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LATITUDE and STAMPEDE Trials Presented at ASCO 2017 offer Refreshing,Practicing-Changing Alternatives to Upfront Docetaxel for Men with High-RiskMetastatic Prostate Cancer, but Questions Remain 在ASCO 2017上公布的LATITUDE和STAMPEDE试验为男性高风险转移性前列腺癌患者提供了令人耳目一新的、改变实践的替代方案,但问题仍然存在
Pub Date : 2017-01-01 DOI: 10.4172/2168-9857.1000E120
M. Matrana
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引用次数: 0
Pediatric Urolithiasis in Children: Diagnosis and Management 儿童尿石症:诊断和管理
Pub Date : 2017-01-01 DOI: 10.4172/2168-9857.1000196
B. Maâlej, H. Louati, H. Abid, H. Zitouni, M. Weli, M. Zghal, L. Gargouri, R. Mhiri, A. Mahfoudh
Introduction: Pediatric urolithiasis remains endemic in low-resource countries affecting children <1 to 15 years. This study aimed to investigate the diagnosis and the treatment options of pediatric urolithiasis and compare that with the literature. Materials and methods: This study retrospectively evaluated patients who had been diagnosed with urolithiasis in the in department of pediatric emergency and reanimation and the department of pediatric surgery in Hedi Chaker hospital in Sfax between 2001 and 2016. Results: Over 16 years period, we diagnosed and managed 78 children with urolithiasis. 44 were male (56%) and 34 were female (44%). The median age was 54 months (4 to 144 months). Family history of urolithiasis was found in 23 patients (29.5%). The diagnosis of urolithiasis was made after Urinary tract infection in 23 (29.5%), abdominal pain in 16 (20.5%), Hematuria in 9 (11.5%), nephritic colic in 8 (10.5%), dysuria in 11(14%) and after antenatal diagnosis of malformative uropathies in 11 (14%) patients. The treatment were surgery in 32, medical in 30, LEC and endoscopy in 8 patients. The mean of follow up was 36 months and we had 11 recurrent urolithiasis. Conclusion: Pediatric urolithiasis remains a devastating health problem. Their management requires more exploration especially in the etiology research for a best management.
儿童尿石症在资源匮乏的国家仍然流行,影响1至15岁的儿童。本研究旨在探讨小儿尿石症的诊断和治疗方案,并与文献进行比较。材料与方法:本研究回顾性评价2001 - 2016年在Sfax Hedi Chaker医院儿科急诊与复苏科和儿科外科诊断为尿石症的患者。结果:在16年的时间里,我们诊断和治疗了78例尿石症患儿。男性44例(56%),女性34例(44%)。中位年龄为54个月(4 ~ 144个月)。有尿石症家族史的23例(29.5%)。尿路感染后诊断尿石症23例(29.5%),腹痛16例(20.5%),血尿9例(11.5%),肾病性绞痛8例(10.5%),排尿困难11例(14%),产前诊断为泌尿系统病变后诊断尿石症11例(14%)。手术32例,内科30例,LEC +内镜8例。平均随访36个月,11例尿石症复发。结论:小儿尿石症仍然是一个严重的健康问题。其管理需要更多的探索,特别是在病因研究方面,以达到最好的管理。
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引用次数: 1
Female Prostate, Saddle Bag and Spoke Wheel Signs-Classical Imaging Features of Urethral Diverticulum 女性前列腺、鞍袋和轮辐征——尿道憩室的经典影像特征
Pub Date : 2017-01-01 DOI: 10.4172/2168-9857.1000201
S. Nathani, Ramesh Sethia, P. Mehta
A 32-year-old female presented with complaints of recurrent urinary tract infections, tender vaginal swelling and painful intercourse. She underwent repeated aspirations of anterior vaginal wall swelling by gynecologist considering it as primary vaginal cyst but the swelling was recurrent after short course of time. MRI imaging of pelvis was performed after the opinion of urologist considering the possibility of the infected urethral diverticulum. MRI examination revealed multiloculated fluid containing lesion around urethra appearing like saddle bag and spoke wheel on axial images and mimicking like enlarged prostate on sagittal images with submucosal enhancement and diffusion restriction of contents suggesting infected urethral diverticulum. Objective: We are discussing role of MRI imaging with the help of radiological signs in the accurate diagnosis of urethral diverticula in symptomatic patients to avoid painful and complicated interventional imaging procedures and narrow down the possibility of alternate diseases in the same territory.
