Biomedical Journal最新文献_第7页

Associations with lip cant and facial midline correction following bimaxillary surgery in class III asymmetry: A CBCT-based analysis 双颌III类不对称手术后唇斜和面部中线矫正的相关性：基于cbct的分析。

IF 4.4 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal

Pub Date : 2025-06-12 DOI: 10.1016/j.bj.2025.100877

Chih-Ling Lin , Yun-Fang Chen , Ying-An Chen , Chuan-Fong Yao , Tong Xi , Yu-Fang Liao , Yu-Ray Chen

Background

This study evaluated the outcomes of bimaxillary surgery for class III asymmetry and lip cant, and identified factors associated with lip cant and facial midline correction.

Materials and methods

Fifty adult patients (22 females, 28 males; mean age: 24.8 ± 5.1 years) with class III asymmetry and lip cant who underwent bimaxillary surgery were prospectively and consecutively analyzed. Cone-beam computed tomography scans obtained preoperatively and at postoperative follow-up were superimposed to assess surgical jaw movements in six degrees of freedom and their effects on lip cant and facial midline symmetry.

Results

Significant reductions were observed in lip cant (1.6 ± 1.6 mm), lower lip deviation (2.4 ± 1.7 mm), chin deviation (5.8 ± 4.2 mm), and facial midline deviation (9.7 ± 7.2 mm). Multiple linear regression analysis identified mandibular roll correction (β = 0.456, p < 0.01) and pre-treatment lip cant severity (β = 0.394, p < 0.01) as significant factors of lip cant reduction. Additionally, chin shift (β = 0.495, p < 0.01) and mandibular shift (β = 0.461, p < 0.01) were significant factors of facial midline correction.

Conclusion

Bimaxillary surgery significantly improved lip cant and facial midline deviation in patients with class III asymmetry and lip cant. Mandibular roll correction and pre-treatment lip cant severity were key factors associated with lip cant correction, while chin and mandibular shift correction were associated with facial midline improvement.

背景：本研究评估了III类不对称和唇斜的双颌手术的结果，并确定了唇斜和面部中线矫正的相关因素。材料与方法：50例成人患者(女性22例，男性28例；平均年龄：24.8±5.1岁)，伴有III类不对称和唇裂，行双颌手术的患者进行前瞻性和连续性分析。术前和术后随访的锥形束计算机断层扫描（CBCT）进行了叠加，以评估手术下颌在六自由度的运动及其对唇斜和面部中线对称的影响。结果：唇部偏斜（1.6±1.6 mm）、下唇偏斜（2.4±1.7 mm）、下颌偏斜（5.8±4.2 mm）、面部中线偏斜（9.7±7.2 mm）明显减小。多元线性回归分析发现，下颌侧倾矫正（β = 0.456, P < 0.01）和治疗前唇斜严重程度（β = 0.394, P < 0.01）是唇斜减少的显著因素。下颌移位（β = 0.495, P < 0.01）和下颌移位（β = 0.461, P < 0.01）是面部中线矫正的显著影响因素。结论：双颌手术可明显改善III类不对称伴唇斜患者的唇斜和面部中线偏斜。下颌侧倾矫正和治疗前唇斜矫正的严重程度是影响唇斜矫正的关键因素，而下颌侧移矫正与面部中线改善相关。

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引用次数: 0

Influence of acupuncture twisting parameters on analgesic effects mediated by mast cells in AA rat models 针刺扭转参数对AA大鼠肥大细胞介导的镇痛作用的影响。

IF 4.4 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal

Pub Date : 2025-06-04 DOI: 10.1016/j.bj.2025.100876

Yi Yu , Yi-Xuan Wang , Xuan Qiao , Ying-Chen Li , Yu-Hang Liu , Zouqin Huang , Wei Yao

