BMC Psychiatry最新文献

With rapid technological advances, social media has become an everyday form of human social interactions. For the first time in evolutionary history, people can now interact in virtual spaces where temporal, spatial, and embodied cues are decoupled from one another. What implications do these recent changes have for socio-cognitive phenotypes and mental disorders? We have conducted a systematic review on the relationships between social media use and mental disorders involving the social brain. The main findings indicate evidence of increased social media usage in individuals with psychotic spectrum phenotypes and especially among individuals with disorders characterized by alterations in the basic self, most notably narcissism, body dysmorphism, and eating disorders. These findings can be understood in the context of a new conceptual model, referred to here as 'Delusion Amplification by Social Media', whereby this suite of disorders and symptoms centrally involves forms of mentalistic delusions, linked with altered perception and perpetuation of distorted manifestations of the self, that are enabled and exacerbated by social media. In particular, an underdeveloped and incoherent sense of self, in conjunction with 'real life' social isolation that inhibits identify formation and facilitates virtual social interactions, may lead to use of social media to generate and maintain a more or less delusional sense of self identity. The delusions involved may be mental (as in narcissism and erotomania), or somatic (as in body dysmorphic disorder and eating disorders, encompassing either the entire body or specific body parts). In each case, the virtual nature of social media facilitates the delusionality because the self is defined and bolstered in this highly mentalistic environment, where real-life exposure of the delusion can be largely avoided. Current evidence also suggests that increased social media usage, via its disembodied and isolative nature, may be associated with psychotic spectrum phenotypes, especially delusionality, by the decoupling of inter and intra-corporeal cues integral to shared reality testing, leading to the blurring of self-other boundaries.

Background: The effects of tPBMT are from influencing compounds by triggering specific reactions, which stimulate Adenosine triphosphate biosynthesis and neurogenesis. According to these effects, tPBMT has been applied as a potential treatment for various neural-related diseases. The purpose of this study was to evaluate the impact of tPBMT on reducing anxiety, depression, and opioid craving in patients undergoing MMT.

Methods: This randomized controlled clinical trial included two groups of substance-dependent patients undergoing MMT. They were randomly assigned to receive tPBMT or a sham tPBMT. The intervention group received PBM in the form of Light- Emitting Diodes (LEDs) for four minutes of light exposure at 810 nm wavelength producing 250 mW/cm² when applied to 4 mm skin depth (totaling 60 J/cm²) in both forehead locations. The levels of anxiety, depression, and opioid craving were compared between the two groups before and after the intervention, as well as at one-month and three-month follow-up assessments.

Results: Both groups consisted of 32 (91.4%) males and 3 (8.6%) females, with the mean age of patients in the intervention group being 37.97 ± 10.58 years, and 39.66 ± 9.94 years in the control group (P = 0.495). There were no significant differences between the two groups in terms of depression, anxiety, and opioid craving scale scores before the intervention (p>0.05). However, the tPBMT group had statistically significant reductions in their scores compared to the sham tPBMT group. (p<0.05).

Conclusion: tPBMT led to significant improvements in anxiety, depression, and opioid craving among individuals in MMT, and these improvements were sustained at one month and three months after treatment, indicating a long-lasting positive effect.

Trial registration: Trial registration: IRCT code: IRCT20210502051162N1, Approval ID: IR.SBMU.MSP.REC.1400.111, registered on 01.06.2021.

Background: Antidepressants (ADs) are prescribed for various conditions, including neurological and rheumatoid diseases. This study aims to analyze ADs prescribing trends in Iranian outpatients over three years, with a focus on age, sex, and ADs class.

Methods: A retrospective cohort study was conducted using prescription data from the Iranian Health Insurance Organization (IHIO) between March 2021 and March 2024. The dataset included 8,924,431 prescriptions from 3,524,273 patients who received at least one ADs. ADs were classified into four groups: tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and atypical ADs. The data were processed via the cross-industry standard process for data mining and analyzed using a multivariate logistic regression model.