32岁女性,主诉尿路感染复发,阴道肿胀,性交疼痛。她反复出现阴道前壁肿胀,妇科医生认为这是原发性阴道囊肿,但肿胀在短时间内复发。经泌尿科医生考虑感染尿道憩室的可能性后,行骨盆MRI检查。MRI示尿道周围多室积液病变,轴位像鞍袋、辐轮样,矢状位像前列腺增大样,粘膜下强化,内容物扩散受限,提示尿道憩室感染。目的:探讨MRI影像结合影像学征象在有症状患者尿道憩室准确诊断中的作用,以避免痛苦和复杂的介入成像程序,减少同一领域交替疾病的可能性。
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引用次数: 0
Genitourinary Emergencies at University Hospital in Cotonou: About 437 Patients 科托努大学医院泌尿生殖急诊:约437名患者
Pub Date : 2017-01-01 DOI: 10.4172/2168-9857.1000200
Dejinnin Avakoudjo Jg, G. Natchagande, Soumanou Fky, Oliyide Ar, Yevi Mid, F. Hodonou, J. Sossa
Purpose: To describe genitourinary emergencies at the university hospital in cotonouMaterial and Methods: This was retrospective descriptive study covering a period of 6 years running January 1, 2011 to January 1, 2017. All patients aged at least 15 years regardless of the sex were involved. We did not involve in this study, patients under aged 15 years old who have supported by the Pediatric surgery department. All departments were concerned by the study: Emergency department, surgery, traumatology, medicine cardiology, nephrology, internal medicine, haematology, rheumatology, neurology, reanimation and gynecology departments. The following items were studied: age, sex, complaints, etiologies and emergencies kinds.Results: The average age of patients was 51.4 years old (15 years’ old-100 years old). Genitourinary emergencies were accounted for 5.4%. A male predominance was noted in 88.6% against 11.4% women. The sex ratio was 7.7. The 55% patients were referred against 45% were admitted. Over 6 year’s period on the study, 46 cases of genitourinary emergencies opinion were done in eleven departments Anesthesia-reanimation department predominance was noted in 32.61%. In emergency department we were seen 391 patients for genitourinary emergencies. The discovery circumstances were urine complete retention in 45.49% with 43.40% of non–traumatic urine complete retention against 2.09% urine complete retention for traumatic urinary tract following up by genitourinary trauma in 19.8%.Conclusion: Genitourinary emergencies are different group of pathologies or symptoms.
目的:描述科罗拉多州大学医院的泌尿生殖系统急诊情况。材料和方法:本研究为回顾性描述性研究,时间跨度为6年,从2011年1月1日至2017年1月1日。所有年龄在15岁以上的患者不分性别。我们没有参与这项研究,患者年龄在15岁以下,由儿科外科支持。所有部门都参与了这项研究:急诊科、外科、创伤科、内科、心脏病科、肾病科、内科、血液科、风湿科、神经内科、康复科和妇科。调查项目包括:年龄、性别、主诉、病因、急症种类。结果:患者平均年龄51.4岁(15岁~ 100岁)。泌尿生殖系统急症占5.4%。男性占88.6%,女性占11.4%。性别比为7.7。55%的患者转诊,45%的患者入院。在6年的研究中,11个科室共收治了46例泌尿生殖系统急诊意见,其中麻醉-复苏科占32.61%。在急诊科,我们接待了391名泌尿生殖急诊患者。发现情况为尿完全潴留占45.49%,非创伤性尿完全潴留占43.40%,创伤性尿路并发泌尿生殖系统创伤的尿完全潴留占2.09%,占19.8%。结论:泌尿生殖系统急症是不同类型的病理或症状。
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引用次数: 1
Relationship of Positive Resection Margin, Cancer Location and Learning Curve after Laparoscopic Radical Prostatectomy 腹腔镜前列腺根治术后阳性切缘、癌位与学习曲线的关系
Pub Date : 2017-01-01 DOI: 10.4172/2168-9857.1000194
K. Hashine, T. Kakuda, Shunsuke Iuchi, T. Hosokawa, I. Ninomiya, N. Teramoto, N. Yamashita
