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A rare Case of Right Sided Bochdalek Hernia Co-existing with Intrathoracic Kidney 右侧Bochdalek疝合并胸内肾1例
Pub Date : 2020-12-31 DOI: 10.31173/bomj.bomj_204_17
D. H, S. K.
Background: Congenital diaphragmatic hernias are developmental defects involving the diaphragm. Three major types have been identified; Bochdalek hernia, Morgagni hernia, and hiatus/hiatal hernia, with the postero-lateral Bochdalek type being the most common. Rare concomitant existence with intrathoracic kidney was reported. Cases of left sided Bochdalek hernia were previously reported in the literature but none is associated with intrathoracic kidney. A successfully surgically treated rare case of right sided Bochdalek hernia co-existing with intrathoracic kidney in a neonate is therefore presented.
背景:先天性膈疝是累及膈的发育缺陷。已经确定了三种主要类型;Bochdalek疝,Morgagni疝和裂孔/裂孔疝,以Bochdalek后外侧型最常见。罕见的同时存在胸内肾的报道。以前文献报道过左侧Bochdalek疝的病例,但没有一例与胸内肾相关。一例成功手术治疗的罕见病例右侧Bochdalek疝共存的胸内肾在新生儿因此提出。
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引用次数: 0
Influences on the Incidence and Pathomorphological Picture of Thyroid Disease 对甲状腺疾病发病率和病理形态学的影响
Pub Date : 2020-12-31 DOI: 10.31173/bomj.bomj_194_17
I. Emmanuel, M. Ramalan, A. Longwap, A. Dauda
Background: The thyroid serves the body with important endocrine functions. A variety of influences impinges on the incidence and pathomorphological picture of the thyroid gland. These influences that include: iodine deficiency; iodine sufficiency; gender and; imaging technology are elucidated further in this work. We used the Google search engine to search for literature on the subject from the internet. Iodine is associated with increased incidence of nodular goiter and follicular carcinoma. The world over the last few decades had transited from an era of iodine deficiency to its sufficiency leading to an increase in incidence of thyroiditis and papillary thyroid carcinoma. Estrogen and Estrogen receptor discovered in the thyroid is implicated in the increased frequency of thyroid disorders in females. Finally, advancement in thyroid imaging technology and its utilization has led to over-diagnosis and overtreatment of thyroid diseases.
背景:甲状腺在人体中具有重要的内分泌功能。各种各样的影响影响甲状腺的发病率和病理形态学。这些影响包括:缺碘;碘充足;性别和;本文对成像技术作了进一步的阐述。我们使用谷歌搜索引擎从互联网上搜索有关该主题的文献。碘与结节性甲状腺肿和滤泡性癌的发病率增加有关。在过去的几十年里,世界已经从缺碘的时代过渡到碘充足的时代,导致甲状腺炎和甲状腺乳头状癌的发病率增加。在甲状腺中发现的雌激素和雌激素受体与女性甲状腺疾病的发病率增加有关。最后,甲状腺成像技术的进步及其应用导致甲状腺疾病的过度诊断和过度治疗。
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引用次数: 0
Penetrating Intracranial Arrow Extraction: our Experience 穿透颅内箭头提取:我们的经验
Pub Date : 2020-12-31 DOI: 10.31173/bomj.bomj_202_17
Usman B, M. B., Shuwa F A, Garandawa H I
Background: Arrow injury is one of the causes of non-missile penetrating head injury. Penetration may be through natural openings like the eye, nose, or a thin bone. At presentations, most patients are clinically stable. However, some may present with catastrophic vascular injury. Noncontrast Computed Tomography (CT scan) with or without angiography, when indicated, is essential for surgical planning. When impacted to a bone, craniectomy is an option, but when not impacted the best option is a craniotomy with antegrade extraction under vision especially when the arrow is barbed. Often surgery may involve multiple specialists. Broad-spectrum antibiotic prophylaxis is advised likewise tetanus and seizure prevention. Postoperatively patients are followed up and complications are treated.
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引用次数: 1
The Effect of Intracervical Lidocaine Versus Intramuscular Diclofenac for Pain Relief During Hysterosalpingography Among Infertile Women in A Tertiary Hospital in Kano: A Randomised Controlled Trial 卡诺某三级医院不孕妇女子宫输卵管造影期间,宫颈内利多卡因与肌内双氯芬酸缓解疼痛的效果:一项随机对照试验
Pub Date : 2020-12-31 DOI: 10.31173/bomj.bomj_193_17
A. Avidime, Sulaiman Daneji Muhammad, Ibrahim S Adamu
Background: Hysterosalpingography (HSG) is the radiographic evaluation of the uterus and fallopian tubes and is used predominantly in the evaluation of infertility. HSG can cause discomfort or pain during or after the procedure, up to 72 % of women complain of significant discomfort with this test. This pain can hinder patient’s co-operation, therefore limiting the usefulness of the procedure, and willingness to do other similar diagnostic studies. It can also result in fortuitous tubal blockade by provoking cornual spasms. Objectives: To compare the effect of intracervical block with 1% lidocaine and intramuscular diclofenac 75mg in decreasing pain perception during hysterosalpingography. Methods: The study was carried out between September 2016 and January 2017. One hundred and forty women with infertility referred for hysterosalpingography were randomly recruited and assigned to two study groups. Women in the study group A were given an intracervical block with 1% lidocaine while women in the Study Group B were given intramuscular diclofenac sodium 75mg 30 minutes before the procedure. Pain levels during specified stages of HSG were assessed using visual analogue score. The statistical package for social sciences (SPSS) version 16.0 was used to analyze the data. The data obtained were presented in tables. Categorical data were analyzed using chi-squared test and Fishers exact correction, continuous data were analyzed using student t-test; level of significance (p-value) was set at p< 0.05. Results: There was no statistically significant difference in the two study groups in their baseline characteristics; but there were statistically significant differences in some gynaecological characteristics that include previous vaginal delivery and previous pregnancy loss. The two most painful steps of the procedure were during grasping of the cervix and uterine distension with contrast medium mean visual analogue score (VAS) of 4.26±1.62 and 6.37±1.62 (t = -7.726, p-value <0.001), 6.14±1.85 and 7.37±2.23 (t = -3.543 p-value 0.001) respectively in groups A and B. Conclusion: There was significant reduction in VAS pain scores with intracervical block with lidocaine when performing HSG for infertility.
