Cisplatin (DDP) is one of most used anticancer agents. It has shown antitumor activity in testicular cancer, head and neck cancer, ovarian cancer, lung cancer, malignant lymphoma and bladder cancer. It causes much toxicity such as skin and mucous membranes toxicity, ototoxicity and nephrotoxicity especially at higher dose, which might be involved with DNA damage and subsequently renal cell death. Ginseng is a group of cosmopolitan plants. As the root of Panax ginseng C.A. Meyer, ginseng is well known as a tonic medicine for restoring and enhancing human health. Ginseng extract contains numerous phytochemicals such as ginsenoside, phenols and acidic polysaccharides that have significant pharmacological activities. In vivo and in vitro studies demonstrated that ginseng extract and its constituents are able to prevent cisplatin-induced toxicity through reducing the oxidative stress by restoring the antioxidant enzymes level and exerting anti-inflammatory effect. Multidrug resistance (MDR) is a principal obstacle to successful cancer chemotherapy. Because of low toxicity and diversity of effect, ginseng extract constituents have been attached more and more attention in MDR reversal. Evidences showed that ginseng extract and its constituents are promising potential for cisplatin resistance in cancer treatment. *Correspondence to: Huihong Huang, Fengxian Traditional Chinese Medicine Hospital, 9588 Nanfeng Hwy, Shanghai 201400, China, E-mail: HYPERLINK "mailto:1142269435@qq.com" 1142269435@qq.com
{"title":"Ginseng extract and its constituents alleviate cisplatin toxicity and reverse cisplatin resistance","authors":"Jian Cai, Huihong Huang","doi":"10.15761/icst.1000326","DOIUrl":"https://doi.org/10.15761/icst.1000326","url":null,"abstract":"Cisplatin (DDP) is one of most used anticancer agents. It has shown antitumor activity in testicular cancer, head and neck cancer, ovarian cancer, lung cancer, malignant lymphoma and bladder cancer. It causes much toxicity such as skin and mucous membranes toxicity, ototoxicity and nephrotoxicity especially at higher dose, which might be involved with DNA damage and subsequently renal cell death. Ginseng is a group of cosmopolitan plants. As the root of Panax ginseng C.A. Meyer, ginseng is well known as a tonic medicine for restoring and enhancing human health. Ginseng extract contains numerous phytochemicals such as ginsenoside, phenols and acidic polysaccharides that have significant pharmacological activities. In vivo and in vitro studies demonstrated that ginseng extract and its constituents are able to prevent cisplatin-induced toxicity through reducing the oxidative stress by restoring the antioxidant enzymes level and exerting anti-inflammatory effect. Multidrug resistance (MDR) is a principal obstacle to successful cancer chemotherapy. Because of low toxicity and diversity of effect, ginseng extract constituents have been attached more and more attention in MDR reversal. Evidences showed that ginseng extract and its constituents are promising potential for cisplatin resistance in cancer treatment. *Correspondence to: Huihong Huang, Fengxian Traditional Chinese Medicine Hospital, 9588 Nanfeng Hwy, Shanghai 201400, China, E-mail: HYPERLINK \"mailto:1142269435@qq.com\" 1142269435@qq.com","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67477103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joseph Blitman, B. Buscaglia, Christa L. Whitney-Miller, David Hicks, Aaron R. Huber
Background: Monitoring frozen section (FS) and final permanent section (PS) correlation is a valuable quality assurance metric in surgical pathology. The discordant FSs, at our institution, are categorized as minor if there is little or no perceived or actual clinical significance and major if there is major or potentially major clinical significance, which is determined by the final sign out pathologist. We sought to determine if the subspecialty sign out (SSSO) model, which was instituted in July of 2015, has adversely impacted our discordance rate. Methods: We retrospectively reviewed the discordance rates (DRs) before (January 2012-June 2015) and after (July 2015-2017) SSSO. The monthly intraoperative consultation FS and PS correlation data were analyzed from January 2012 to January 2018. The DRs were compared for minor, major and combined disagreements (minor + major) before and after SSSO. Results: There were 7,045 total frozen sections with 2,989 after SSSO and 4,056 prior to SSSO, of which 139 had minor disagreements (74 prior to SSSO and 65 after SSSO) and 42 had major disagreements (26 prior to SSSO and 16 after SSSO). The average combined DRs per month; pre and post SSSO were 2.17 and 3.0, respectively. The difference was statistically significant for the minor (p=0.005), not statistically significant for the major (p=1) and statistically significant for the combined (p=0.014) disagreements. Conclusion: Our data shows that SSSO appears to increase FS discordance rates (minor and combined disagreements). This suggests that when adopting a SSSO model, maintaining competency with a wide array of specimens seen on a general intraoperative consultation service may be challenging and warrants careful monitoring of frozen and permanent section discrepancy rates.