Background: One of surgical goals is decreasing of positive resection margin (PRM). In radical prostatectomy, PRM is important because of prognostic factor. We examine the relationship of PRM, cancer location and learning curve after laparoscopic radical prostatectomy (LRP). Methods: Between May, 2009 and May, 2015, 331 consecutive patients were treated with LRP. The resection margin status, Gleason score, pathological stage, cancer location and diameter were assessed in each surgical specimen, and the independent factors for PRM and prostate-specific antigen (PSA) failure were identified. The learning curve for PRM was calculated and the number of cases until the plateau was obtained. Results: PRM was found in 30.5% of all patients, with 27.7% in the pT2 patients and 39.0% in the pT3 patients. The most common site of PRM was in the apex-anterior. The 5-year PSA failure-free survival rate was 73.9%. In patients with a negative resection margin, the 5-year PSA failure-free survival rate was 81.6%, and in patients with PRM, it was 57.4%. The factors associated with PSA failure-free survival were PRM and elevated PSA. The tumor location was not associated with PSA failure-free survival. The factors associated with PRM were tumor location, nerve sparing procedure, and tumor diameter. When the tumor was localized in the apex-anterior, the rate of PRM was elevated 3-fold comparing the tumor in apex-posterior. The learning curve of all surgeons for obtaining a negative resection margin plateaus after 167 cases. The curve of a single surgeon was more improved than all surgeons and the rate of PRM was 16.7%. Conclusions: PRM was associated with both cancer location and diameter. The learning curve of PRM reached a plateau in about 170 cases. However, PRM can be further reduced. These findings related to LRP outcomes are useful for improvement in surgical techniques and for determining prognosis.
背景:外科手术的目标之一是减少阳性切缘(PRM)。在根治性前列腺切除术中,PRM是一个重要的预后因素。我们研究了腹腔镜根治性前列腺切除术(LRP)后PRM、肿瘤位置和学习曲线的关系。方法:2009年5月至2015年5月,331例患者连续接受LRP治疗。评估每个手术标本的切除边缘状态、Gleason评分、病理分期、肿瘤位置和直径,并确定PRM和前列腺特异性抗原(PSA)失败的独立因素。计算了PRM的学习曲线,得到了到达平台的病例数。结果:PRM发生率为30.5%,其中pT2组为27.7%,pT3组为39.0%。PRM最常见的部位是前尖。5年PSA无失败生存率为73.9%。在切除边缘阴性的患者中,5年PSA无失败生存率为81.6%,而在PRM患者中,这一生存率为57.4%。与PSA无失败生存相关的因素是PRM和PSA升高。肿瘤位置与PSA无失败生存无关。与PRM相关的因素是肿瘤位置、神经保留手术和肿瘤直径。当肿瘤位于脑尖前部时,PRM的发生率比位于脑尖后部的肿瘤高3倍。167例手术后所有外科医生获得阴性切除边缘平台的学习曲线。单个外科医生的曲线改善程度高于所有外科医生,PRM率为16.7%。结论:PRM与肿瘤部位和直径均相关。PRM的学习曲线在170例左右达到平台期。然而,PRM可以进一步降低。这些与LRP结果相关的发现对于改进手术技术和确定预后是有用的。
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引用次数: 0
Ancient Surgical Treatment of Hypospadias (From Hippocrates (5th-4th century B.C.) to the 12th century A.D.) 古代尿道下裂的外科治疗(从希波克拉底(公元前5 -4世纪)到公元12世纪)
Pub Date : 2016-12-30 DOI: 10.4172/2168-9857.1000176
S. Musitelli
Introduction: No ancient Greek and Roman physician and surgeon ever observed, diagnosed or described either cases of female hypospadias and epispadias, or male epispadias, but only cases of male hypospadias. However they devised and practised exceptionally skilful surgeries to correct this anatomical defect in men. Material and methods: A critical and philological review of the passages of ancient surgical treatises dealing with hypospadias and its surgical treatment. Results: The medieval physicians confined themselves to inheriting and repeating the surgical achievements of the Greek and Roman surgeons. Conclusion: The surgical techniques, the skill and the anatomophysiological acumen of the Hellenistic surgeons are still astonishing.