Acupuncture has been recognized for its potential effectiveness in pain relief without the side effects commonly associated with pharmaceutical treatments. This study investigates the effects of various acupuncture twisting parameters on analgesia using an acute adjuvant-induced arthritis (AA) rat model, focusing on the roles of mast cell activation, histamine (HIS) release, and local neural pathways. Utilizing robot-assisted acupuncture, we varied rotation angles (60°–360°) and frequencies (0.5–2.5 Hz) to evaluate their influence on pain modulation. The pain threshold recovery ratio (PTRR) was used to quantify the analgesic effect. The optimal combination of a 180° rotation angle and 1.0 Hz frequency resulted in the strongest analgesic effect, as indicated by increased PTRR and elevated mast cell degranulation rates (MCdR). Additionally, local HIS injections replicated the analgesic effects of acupuncture, whereas administration of an H1 receptor antagonist and lidocaine reduced these effects, highlighting the essential roles of HIS and local nerve conduction in acupuncture-induced analgesia. This study demonstrates the existence of optimal acupuncture parameters for achieving maximal analgesic effects in rat models, and elucidates the critical role of mast cell-mediated neural pathways, thus providing insights into optimizing acupunctire's clinical application in pain management.

针灸因其在缓解疼痛方面的潜在有效性而被公认，而且没有通常与药物治疗相关的副作用。本研究采用急性佐剂性关节炎（AA）大鼠模型，研究不同针刺扭转参数对镇痛的影响，重点研究肥大细胞活化、组胺（HIS）释放和局部神经通路的作用。利用机器人辅助针灸，我们改变了旋转角度（60°-360°）和频率（0.5-2.5 Hz）来评估它们对疼痛调节的影响。采用痛阈恢复比（PTRR）评价镇痛效果。180°旋转角度和1.0 Hz频率的最佳组合产生最强的镇痛效果，PTRR升高，肥大细胞脱颗粒率（MCdR）升高。此外，局部注射HIS可以复制针灸的镇痛效果，而H1受体拮抗剂和利多卡因则会降低这些效果，这突出了HIS和局部神经传导在针灸镇痛中的重要作用。本研究在大鼠模型中证实了最佳针刺参数的存在，并阐明了肥大细胞介导的神经通路的关键作用，从而为优化针刺在疼痛管理中的临床应用提供了见解。

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引用次数: 0

IRE1α-mediated endoplasmic reticulum stress response regulates oxidative damage in CYP4V2 deficient human retinal pigment epithelial cells ire1介导的内质网应激反应调节CYP4V2缺陷人视网膜色素上皮细胞的氧化损伤

IF 4.4 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal

Pub Date : 2025-06-02 DOI: 10.1016/j.bj.2025.100875

Yu-Ting Hsiao , Chang-Chun Hsiao , Jong-Jer Lee

Background

Given the role of polyunsaturated fatty acid (PUFA) overload and mitochondrial dysfunction in retinal pigment epithelium (RPE) cells in causing retinal degeneration in Bietti crystalline dystrophy (BCD), we aimed to identify the pathways responsible for intracellular oxidative stress and mitochondrial damage in CYP4V2-deficient RPE cells.

Materials and methods

Proteomic analysis of control and CYP4V2-knockdown (KD) ARPE-19 cells revealed that endoplasmic reticulum (ER) stress was the most enriched pathway. The effects of CYP4V2 deficiency on intracellular reactive oxygen species, mitochondrial integrity, and ATP production were assessed.

Results

Inositol-requiring enzyme 1 α (IRE1α) inhibitors suppressed upregulation of endoplasmic reticulum oxidoreductase 1 alpha (ERO1-Lα) protein expression, which contributed to ER-associated oxidative stress. Loss of mitochondrial transmembrane potential and reduced ATP production were mitigated with IRE1α inhibitor in CYP4V2-KD ARPE-19 cells.

Conclusions

Our findings reveal a novel regulatory mechanism involving potential reduction in PUFA utilization, IRE1α signaling mediated ER oxidative stress, and mitochondrial dysfunction in BCD, potentially offering future therapeutic avenues.

