Pub Date : 2020-04-22DOI: 10.17554/j.issn.2224-3992.2020.09.919
O. Oguntoye, M. Yusuf, P. Olowoyo, Olagoke Erinomo, O. Omoseebi, Michael Soje, O. Oguntoye, Oluwafemi Fatudimu
Abstract Gastric adenocarcinoma is uncommon among young Nigerians. We present Mrs O.V. a 41year old Nigerian who presented with one year history of recurrent epigastric pain that was peppery/burning in nature, non-radiating, aggravated by eating and temporarily relieved with the use of antacids. There is associated progressive weight loss and secondary amenorrhea since the onset of her illness. She started vomiting two weeks prior to presentation which was non-projectile, containing both recently ingested meals and partially digested stale food substances, vomitus was non-bilous. Episodes of vomiting is usually preceded by abdominal bloating or feeling of indigestion. Clinical examination revealed a chronically ill-looking young woman with a positive succussion splash on abdominal examination. Examination of the other systems was normal. Provisional diagnosis was suspected Chronic Gastric Antral Ulcer complicated by Gastric Outlet Obstruction to rule out Gastric Antral Adenocarcinoma. Abdominal ultrasound and CT scans showed features consistent with Gastric Outlet Obstruction. Upper GI Endoscopy revealed Gastric Antral Adenocarcinoma with Duodenal extension and Chronic Duodenal Ulcer complicated by Gastric Outlet Obstruction. Histology showed well differentiated Gastric Antral Adenocarcinoma. She had a Bilroth II procedure(Partial Gastrectomy and Gastro-Jejunostomy)and was commenced on adjunct chemotherapy: FAM regimen(5-Fluorouracil, Adriamycin and Mitomycin). She was also placed on long term proton pump inhibitor therapy. She has sustained remarkable clinical improvement with resolution of all her initial symptoms and she is currently on regular clinic follow-up. More cases of Gastric Adenocarcinoma among young Nigerians are being reported. There is a need for more extensive studies on this and possibly an indication for commencing endoscopy screening at an earlier age among individuals presenting with recent onset dyspepsia. Key words: Gastric, Adenocarcinoma, Young, Nigerians.
{"title":"Gastric Adenocarcinoma in a Young Nigerian – A Case Report","authors":"O. Oguntoye, M. Yusuf, P. Olowoyo, Olagoke Erinomo, O. Omoseebi, Michael Soje, O. Oguntoye, Oluwafemi Fatudimu","doi":"10.17554/j.issn.2224-3992.2020.09.919","DOIUrl":"https://doi.org/10.17554/j.issn.2224-3992.2020.09.919","url":null,"abstract":"Abstract Gastric adenocarcinoma is uncommon among young Nigerians. We present Mrs O.V. a 41year old Nigerian who presented with one year history of recurrent epigastric pain that was peppery/burning in nature, non-radiating, aggravated by eating and temporarily relieved with the use of antacids. There is associated progressive weight loss and secondary amenorrhea since the onset of her illness. She started vomiting two weeks prior to presentation which was non-projectile, containing both recently ingested meals and partially digested stale food substances, vomitus was non-bilous. Episodes of vomiting is usually preceded by abdominal bloating or feeling of indigestion. Clinical examination revealed a chronically ill-looking young woman with a positive succussion splash on abdominal examination. Examination of the other systems was normal. Provisional diagnosis was suspected Chronic Gastric Antral Ulcer complicated by Gastric Outlet Obstruction to rule out Gastric Antral Adenocarcinoma. Abdominal ultrasound and CT scans showed features consistent with Gastric Outlet Obstruction. Upper GI Endoscopy revealed Gastric Antral Adenocarcinoma with Duodenal extension and Chronic Duodenal Ulcer complicated by Gastric Outlet Obstruction. Histology showed well differentiated Gastric Antral Adenocarcinoma. She had a Bilroth II procedure(Partial Gastrectomy and Gastro-Jejunostomy)and was commenced on adjunct chemotherapy: FAM regimen(5-Fluorouracil, Adriamycin and Mitomycin). She was also placed on long term proton pump inhibitor therapy. She has sustained remarkable clinical improvement with resolution of all her initial symptoms and she is currently on regular clinic follow-up. More cases of Gastric Adenocarcinoma among young Nigerians are being reported. There is a need for more extensive studies on this and possibly an indication for commencing endoscopy screening at an earlier age among individuals presenting with recent onset dyspepsia. Key words: Gastric, Adenocarcinoma, Young, Nigerians.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"9 1","pages":"3150-3154"},"PeriodicalIF":0.0,"publicationDate":"2020-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47918707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-21DOI: 10.17554/j.issn.2224-3992.2020.09.907
Oguntoye Oluwatosin Oluwagbenga, Yusuf Musah, O. Paul, Erinomo Olagoke, O. Oladipo, Soje Michael Osisiogu, Oguntoye Oluwafunmilayo Adenike, Fatudimu Oluwafemi
