BMC Psychiatry最新文献

Backgrounds: Dissociative experiences are described as crucial psychological mechanisms involving the organism's responses to severe psychological traumas and unpleasant past experiences. This research was conducted to examine the psychometric properties of the Dissociative Experiences Measure, Oxford (DEMO) in the Iranian general population.

Methods: This study used cross-sectional correlation, and the statistical population consisted of Iranians over 15 years old. Among them, 712 subjects were chosen as the study sample using the convenience sampling technique. Data were acquired between February and April 2022 using DEMO, Dissociative Experiences Scale II (DES-II), and Depression Anxiety and Stress Scale (DASS-21). In order to determine DEMO's psychometric properties, Confirmatory Factor Analysis (CFA) was used to investigate the factorial structure, Cronbach's alpha analyses to examine the internal consistency reliability, and Pearson correlation analyses to examine the relationships between DEMO's subscales and the subscales of DES-II and DASS-21, indicating convergent validity. In order to analyze the data, LISREL 8.0 and SPSS-26 were used.

Results: Based on the results of the CFA, the proposed five-factor structure of DEMO showed an acceptable fit to the data (χ² = 1939.81, SRMR = 0.078, CFI = 0.96, RMSEA = 0.074). The internal reliability was satisfactory for the total scale (Cronbach's alpha = 0.93) and the five subscales (Cronbach's alpha = 0.89 for unreality, 0.87 for numb and disconnected, 0.80 for memory blanks, 0.85 for zoned out, and 0.79 for vivid internal world). The CFA results indicated that the five factors explained 60.69% of the variance. Significant correlations were observed between the DEMO subscales and the respective subscales of DES-II and DASS-21, confirming the measure's convergent validity.

Conclusion: It can be concluded from the results of this study that the DEMO has high reliability and validity among the Iranian general population.

Background: Adolescents face numerous challenges that influence their sexual behaviors. Among these, bullying victimization is a critical yet understudied factor that may impact engagement in unprotected sex. This study investigated the correlates of condom use among school-going Thai adolescents, with a main focus on bullying victimization.

Methods: This study is a secondary analysis of the Global School-based Student Health Survey (GSHS) conducted in 2021 among a nationally representative sample of students in grades 7-12 in Thailand. The analysis included all the sexually active students with condom use in the last sex as the main outcome variable. Bivariate binary logistic regression analysis was used to examine the odds of using condom across various explanatory variables. Additional adjusted logistic regression models were constructed to examine the association between bullying experiences and condom use while controlling for the potential confounding effect of other explanatory variables.

Results: Among sexually active participants, 416 (69%) reported using condoms in their last sex and more than half of them reported bullying experiences. Besides bullying, this study identifies several factors such as older age (< 14) and higher grades that were associated with lower use of condoms. Additionally, other psychosocial factors such as suicidal ideation and attempts as well as physical violence, and lack of close friends decrease the odds of condom use. Substance use, particularly marijuana and amphetamine/methamphetamine, was also associated with lower condom use. Although all types of bullying experiences were associated with lower condom use in bivariate analyses, the association remained significant only for bullying at school in the adjusted model (AOR = 0.39, 95% CI: 0.18-0.86).

Conclusion: The findings emphasize a holistic approach to addressing bullying, particularly within schools, and promoting protected sexual behaviors among school-going adolescents through early anti-bullying interventions and incorporating tailored sex education into school curricula, and at Thai schools.

Background: This study investigated the effects of phototherapy on serum BH4 levels, evoked potentials, and cognitive impairment in post-stroke depression patients.

Methods: We conducted a prospective study with 160 post-stroke depression patients, randomly assigned to an experimental group receiving daily 40 min of phototherapy alongside routine treatment, and a control group receiving only routine treatment. Serum tetrahydrobiopterin (BH4) levels were measured via ELISA. Evoked potentials were assessed using an ERP recorder, depressive symptoms were evaluated with the Hamilton Depression Scale (HAM-D), and cognitive function was analyzed using the Montreal Cognitive Assessment (MoCA). Inflammatory factor expression was detected via RT-PCR.