背景：考虑到视网膜色素上皮（RPE）细胞中多不饱和脂肪酸（PUFA）过载和线粒体功能障碍在引起Bietti晶体营养不良（BCD）视网膜变性中的作用，我们旨在确定cyp4v2缺陷RPE细胞内氧化应激和线粒体损伤的途径。材料和方法：对照和cyp4v2敲低（KD）的ARPE-19细胞的蛋白质组学分析显示，内质网（ER）应激是最富集的途径。评估CYP4V2缺乏对细胞内活性氧、线粒体完整性和ATP产生的影响。结果：肌醇要求酶1α (IRE1α)抑制剂抑制内质网氧化还原酶1α (ERO1-Lα)蛋白表达上调，该蛋白参与内质网氧化应激。在CYP4V2-KD ARPE-19细胞中，IRE1α抑制剂可以减轻线粒体跨膜电位的丧失和ATP产生的减少。结论：我们的研究结果揭示了一种新的调节机制，涉及BCD中PUFA利用的潜在减少、IRE1α信号介导的内质网氧化应激和线粒体功能障碍，可能为未来的治疗提供途径。

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引用次数: 0

Association between pentoxifylline use and diabetic retinopathy in patients with type 2 diabetes mellitus and chronic kidney disease: A multi-institutional cohort study 2 型糖尿病合并慢性肾脏病患者使用五氧嘧啶与糖尿病视网膜病变之间的关系：一项多机构队列研究。

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal

Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2024.100771

Tzu-Yi Lin , Eugene Yu-Chuan Kang , Nan-Kai Wang , Je-Ho Kang , Kuan-Jen Chen , Wei-Chi Wu , Chi-Chun Lai , Yih-Shiou Hwang

Background

Pentoxifylline is administered to improve the hemodynamics of patients with chronic kidney disease (CKD). Despite the improvement of capillary blood flow velocity in the retina after pentoxifylline use, no evidence has been provided to prove the protective effect against diabetic retinopathy (DR). Therefore, this study aimed to assess the risk of DR in pentoxifylline users with CKD and diabetes mellitus (DM).

Material and methods

In this retrospective cohort study, the Chang Gung Research Database, which includes the data of patients with CKD and DM from 2003 to 2019, was used. Each calendar year was divided into 4 data units with 3 months each for every patient and every year during the follow-up. The ocular outcomes were new-onset DR, DR-related complications, and vitreoretinal interventions.

Results

A total of 56,439 patients without preexisting DR and 5039 patients with preexisting DR were included in this study. Exposure to pentoxifylline was associated with an elevated risk of new-onset DR (adjusted hazard ratio = 1.24, 95% confidence interval = 1.13–1.36) in patients without preexisting DR. Additionally, exposure to pentoxifylline was associated with an elevated risk of DR-related complications and vitreoretinal interventions in patients with or without preexisting DR.

Conclusions

Exposure to pentoxifylline is associated with an elevated risk of DR, regardless of whether patients have preexisting DR.

背景：使用五氧去氧肾上腺素可改善慢性肾脏病（CKD）患者的血液动力学。尽管使用五氧去氧肾上腺素后视网膜毛细血管血流速度有所改善，但尚无证据证明其对糖尿病视网膜病变（DR）有保护作用。因此，本研究旨在评估患有慢性肾脏病和糖尿病（DM）的戊唑醇使用者发生 DR 的风险：在这项回顾性队列研究中，使用了长庚研究数据库，其中包括 2003 年至 2019 年期间 CKD 和 DM 患者的数据。在随访期间，每个日历年分为 4 个数据单元，每个单元为每个患者和每年 3 个月。眼部结果包括新发 DR、DR 相关并发症和玻璃体视网膜干预：本研究共纳入了 56439 名未患 DR 的患者和 5039 名已患 DR 的患者。在无原有 DR 的患者中，接触戊氧地塞米松与新发 DR 风险升高有关（调整后危险比 = 1.24，95% 置信区间 = 1.13-1.36）。此外，无论是否已存在DR，暴露于戊氧肾上腺素均与DR相关并发症和玻璃体视网膜干预风险升高有关：结论：无论患者是否患有先天性DR，接触戊乙福林都与DR风险升高有关。

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引用次数: 0

miRNA-mediated regulation of clock gene expression in men and women with colorectal cancer and possible consequences for disease management miRNA 介导的男性和女性结直肠癌患者时钟基因表达调控及对疾病管理的可能影响。

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal

Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2024.100784

Iveta Herichová

Background

The incidence and mortality of colorectal cancer (CRC) are persistently higher in men than in women. CRC malignancy is strongly influenced by small non-coding RNAs (miRNAs). Moreover, deregulation of the circadian molecular oscillator has been associated with CRC facilitation. To analyse possible cumulative effects of the above-mentioned factors on CRC progression, we focused on functions of sex-biased miRNAs associated with the clock genes per2 and/or cry2, which are involved in the cell cycle control and DNA damage response.