Ulcerative colitis is a rare condition among Nigerians. We present a 37year old male Nigerian who presented with recurrent passage of bloody stool of seven years duration. He has been passing watery, mucoid and bloody stool of about 3 to 5 bowel motions per day with each episode lasting for about three to six weeks following which there will be remission that lasts for about 1 to 2months. There is associated tenesmus, low grade fever and abdominal pain during each episode. There is weight loss despite intact appetite. No family history of inflammatory bowel disease or colorectal cancer. He does not take alcohol nor smoke cigarette. Clinical examination was not remarkable. On digital rectal examination however, the examining finger was stained with maroon-colored blood, no rectal mass was felt. Other systems were essentially normal. Provisional diagnosis was suspected Ulcerative colitis to rule out Crohn’s disease and to rule out Colorectal cancer. Colonoscopy revealed circumferential mucosa inflammation with multiple areas of erosion and presence of numerous mucosal debris extending from the rectum to involve the sigmoid colon, descending colon, transverse colon and the ascending colon. No diverticula, no polyps or masses seen. Endoscopic features indicate Extensive Ulcerative Colitis (Proctitis with Pancolitis). Histologic sections show features consistent with Ulcerative Colitis. Upper GI Endoscopy revealed essentially normal findings. He was commenced on long-term Amino-salicylate(Mesalamine), antioxidants and a short course of antibiotics (Ofloxacin and Metronidazole). He presented at our clinic three months later with complete resolution of all the symptoms and was scheduled for regular clinic follow-up. Although ulcerative colitis is uncommon among Nigerians, a high index of suspicion with colonoscopy work-up will help to make the diagnosis.
{"title":"Ulcerative Colitis in A Nigerian – A Case Report","authors":"Oguntoye Oluwatosin Oluwagbenga, Yusuf Musah, O. Paul, Erinomo Olagoke, O. Oladipo, Soje Michael Osisiogu, Oguntoye Oluwafunmilayo Adenike, Fatudimu Oluwafemi","doi":"10.17554/j.issn.2224-3992.2020.09.907","DOIUrl":"https://doi.org/10.17554/j.issn.2224-3992.2020.09.907","url":null,"abstract":"Ulcerative colitis is a rare condition among Nigerians. We present a 37year old male Nigerian who presented with recurrent passage of bloody stool of seven years duration. He has been passing watery, mucoid and bloody stool of about 3 to 5 bowel motions per day with each episode lasting for about three to six weeks following which there will be remission that lasts for about 1 to 2months. There is associated tenesmus, low grade fever and abdominal pain during each episode. There is weight loss despite intact appetite. No family history of inflammatory bowel disease or colorectal cancer. He does not take alcohol nor smoke cigarette. Clinical examination was not remarkable. On digital rectal examination however, the examining finger was stained with maroon-colored blood, no rectal mass was felt. Other systems were essentially normal. Provisional diagnosis was suspected Ulcerative colitis to rule out Crohn’s disease and to rule out Colorectal cancer. Colonoscopy revealed circumferential mucosa inflammation with multiple areas of erosion and presence of numerous mucosal debris extending from the rectum to involve the sigmoid colon, descending colon, transverse colon and the ascending colon. No diverticula, no polyps or masses seen. Endoscopic features indicate Extensive Ulcerative Colitis (Proctitis with Pancolitis). Histologic sections show features consistent with Ulcerative Colitis. Upper GI Endoscopy revealed essentially normal findings. He was commenced on long-term Amino-salicylate(Mesalamine), antioxidants and a short course of antibiotics (Ofloxacin and Metronidazole). He presented at our clinic three months later with complete resolution of all the symptoms and was scheduled for regular clinic follow-up. Although ulcerative colitis is uncommon among Nigerians, a high index of suspicion with colonoscopy work-up will help to make the diagnosis.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"9 1","pages":"3146-3149"},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48986780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-21DOI: 10.17554/j.issn.2224-3992.2020.09.904
A. Yagi, M. Hasegawa, H. Abe
Multiple myeloma (MM) belongs to hematological malignancy that derives pro-survival/proliferative signals from the bone marrow niche, and its incidence is increasing worldwide. Butyrate, a well-known epigenetic histone deacetylase inhibitor, reduces the viability of MM cells, induces MM cell apoptosis via transcriptional activation of p21. Inpresent review we discuss butyrate as a potential therapeutic drug for MM and case reports of MM, acute leukemia, malignant lymphoma and glioma patients.