Results: Both groups exhibited increased BH4 levels, but the phototherapy group had significantly higher levels (P < 0.05). The phototherapy group also demonstrated improved ERP parameters, with higher MMN latency, P300 latency, and amplitudes compared to controls (P < 0.05). HAM-D scores decreased more in the phototherapy group (P < 0.05), while MoCA scores increased significantly (P < 0.05). Additionally, inflammatory markers IL-6, TNF-α, and IL-1β were lower in the phototherapy group (P < 0.05).

Conclusions: Phototherapy positively influenced BH4 levels, improved evoked potentials, alleviated depressive symptoms, enhanced cognitive function, and reduced inflammation in post-stroke depression patients.

Background: The Bergen 4-Day Treatment (B4DT) is a concentrated cognitive behaviour therapy (CBT) approach that has shown promise in treating panic disorder (PD). However, the effectiveness of the B4DT, particularly regarding long-term outcomes in rural clinical settings, remains underexplored.

Methods: A total of 58 patients were included using a naturalistic open-label trial design. Patients were assessed at 12-month follow-up. Measures included the Panic Disorder Severity Scale (PDSS), the Patient Health Questionnaire-9 (PHQ-9), and the Generalized Anxiety Disorder-7 scale (GAD-7).

Results: The study revealed significant and lasting reductions in PD symptoms, with a high rate of remission maintained at 12-month follow-up (82.8%). Regarding the secondary outcomes, significant improvements in symptoms of depression and generalized anxiety were also shown.

Conclusions: The B4DT represents a promising treatment approach for PD, demonstrating stable long-term outcomes in rural settings. This finding supports the potential of concentrated CBT formats in achieving sustained symptom improvement in patients with PD, warranting further investigation and broader implementation.

Trial registration: The study was reviewed by the Regional Committee for Medical Research Ethics Northern Norway, REK North (REK Nord2021/273145).

Background: The high comorbidity and symptom overlap of generalized anxiety disorder (GAD), posttraumatic stress disorder (PTSD), and social anxiety disorder (SAD), has led to the study of their shared and disorder-specific neural substrates. However, the morphometric similarity network (MSN) differences among these disorders remain unknown.

Methods: MSN derived from T1-weighted images in patients of GAD, PTSD, and SAD, and health controls (HC) using a Siemens 3T magnetic resonance imaging system. Covariance analysis and post hoc tests were used to investigate group differences. In addition, the relationship between MSN and clinical characteristics was analyzed.

Results: Increased morphometric similarity (MS) between left bankssts (BA22, superior temporal cortex, STC) and right precentral gyrus, and decreased MS between left precentral gyrus and right cuneus_part1/part2, and between right rostral middle frontal cortex (rMFC) and right STC were common in GAD and PTSD relative to HC and SAD. Compared to the other three groups, SAD exhibited disorder-specific alterations of increased MS between right rMFC and right STC, and between left cuneus and right inferior parietal cortex. Additionally, increased regional MSN in left precentral gyrus was found in PTSD compared to HC and SAD. A mild positive correlation of the MS value between left bankssts and right precentral gyrus and the Hamilton Anxiety Rating Scale scores (uncorrected p = 0.041) was found in PTSD.

Conclusions: Our study provides the first evidence for common and distinct brain MSN abnormalities underlying the pathophysiology of GAD, PTSD, and SAD, which may aid in differential diagnosis and determining potential disorder-specific intervention targets.

Background: Colleges and universities are currently facing the major public health issue of poor sleep quality. Sleep quality must be taken seriously to maintain the students' emotional and physical well-being. Thus, this study sought to determine how university students' levels of physical activity related to the quality of their sleep, as well as to explore the mechanisms via which physical activity affects sleep and provide suggestions for improving it.

Methods: A total of 883 university students from Ganzhou City, Jiangxi Province, China participated in the study. Their physical activity, sleep quality, ruminative thinking levels, and depression were assessed using various questionnaires.

Results: Through the mediating effects of rumination and depression as well as the chain-mediated effects of these two factors, physical exercise changed the quality of sleep.

Conclusion: University students' sleep quality can be improved by increasing their physical activity and decreasing ruminative thinking and depression levels.

Background: Health-related quality of life is a multi-dimensional concept that involves individual's perceived physical and mental health, social relationships, and environment. Family members are the primary caregivers of people living with schizophrenia in China, the quality of life of caregiver of people living with schizophrenia is generally poorer, which may indirectly affect the quality of life of the people with schizophrenia.