{"title":"Is the rate of frozen section discordance affected by subspecialty sign out? A quality improvement study","authors":"Joseph Blitman, B. Buscaglia, Christa L. Whitney-Miller, David Hicks, Aaron R. Huber","doi":"10.15761/icst.1000321","DOIUrl":"https://doi.org/10.15761/icst.1000321","url":null,"abstract":"Background: Monitoring frozen section (FS) and final permanent section (PS) correlation is a valuable quality assurance metric in surgical pathology. The discordant FSs, at our institution, are categorized as minor if there is little or no perceived or actual clinical significance and major if there is major or potentially major clinical significance, which is determined by the final sign out pathologist. We sought to determine if the subspecialty sign out (SSSO) model, which was instituted in July of 2015, has adversely impacted our discordance rate. Methods: We retrospectively reviewed the discordance rates (DRs) before (January 2012-June 2015) and after (July 2015-2017) SSSO. The monthly intraoperative consultation FS and PS correlation data were analyzed from January 2012 to January 2018. The DRs were compared for minor, major and combined disagreements (minor + major) before and after SSSO. Results: There were 7,045 total frozen sections with 2,989 after SSSO and 4,056 prior to SSSO, of which 139 had minor disagreements (74 prior to SSSO and 65 after SSSO) and 42 had major disagreements (26 prior to SSSO and 16 after SSSO). The average combined DRs per month; pre and post SSSO were 2.17 and 3.0, respectively. The difference was statistically significant for the minor (p=0.005), not statistically significant for the major (p=1) and statistically significant for the combined (p=0.014) disagreements. Conclusion: Our data shows that SSSO appears to increase FS discordance rates (minor and combined disagreements). This suggests that when adopting a SSSO model, maintaining competency with a wide array of specimens seen on a general intraoperative consultation service may be challenging and warrants careful monitoring of frozen and permanent section discrepancy rates.","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67477058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pomuceno-Orduñez Jp, E. Silva, R. Martin, I. Durán, M. Bizzarri, G. Cocho, R. Mansilla, J. Nieto-Villar
{"title":"Phase transitions in tumor growth VII: The effect of periodic glucose pulses and privations in a cancer model","authors":"Pomuceno-Orduñez Jp, E. Silva, R. Martin, I. Durán, M. Bizzarri, G. Cocho, R. Mansilla, J. Nieto-Villar","doi":"10.15761/icst.1000301","DOIUrl":"https://doi.org/10.15761/icst.1000301","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67475926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Makino, S. Nomura, H. Maruyama, T. Yokoyama, A. Hirakata, Y. Kikuchi, Masafumi Yoshioka, T. Iwai, T. Nomura, H. Yoshida
After esophagectomy and total gastrectomy, anastomotic leakage is a serious complication associated with a high mortality. Complications such as abscesses, sepsis and malnutrition may occur. In cases of anastomotic leakage after esophagectomy and gastrectomy, occurrence of an esophago-respiratory fistula or pancreatic fistula can be a very dangerous, even fatal complication. Various endoscopic techniques have been recently developed to treat leakage and fistula using minimally invasive approaches. Treatment methods including techniques such as fibrin glue injection, use of clips or self-expandable stents which are more conservative than surgery have become available. We report successful endoscopic clipping and application of fibrin glue, which is more conservative than surgery, for an esophago-mediastinal fistula. In addition to reporting endoscopic application of transnasal tube, over-the-scope clip (OTSC) and stenting, we also performed clipping for difficult cases with leakage or fistula. In this paper, indications of these endoscopic therapeutic methods are described for each case. With a broad range of conservative and endoscopic therapeutic methods available, encouraging progress has been made with regards to a shorter closure time of leakage and less risk of severe systemic complications. *Correspondence to: Hiroshi Makino, Department of Surgery, Tama Nagayama Hospital, Nippon Medical School, 1-7-1 Nagayama, Tama-City, Tokyo, Japan206-8512, Tel: +81-42-371-2111, Fax +81-42-372-7384, E-mail: himiyumo@nms.ac.jp
{"title":"Endoscopic application of clipping, over-the-scope clip (OTSC) and stenting for a fistula and anastomotic leakage of upper gastro- intestinal tract","authors":"H. Makino, S. Nomura, H. Maruyama, T. Yokoyama, A. Hirakata, Y. Kikuchi, Masafumi Yoshioka, T. Iwai, T. Nomura, H. Yoshida","doi":"10.15761/icst.1000309","DOIUrl":"https://doi.org/10.15761/icst.1000309","url":null,"abstract":"After esophagectomy and total gastrectomy, anastomotic leakage is a serious complication associated with a high mortality. Complications such as abscesses, sepsis and malnutrition may occur. In cases of anastomotic leakage after esophagectomy and gastrectomy, occurrence of an esophago-respiratory fistula or pancreatic fistula can be a very dangerous, even fatal complication. Various endoscopic techniques have been recently developed to treat leakage and fistula using minimally invasive approaches. Treatment