya P. Singh
Microbial proteases are useful in silk degumming, leather processing, detergent additives and waste water treatment. It is important to explore the cheap and easily available substrates for the growth and protease production by the microorganisms. A haloalkaliphilic actinobacterium, Nocardiopsis alba OM-4 was grown on solid waste materials and the media were optimized for the maximum protease production. The haloalkaliphilic actinobacterial culture was inoculated in house hold waste and agro-industrial waste products including wheat bran, lentil husk, green gram husk, corn cob, vegetables peels, fruit peels, agricultural waste, pulses flour, walnut shell, pista shell, ground nut been husk and gelatine. All the ingredients of the solid state media were in the range of 0.5-5.0 g/ml and the growth along with protease production was monitored for fifteen days. The aliquots of the grown culture were harvested each day and protease activity and growth were measured. Different combinations of medium components were assessed for the growth and protease production. The comparison of the protease activity revealed that pulse flour, corn cob, vegetable pills and green gram husk followed by agriculture waste supported the protease production. Walnut shell and Pista shell didn’t enhance the growth and protease production. Other ingredients were also useful for growth and protease production.
微生物蛋白酶可用于丝绸脱胶、皮革加工、洗涤剂添加剂和废水处理。为微生物的生长和蛋白酶生产寻找廉价易得的底物是很重要的。在固体废物上培养嗜盐嗜碱放线菌白诺卡菌OM-4,并对培养基进行优化,使其蛋白酶产量达到最大。对小麦麸、扁豆皮、绿革皮、玉米芯、蔬菜皮、水果皮、农业废弃物、豆类粉、核桃壳、开心果壳、碎坚果壳和明胶等生活垃圾和农工废弃物进行了嗜卤碱性放线菌培养。固体培养基的所有成分在0.5 ~ 5.0 g/ml范围内,监测15 d的生长和蛋白酶的产生。每天收获培养物等分,测定蛋白酶活性和生长情况。对培养基成分的不同组合进行了生长和蛋白酶产量的评估。蛋白酶活性的比较表明,脉冲面粉、玉米芯、蔬菜丸和绿克皮最有利于蛋白酶的产生,其次是农业废弃物。核桃壳和Pista壳对生长和蛋白酶产量没有促进作用。其他成分也有助于生长和蛋白酶的产生。
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引用次数: 1
Assessment of Vessel and Fiber Characteristics of Blighia Sapida Konig. And Lecaniodiscus Cupanoides Planch Ex Benth. Growing in Rainforest and Derived Savanna Areas of Edo State, Nigeria 白螺旋藻血管和纤维特性的评价。Lecaniodiscus Cupanoides Planch Ex Benth。生长在尼日利亚埃多州的热带雨林和衍生稀树草原地区
Pub Date : 2020-04-01 DOI: 10.33472/afjbs.2.2.2020.58-69
Okoegwale E. E., Idialu J. E., Ehilen O. E., Ogie-Odia E. A.
This study was carried out to assess the vessel and fiber dimensions and characteristics of Blighia sapida Konig. and Lecaniodiscus cupanoides Planch ex Benth. growing in the rainforest and derived savanna regions of Edo state, Nigeria. In both taxa, rainforest species possessed wider and longer vessels than the derived savanna species. Also, significant variations were recorded in taxa vessel wall thickness between the two ecozones. The derived savanna plants had thicker vessel wall to counterbalance the water stress prevalent in that environment. In both species, vessel members lacked tails. Also, taxa fibers were of short and medium lengths. Significant variations between fiber lengths of species occurring in both habitats were not encountered. Fiber elements of taxa were of moderately thick wall while fiber/vessel length ratio was greater than 1 in both taxa. Although runkel ratios of both species studied were less than 1, they may however not be suitable for high grade pulp because of their low fiber length values. The study has revealed that the woods are suitable for various end uses because of the presence and distribution of vessels and fiber with thick walls.