古希腊和古罗马的内科医生和外科医生从未观察、诊断或描述过女性尿道下裂和尿道上裂或男性尿道上裂的病例,只有男性尿道下裂的病例。然而,他们设计并实践了非常熟练的手术来纠正男性的这一解剖缺陷。材料和方法:对有关尿道下裂及其外科治疗的古代外科文献进行批判性和文献学回顾。结果:中世纪的医生局限于继承和重复希腊和罗马外科医生的手术成就。结论:希腊化外科医生的手术技术、技巧和解剖生理敏锐度仍令人惊叹。
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引用次数: 0
Endovascularar Management of Iatrogenic Renal Vascular Injuy Complicating Percutaneous Nephrolithotripsy: An Atypical Case Report 医源性肾血管损伤并发经皮肾镜碎石术的血管内处理:一个不典型病例报告
Pub Date : 2016-12-29 DOI: 10.4172/2168-9857.1000174
P. A. Khan, T. Matia
Minimally invasive urological procedures have gained in popularity and replaced open surgery in various urological procedures. Although considered minimally invasive, these procedures are not free from complications, and life-threatening hemorrhage may occur. In hemodynamic stable patients endovascular embolization allows bleeding cessation with maximal preservation of the bleeding kidney tissue. Herein we describe a case who underwent minimally invasive urological procedure (PCNL) that was complicated with bleeding due to lacerated renal vasculature and not the usual mode of pseudoaneurysm. We used superselective angiographic coil embolization to stop hemorrhage and preserved more than 50% of the affected kidney.
微创泌尿外科手术越来越受欢迎,在各种泌尿外科手术中取代了开放手术。虽然被认为是微创的,但这些手术并不是没有并发症,可能会发生危及生命的出血。对于血流动力学稳定的患者,血管内栓塞可以止血,最大限度地保留出血的肾组织。在此,我们描述了一例接受微创泌尿外科手术(PCNL)的病例,该病例因肾血管破裂而出血,而不是通常的假性动脉瘤。我们采用超选择性血管造影线圈栓塞术止血,保留了50%以上的受累肾脏。
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引用次数: 0
A Rare Case of Chin Cutaneous Metastases from Transitional Cell Carcinoma of Bladder in a Patient Who Underwent Radical Cystectomy 一例膀胱移行细胞癌行根治性膀胱切除术后发生皮肤转移的罕见病例
Pub Date : 2016-12-29 DOI: 10.4172/2168-9857.1000175
G. Giliberto, C. D. Franco, B. Rovereto
Facial cutaneous metastases from primary bladder cancers are very rare and usually they are associated with poor prognosis. In literature, very few cases of cutaneous metastases from urothelial malignancies are reported but we did not find any case of bladder cancer metastases localised to chin; usually cutaneous metastases from bladder are localised in chest or scrotal skin. We report a 66 year-old patient affected by muscle-invasive transitional cell carcinoma of bladder who underwent radical cystectomy and who developed in two months after operation a skin lesion localised to chin. Clinical stage of bladder cancer was cT2 N0 M0; the patient was studied before operation through total body CT-scan, TB bone-scan negative for metastases. The patient was totally asymptomatic and he had a good performance status. We discuss the need to have suspicion in presence of cutaneous lesions, apparently benign, in a patient affected by malignancy in order to start quickly a proper treatment.