{"title":"Beneficial Roles of Histone Deacetylase Inhibitor Butyrate to Multiple Myeloma, Acute Leukemia and Acute Myeloid Leukemia: Case Reports","authors":"A. Yagi, M. Hasegawa, H. Abe","doi":"10.17554/j.issn.2224-3992.2020.09.904","DOIUrl":"https://doi.org/10.17554/j.issn.2224-3992.2020.09.904","url":null,"abstract":"Multiple myeloma (MM) belongs to hematological malignancy that derives pro-survival/proliferative signals from the bone marrow niche, and its incidence is increasing worldwide. Butyrate, a well-known epigenetic histone deacetylase inhibitor, reduces the viability of MM cells, induces MM cell apoptosis via transcriptional activation of p21. Inpresent review we discuss butyrate as a potential therapeutic drug for MM and case reports of MM, acute leukemia, malignant lymphoma and glioma patients.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"9 1","pages":"3107-3112"},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46985362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-21DOI: 10.17554/j.issn.2224-3992.2020.09.909
Anam Ahmed, Atreyi Pramanik, Alka Singh
Introduction: Human Leukocyte Antigen (HLA) is a crucial component for the regulation of human immune systems. Celiac disease (CeD) is a gluten dependent multifactorial disorder with a strong association with HLA-DQ alleles. HLA-DQ alleles are also have role in Non-Celiac Gluten Sensitivity (NCGS), Dermatitis herpetiformis (DH), and CeD associated autoimmune diseases like Type 1 diabetes (T1D), Rheumatoid arthritis (RA), Multiple sclerosis (MS). However, contribution of HLA in all these diseases is not fully understood. We aimed to provide a concise information about the HLA status in these autoimmune diseases. Methodology: We explored already published articles having information about HLA in autoimmune diseases in relation to CeD from different scientific platforms. We filtered the HLA data from them. We included original and review articles and excluded articles which had only clinical information, and case reports. Results: We found that HLA alleles have strong association in the development of CeD and other autoimmune diseases. HLA-B1*02 is the most critical allele associated with the susceptibility to CeD and also have major role in other gluten related disorders (GRD). Conclusions: We concluded that although HLA has a major role in the autoimmune disease development, multiple unknown non-HLA genes are also critically involved and must be explored frantically.
{"title":"Human Leukocyte Antigen and its Association with Celiac Disease and Associated Autoimmune Diseases","authors":"Anam Ahmed, Atreyi Pramanik, Alka Singh","doi":"10.17554/j.issn.2224-3992.2020.09.909","DOIUrl":"https://doi.org/10.17554/j.issn.2224-3992.2020.09.909","url":null,"abstract":"Introduction: Human Leukocyte Antigen (HLA) is a crucial component for the regulation of human immune systems. Celiac disease (CeD) is a gluten dependent multifactorial disorder with a strong association with HLA-DQ alleles. HLA-DQ alleles are also have role in Non-Celiac Gluten Sensitivity (NCGS), Dermatitis herpetiformis (DH), and CeD associated autoimmune diseases like Type 1 diabetes (T1D), Rheumatoid arthritis (RA), Multiple sclerosis (MS). However, contribution of HLA in all these diseases is not fully understood. We aimed to provide a concise information about the HLA status in these autoimmune diseases. Methodology: We explored already published articles having information about HLA in autoimmune diseases in relation to CeD from different scientific platforms. We filtered the HLA data from them. We included original and review articles and excluded articles which had only clinical information, and case reports. Results: We found that HLA alleles have strong association in the development of CeD and other autoimmune diseases. HLA-B1*02 is the most critical allele associated with the susceptibility to CeD and also have major role in other gluten related disorders (GRD). Conclusions: We concluded that although HLA has a major role in the autoimmune disease development, multiple unknown non-HLA genes are also critically involved and must be explored frantically.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47473075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-21DOI: 10.17554/j.issn.2224-3992.2020.09.881
Muntaser S. Ahmad, N. Suardi, A. Shukri, N. A. Razak, A. Oglat, Hjouj Mohammad
Hepatocellular Carcinoma (HCC) is the third most common cancers, and it considers having resulted in mortality and morbidity in the world. It is also known as the most primary Hepatocarcinogenesis. Magnetic resonance imaging (MRI) is used to detect and diagnosis tumours and staging of cancer, and to predict tumour biology through biomarkers imaging. Moreover, the MRI technique is used to predict the small size of HCC, high ADC value, and fibrous capsule or pseudo-capsule. In this review, the HCC features in MRI and their implications for prognosis and diagnosis as biomarkers imaging are discussed. Furthermore, the significant findings of HCC staging during the multistep hepatocarcinogenesis are summarized through histopathology and MRI. The review also provides a good Knowledge about early HCC diagnosis, MRI contrast agents, the functional imaging application through MRI include diffusion-weighted sequences, perfusion imaging, radionics analysis, and hepatobiliary contrast agents.