methods including techniques such as fibrin glue injection, use of clips or self-expandable stents which are more conservative than surgery have become available. We report successful endoscopic clipping and application of fibrin glue, which is more conservative than surgery, for an esophago-mediastinal fistula. In addition to reporting endoscopic application of transnasal tube, over-the-scope clip (OTSC) and stenting, we also performed clipping for difficult cases with leakage or fistula. In this paper, indications of these endoscopic therapeutic methods are described for each case. With a broad range of conservative and endoscopic therapeutic methods available, encouraging progress has been made with regards to a shorter closure time of leakage and less risk of severe systemic complications. *Correspondence to: Hiroshi Makino, Department of Surgery, Tama Nagayama Hospital, Nippon Medical School, 1-7-1 Nagayama, Tama-City, Tokyo, Japan206-8512, Tel: +81-42-371-2111, Fax +81-42-372-7384, E-mail: himiyumo@nms.ac.jp","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67476212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Received: May 15, 2019; Accepted: June 05, 2019; Published: June 10, 2019 In our “macroscopic” world it is a truism that an action is often followed by an equal and opposite reaction. In the “microscopic” realms (chemical, biological, quantum environments), that response often is mimicked. For example, stressed cancer cells can exhibit enhanced resistance to therapy and development of alternate genetic/epigenetic responses that increase proliferation and developmental / proliferative events unanticipated by the physician. These considerations provide a background for considering these and other possible consequences to hypoxia or other cellular stresses by deterministic, or by random, stochastic cancer cell responses to stresses. According to some, random refers to a variable, stochastic to a process or system.
{"title":"If the statistics underlying macroscopic and microscopic (quantum scale) events were to fundamentally differ would this affect the biology of cancer?","authors":"Anderson Km, Patel Mk","doi":"10.15761/icst.1000311","DOIUrl":"https://doi.org/10.15761/icst.1000311","url":null,"abstract":"Received: May 15, 2019; Accepted: June 05, 2019; Published: June 10, 2019 In our “macroscopic” world it is a truism that an action is often followed by an equal and opposite reaction. In the “microscopic” realms (chemical, biological, quantum environments), that response often is mimicked. For example, stressed cancer cells can exhibit enhanced resistance to therapy and development of alternate genetic/epigenetic responses that increase proliferation and developmental / proliferative events unanticipated by the physician. These considerations provide a background for considering these and other possible consequences to hypoxia or other cellular stresses by deterministic, or by random, stochastic cancer cell responses to stresses. According to some, random refers to a variable, stochastic to a process or system.","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67476284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guben Yiliu II (GY II), a mixture of extracts from 13 species of herbs, has been prescribed in China as traditional Chinese medicine. Bai et al. [1] determined anti-tumor activity of GY II, using cell line models for laryngeal cancer. GY II was found to considerably inhibit the cell viability of the Hep-2 line and primary culture from patients and induce G0/G1 cell-cycle arrest as well as apoptosis. GY II also inhibited cell migration and invasion. These observations supported anti-tumor property of traditional Chinese medicine.
{"title":"Editorial comments to the articles published in Issues 1-3 of Volume 6","authors":"H. Miyamoto","doi":"10.15761/icst.1000312","DOIUrl":"https://doi.org/10.15761/icst.1000312","url":null,"abstract":"Guben Yiliu II (GY II), a mixture of extracts from 13 species of herbs, has been prescribed in China as traditional Chinese medicine. Bai et al. [1] determined anti-tumor activity of GY II, using cell line models for laryngeal cancer. GY II was found to considerably inhibit the cell viability of the Hep-2 line and primary culture from patients and induce G0/G1 cell-cycle arrest as well as apoptosis. GY II also inhibited cell migration and invasion. These observations supported anti-tumor property of traditional Chinese medicine.","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67476302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Received: August 09, 2019; Accepted: October 23, 2019; Published: October 26, 2019 If we start the discussion from the consideration that there are two modalities to approach the treatment for a patient, we will understand the need to integrate these approaches. The essential aspects of the integration of medical oncology with palliative care are summarized in a very concise manner in an article by Kaasa et al. published in Lancet Oncology in 2018. “The full integration of oncology and palliative care relies on the specific knowledge and skills of two modes of care: the tumour-directed approach, the main focus of which is on treating the disease; and the host-directed approach, which focuses on the patient with the disease” [1].
