IF 7.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast

Pub Date : 2025-12-01 DOI: 10.1016/j.breast.2025.104608

Vicki Durston , Charlotte E. Coles , Adele Gautier , Andrea L. Smith , Alexandra Lewis , Georgia Attfield , Fatima Cardoso

The systematic collection and analysis of high-quality advanced breast cancer (ABC) data is necessary to advance understanding, optimize care, and improve patient outcomes. High-quality data enables understanding of treatment effectiveness, thereby facilitating the development of innovative therapies. ABC data may also help to counter stigma, by demonstrating that many living with the disease continue to contribute meaningfully to society. Data is an essential tool in highlighting global inequities and advocating to overcome them, and prevalence data is key to determining the burden of ABC worldwide, informing healthcare policies and investment in ABC care.

This manuscript reviews global efforts to improve the collection and analysis of ABC data over the past decade. It highlights the advances and persistent challenges to high-quality data collection and proposes actions for the decade ahead. It summarizes research conducted for the ABC Global Alliance's Global Decade Report 2.0. The main findings are: a) New methodologies yield more accurate estimates of the number of people with ABC; b) Data linkage initiatives reveal ABC prevalence far higher than earlier projections; c) ABC-focused registries have advanced data collection globally over the decade; d) High-quality ABC data has been shown to drive treatment access and policy change; e) Persistent gaps in recurrence data and registries remain.

The findings from the ABC Global Alliance's Global Decade Report 2.0 have informed the development of a new ABC Global Charter. The ABC Global Charter 2.0 defines ten new achievable and measurable goals for the decade 2025–2035, aiming at improving the lives of people living with ABC worldwide.

系统地收集和分析高质量的晚期乳腺癌（ABC）数据对于提高认识、优化护理和改善患者预后是必要的。高质量的数据有助于了解治疗效果，从而促进创新疗法的发展。ABC数据还可能有助于消除耻辱感，因为它表明许多艾滋病患者继续为社会做出有意义的贡献。数据是强调全球不平等和倡导克服这些不平等的重要工具，流行数据是确定全球ABC负担、为医疗保健政策和ABC护理投资提供信息的关键。本文回顾了过去十年来全球为改进ABC数据的收集和分析所做的努力。报告强调了高质量数据收集的进展和持续挑战，并提出了未来十年的行动建议。它总结了为ABC全球联盟全球十年报告2.0所做的研究。主要发现有：a)新的方法可以更准确地估计拥有ABC的人数；b)数据联动举措显示ABC的流行率远高于早先的预测；c)十年来，以abc为重点的登记处在全球范围内进行了先进的数据收集；d)高质量的ABC数据已被证明可以推动治疗获取和政策变化；e)在复发数据和注册中仍然存在持续的差距。ABC全球联盟全球十年报告2.0的调查结果为新的ABC全球宪章的制定提供了信息。《ABC全球宪章2.0》为2025-2035年制定了10个新的可实现和可衡量的目标，旨在改善全球ABC患者的生活。

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引用次数: 0

Brain imaging screening in metastatic breast cancer: patients’ and physicians’ perspectives 转移性乳腺癌的脑成像筛查：患者和医生的观点。

IF 7.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast

Pub Date : 2025-12-01 DOI: 10.1016/j.breast.2025.104558

Leonor Matos , Mette van Ramshorst , Volkmar Müller , Elisa Agostinetto , Sabine Linn , Matteo Lambertini , Veronique Dieras , Fanny le Du , Sofia Braga , Carmen Criscitiello , Katarzyna J. Jerzak , Gil Morgan , Sara Brucker , Patricia von Kroge , Renate Haidinger , Gema Rodríguez Recio , Eva Schumacher-Wulf , Mario Fontes Sousa , Francesco Schettini , Elena Laakmann

Background

Routine brain imaging screening (BIS) in patients with metastatic breast cancer (BC) without neurological symptoms is currently not recommended, as no survival/quality-of-life improvements have been demonstrated. We aimed to examine physicians and patients’ attitudes and perceptions toward BIS.

Methods

International cross-sectional online survey for patients and physicians, distributed from May 2023 to February 2024. Patients with BC diagnosis were deemed eligible for patients' survey completion and BC-treating physicians were invited to fill the physicians’ questionnaire.

