ACS Biomaterials Science & Engineering最新文献

The development of novel wound dressings is critical in medical care. Graphene and its derivatives possess excellent biomedical properties, making them highly suitable for various applications in medical dressings. This review provides a comprehensive technical analysis and the current application status of graphene-based medical dressings. Initially, we discuss the chemical structure and the fabrication method of graphene and its derivatives. We then provide a detailed summary of the mechanisms by which graphene materials promote wound repair across the four stages of wound healing. Subsequently, we categorize the types of graphene-based wound dressings and analyze corresponding characteristics. Finally, we analyze the challenges encountered at present and propose solutions regarding future development trends. This paper aims to serve as a reference for further research in skin tissue engineering and the development of innovative graphene-based medical dressings.

Hyperlipidemic acute pancreatitis (HAP) is a serious inflammatory pancreatic disease commonly seen in patients with disorders of lipid metabolism. Decreasing blood triglyceride levels and proinflammatory factors can alleviate hyperlipidemic pancreatitis. The lipase that enhanced the Brownian motion of mesoporous silica in triglyceride solutions could accelerate decomposition of the lipid and improve the efficiency of absorption. In this study, we developed a mesoporous silica nanoparticle with dual modification of IL-6 aptamer and lipase for the treatment of HAP. The nanoparticle could increase the ability of particles to absorb inflammatory factor IL-6 and decompose triglycerides. For every 10 mg of the dual-modified nanoparticles, the efficiency of capturing IL-6 was approximately 9.67 pg/mL and of decomposing triglycerides was approximately 3.88 mg/mL in the plasma of HAP patients within 2 h. In summary, the mesoporous silica nanoparticle could absorb the IL-6 inflammatory factor through IL-6 aptamers and decompose triglycerides through lipase. Furthermore, based on clinically available plasma exchange technology, combined with our developed dual-modified nanoparticles, we designed an absorption device for the treatment of hyperlipidemic pancreatitis; it works to promote the treatment of hyperlipidemic pancreatitis.

DNA is a kind of flexible and versatile biomaterial for constructing nanostructures and nanodevices. Due to high biocompatibility and programmability and easy modification and fabrication, DNA nanotechnology has emerged as a powerful tool for application in intracellular targeted protein degradation. In this review, we summarize the recent advances in the design and mechanism of targeted protein degradation technologies such as protein hydrolysis targeted chimeras, lysosomal targeted chimeras, and autophagy based protein degradation. Subsequently, we introduce the DNA nanotechnologies of DNA cascade circuits, DNA nanostructures, and dynamic machines. Moreover, we present the latest developments in DNA nanotechnologies in targeted protein degradation. Finally, the vision and challenges are discussed.

Cryopreservation in cryovials extends cell storage at low temperatures, and advances in organoid cryopreservation improve reproducibility and reduce generation time. However, cryopreserving human organoids presents challenges due to the limited diffusion of cryoprotective agents (CPAs) into the organoid core and the potential toxicity of these agents. To overcome these obstacles, we developed a cryopreservation technique using a pillar plate platform. To demonstrate cryopreservation application to human brain organoids (HBOs), early stage HBOs were produced by differentiating induced pluripotent stem cells (iPSCs) into neuroectoderm (NE) in an ultralow attachment (ULA) 384-well plate. The NE was transferred and encapsulated in Matrigel on the pillar plate. The NE on the pillar plate was exposed to four commercially available CPAs, including the PSC cryopreservation kit, CryoStor CS10, 3dGRO, and 10% DMSO, before being frozen overnight at -80 °C and subsequently stored in a liquid nitrogen dewar. We examined the impact of the CPA type, organoid size, and CPA exposure duration on cell viability post-thaw. Additionally, the differentiation of NE into HBOs on the pillar plate was assessed using RT-qPCR and immunofluorescence staining. The PSC cryopreservation kit proved to be the least toxic for preserving the early stage HBOs on the pillar plate. Notably, smaller HBOs showed higher cell viability postcryopreservation than larger ones. An incubation period of 80 min with the PSC kit was essential to ensure optimal CPA diffusion into HBOs with a diameter of 400-600 μm. These cryopreserved early stage HBOs successfully matured over 30 days, exhibiting gene expression patterns akin to noncryopreserved HBOs. The cryopreserved early stage HBOs on the pillar plate maintained high viability after thawing and successfully differentiated into mature HBOs. This on-chip cryopreservation method could extend to other small organoids, by integrating cryopreservation, thawing, culturing, staining, rinsing, and imaging processes within a single system, thereby preserving the 3D structure of the organoids.

Although there have been numerous reports on broadband near-infrared (NIR) emitting phosphors, their emissions are mainly concentrated in the range of 700–1000 nm (NIR-I). Herein, we successfully synthesized a broadband near-infrared phosphor CaMgGeO₄:Cr⁴⁺(CMG:Cr⁴⁺) with an emission in the range of 1000–1600 nm (NIR-II). The introduction of Er³⁺ ions into CMG:Cr⁴⁺ resulted in a wider near-infrared emission phosphor CaMgGeO₄:Cr⁴⁺,Er³⁺ (fwhm = 361 nm), compensating for the luminescence of 1500–1600 nm. More importantly, an energy transfer from Cr⁴⁺ to Er³⁺ ions has been discovered. Furthermore, a NIR pc-LED was fabricated by combining the CMG:Cr⁴⁺,Er³⁺ phosphor with a 590 nm chip. The changes in intensity and profile of the transmission spectra of light passing through different liquids reveal its potential application in organic compound recognition. This work opens a direction for the development of NIR-II phosphors.

