Pub Date : 2026-03-13DOI: 10.1186/s12888-026-07903-7
Seyed Hamdollah Mosavat, Ali Sahraian, Mehdi Kalani, Foroogh Namjoyan, Younes Ghasemi
Background: Substance-Induced Depressive Disorder (SIDD) accounts for a high health burden and requires new therapies. Bidirectional communications between the gut and the brain mediated by the microbiota point to a possible influence of probiotics as a tool for preserving mental health.
Materials and methods: Double-blind, placebo-controlled, randomized clinical trial on a sample of 40 patients with SIDD. Patients were then randomly assigned into probiotic and placebo arms and underwent interventions for four continuous weeks. The clinical assessment was done using BDI and HAM-A. Immunologic outcomes were measured through analysis of inflammatory markers, cytokines, and other immunological parameters. The trial was registered with ClinicalTrials.gov, under the identifier NCT06790823 (18/1/2025).
Results: The change in the intensity of depression and anxiety in both probiotic and placebo groups was statistically significant after intervention. No differences were also noted between the two groups. Immunologic results showed a suggestive changes in IL6 and INFG levels in the probiotic group as compared with placebo, which may indicate possible immune-modulating effects.
Conclusion: In this randomized, double‑blind, placebo‑controlled pilot trial, both probiotic and placebo groups showed significant improvements in depressive and anxiety symptoms over time, with no significant between‑group differences. Probiotic supplementation was associated with non‑significant trends in selected inflammatory markers, suggesting possible immunological effects that warrant further investigation. Larger, multicenter trials with comprehensive microbiome and immunologic assessments are needed to clarify the potential role of probiotics as an adjunctive strategy in substance‑induced depressive disorder.
{"title":"Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial.","authors":"Seyed Hamdollah Mosavat, Ali Sahraian, Mehdi Kalani, Foroogh Namjoyan, Younes Ghasemi","doi":"10.1186/s12888-026-07903-7","DOIUrl":"https://doi.org/10.1186/s12888-026-07903-7","url":null,"abstract":"<p><strong>Background: </strong>Substance-Induced Depressive Disorder (SIDD) accounts for a high health burden and requires new therapies. Bidirectional communications between the gut and the brain mediated by the microbiota point to a possible influence of probiotics as a tool for preserving mental health.</p><p><strong>Materials and methods: </strong>Double-blind, placebo-controlled, randomized clinical trial on a sample of 40 patients with SIDD. Patients were then randomly assigned into probiotic and placebo arms and underwent interventions for four continuous weeks. The clinical assessment was done using BDI and HAM-A. Immunologic outcomes were measured through analysis of inflammatory markers, cytokines, and other immunological parameters. The trial was registered with ClinicalTrials.gov, under the identifier NCT06790823 (18/1/2025).</p><p><strong>Results: </strong>The change in the intensity of depression and anxiety in both probiotic and placebo groups was statistically significant after intervention. No differences were also noted between the two groups. Immunologic results showed a suggestive changes in IL6 and INFG levels in the probiotic group as compared with placebo, which may indicate possible immune-modulating effects.</p><p><strong>Conclusion: </strong>In this randomized, double‑blind, placebo‑controlled pilot trial, both probiotic and placebo groups showed significant improvements in depressive and anxiety symptoms over time, with no significant between‑group differences. Probiotic supplementation was associated with non‑significant trends in selected inflammatory markers, suggesting possible immunological effects that warrant further investigation. Larger, multicenter trials with comprehensive microbiome and immunologic assessments are needed to clarify the potential role of probiotics as an adjunctive strategy in substance‑induced depressive disorder.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1186/s12888-026-07955-9