Results: SSRIs were the most commonly prescribed class, accounting for 63.71% of prescriptions, with sertraline being the most common drug (24.65%). Females accounted for 66.11% of the patient population. ADs prescriptions increased with age, and females were more likely to receive TCAs and SNRIs than males, who had higher rates of atypical ADs use.

Conclusions: This study revealed a notable increase in ADs prescriptions in Iran, particularly among women and older individuals. Continued monitoring of ADs prescription is crucial for optimizing outcomes, especially for vulnerable groups such as elderly individuals.

Background: The prevalence of obesity currently represents a significant public health concern. Besides the physical burden, obesity is also associated with mental health issues. The mutual relationship between mental health issue and surgical outcome remains unclear, particularly in the population of ethnic Chinese patients. The objective of this Taiwanese study aims to evaluate the changes in physical and mental health before and after surgery and investigate the association between surgical outcome and mental health status.

Methods: The study population comprised patients who had undergone bariatric surgery at least one year prior (with the follow-up durations predominantly within two years). We collected and compared pre- and post-operative mental health status (using the Chinese Health Questionnaire, CHQ, and the Taiwanese Depressive Questionnaire, TDQ) and physical indicators to evaluate and establish their relationships. Furthermore, formal psychiatric diagnoses were confirmed by psychiatrists to analyze the differences between the groups with and without such diagnoses.

Results: A total of 147 patients were included in the study. Following surgery, notable improvements were observed in physical condition and mental health. The average body mass index (BMI) decreased by 13.46 (SD 8.28), the CHQ scores decreased by 1.52 (SD 2.76), and the TDQ scores decreased by 5.08 (SD 8.58). The prevalence of any psychiatric disorder in these patients was found to be 34%. There was no significant difference in the Percentage of Total Weight Loss (%TWL) between individuals with or without psychiatric disorders. However, patients with psychiatric disorders had higher CHQ and TDQ scores after surgery. In multiple linear regression models, the TDQ-by-follow-up duration interaction was predictive of the %TWL, and both married status and the level of tertiary education were identified as negatively associated factors.

Conclusions: Patients who underwent bariatric surgery exhibited a high prevalence of psychiatric disorders, but the presence of pre-operative psychiatric disorders did not significantly affect weight change after surgery. Despite the improvements in physical and mental health post-surgery, the findings indicate that the impact of depression on effectiveness of bariatric surgery is modulated by the time elapsed since the surgery, emphasizing the importance of ongoing mental health care for these patients.

Clinical trial number: Not applicable.

Background: Alcohol dependence (AD) confers susceptibility to distressing withdrawal symptoms that often lead to relapse. While neuroadaptation during withdrawal influences symptoms, the genetic factors behind it have not been thoroughly investigated. We utilized propensity score matching and investigated connections between AD, OXT rs6133010, and withdrawal symptoms to address confounding variables. By elucidating the OXT rs6133010-AD interaction, we aim to gain insights into alcohol withdrawal variability and contribute to personalized treatment approaches.

Methods: A cross-sectional study design was employed involving a total of 389 AD patients and 184 healthy controls who were genotyped for the OXT rs6133010 polymorphism. Psychiatric symptoms were evaluated using standardized scales during early withdrawal. Propensity score matching mitigated age and education differences.

Results: A two-way ANOVA demonstrated a significant AD x OXT rs6133010 interaction effect on hostility and anxiety. Further analysis revealed that the regulatory impact of OXT rs6133010 was exclusively in AD patients. Specifically, AD patients with the AA homozygote showed robust protection against hostility and anxiety. Path analysis unveiled the underlying mechanism of OXT symptom regulation.

Conclusion: This study presents novel evidence that OXT rs6133010 specifically modulates psychiatric symptoms in AD. The G allele may heighten hostility and anxiety vulnerability during alcohol withdrawal. These findings emphasize considering environmental factors when studying and utilizing oxytocin therapeutically. Additionally, OXT may not directly act as an anxiolytic but instead regulates anxiety by modulating hostility.