Major findings

We identified miR-24, miR-92a, miR-181a, and miR-21 associated with per2 that are up-regulated in transformed colon tissue of men. miR-93, miR-17, miR-20a, and miR-24 with higher expression in males compared to females were linked to cry2. All these miRNAs possess oncogenic potential and exert their effects mainly via inhibition of the tumour suppressors phosphatase and tensin homolog (PTEN) and/or p53. Down-regulation of PTEN and p53 in men was further strengthened by inhibition of tumour suppressor per2. Oncogenic up-regulated miRNAs associated with per2 or cry2 in the transformed colon tissue of women were not detected.

Conclusion

We conclude that the cancer-promoting, sex-biased miRNAs miR-24, miR-92a, miR-181a, miR-93, miR-17, miR-20a, and miR-21 associated with clock genes per2 and/or cry2 can contribute to the sex-dependent development of CRC via inhibition of the PTEN and p53 pathways.

背景：男性结直肠癌（CRC）的发病率和死亡率一直高于女性。CRC 的恶性程度受小非编码 RNA（miRNA）的强烈影响。此外，昼夜节律分子振荡器的失调也与 CRC 的诱发有关。为了分析上述因素对 CRC 进展可能产生的累积效应，我们重点研究了与时钟基因 per2 和/或 cry2 相关的性别偏向 miRNA 的功能，这些基因参与细胞周期控制和 DNA 损伤反应：我们发现了与per2相关的miR-24、miR-92a、miR-181a和miR-21，它们在男性转化结肠组织中上调。所有这些 miRNA 都具有致癌潜能，主要通过抑制肿瘤抑制因子磷酸酶和天丝同源物（PTEN）和/或 p53 发挥作用。男性 PTEN 和 p53 的下调通过抑制肿瘤抑制因子 per2 得到进一步加强。在女性的转化结肠组织中，未检测到与 per2 或 cry2 相关的致癌上调 miRNA：结论：我们得出结论，与时钟基因 per2 和/或 cry2 相关的具有性别偏见的促癌 miRNAs miR-24、miR-92a、miR-181a、miR-93、miR-17、miR-20a 和 miR-21 可通过抑制 PTEN 和 p53 通路，促进 CRC 的性别依赖性发展。

{"title":"miRNA-mediated regulation of clock gene expression in men and women with colorectal cancer and possible consequences for disease management","authors":"Iveta Herichová","doi":"10.1016/j.bj.2024.100784","DOIUrl":"10.1016/j.bj.2024.100784","url":null,"abstract":"<div><h3>Background</h3><div>The incidence and mortality of colorectal cancer (CRC) are persistently higher in men than in women. CRC malignancy is strongly influenced by small non-coding RNAs (miRNAs). Moreover, deregulation of the circadian molecular oscillator has been associated with CRC facilitation. To analyse possible cumulative effects of the above-mentioned factors on CRC progression, we focused on functions of sex-biased miRNAs associated with the clock genes per2 and/or cry2, which are involved in the cell cycle control and DNA damage response.</div></div><div><h3>Major findings</h3><div>We identified miR-24, miR-92a, miR-181a, and miR-21 associated with per2 that are up-regulated in transformed colon tissue of men. miR-93, miR-17, miR-20a, and miR-24 with higher expression in males compared to females were linked to cry2. All these miRNAs possess oncogenic potential and exert their effects mainly via inhibition of the tumour suppressors phosphatase and tensin homolog (PTEN) and/or p53. Down-regulation of PTEN and p53 in men was further strengthened by inhibition of tumour suppressor per2. Oncogenic up-regulated miRNAs associated with per2 or cry2 in the transformed colon tissue of women were not detected.</div></div><div><h3>Conclusion</h3><div>We conclude that the cancer-promoting, sex-biased miRNAs miR-24, miR-92a, miR-181a, miR-93, miR-17, miR-20a, and miR-21 associated with clock genes per2 and/or cry2 can contribute to the sex-dependent development of CRC via inhibition of the PTEN and p53 pathways.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 3","pages":"Article 100784"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Additional insights on SARS-CoV-2 spike protein variants and red blood cells biology 关于SARS-CoV-2刺突蛋白变异和红细胞生物学的其他见解。