SiO_x is a highly promising anode material for realizing high-capacity lithium-ion batteries owing to its high theoretical capacity. However, the large volume change during cycling limits its practical application. The development of a binder has been demonstrated as one of the most economical and efficient strategies for enhancing the SiO_x anode’s electrochemical performance. In this work, a multifunctional binder (T-PGA) is fabricated by cross-linking γ-polyglutamic acid (PGA) and tannic acid (TA) for SiO_x anodes. The introduction of TA into PGA helps to buffer the volume changes of the SiO_x anodes, facilitate diffusion of Li⁺, and construct stable SEI layers. Benefiting from this proposed binder, the SiO_x anode maintains a reversible capacity of 973.0 mAh g^–1 after 500 cycles at 500 mA g^–1 and the full cell, pairing with LiNi_0.5Co_0.2Mn_0.3O₂ cathode, delivers a reversible capacity of 133 mA h g^–1 (73.2% retention) after 100 cycles. This study offers valuable insights into advanced binders that are used in high-performance Li-ion batteries.

Advances in lithium–sulfur batteries (LSBs) are impeded by the inefficiency of anchoring materials in facilitating long-term cycling and rate performance. To address this challenge, an exploration of two-dimensional MA₂Z₄ monolayers as potential anchoring materials for LSBs is proposed based on density functional theory calculations and machine learning (ML) techniques. Adsorption features, sulfur reduction reaction behaviors, and solvent interactions are assessed and analyzed; and MoGe₂N₄ and WGe₂N₄ are identified as the most promising candidates because they have optimal adsorption energies for lithium polysulfides to suppress the shuttle effect and exhibit enhanced catalytic activity. Meanwhile, ML analysis highlights the critical influence of the electronegativity of element Z in MA₂Z₄ on anchoring properties, providing valuable insights into future anchoring material design for high-performance LSBs.

The potential applications of hydrogel microrobots in biomedicine and environmental exploration have sparked significant interest in understanding their behavior under multiphysical fields. This study explores the multimodal locomotion and dynamic interaction of hydrogel microrobots at the air–water interface under magnetic and light stimuli. A pair of hydrogel microrobots at the air–water interface exhibits a transition from cooperative, combined rotation to interactive behavior, involving both rotation and revolution under the influence of a rotating magnetic field (RMF), and a shift from attraction to separation under near-infrared (NIR) light, demonstrating the dynamic modulation of their behaviors in response to different stimuli. Notably, the behavioral patterns of multiple hydrogel microrobots under multiphysical fields indicate that NIR light can enhance interactive motion behaviors under RMFs and extend the range of motion trajectories. Dynamic models for each condition are established and analyzed based on dynamic equilibrium, and their behavior can be modulated by parameters such as magnetic particle concentration, magnetic field frequency, and NIR light intensity. This work introduces a novel strategy for regulating and controlling the dynamic behaviors of hydrogel microrobots, offering new insights into their multiphysical field locomotion.

Materials with anisotropic emission characteristics have attracted considerable attention for thermal management. Although many dual-mode emitters have been developed for this purpose in the form of textiles, multilayer films, and photonic structures, multiple functionalities are essential for their versatile applications. Herein, a highly stretchable dual-mode emitter with programmable emissivity and air permeability is presented. The emitter comprises a planar Ge₂Sb₂Te₅ (GST) cavity on one side of a perforated elastomer substrate and an infrared-reflecting metal layer on the other side. With a laser-induced phase transition from amorphous to crystalline GST, the emitter exhibits a large emissivity difference of 0.52 between both sides. The dual-mode emitter remains highly stable without mechanical failure after repeated stretching cycles to a strain of 50%. This air-permeable and stretchable emitter can be attached to any curved surface, including the human body. The GST-side emissivity can be programmed into an arbitrary emissivity pattern using a spatially modulated laser beam, ultimately enabling the printing of mutually independent visible and thermal images in a single emitter. This study provides a promising structure for multispectral optical security as well as thermal management.

Indium, copper, and mercury are important raw materials in the electronics industry and often coexist in factory wastewater. Therefore, the development of a highly sensitive and selective method for the simultaneous detection of these heavy metal ions is of great significance for water quality monitoring and environmental protection. Herein, we report a NH₂-MIL-53 fluorescent probe for the simultaneous detection of trace In³⁺, Cu²⁺, and Hg²⁺ in water. After a low-temperature NH₃ plasma tailoring treatment for grafting electron-donor amine groups, the obtained NH₂-MIL-53-M exhibited enhanced fluorescence emission intensity (∼6 times) coupled with selective adsorption of In³⁺, Cu²⁺, and Hg²⁺. This quenched the NH₂-MIL-53-M fluorescence and allowed to significantly increase the selectivity and sensitivity for detection of In³⁺, Cu²⁺, and Hg²⁺. The fluorescence quenching constant (K_sv) values were 2.23 × 10⁵, 1.00 × 10⁵, and 2.74 × 10⁴ M^–1, while the limit of detection (LODs) values were 0.06, 0.14, and 0.53 μM, for In³⁺, Cu²⁺, and Hg²⁺, respectively. The concentrations of In³⁺, Cu²⁺, and Hg²⁺ in real environmental samples could be determined by addition of appropriate masking agents, and the recoveries were within the range of 94–110%. This study not only supplied a strategy for constructing a highly sensitive and selective fluorescent probe but also established a platform for simultaneous detection of multiple heavy metal ions in water.