Josefin Sveen, Maarten C Eisma, Lilian Pohlkamp, Ulrika Kreicbergs, Lonneke I M Lenferink
{"title":"Prolonged grief and insomnia symptoms in cancer-bereaved parents: a latent class analysis.","authors":"Josefin Sveen, Maarten C Eisma, Lilian Pohlkamp, Ulrika Kreicbergs, Lonneke I M Lenferink","doi":"10.1186/s12888-026-07955-9","DOIUrl":"https://doi.org/10.1186/s12888-026-07955-9","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-12DOI: 10.1186/s12888-026-07951-z
Esther Wangari Wahome, Amsalu Degu
{"title":"Assessment of treatment outcomes among bipolar patients at Mathari National Teaching and Referral Hospital, Kenya.","authors":"Esther Wangari Wahome, Amsalu Degu","doi":"10.1186/s12888-026-07951-z","DOIUrl":"https://doi.org/10.1186/s12888-026-07951-z","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-11DOI: 10.1186/s12888-026-07959-5
Guiyun Gan, Chenxia Song, Li Zhang, Jin Liu, Juan Chen, Feifei Ye
{"title":"Effect of group reminiscence therapy combined with cognitive restructuring on middle-aged and elderly participants with schizophrenia.","authors":"Guiyun Gan, Chenxia Song, Li Zhang, Jin Liu, Juan Chen, Feifei Ye","doi":"10.1186/s12888-026-07959-5","DOIUrl":"https://doi.org/10.1186/s12888-026-07959-5","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-11DOI: 10.1186/s12888-026-07950-0
Yuanpeng Zhu, Di Liu, Xiangjie Yin, Terry Jianguo Zhang, Nan Wu
{"title":"Association of childhood maltreatment with DXA‑derived body composition in middle‑aged and older adults: mediating roles of unhealthy lifestyle and depression.","authors":"Yuanpeng Zhu, Di Liu, Xiangjie Yin, Terry Jianguo Zhang, Nan Wu","doi":"10.1186/s12888-026-07950-0","DOIUrl":"https://doi.org/10.1186/s12888-026-07950-0","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of BDNF rs10835210 on right parahippocampal volume and its related cognitive function in first- and multiple-episode bipolar disorder.","authors":"Ruilan Yang, Jianshan Chen, Tianlang Ke, Xiaofei Zhang, Xiaofang Cheng, Qiuxia Wu, Jiaqi Sun, Wenhao Deng, Xiongchao Cheng, Wenjin Zou, Yizhi Zhang, Chanjuan Yang, Liqian Cui, Biyu Ye, Xuan Li, Liping Cao","doi":"10.1186/s12888-026-07949-7","DOIUrl":"https://doi.org/10.1186/s12888-026-07949-7","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-11DOI: 10.1186/s12888-026-07962-w
Eeva-Eerika Helminen, Suoma E Saarni, Kasperi Mikkonen, M Katariina Mattila, Tom H Rosenström, Max Karukivi, Erkki Isometsä, Jan-Henry Stenberg, Jesper Ekelund, Samuli I Saarni
{"title":"Effectiveness of guided self-help, guided internet-delivered cognitive behavioral therapy, and face-to-face cognitive behavioral therapy for depression and anxiety: protocols of four parallel randomized controlled non-inferiority trials of the Finnish First-Line Therapies -Initiative (FLT-Step).","authors":"Eeva-Eerika Helminen, Suoma E Saarni, Kasperi Mikkonen, M Katariina Mattila, Tom H Rosenström, Max Karukivi, Erkki Isometsä, Jan-Henry Stenberg, Jesper Ekelund, Samuli I Saarni","doi":"10.1186/s12888-026-07962-w","DOIUrl":"https://doi.org/10.1186/s12888-026-07962-w","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1186/s12888-026-07930-4
Shivani M Reddy, Caroline B Rains, Valerie C Ng, Shannon A Kugley, Colleen M Ovelman, Bradley N Gaynes, Leila C Kahwati
{"title":"A systematic review of transcranial magnetic stimulation for generalized anxiety disorder, obsessive-compulsive disorder, and posttraumatic stress disorder.","authors":"Shivani M Reddy, Caroline B Rains, Valerie C Ng, Shannon A Kugley, Colleen M Ovelman, Bradley N Gaynes, Leila C Kahwati","doi":"10.1186/s12888-026-07930-4","DOIUrl":"https://doi.org/10.1186/s12888-026-07930-4","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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