原发性膀胱癌的面部皮肤转移是非常罕见的,通常与预后不良有关。在文献中,很少有泌尿上皮恶性肿瘤的皮肤转移病例被报道,但我们没有发现膀胱癌转移到下巴的病例;膀胱的皮肤转移通常局限于胸部或阴囊皮肤。我们报告一位66岁的肌肉侵袭性膀胱移行细胞癌患者,接受根治性膀胱切除术,术后两个月出现局部颏部皮肤病变。膀胱癌临床分期为cT2 N0 M0;术前行全身ct扫描,结核骨扫描未见转移灶。患者完全无症状,表现良好。我们讨论有必要怀疑存在皮肤病变,显然是良性的,在病人受恶性肿瘤的影响,以便迅速开始适当的治疗。
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引用次数: 2
Renal Cell Carcinoma in Children: About Two Case Report 儿童肾细胞癌2例报告
Pub Date : 2016-12-15 DOI: 10.4172/2168-9857.1000173
H. Louati, S. Jlidi, A. Charieg, Wiem Hannechi, Y. Ahmed, F. Nouira, R. Jouini
Introduction Renal cell carcinoma (RCC) is extremely rare in children. Several factors could influence prognosis, including stage, grade, histology, symptomatic presentation, and performance status. Among these, tumor stage is the most important predictor of disease prognosis for RCC. We report our experience with two cases of children with renal cell carcinoma in children. Cases Case 1: A 13-year-old girl presented macroscopic hematuria after a right lumbar trauma. The renal ultrasonography and CT urography showed a very limited rounding medio renal mass. Fine needle renal aspiration objectified RCC. Patient underwent transabdominal radical nephrectomy. Histopathology revealed RCC grade 2 of Furhrman T1b N0 M0. The postoperative course was uneventful. Case 2: A 9-year-old girl presented macroscopic hematuria. The renal ultrasonography showed a horseshoe left kidney with limited rounding mass. CT urography showed limited left renal mass of 31 × 25 mm. Fine needle renal aspiration objectified RCC. Patient underwent transabdominal radical nephrectomy with regional lymphadenectomy. Histopathology revealed RCC associated with translocation Xp11.2 grade 2 of Furhrman T1a N1M0. The postoperative course was uneventful. Conclusion RCC is rare in children but in children older than 5 years with renal masses it is very important to suspect diagnosis. Surgery is the best treatment and prognosis is favorable when the tumor is localized and completely eradicated.
肾细胞癌(RCC)在儿童中极为罕见。影响预后的因素包括分期、分级、组织学、症状表现和表现状况。其中,肿瘤分期是RCC疾病预后最重要的预测因子。我们报告我们的经验与儿童肾细胞癌的儿童两例。病例1:一名13岁女孩右腰椎外伤后出现肉眼血尿。肾脏超声及CT尿路造影显示有一个非常有限的圆形肾中位肿块。细针肾穿刺客观化肾癌。患者行经腹根治性肾切除术。组织病理学显示Furhrman T1b N0 M0为RCC 2级。术后过程平淡无奇。病例2:1例9岁女童,肉眼可见血尿。肾脏超声显示左肾呈马蹄形,有少量圆形肿块。CT尿路造影显示左肾有限肿块31 × 25 mm。细针肾穿刺客观化肾癌。患者行经腹根治性肾切除术并局部淋巴结切除术。组织病理学显示RCC与Furhrman T1a N1M0的Xp11.2级2位易位相关。术后过程平淡无奇。结论儿童肾小细胞癌罕见,但对大于5岁的儿童肾包块应慎诊。手术是最好的治疗方法,当肿瘤被定位和完全根除时,预后良好。
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引用次数: 3
Surgical Treatment of Urolithiasis in Children: Experience of a Pediatric Surgery Department in Tunisia 儿童尿石症的外科治疗:突尼斯儿科外科的经验
Pub Date : 2016-12-02 DOI: 10.4172/2168-9857.1000172
H. Bouthour, F. Trabelsi, Samer Bustame, A. Jabloun, N. Kaâbar
Urolithiasis is uncommon in children. This is a recurrent disease with severe evolution, which can lead to chronic renal failure. The management is multidisciplinary. Despite the innovation of new minimally invasive techniques, conventional surgery in our country remains the reference treatment. We bring our experience in the diagnostic and therapeutic management.
尿石症在儿童中并不常见。这是一种复发性疾病,病情发展严重,可导致慢性肾功能衰竭。管理是多学科的。尽管新的微创技术不断创新,但在我国传统手术仍是参考治疗方法。我们带来了我们在诊断和治疗管理方面的经验。
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引用次数: 0
期刊
British journal of medical & surgical urology
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