Background: Depression among undergraduate health science students is increasingly recognized as a significant public health issue globally. These students face immense academic pressure, often leading to stress and mental exhaustion, particularly for students studying in a humanitarian crisis situation. However, there is a scarcity of information in this regard in higher education institutions in Somalia. Hence, this investigation was conducted to assess the prevalence of depression and its correlates health science students in Somalia.

Methods: A cross-sectional study was conducted on 321 health science students from some universities in Mogadishu, Somalia. The data was collected from students studying medicine, nursing and midwifery, laboratory science and public health at SIMAD university, Banadir university, Mogadishu university and Jamhuriya university, all located in Mogadishu. Simple random sampling based on class list was used to select the participants and a web-based self-administered Patient Health Questionnaire (PHQ-9) was used to screen for depression. The collected data were cleaned and checked for completeness before exporting into SPSS version 27 Statistical software for analysis, where descriptive statistics as well as logistic regression analysis was done to determine the independent predictors of the outcome variable. Significant association was determined at a 95% confidence interval and p-value < 0.05.

Result: The prevalence of depression among the students was 58.6%. A total of 41.5% (133/321) of the participants were free from depression (Normal), while 30.8% had mild depression, 27.1% had moderate depression and 0.6% had severe depression. Analysis of the association between the sociodemographic variables and depressive state of the participant showed statistical significance (p-value = 0.045) for course of study. Students studying nursing and midwifery had the highest case of depression with 68.6% (59/86), followed by public health 66.7% (30/45), laboratory science 52.3% (34/65), and medicine having the least number of depressed students with 52.0% students (65/125). Similarly, gender of students was also found to be statistically significant (p-value = 0.001) with female students having 65% depression which is 41.1% of the total students studied.

Conclusion: The prevalence of depression among health science students in Mogadishu was high and positively associated with gender, having trouble with authorities, emotional problems, as well as experience of sexual abuse or violence. Hence, routine screening and monitoring of students' mental health state on the campus and providing mental health services is necessary to address this growing problem.

Background: We validated the German version of the Glasgow Sensory Questionnaire (GSQ), a self-report questionnaire for adults assessing the processing of stimuli regarding hypo- and hypersensitivity in seven sensory modalities. Since the GSQ is intended for the use in autistic adults, we aimed to complement our previous study on students with high and low Autism Spectrum Quotient (AQ; Zeisel et al., BMC Psychiatry 23:426, 2023), by surveying groups of autistic and non-autistic adults, to present the sensory processing profiles of the two groups, to identify the factor structure of the questionnaire in a group of autistic individuals and to identify the diagnostic value of a cut-off score for heightened sensory sensitivity in German autistic adults.

Methods: A sample of autistic and non-autistic adults (each n = 86) completed the same German version of the GSQ as used in Zeisel et al. (BMC Psychiatry 23:426, 2023), the AQ and the Symptom Checklist-90-Revised. Factor analyses were applied.

Results: The German GSQ showed good to excellent reliability. While the factor structure could not be confirmed, main findings of other validation studies were replicated: AQ and GSQ scores were moderately to strongly associated, with higher AQ and GSQ scores for autistic than for non-autistic individuals. Autistic individuals also showed more consistency in their sensitivity across sensory modalities. A third of the autistic participants had heightened sensory sensitivity, when a cut-off was set at the 95th percentile of the non-autism group.

Conclusions: Overall, this German version of the GSQ can be considered a validated self-report questionnaire assessing sensory sensitivity particularly in autistic individuals. It can be used to assess sensory sensitivity in the diagnostic process of autism spectrum disorder and to assess an individual's sensory needs and strengths for best possible support. Further studies are required, especially to assess the internal structure of the GSQ.