{"title":"A Recent Short Review in Non-Invasive Magnetic Resonance Imaging on Assessment of HCC Stages: MRI Findings and Pathological Diagnosis","authors":"Muntaser S. Ahmad, N. Suardi, A. Shukri, N. A. Razak, A. Oglat, Hjouj Mohammad","doi":"10.17554/j.issn.2224-3992.2020.09.881","DOIUrl":"https://doi.org/10.17554/j.issn.2224-3992.2020.09.881","url":null,"abstract":"Hepatocellular Carcinoma (HCC) is the third most common cancers, and it considers having resulted in mortality and morbidity in the world. It is also known as the most primary Hepatocarcinogenesis. Magnetic resonance imaging (MRI) is used to detect and diagnosis tumours and staging of cancer, and to predict tumour biology through biomarkers imaging. Moreover, the MRI technique is used to predict the small size of HCC, high ADC value, and fibrous capsule or pseudo-capsule. In this review, the HCC features in MRI and their implications for prognosis and diagnosis as biomarkers imaging are discussed. Furthermore, the significant findings of HCC staging during the multistep hepatocarcinogenesis are summarized through histopathology and MRI. The review also provides a good Knowledge about early HCC diagnosis, MRI contrast agents, the functional imaging application through MRI include diffusion-weighted sequences, perfusion imaging, radionics analysis, and hepatobiliary contrast agents.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"9 1","pages":"3113-3123"},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41958455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-21DOI: 10.17554/j.issn.2224-3992.2020.09.912
C. Hui, Kit Hui
Background/Aim: Intestinal lymphangiectasia (IL) is associated with co-existing pathology such as autoimmune diseases or tumors. It can also be incidentally found on esophagogastroduodenoscopy (EGD). However, the clinical significance of this finding is still uncertain. The aim of this study is to determine if those with incidental finding of IL on EGD have a higher risk of co-existing pathology. Methods: This is a cross-sectional case-controlled study. A total of 4948 patients underwent EGD. Results: One-hundred and twenty seven of these 4948 patients (2.6%) had histologically confirmed IL (IL group). Seven hundred and six patients without IL on EGD performed in the same session as those with IL were recruited as control (Control group). Twenty-two of the 127 patients (17.3%) in the IL group had co-existing pathology when compared with 54 of the 706 patients (7.6%) in the Control group (p = 0.001). Patients with co-existing pathology were more likely to have IL in the duodenum [22/76 (28.9%) vs. 105/757 (13.9%), p = 0.001], be older in age [median (range) 56 (34-79) years vs. 53 (21-82) years, p = 0.015], have a higher serum erythrocyte sedimentation rate [median (range) 19 (3-108) mm/hr vs. 15 (1-96) mm/hr, p < 0.001)] and to have an elevated serum erythrocyte sedimentation rate [21/76 (27.6%) vs. 56/757 (7.4%), p < 0.001] when compared with patients without co-existing pathology. On multiple analyses, IL in the duodenum [p = 0.036, Odds Ratio 1.043, 95% confidence interval 0.925-1.175] was an independent factor associated with co-existing pathology. Conclusion: Those with IL are more likely to have co-existing pathology.