Results

A total of 529 physicians from 50 countries (80 % European) responded, mostly medical oncologists (70 %) working in academic hospitals (53 %). Most physicians request BIS (65 %), mainly when extracranial progression occurs, especially for HER2+ and triple negative BC (TNBC). Among physicians never performing BIS (35 %), 91 % would in case of proved clinical benefit. A total of 545 patients from 14 European countries completed the questionnaire. Median age was 50 years, 86 % had metastatic BC, 51 % hormone receptor-positive (HR+)/HER2-negative, 30 % HER2-positive (HER2+) and 19 % TNBC. BM were diagnosed in 11.5 % patients with metastatic BC. 85 % patients would like to undergo BIS, especially younger ones (p = 0.02) and with HR-disease (p = 0.03), despite the uncertain clinical benefit. Notably, 91 % of patients would like to receive information regarding BM, while only 13 % of physicians routinely address the issue.

Conclusions

These results underline the willingness of patients to know more about the prospects of BM development, in contrast to the lack of routine discussion of this topic by physicians. Further investigation is warranted to demonstrate the clinical utility of routine BIS.

背景：目前不推荐对无神经症状的转移性乳腺癌（BC）患者进行常规脑成像筛查（BIS），因为没有证据表明生存/生活质量得到改善。我们的目的是检查医生和患者对BIS的态度和看法。方法：2023年5月至2024年2月对患者和医生进行国际横断面在线调查。诊断为BC的患者被认为有资格完成患者调查，并邀请治疗BC的医生填写医生问卷。结果：共有来自50个国家的529名医生（80%是欧洲人）参与了调查，其中大部分是在学术医院工作的肿瘤学家（70%）（53%）。大多数医生要求BIS(65%)，主要是在发生颅外进展时，特别是HER2+和三阴性BC （TNBC）。在从未实施BIS的医生中（35%），91%的医生会在证明临床获益的情况下进行BIS。共有来自14个欧洲国家的545名患者完成了问卷调查。中位年龄为50岁，86%为转移性BC， 51%为激素受体阳性(HR+)/HER2阴性，30%为HER2阳性（HER2+）， 19%为TNBC。11.5%的转移性BC患者被诊断为脑转移。85%的患者愿意接受BIS，尤其是年轻患者（p = 0.02）和患有hr疾病的患者（p = 0.03），尽管临床获益不确定。值得注意的是，91%的患者希望获得有关BM的信息，而只有13%的医生经常解决这个问题。结论：这些结果强调了患者愿意更多地了解BM发展的前景，而不是医生对这一主题缺乏常规讨论。需要进一步的研究来证明常规BIS的临床应用。

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引用次数: 0

Corrigendum to “Current pattern of care in radiation therapy for DCIS in Australia - where are we heading?” [The Breast 82(2025) 104482] “澳大利亚DCIS放射治疗的当前护理模式——我们将走向何方？”的勘误表。[乳房82(2025)104482]。

IF 7.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast

Pub Date : 2025-12-01 DOI: 10.1016/j.breast.2025.104582

Adam Ofri , Sze Ki Melanie Tam , Suki Gill , Andrew J. Spillane

引用次数: 0

Emerging technologies for monitoring breast cancer response to neoadjuvant chemotherapy: a systematic scoping review 监测乳腺癌对新辅助化疗反应的新兴技术：系统范围综述

IF 7.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast

Pub Date : 2025-12-01 DOI: 10.1016/j.breast.2025.104663

Georgia C. Wright , Luke T. Glover , Thomas J.E. Hubbard

Introduction

Neoadjuvant chemotherapy (NACT) is increasingly used in early breast cancer treatment and responses are highly variable. Accurate monitoring of tumour response is crucial for enabling precise surgical de-escalation, yet current methods are inadequate.

This systematic scoping review explores emerging technologies for predicting, monitoring, and diagnosing pre-operative breast cancer response to NACT.

Methods

A search of Embase, Medline, PubMed, and Cochrane databases was conducted until January 26, 2024. Studies investigating ability to detect tumour response during or after NACT, and prior to surgery, were included, and placed into 12 technology categories. Those investigating novel technologies were further categorised by Technology Readiness Level.