Background: Sleep disturbances (SD) among resident physicians have been shown to negatively impact their mental health, potentially leading to suicidal ideation (SI) and reduced life satisfaction (LS). Psychological resilience (PR) is thought to buffer the negative effects of stressors, including SD, and may play a mediating role in this relationship. However, the specific mechanisms linking SD, PR, SI, and LS remain underexplored. This study aimed to examine the mediating role of PR in the relationship between SD, SI, and LS among resident physicians in China, building upon existing theories of resilience and stress in medical professionals.

Methods: An anonymous four-part survey was conducted with 453 resident physicians training in tertiary hospital in China. Descriptive statistics and correlation analyses were performed using the Statistical Package for the Social Sciences software (version 27.0). The study employed structural equation modeling(SEM) to examine the interplay of variables and conducted a multiple-group analysis using Analysis of Moment Structure (version 23.0).

Results: Based on a hypothetical model, SEM revealed that PR played a partial mediating role in the relationship between SD and SI (52.10% of the total effect of SD on SI was direct, and 47.90% of the total effect was mediated by PR). Moreover, in the relationship between SD and LS, PR also acted as a partial mediator, accounting for 79.00% of the direct effect of SD on LS and 21.00% of the effect mediated by PR. The multiple-group analysis further revealed that individuals over 25 years exercise more PR to enhance LS (t = 2.703, p < 0.01), and those with normal weight were less affected by SD in terms of LS (t = - 2.322, p = 0.02).

Conclusions: PR serves as a significant mediator in the relationship between SD and both SI and LS. These findings highlight the importance of fostering PR in resident physicians to mitigate the adverse effects of SD on their mental health and well-being. Policymakers and medical institutions should prioritize interventions aimed at improving sleep quality and supporting mental health to enhance the overall well-being of resident physicians.

Background: There is growing evidence that individuals with cardiovascular disease (CVD) are more likely to develop depression. The timing of food intake can significantly alter the body's circadian rhythm and affect the occurrence of depression. Currently, it is unknown whether and how energy or macronutrient intake times are associated with depression in adults with CVD.

Objective: To evaluate dietary energy or macronutrient intake (across three meals) associations with depression in adults with CVD in a nationally representative sample.

Methods: The study population consisted of 3,490 U.S. adults with CVD (including 554 with depression) from the National Health and Nutrition Examination Survey 2003-2018. Energy and macronutrient intake was measured by a 24-h dietary recall, and depression was diagnosed by the Patient Health Questionnaire (PHQ-9, score ≥ 10). According to dietary energy or macronutrient intake across three meals, adults with CVD were divided into five groups. Logistic regression analysis was performed to examine associations between energy or macronutrient intake and depression after adjusting for a series of confounding factors, including age, gender, education level, household income, smoking status, drinking status, physical activity, marital status, skipping breakfast/lunch/dinner, total energy, carbohydrate, protein, dietary fiber, SFA, MUFA, and PUFA intake, T2DM and hypertension status, and BMI. Dietary substitution models were used to explore changes in depression risk when 5% dietary energy intake at dinner or lunch was substituted with energy intake at breakfast.

Results: When compared with participants in the lowest quintile of breakfast energy intake, those who received energy intake in the highest quintile at breakfast were associated with lower depression risk in those with CVD, and the adjusted odds ratio (OR) was 0.71 (95% CI, 0.51 to 0.91). When compared with participants in the lowest quintile of lunch or dinner energy intake, the risk of depression did not exhibit statistical significance when lunch or dinner energy intake was in the highest quintile, and the adjusted ORs were 1.08 (95% CI, 0.65 to 1.83) and 0.92 (95% CI, 0.62 to 1.37), respectively. Isocalorically replacing 5% of total energy at dinner or lunch with breakfast was associated with 5% (OR: 0.95, 95% CI 0.93 to 0.97) and 5% (OR: 0.95, 95% CI 0.93 to 0.96) lower risk of depression, respectively.

Conclusions: High energy intake at breakfast may be associated with a lower risk of depression in those with CVD. We should focus on the potential role of breakfast energy intake in preventing the onset of depression.