{"title":"How to integrate medical oncology and palliative care?","authors":"A. Grigorescu, Teodor Mihaela","doi":"10.15761/icst.1000322","DOIUrl":"https://doi.org/10.15761/icst.1000322","url":null,"abstract":"Received: August 09, 2019; Accepted: October 23, 2019; Published: October 26, 2019 If we start the discussion from the consideration that there are two modalities to approach the treatment for a patient, we will understand the need to integrate these approaches. The essential aspects of the integration of medical oncology with palliative care are summarized in a very concise manner in an article by Kaasa et al. published in Lancet Oncology in 2018. “The full integration of oncology and palliative care relies on the specific knowledge and skills of two modes of care: the tumour-directed approach, the main focus of which is on treating the disease; and the host-directed approach, which focuses on the patient with the disease” [1].","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67476867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Imad Abrao Nemeir, J. Saab, W. Hleihel, A. Errachid, N. Zine
In this paper we present the preliminary results on the development of an electrochemical gold integrated SPE biosensor for the detection of EGFR. The strategy followed concerned the biofunctionalization of the gold electrode through the in-situ electrochemical deposition of 4-carboxymethylanailine (CMA) then the grafting of AntiEGFR antibodoy. The biosensor developed was characterized using electrochemical impedance spectroscopy (EIS) and as a result it was found to be highly sensitive within a range of 50-120 pg/mL in phosphate buffer saline (PBS) as well as very selective toward the EGFR when compared to other interferences such as HER2 and HER3.
{"title":"Impedimetric label-free detection of salivary EGFR on screen printed electrode","authors":"Imad Abrao Nemeir, J. Saab, W. Hleihel, A. Errachid, N. Zine","doi":"10.15761/icst.1000319","DOIUrl":"https://doi.org/10.15761/icst.1000319","url":null,"abstract":"In this paper we present the preliminary results on the development of an electrochemical gold integrated SPE biosensor for the detection of EGFR. The strategy followed concerned the biofunctionalization of the gold electrode through the in-situ electrochemical deposition of 4-carboxymethylanailine (CMA) then the grafting of AntiEGFR antibodoy. The biosensor developed was characterized using electrochemical impedance spectroscopy (EIS) and as a result it was found to be highly sensitive within a range of 50-120 pg/mL in phosphate buffer saline (PBS) as well as very selective toward the EGFR when compared to other interferences such as HER2 and HER3.","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67476913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İ. Eroğlu, B. Aktaş, O. Kurtulan, D. Guven, S. Aksoy
In the absence of axillary lymph node involvement, the thyroid nodule and cervical lymph nodes made us concern about a second primary malignancy, most probably a thyroid neoplasm. Thyroid fine needle aspiration biopsy showed normal thyroid glands and tru-cut biopsy of the right supraclavicular lymph node showed granulomatous lymphadenitis which is consistent with tuberculosis lymphadenitis (Figure 2A). The PPD test measured 15 mm and serum quantiferon were positive. The patient was consulted to the infectious disease department and an initial intensive-phase therapy with four antibiotics (INH, RIF, PZA, EMB) and continuation-phase therapy with 2 antibiotics (INH, RFA) planned.
{"title":"Clinically unexpected lymph node: An old enemy to remember in the cancer diagnosis and treatment","authors":"İ. Eroğlu, B. Aktaş, O. Kurtulan, D. Guven, S. Aksoy","doi":"10.15761/icst.1000325","DOIUrl":"https://doi.org/10.15761/icst.1000325","url":null,"abstract":"In the absence of axillary lymph node involvement, the thyroid nodule and cervical lymph nodes made us concern about a second primary malignancy, most probably a thyroid neoplasm. Thyroid fine needle aspiration biopsy showed normal thyroid glands and tru-cut biopsy of the right supraclavicular lymph node showed granulomatous lymphadenitis which is consistent with tuberculosis lymphadenitis (Figure 2A). The PPD test measured 15 mm and serum quantiferon were positive. The patient was consulted to the infectious disease department and an initial intensive-phase therapy with four antibiotics (INH, RIF, PZA, EMB) and continuation-phase therapy with 2 antibiotics (INH, RFA) planned.","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67477389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aquaporin 1 (AQP1) regulates plasma membrane bleb formation by facilitating bleb retraction phase in cancer cells","authors":"Godwin A. Ponuwei, Phil R. Dash","doi":"10.15761/icst.1000305","DOIUrl":"https://doi.org/10.15761/icst.1000305","url":null,"abstract":"","PeriodicalId":90850,"journal":{"name":"Integrative cancer science and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67475727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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