Results

From 2497 studies, 1329 met the inclusion criteria. 479/1329 (36 %) investigated conventional imaging; 19 % (253) investigated MRI, 5 % (64) mammography/ultrasound, 0.5 % (6) computed tomography, 0.4 % (5) digital breast tomosynthesis. Established technologies included gene panels (134/1329; 10 %) and post treatment core biopsy 35/1329; (3 %). 107/1329 (8 %) of studies developed nomograms based on routine clinical investigations, and 493/1329 (37 %) correlated established biomarkers e.g. Ki-67 with pathological response.

81 studies (6 %) addressed novel technologies, such as circulating nucleic acids (49/81), diffuse optical imaging (17/81), and elastography (15/81). A Technology Readiness Assessment revealed that all were between Technology Readiness Level 2 (Invention and Research) and 6 (Large Scale).

Conclusions

The majority of current research activity focuses on optimising existing technologies which may never provide the step change in diagnostic accuracy required to advance surgical de-escalation. Research activity should be focused on identifying effective novel technologies and driving translation into the clinical environment.

新辅助化疗（NACT）越来越多地用于早期乳腺癌治疗，其疗效变化很大。准确监测肿瘤反应对于实现精确的手术降级至关重要，但目前的方法还不充分。这篇系统的综述探讨了预测、监测和诊断术前乳腺癌对NACT反应的新兴技术。方法检索Embase、Medline、PubMed、Cochrane数据库至2024年1月26日。研究包括在NACT期间或之后以及手术前检测肿瘤反应的能力，并将其分为12个技术类别。研究新技术的人员进一步按技术准备程度分类。结果2497项研究中，1329项符合纳入标准。479/1329（36%）调查常规影像学；19%（253例）进行了MRI检查，5%（64例）进行了乳房x线摄影/超声检查，0.5%（6例）进行了计算机断层扫描，0.4%（5例）进行了数字乳房断层合成检查。已建立的技术包括基因面板（134/1329;10%）和治疗后核心活检（35/1329）；(3%)。107/1329（8%）的研究开发了基于常规临床调查的形态图，493/1329（37%）将已建立的生物标志物（如Ki-67）与病理反应相关联。81项研究（6%）涉及新技术，如循环核酸（49/81）、漫射光学成像（17/81）和弹性成像（15/81）。技术准备评估显示，所有的技术准备水平都在2级（发明和研究）和6级（大规模）之间。目前大多数研究活动都集中在优化现有技术上，这些技术可能永远无法提供推进手术降级所需的诊断准确性的步骤变化。研究活动应侧重于识别有效的新技术并将其转化为临床环境。

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引用次数: 0

Reply letter: Pathologic complete response in TNBC: A shield against recurrence, but not the brain? 复信：TNBC的病理完全缓解：防止复发，但不是大脑？

IF 7.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast

Pub Date : 2025-12-01 DOI: 10.1016/j.breast.2025.104605

Gabriel Berlingieri Polho , Yumi Ricucci Shinkado , Leticia Kimie Murazawa , Vinicius Vitor Oliveira , Victor Rocha Pinheiro , Diana del Cisne Pineda Labanda , Romualdo Barroso-Sousa , Luciana Rodrigues Carvalho Barros , Laura Testa , Renata Colombo Bonadio

引用次数: 0

Advancing the legal rights of people with advanced breast cancer: a global expert review and call-to-action for 2025–2035 (Goal 10) 推进晚期乳腺癌患者的法律权利：全球专家审查和2025-2035年行动呼吁（目标10）

IF 7.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast

Pub Date : 2025-12-01 DOI: 10.1016/j.breast.2025.104613

Sarah McHutchison , Tarishi Desai , Hayley Jones , Georgia Attfield , Alexandra Lewis , Fatima Cardoso

A diagnosis of advanced breast cancer (ABC) can be life-altering, presenting challenges that extend far beyond the clinical domain. Among these challenges is the ability to continue or return to work, a decision often influenced by financial necessity, social support, and the psychological desire for normalcy. Yet, systemic barriers such as treatment-related side effects, physical and cognitive impairments, and workplace stigma frequently hinders people with ABC from maintaining employment. The right to work is fundamental to dignity, independence, and quality of life, but for people with ABC this right is too often denied due to a lack of workplace support and insufficient legal protection.