{"title":"A Cross-sectional Case-controlled Study on the Significance of Intestinal Lymphangiectasia Incidentally found in the Duodenum on EGD","authors":"C. Hui, Kit Hui","doi":"10.17554/j.issn.2224-3992.2020.09.912","DOIUrl":"https://doi.org/10.17554/j.issn.2224-3992.2020.09.912","url":null,"abstract":"Background/Aim: Intestinal lymphangiectasia (IL) is associated with co-existing pathology such as autoimmune diseases or tumors. It can also be incidentally found on esophagogastroduodenoscopy (EGD). However, the clinical significance of this finding is still uncertain. The aim of this study is to determine if those with incidental finding of IL on EGD have a higher risk of co-existing pathology. Methods: This is a cross-sectional case-controlled study. A total of 4948 patients underwent EGD. Results: One-hundred and twenty seven of these 4948 patients (2.6%) had histologically confirmed IL (IL group). Seven hundred and six patients without IL on EGD performed in the same session as those with IL were recruited as control (Control group). Twenty-two of the 127 patients (17.3%) in the IL group had co-existing pathology when compared with 54 of the 706 patients (7.6%) in the Control group (p = 0.001). Patients with co-existing pathology were more likely to have IL in the duodenum [22/76 (28.9%) vs. 105/757 (13.9%), p = 0.001], be older in age [median (range) 56 (34-79) years vs. 53 (21-82) years, p = 0.015], have a higher serum erythrocyte sedimentation rate [median (range) 19 (3-108) mm/hr vs. 15 (1-96) mm/hr, p < 0.001)] and to have an elevated serum erythrocyte sedimentation rate [21/76 (27.6%) vs. 56/757 (7.4%), p < 0.001] when compared with patients without co-existing pathology. On multiple analyses, IL in the duodenum [p = 0.036, Odds Ratio 1.043, 95% confidence interval 0.925-1.175] was an independent factor associated with co-existing pathology. Conclusion: Those with IL are more likely to have co-existing pathology.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"9 1","pages":"3128-3133"},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45698395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-21DOI: 10.17554/j.issn.2224-3992.2020.09.898
Hien M. Nguyen, M. Q. Dao, H. Bui, T. Luu
Aims: This study aimed to analyze the diagnostic values of the Adenosine Deaminase (ADA) test for detecting Tuberculosis (TB) ascites in Vietnam. Materials and Methods: A cross-sectional study was conducted on 43 patients with ascites. ADA, acid-fast bacilli (AFB) smear microscopy and culture as well as histological tests were performed. Diagnostic values including sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were estimated. Results : The area under the curve (AUC) of ascitic fluid ADA in diagnosis of TB ascites was 0.937 with p <0.001. The optimal cut-off value was 30.2 U/L with high sensitivity (100%) and specificity (88.5%), 85% PPV and 100% NPV. Conclusions : Ascitic fluid ADA assay is a useful diagnostic tool to detect TB ascites.
{"title":"Using Ascitic Fluid Adenosine Deaminase Assay in the Diagnosis of Tuberculous Ascites","authors":"Hien M. Nguyen, M. Q. Dao, H. Bui, T. Luu","doi":"10.17554/j.issn.2224-3992.2020.09.898","DOIUrl":"https://doi.org/10.17554/j.issn.2224-3992.2020.09.898","url":null,"abstract":"Aims: This study aimed to analyze the diagnostic values of the Adenosine Deaminase (ADA) test for detecting Tuberculosis (TB) ascites in Vietnam. Materials and Methods: A cross-sectional study was conducted on 43 patients with ascites. ADA, acid-fast bacilli (AFB) smear microscopy and culture as well as histological tests were performed. Diagnostic values including sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were estimated. Results : The area under the curve (AUC) of ascitic fluid ADA in diagnosis of TB ascites was 0.937 with p <0.001. The optimal cut-off value was 30.2 U/L with high sensitivity (100%) and specificity (88.5%), 85% PPV and 100% NPV. Conclusions : Ascitic fluid ADA assay is a useful diagnostic tool to detect TB ascites.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"9 1","pages":"3124-3127"},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48528871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-21DOI: 10.17554/J.ISSN.2224-3992.2020.09.872
T. Fujikawa
In patients taking antithrombotic therapy ( ATT ) , we have to manage two conflicting risks of bleeding and thromboembolism perioperatively. W e have established our ow n perioperative antithrombotic management protocol for ATT-burdened patients (“Kokura Protocol”), and b ased on th is protocol, the hospital guideline for gastroenterological and general surgery in patients re c eiving ATT was made and have been used. Thereafter, in consideration of newly launched anticoagulants called direct oral anticoagulants ( DOACs ) , the guideline has been updated with appendix on DOACs. In this paper, our current updated guideline concerning perioperative ATT management during GE and general surgery will be outline d.