本研究旨在研究白螺旋藻(Blighia sapida Konig)的血管和纤维尺寸及其特性。和Lecaniodiscus cupanoides Planch ex Benth。生长在尼日利亚埃多州的热带雨林和衍生稀树草原地区。在这两个分类群中,热带雨林物种比衍生的热带稀树草原物种具有更宽和更长的导管。此外,两个生态区的分类群血管壁厚度也存在显著差异。衍生的热带稀树草原植物具有较厚的血管壁,以抵消该环境中普遍存在的水分胁迫。在这两个物种中,导管成员都没有尾巴。分类群的纤维长度均为中短。在两种生境中,没有发现物种纤维长度的显著差异。两个类群的纤维成分均为中等厚壁,纤维/导管长度比均大于1。虽然所研究的两种植物的朗克尔比都小于1,但由于它们的纤维长度值较低,可能不适合用于优质纸浆。研究表明,由于厚壁容器和纤维的存在和分布,这些木材适用于各种最终用途。
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引用次数: 2
Reduced Proteoglycan-Rich Layer and Altered Immunotolerance Capacity of C4ST-1-Depleted Bone Marrow Mesenchymal Stem Cells on Titanium Dioxide c4st -1缺失骨髓间充质干细胞对二氧化钛的免疫耐受能力改变及富蛋白多糖层减少
Pub Date : 2020-03-26 DOI: 10.2139/ssrn.3559965
Hisanobu Kamio, Shuehi Tsuchiya, K. Kuroda, M. Okido, Kazuto Okabe, H. Hibi
Successful osseointegration of a bone and implant directly must be achieved for treatment of a dental implant. However, the mechanism of osseointegration at the molecular level has yet to be fully elucidated. In this study, we focused on the proteoglycans (PGs)-rich layer between titanium dioxide (TiO2) and bone and chondroitin-4-sulfate transferase-1 (C4ST-1) that forms the sugar chain in PGs. Human bone marrow mesenchymal stem cells (hBMSCs) depleted of C4ST-1 were cultured on TiO2, and the interface between hBMSCs and TiO2 was analyzed by transmission electron microscopy. Further, the immunotolerance capacity, cell proliferation, initial attachment, and calcification were analyzed in vitro. At 14 days cultivation, a PGs-rich layer was observed between hBMSCs and TiO2. However, the PGs-rich layer was reduced in C4ST-1-depleted hBMSCs on TiO2. Further, real-time RT-PCR showed that conditioned media increased gene expression levels of M1-macrophage markers in human macrophages. However, C4ST-1 did not affect calcification, cell proliferation, and initial cell attachment on TiO2. These results suggested that C4ST-1 in hBMSCs affected the width of the PGs-rich layer on TiO2 and their immunotolerance capacity.
牙种植体的治疗必须实现骨与种植体的直接骨融合。然而,骨整合在分子水平上的机制尚未完全阐明。在本研究中,我们重点研究了二氧化钛(TiO2)和骨骼之间富含蛋白聚糖(pg)的层以及形成pg糖链的硫酸软骨素-4-硫酸软骨素转移酶-1 (C4ST-1)。将C4ST-1缺失的人骨髓间充质干细胞(hBMSCs)培养在TiO2上,通过透射电镜分析hBMSCs与TiO2之间的界面。进一步分析了体外免疫耐受能力、细胞增殖、初始附着和钙化。培养第14天,在hBMSCs和TiO2之间形成了一层富含pgs的层。然而,在TiO2上缺失c4st -1的hBMSCs中,富pgs层减少。此外,实时RT-PCR结果显示,条件培养基增加了人巨噬细胞中m1 -巨噬细胞标志物的基因表达水平。然而,C4ST-1不影响TiO2上的钙化、细胞增殖和初始细胞附着。这些结果表明,hBMSCs中的C4ST-1影响了TiO2上富pgs层的宽度和免疫耐受能力。
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引用次数: 0
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