This manuscript explores the current landscape and future opportunities to advance the legal rights of people with ABC. It summarizes research conducted for the ABC Global Alliance's Global Decade Report 2.0. The main findings are: a) ABC diagnosis severely limits work participation and employment retention; b) Legal protections for ABC patients and informal caregivers (often unpaid family members and friends) remain inconsistent globally; c) Flexible work policies can reduce economic loss and support workplace inclusion; d) ABC informal caregiver burden causes significant economic and social impact.

The findings from the ABC Global Alliance's Global Decade Report 2.0 have informed the development of a new ABC Global Charter. The ABC Global Charter 2.0 defines ten new achievable and measurable goals for the decade 2025–2035, aiming at improving the lives of people living with ABC worldwide.

晚期乳腺癌（ABC）的诊断可以改变生活，提出的挑战远远超出了临床领域。这些挑战包括继续或重返工作岗位的能力，这一决定往往受到经济需要、社会支持和对正常生活的心理渴望的影响。然而，系统性障碍，如治疗相关的副作用、身体和认知障碍以及工作场所的耻辱感，经常阻碍ABC患者继续就业。工作权利是尊严、独立和生活质量的基础，但对于患有ABC的人来说，由于缺乏工作场所支持和法律保护不足，这项权利往往被剥夺。本文探讨了目前的情况和未来的机会，以促进与ABC的人的合法权利。它总结了为ABC全球联盟全球十年报告2.0所做的研究。主要发现是：a) ABC诊断严重限制了工作参与和就业保留；b)对ABC患者和非正式护理人员（通常是无偿的家庭成员和朋友）的法律保护在全球范围内仍然不一致；c)灵活的工作政策可以减少经济损失，支持工作场所的包容性；d) ABC非正规照护者负担造成显著的经济和社会影响。ABC全球联盟全球十年报告2.0的调查结果为新的ABC全球宪章的制定提供了信息。《ABC全球宪章2.0》为2025-2035年制定了10个新的可实现和可衡量的目标，旨在改善全球ABC患者的生活。

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引用次数: 0

Pathologic complete response in TNBC: A shield against recurrence, but not the brain? TNBC的病理完全缓解：防止复发，而不是大脑？

IF 7.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast

Pub Date : 2025-12-01 DOI: 10.1016/j.breast.2025.104606

Kadri Altundag

引用次数: 0

Meeting the informational needs of people with advanced breast cancer: a global expert review and call-to-action for 2025–2035 (Goal 6) 满足晚期乳腺癌患者的信息需求：全球专家审查和2025-2035年行动呼吁（目标6）

IF 7.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast

Pub Date : 2025-12-01 DOI: 10.1016/j.breast.2025.104611

Anna Cabanes , Jenny Gilchrist , Marzia Zambon , Maya Gilbert , Alexandra Lewis , Georgia Attfield , Fatima Cardoso

For people living with advanced breast cancer (ABC), the complexities of making treatment decisions, adhering to medication regimens, and balancing the social and personal aspects of the disease can be overwhelming. People with ABC need comprehensive information and resources to understand their disease, prognosis, and treatment options. However, this information is often difficult to access, interpret or navigate, leaving many feeling confused, frustrated and helpless.

This manuscript evaluates the global ABC information landscape and its evolution since 2015, it analyzes the ongoing challenges faced by people with ABC, and outlines recommendations for the ABC community over the next decade. It summarizes research conducted for the ABC Global Alliance's Global Decade Report 2.0. The main findings are: a) The availability of ABC information has increased, but topics remain limited; b) ABC information from healthcare professionals is often limited to clinical topics; c) Patient advocacy groups are now crucial, trusted sources of ABC information; d) Online ABC information presents both opportunities and challenges; e) Global disparities in access to some topics of ABC information persist.

The findings from the ABC Global Alliance's Global Decade Report 2.0 have informed the development of a new ABC Global Charter. The ABC Global Charter 2.0 defines ten new achievable and measurable goals for the decade 2025–2035, aiming at improving the lives of people living with ABC worldwide.