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal

Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2025.100856

Francesco Dima, Gian Luca Salvagno, Giuseppe Lippi

引用次数: 0

Chronic low-dose REV-ERBs agonist SR9009 mitigates constant light-induced weight gain and insulin resistance via adipogenesis modulation 慢性低剂量REV-ERBs激动剂SR9009通过调节脂肪生成减轻恒定光诱导的体重增加和胰岛素抵抗。

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal

Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2025.100830

Ming-Yu Yang , Hugo Y.-H. Lin , Yi-Ywan M. Chen , Ming-Luen Hu , I-Ya Chen , Chao-Hui Yang

Background

Obesity and circadian rhythm disruption are significant global health concerns, contributing to an increased risk of metabolic disorders. Both adipose tissue and circadian rhythms play critical roles in maintaining energy homeostasis, and their dysfunction is closely linked to obesity. This study aimed to assess the effects of chronic low-dose SR9009, a REV-ERB ligand, on circadian disruption induced by constant light exposure in mice.

Material and methods

Mice were exposed to constant light for eight weeks (LL mice), resulting in increased body weight, insulin resistance, white fat mass, and altered circadian clock gene expression. Low-dose SR9009 (10 mg/kg daily) was administered chronically to assess its impact on these metabolic disruptions.

Results

LL mice treated with SR9009 for eight weeks showed reduced weight gain, insulin resistance, and white fat mass but no significant impact on overall energy homeostasis. SR9009 suppressed Bmal1 expression and restored Rev-erbα and Rev-erbβ expression in white and brown adipose tissue (WAT and BAT). In vitro studies using 3T3-L1 cells indicated that SR9009 inhibited adipogenesis, leading to further investigation in vivo. SR9009 restored ChREBP1a and Srebp-1c expression in BAT but did not affect inflammatory cytokine or adipokine gene expression, nor did it restore Fasn, Pparγ, and Prom1 expression in both WAT and BAT.

Conclusions

These findings suggest that SR9009 may be a potential therapeutic approach for preventing weight gain and insulin resistance caused by circadian disruptions, likely through adipogenesis inhibition, though its effects on other metabolic pathways remain limited at low doses.

背景：肥胖和昼夜节律紊乱是重大的全球健康问题，导致代谢紊乱的风险增加。脂肪组织和昼夜节律在维持能量稳态中都起着至关重要的作用，它们的功能障碍与肥胖密切相关。本研究旨在评估慢性低剂量SR9009 （REV-ERB配体）对持续光照射引起的小鼠昼夜节律紊乱的影响。材料和方法：小鼠（LL小鼠）暴露在恒定光下8周，导致体重增加，胰岛素抵抗，白色脂肪量增加，昼夜节律时钟基因表达改变。长期服用低剂量SR9009（每日10 mg/kg）以评估其对这些代谢紊乱的影响。结果：SR9009治疗8周后，LL小鼠体重增加、胰岛素抵抗和白色脂肪量减少，但对整体能量稳态没有显著影响。SR9009抑制Bmal1的表达，恢复白色和棕色脂肪组织（WAT和BAT）中Rev-erbα和Rev-erbβ的表达。利用3T3-L1细胞进行的体外研究表明，SR9009可以抑制脂肪生成，因此需要进一步的体内研究。SR9009恢复了BAT中ChREBP1a和srebp1c的表达，但不影响炎症细胞因子或脂肪因子基因的表达，也不恢复WAT和BAT中Fasn、Pparγ和Prom1的表达。结论：这些发现表明，SR9009可能是一种潜在的治疗方法，可以预防由昼夜节律紊乱引起的体重增加和胰岛素抵抗，可能是通过抑制脂肪生成引起的，尽管其在低剂量下对其他代谢途径的影响仍然有限。