{"title":"Guideline for General and Gastroenterological Surgery in Patients Undergoing Antithrombotic Treatment: “Kokura Protocol 2019” with Appendix on Direct Oral Anticoagulants (DOACs)","authors":"T. Fujikawa","doi":"10.17554/J.ISSN.2224-3992.2020.09.872","DOIUrl":"https://doi.org/10.17554/J.ISSN.2224-3992.2020.09.872","url":null,"abstract":"In patients taking antithrombotic therapy ( ATT ) , we have to manage two conflicting risks of bleeding and thromboembolism perioperatively. W e have established our ow n perioperative antithrombotic management protocol for ATT-burdened patients (“Kokura Protocol”), and b ased on th is protocol, the hospital guideline for gastroenterological and general surgery in patients re c eiving ATT was made and have been used. Thereafter, in consideration of newly launched anticoagulants called direct oral anticoagulants ( DOACs ) , the guideline has been updated with appendix on DOACs. In this paper, our current updated guideline concerning perioperative ATT management during GE and general surgery will be outline d.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48508926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-21DOI: 10.17554/j.issn.2224-3992.2020.09.908
M. Sharbaugh, T. Shope, T. Koch
As the result of incomplete treatments, obesity continues to be a worldwide origin for multiple medical problems, including metabolic disorders. With the worldwise rise in obesity, the prevalence of type 2 diabetes mellitus has increased in both men and women. Effective treatments for obesity can improve the treatment of metabolic disorders. The adjustable gastric band and the vertical sleeve gastrectomy are less complex gastric surgeries utilized by bariatric surgeons for the treatment of metabolic disorders. Studies have supported the utility of both of these gastric surgeries for the treatment of subgroups of individuals with diabetes mellitus. The field of gastroenterology has mainly been examining four major endoscopic procedures for the treatment of obesity: intragastric balloons, intragastric aspiration systems, intraluminal gastric suturing, and intraluminal barriers deployed within the upper small intestine. Ongoing studies are examining the ability of these endoscopic procedures to treat metabolic disorders, which includes reduction in the blood levels of hemoglobin A1C in individuals with diabetes mellitus. Ongoing issues are discussed that should be addressed prior to the wide spread utilization of endoscopic procedures for the treatment of this metabolic disorder.
{"title":"Will Gastroenterologists Be Successful as Metabolic Physicians?","authors":"M. Sharbaugh, T. Shope, T. Koch","doi":"10.17554/j.issn.2224-3992.2020.09.908","DOIUrl":"https://doi.org/10.17554/j.issn.2224-3992.2020.09.908","url":null,"abstract":"As the result of incomplete treatments, obesity continues to be a worldwide origin for multiple medical problems, including metabolic disorders. With the worldwise rise in obesity, the prevalence of type 2 diabetes mellitus has increased in both men and women. Effective treatments for obesity can improve the treatment of metabolic disorders. The adjustable gastric band and the vertical sleeve gastrectomy are less complex gastric surgeries utilized by bariatric surgeons for the treatment of metabolic disorders. Studies have supported the utility of both of these gastric surgeries for the treatment of subgroups of individuals with diabetes mellitus. The field of gastroenterology has mainly been examining four major endoscopic procedures for the treatment of obesity: intragastric balloons, intragastric aspiration systems, intraluminal gastric suturing, and intraluminal barriers deployed within the upper small intestine. Ongoing studies are examining the ability of these endoscopic procedures to treat metabolic disorders, which includes reduction in the blood levels of hemoglobin A1C in individuals with diabetes mellitus. Ongoing issues are discussed that should be addressed prior to the wide spread utilization of endoscopic procedures for the treatment of this metabolic disorder.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"9 1","pages":"3101-3106"},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42709890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preliminary study on Xiaoliusan-induced inhibition of hepatocellular carcinoma using gene chip analysis","authors":"Mei Wu, Kun Wu, Chao-feng Zhang","doi":"10.12032/GHR2020-03-008","DOIUrl":"https://doi.org/10.12032/GHR2020-03-008","url":null,"abstract":"","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75007873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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