对于患有晚期乳腺癌（ABC）的人来说，做出治疗决定、坚持药物治疗方案以及平衡疾病的社会和个人方面的复杂性可能是压倒性的。ABC患者需要全面的信息和资源来了解他们的疾病、预后和治疗方案。然而，这些信息往往难以获取、解释或导航，让许多人感到困惑、沮丧和无助。本文评估了自2015年以来全球ABC信息格局及其演变，分析了ABC人群面临的持续挑战，并概述了未来十年ABC社区的建议。它总结了为ABC全球联盟全球十年报告2.0所做的研究。主要发现是：a) ABC信息的可用性有所增加，但主题仍然有限；b)来自卫生保健专业人员的ABC信息通常仅限于临床主题；c)患者倡导团体现在是ABC信息的重要可靠来源；d)在线ABC信息既是机遇也是挑战；e)获取ABC信息某些主题的全球差异仍然存在。ABC全球联盟全球十年报告2.0的调查结果为新的ABC全球宪章的制定提供了信息。《ABC全球宪章2.0》为2025-2035年制定了10个新的可实现和可衡量的目标，旨在改善全球ABC患者的生活。

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引用次数: 0

Ensuring access to multidisciplinary care in advanced breast cancer: a global expert review and call-to-action for 2025–2035 (Goal 4) 确保晚期乳腺癌获得多学科护理：全球专家审查和2025-2035年行动呼吁（目标4）

IF 7.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast

Pub Date : 2025-12-01 DOI: 10.1016/j.breast.2025.104609

Shani Paluch-Shimon , Laura Biganzoli , Julie Torode , Ginny Mason , Sung-Bae Kim , Runcie C.W. Chidebe , Merel van Klinken , Georgia Attfield , Alexandra Lewis , Fatima Cardoso

Despite remarkable advances in the management of advanced breast cancer (ABC), profound disparities persist in outcomes and access to quality care globally. A multidisciplinary approach, where specialists collaborate on diagnosis, treatment planning, care continuity, and timely referrals, is widely recognized as the gold standard in ABC management and has been shown to lead to more accurate diagnoses, individualized treatment plans, and improved patient outcomes. Depending on the healthcare system, a multidisciplinary team (MDT) may include a medical oncologist, a radiation/clinical oncologist, radiologist, pathologist, surgeon, specialist nurse, allied healthcare professionals, and administrative staff. A multidisciplinary approach to ABC care is recommended by international guidelines and endorsed by leading bodies such as the European Society of Breast Cancer Specialists (EUSOMA).

This manuscript explores the current multidisciplinary care landscape in ABC, highlighting progress made, persistent challenges, and future directions. It summarizes research conducted for the ABC Global Alliance's Global Decade Report 2.0. The main findings are: a) New EUSOMA quality indicators set benchmarks for multidisciplinary ABC care; b) Most national guidelines now recommend multidisciplinary care for ABC; c) Surveys reveal uneven multidisciplinary team access, notably in low-income settings; d) Telemedicine and virtual MDTs expand access to ABC expertise; e) Palliative care remains poorly integrated in many MDTs globally.

The findings from the ABC Global Alliance's Global Decade Report 2.0 have informed the development of a new ABC Global Charter. The ABC Global Charter 2.0 defines ten new achievable and measurable goals for the decade 2025–2035, aiming at improving the lives of people living with ABC worldwide.

尽管在晚期乳腺癌（ABC）的管理方面取得了显著进展，但在全球范围内，在结局和获得高质量护理方面仍然存在巨大差异。多学科方法，即专家在诊断、治疗计划、护理连续性和及时转诊方面的合作，被广泛认为是ABC管理的黄金标准，并已被证明可以导致更准确的诊断、个性化的治疗计划和改善患者的预后。根据医疗保健系统的不同，多学科团队（MDT）可能包括内科肿瘤学家、放射/临床肿瘤学家、放射科医生、病理学家、外科医生、专科护士、联合医疗保健专业人员和行政人员。国际指南建议采用多学科方法进行ABC护理，并得到欧洲乳腺癌专家协会（EUSOMA）等主要机构的认可。这篇论文探讨了目前ABC的多学科护理景观，突出了取得的进展，持续的挑战和未来的方向。它总结了为ABC全球联盟全球十年报告2.0所做的研究。主要发现有：a)新的EUSOMA质量指标为多学科ABC护理设定了基准；b)大多数国家指南现在推荐ABC的多学科治疗；c)调查显示，多学科团队获得机会不均衡，特别是在低收入环境中；d)远程医疗和虚拟mdt扩大获得ABC专门知识的机会；e)姑息治疗在全球许多mdt中仍未得到很好的整合。ABC全球联盟全球十年报告2.0的调查结果为新的ABC全球宪章的制定提供了信息。《ABC全球宪章2.0》为2025-2035年制定了10个新的可实现和可衡量的目标，旨在改善全球ABC患者的生活。