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引用次数: 0

Chronobioethics: Symphony of biological clocks observed by 7-day/24-h ambulatory blood pressure monitoring and cardiovascular health 时间生物伦理学：通过 7 天/24 小时动态血压监测观察到的生物钟交响乐与心血管健康。

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal

Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2024.100753

Kuniaki Otsuka , Larry A. Beaty , Madoka Sato , Kazunobu Shitakura , Tomoko Kikuchi , Kiyotaka Okajima , Shigehiko Terada , Germaine Cornelissen

Background

The high prevalence of desynchronized biological rhythms is becoming a primary public health concern. We assess complex and diverse inter-modulations among multi-frequency rhythms present in blood pressure (BP) and heart rate (HR).

Subjects

and Methods: We performed 7-day/24-h Ambulatory BP Monitoring in 220 (133 women) residents (23–74 years) of a rural Japanese town in Kochi Prefecture under everyday life conditions.

Results

A symphony of biological clocks contributes to the preservation of a synchronized circadian system. (1) Citizens with an average 12.02-h period had fewer vascular variability disorders than those with shorter (11.37-h) or longer (12.88-h) periods (p < 0.05), suggesting that the circasemidian rhythm is potentially important for human health. (2) An appropriate BP-HR coupling promoted healthier circadian profiles than a phase-advanced BP: lower 7-day nighttime SBP (106.8 vs. 112.9 mmHg, p = 0.0469), deeper nocturnal SBP dip (20.5% vs. 16.8%, p = 0.0101), and less frequent incidence of masked non-dipping (0.53 vs. 0.86, p = 0.0378), identifying the night as an important time window.

Conclusion

Adaptation to irregular schedules in everyday life occurs unconsciously at night, probably initiated from the brain default mode network, in coordination with the biological clock system, including a reinforced about 12-h clock, as “a biological clock-guided core integration system.”

背景：不同步生物节律的高发生率正成为公共健康的首要问题。我们评估了血压（BP）和心率（HR）中多频节律之间复杂多样的相互调制：我们对高知县一个日本农村小镇的 220 名居民（133 名女性）（23 至 74 岁）进行了日常生活条件下的 7 天/24 小时动态血压监测：生物钟的交响乐有助于保持昼夜节律系统的同步。(1) 与昼夜节律较短（11.37 小时）或较长（12.88 小时）的人相比，平均昼夜节律为 12.02 小时的人患血管变异性疾病的几率较低（结论：昼夜节律不规律的生活适应性有助于保持昼夜节律系统的同步：对日常生活中不规则时间安排的适应是在夜间无意识地发生的，可能是由大脑默认模式网络与生物钟系统（包括强化的约 12 小时时钟）协调启动的，是 "生物钟引导的核心整合系统"。

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引用次数: 0

Circadian disruption of feeding-fasting rhythm and its consequences for metabolic, immune, cancer, and cognitive processes 进食-禁食节律的昼夜节律中断及其对代谢、免疫、癌症和认知过程的影响。

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal

Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2025.100827

Manuel Tomás Crespo , Laura Lucía Trebucq , Camila Agustina Senna , Guido Hokama , Natalia Paladino , Patricia Verónica Agostino , Juan José Chiesa