Methods: We conducted a comprehensive survey on quality of life in caregivers of people living with schizophrenia based on the Schizophrenia-specific cohort in the Less-developed Multi-ethnic Region of Southwest China to validate the accessibility and effectiveness of the schizophrenia family care model at the family level, caregivers of people living with schizophrenia were selected as participants in Baoshan City, Yunnan Province from September 2022 to March 2023, quality of life, family burden of disease, sociodemographic and behavioral information of participants were collected.

Results: Domain scores for physical, psychological, social relationships, and environment of quality of life were 13.50 ± 2.61, 12.67 ± 2.40, 13.64 ± 2.32, and 12.46 ± 1.76 respectively. In our study, we found that gender, age, education level, personal monthly income, history of smoking and alcohol consumption, subjective sleep quality, relation to the patient, degree of self-care and the number of relapses in patient all influence 1 to 4 domains of quality of life for caregivers, stratified analysis was conducted to minimize the effect of gender on the results, we still found that history of smoking could positively predict the score of psychological domain and history of alcohol consumption could positively predict the score of social relationships domain. Canonical correlation analysis showed that the 'impact on family interaction' in family burden of disease was most closely related to quality of life.

Conclusion: Building harmonious family relationships can help improve the quality of life for caregivers of People living with schizophrenia.

Background: Understanding the connection between parental wellbeing and its impact on childhood depression is crucial in order to develop targeted interventions and support systems that can mitigate potential long-term effects on mental health. This study focuses on examining the properties of an Arabic translation of a questionnaire called Short Mood and Feelings Questionnaire Parent Version (SMFQ-P) as a preliminary step toward validating a culturally relevant screening tool for childhood depression in Lebanon.

Methods: A total of 502 parents, recruited through a snowball method, took part in the survey with an age of 36.24 years (SD ± 8.29). Among them 74.5% were females 88.8% were married and 72.9% had completed university level education. The children's mean age was 7.95 ± 1.14 years. The SMFQ-P was evaluated using confirmatory factor analysis (CFA), reliability measures, and correlations with parental distress using the Depression Anxiety Stress Scale-8 (DASS-8).

Results: Confirmatory factor analysis (CFA) demonstrated an excellent fit for the one-factor model of SMFQ-P scores (RMSEA = 0.059, 90% CI [0.049, 0.070]; SRMR = 0.034; CFI = 0.967; TLI = 0.960), with standardized factor loadings ranging from 0.58 to 0.82. Male parents reported more depression in their child than female parents (p = .016). Parental distress levels (r = .60, p < .001) correlated strongly with SMFQ-P scores, suggesting indirect concurrent validity.

Conclusion: The SMFQ-P shows promise as a screening tool for childhood depression, offering preliminary evidence of its reliability and validity in the Lebanese context. Limitations, including reliance on parent-reported distress and the lack of a direct child-report validation, should be addressed in future studies.

Background: Cognitive impairment is prevalent in bipolar disorder (BD), and has negative impacts on functional impairments and quality of life, despite euthymic states in most individuals. The underlying neurobiological basis of cognitive impairment in BD is still unclear.

Methods: To further explore potential connectivity abnormalities and their associations with cognitive impairment, we conducted a degree centrality (DC) analysis and DC (seed)-based functional connectivity (FC) approach in unmedicated, euthymic individuals with BD. Our study included 34 euthymic BD patients and 35 healthy controls (HC) matched for age, gender, and education years.

Results: We found extensive DC changes in brain activity, with lower DC values in the left medial frontal gyrus, inferior frontal gyrus, and middle frontal gyrus, and increased DC values in the left insula, bilateral precentral gyrus, and right medial frontal gyrus in BD patients compared to HC. Furthermore, we observed positive or negative correlations between DC values of the inferior frontal gyrus, insula_L, precentral gyrus (L), precentral gyrus (R), and medial frontal gyrus and multiple-domain cognitive assessment scores. Additionally, we identified intranetwork and internetwork functional connectivity alterations in the default mode network (DMN), fronto-parietal network (FPN), and central executive network (CEN) in euthymic BD patients compared to HC.

Conclusion: Our findings highlight abnormal neuronal networks involving multiple frontal brain regions and thalamus, which may contribute to cognitive deficits in individuals with euthymic BD. These findings may serve as potential hallmarks of BD, contributing to a better understanding of the neural mechanism of cognitive impairment during euthymia.