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引用次数: 0

Supplemental imaging modalities for breast cancer screening in women with dense breasts: A systematic review with economic considerations 乳腺致密女性乳腺癌筛查的辅助成像方式：一项考虑经济因素的系统综述。

IF 7.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast

Pub Date : 2025-11-26 DOI: 10.1016/j.breast.2025.104668

Sinéad N. Duggan , Mohammad Azharuddin , Rodolfo Hernández , Clare Robertson , David Cooper , Emma McCall , Paul Manson , Gianni Virgili , Mike Clarke , Shaun Treweek , Miriam Brazzelli

Background

Underdiagnosis of breast cancer is a concern for women with dense breasts. This systematic review and meta-analysis evaluates the performance and cost-effectiveness of supplementary imaging modalities plus standard mammography, versus mammography alone, for detecting breast cancer in women with dense breasts.

Methods

We searched MEDLINE, Embase, Scopus, Cochrane Database, Web of Science, and CENTRAL for English-language studies published January 2014 to November 2024. Eligible studies compared the performance of a supplementary imaging modality with standard mammography in terms of cancer detection rate (CDR) in women with dense breasts undergoing screening. Risk of bias was assessed using QUADAS-2/QUADAS-C. Screening, data extraction, and quality assessment was conducted by one reviewer and checked by a second reviewer. PROSPERO: CRD42024550250.

Results

Out of 1740 search results, 36 studies met the inclusion criteria. Versus mammography alone, magnetic resonance imaging (MRI) identified 18·92 (95 % CI 15·41-22·43) additional cancers per 1000 screenings while digital breast tomosynthesis (DBT), automated breast ultrasound (ABUS), and handheld ultrasound (HHUS) detected 1·69 (95 % CI 0·81-2·58), 2·3 (95 % CI 1·28-3·33), and 2·57 (95 % CI 0·99-4·14) additional cancers, respectively. One study of contrast-enhanced mammography (CEM) reported a CDR comparable to MRI. Economic modelling studies revealed heterogeneous results, with MRI showing potential under specific model assumptions.

Concluding statement

Standard mammography often fails to detect cancers in women with dense breasts. Supplementary MRI provides better detection than DBT, ABUS, and HHUS. CEM seems comparable to MRI, based on limited evidence. These findings should be considered in future screening policy reviews for women with dense breasts.

背景：乳腺癌的诊断不足是致密乳房妇女的一个问题。本系统综述和荟萃分析评估了辅助成像方式加标准乳房x光检查与单独乳房x光检查在致密乳房女性中检测乳腺癌的性能和成本效益。方法：检索MEDLINE、Embase、Scopus、Cochrane Database、Web of Science和CENTRAL，检索2014年1月至2024年11月发表的英文研究。符合条件的研究比较了辅助成像方式与标准乳房x线摄影在接受筛查的致密乳房妇女的癌症检出率（CDR）方面的表现。使用QUADAS-2/QUADAS-C评估偏倚风险。筛选、数据提取和质量评估由一名审稿人进行，并由另一名审稿人进行检查。普洛斯彼罗:CRD42024550250。结果：在1740个检索结果中，有36个研究符合纳入标准。与单独的乳房x光检查相比，磁共振成像（MRI）每1000次筛查发现18.92例（95% CI 15.41 - 22.43）额外的癌症，而数字乳房断层合成（DBT）、自动乳房超声（ABUS）和手持式超声（HHUS）分别发现1.69例（95% CI 0.81 - 1.58）、2.3例（95% CI 1.28 - 3.33）和2.57例（95% CI 0.99 - 4.14）额外的癌症。一项对比增强乳房x线摄影（CEM）的研究报告了与MRI相当的CDR。经济模型研究揭示了异质的结果，MRI显示了特定模型假设下的潜力。结束语：标准的乳房x光检查通常不能检测出致密乳房的癌症。辅助MRI比DBT， ABUS和hus提供更好的检测。基于有限的证据，CEM似乎与MRI相当。这些发现应该在未来对致密性乳房妇女的筛查政策审查中加以考虑。

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引用次数: 0

Breast最新文献

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Introduction

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Concluding statement