The circadian system is composed by a central hypothalamic clock at the suprachiasmatic nuclei (SCN) that communicates with peripheral circadian oscillators for daily coordination of behavior and physiology. The SCN entrain to the environmental 24-h light-dark (LD) cycle and drive daily rhythms of internal synchronizers such as core body temperature, hypothalamic-hypophysary hormones, sympathetic/parasympathetic activity, as well as behavioral and feeding-fasting rhythms, which supply signals setting core molecular clocks at central and peripheral tissues. Steady phase relationships between the SCN and peripheral oscillators keep homeostatic processes such as microbiota/microbiome composition/activity, metabolic supply/demand, energy balance, immunoinflammatory process, sleep amount and quality, psychophysiological stress, etc. Indeed, the risk of health alterations increase when these phase relationships are chronically changed prompting circadian disruption (CD), as occurring after sudden LD cycle changes (so-called jet-lag), or due to changes of activity/feeding-rest/fasting rhythm with respect to LD cycles (as humans subjected to nightwork, or restricting food access at rest in mice). Typical pathologies observed in animal models of CD and epidemiological studies include metabolic syndrome, type-2 diabetes, obesity, chronic inflammation, cancer, sleep disruption, decrease in physical and cognitive performance, and mood, among others. The present review discusses different aspects of such physiological dysregulations observed in animal models of CD having altered feeding-fasting rhythms, with potential translation to human health.

昼夜节律系统由位于视交叉上核（SCN）的下丘脑中央时钟组成，该时钟与周围昼夜节律振荡器通信，以协调日常行为和生理。SCN参与环境的24小时光暗（LD）周期，并驱动内部同步器的日常节律，如核心体温、下丘脑-垂体激素、交感/副交感神经活动，以及行为和进食-禁食节律，这些节律提供信号，设置中央和外周组织的核心分子钟。SCN与外周振荡器之间的稳定相位关系保持了微生物群/微生物组组成/活性、代谢供需、能量平衡、免疫炎症过程、睡眠量和质量、心理生理应激等稳态过程。事实上，当这些阶段关系长期改变，导致昼夜节律中断（CD）时，健康改变的风险增加，如在LD周期突然变化（所谓的时差）之后发生的，或由于活动/喂养-休息/禁食节奏与LD周期的变化（如人类受到夜间工作，或小鼠在休息时限制食物获取）。在动物模型和流行病学研究中观察到的典型病理包括代谢综合征、2型糖尿病、肥胖、慢性炎症、癌症、睡眠中断、身体和认知能力下降以及情绪等。本综述讨论了在乳糜泻动物模型中观察到的这种生理失调的不同方面，这些失调改变了摄食-禁食节律，并可能转化为人类健康。

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引用次数: 0

Effects of light, electromagnetic fields and water on biological rhythms 光、电磁场和水对生物节律的影响。

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal

Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2024.100824

Jan Martel , Nicolas Rouleau , Nirosha J. Murugan , Wei-Chun Chin , David M. Ojcius , John D. Young

The circadian rhythm controls a wide range of functions in the human body and is required for optimal health. Disruption of the circadian rhythm can produce inflammation and initiate or aggravate chronic diseases. The modern lifestyle involves long indoor hours under artificial lighting conditions as well as eating, working, and sleeping at irregular times, which can disrupt the circadian rhythm and lead to poor health outcomes. Seasonal solar variations, the sunspot cycle and anthropogenic electromagnetic fields can also influence biological rhythms. The possible mechanisms underlying these effects are discussed, which include photoentrainment, resonance, radical-pair formation, ion cyclotron resonance, and interference, ultimately leading to variations in melatonin and cortisol. Intracellular water, which represents a coherent, ordered phase that is sensitive to infrared light and electromagnetic fields, may also respond to solar variations and man-made electromagnetic fields. We describe here various factors and underlying mechanisms that affect the regulation of biological rhythms, with the aim of providing practical measures to improve human health.

昼夜节律控制着人体的多种功能，是最佳健康所必需的。昼夜节律的破坏可产生炎症，引发或加重慢性疾病。现代生活方式包括长时间在室内人工照明条件下，以及不规律的饮食、工作和睡眠，这可能会扰乱昼夜节律，导致健康状况不佳。太阳季节变化、太阳黑子周期和人为电磁场也会影响生物节律。讨论了这些影响的可能机制，包括共振，视网膜隐色素中的自由基对形成，离子回旋共振和干扰，最终导致褪黑激素和皮质醇的变化。细胞内水是一种对红外光和电磁场敏感的相干有序相，也可能对太阳变化和人造电磁场作出反应。我们在这里描述了影响生物节律调节的各种因素和潜在机制，目的是提供切实可行的措施来改善人类健康。

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引用次数: 0