背景:子宫输卵管造影(HSG)是子宫和输卵管的放射学评估,主要用于评估不孕症。子宫输卵管造影在手术过程中或手术后会引起不适或疼痛,高达72%的女性抱怨这项检查有明显的不适。这种疼痛会阻碍患者的配合,从而限制了手术的有效性,也限制了他们做其他类似诊断研究的意愿。它也可以导致偶然的输卵管阻塞引起角痉挛。目的:比较1%利多卡因颈内阻滞和双氯芬酸75mg肌注对子宫输卵管造影时疼痛感觉的影响。方法:研究时间为2016年9月至2017年1月。140名不孕症妇女被随机招募并被分配到两个研究组进行子宫输卵管造影。研究小组A的女性在手术前30分钟给予1%利多卡因宫颈内阻滞,而研究小组B的女性在手术前30分钟给予肌肉注射双氯芬酸钠75mg。采用视觉模拟评分法评估HSG特定阶段的疼痛程度。使用社会科学统计软件包(SPSS) 16.0版本对数据进行分析。所得数据以表格形式呈现。分类资料采用卡方检验和fisher精确校正,连续资料采用学生t检验;显著性水平(p值)设为p< 0.05。结果:两组患者基线特征差异无统计学意义;但在一些妇科特征上有统计学上的显著差异,包括以前的阴道分娩和以前的流产。A组和b组的平均视觉模拟评分(VAS)分别为4.26±1.62和6.37±1.62 (t = -7.726, p值<0.001)、6.14±1.85和7.37±2.23 (t = -3.543 p值0.001)。结论:利多卡因宫颈内阻滞治疗不孕症输卵管造影时VAS疼痛评分显著降低。
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引用次数: 1
Changes in Corneal Endothelial Cells Following MSICS VERSUS Conventional ECCE in a Tertiary Eye Hospital in North Western Nigeria 尼日利亚西北部一家三级眼科医院mscs与传统ECCE术后角膜内皮细胞的变化
Pub Date : 2019-12-31 DOI: 10.31173/bomj.bomj_167_16
S. Umar, M. Umar, M. Rabiu, M. Alhassan, V. Pam
Background: This study was undertaken to compare the effect of two surgical techniques of cataract extraction on corneal endothelial cell density in eyes of Nigerian adults with uncomplicated age-related cataract with the view to improving surgical visual function and quality of life. Materials and Methods: It was a prospective randomized non blinded hospital based interventional study. Two hundred and seventy-seven (277) eyes of 269 eligible patients with cataract were randomized to either manual small incision cataract surgery (MSICS) or conventional extracapsular cataract extraction (ECCE). The endothelial cell density (ECD), Coefficient of variation (CV), and Hexagonality (%) were measured pre-operatively, at one, four and twelve weeks post-operatively with a non-contact specular microscope (CSO SP 02). Statistical analysis – Data obtained were entered into microsoft Excel and analyzed using SPSS version 16 software. Result: Of the 277 eyes studied, 263 (94.9%) were analysed. The mean age of patients for MSICS and ECCE was 64.03 (SD + 11.2, range 40 – 95 years) and 62.69 (SD +10.48, range 42 – 94 years) respectively. The Male to female ratio was 1.9:1, in the two study groups. Pre-operatively, corneal parameters (mean ECD, CV and hexagonal cells) were similar between the two surgery groups. Postoperatively cataract surgery induced a mean endothelial cell density loss of 5.31% at one week, 7.28% at 4 weeks and 7.06% at 12 weeks in the study population. There was no statistically significant difference in the mean endothelial cell density loss between MSICS and ECCE groups. Conclusion: Both MSICS and ECCE induced fairly equal moderate and reversible degree of endothelial cell density loss in adults with uncomplicated age related cataract. Keywords; Endothelial cell density, ECCE, MSICS, Uncomplicated Cataract. Department of 1Ophthalmology, Federal Teaching Hospital, Gombe, 2Vitreoretina Department, National Eye Centre, Kaduna, 3Noor Dubai Foundation, Dubai, UAE, 4Department of Ophthalmology, Ahmadu Bello University Teaching Hospital, Zaria. Corresponding Author Dr Saudatu Umar Madaki, Department of Ophthalmology, Federal Teaching Hospital, Gombe P M B 0037 Email addresssaudeumarmadaki@yahoo.com Introduction Cataract is a major cause of blindness worldwide and cataract surgery is the most frequently performed ophthalmic surgery1.In recent decades, ophthalmologists performing cataract surgery have witnessed the successful application of new technology that have increased the efficiency of surgical technique, advanced standard of care and most importantly, given rise to better patient outcomes2.Surgical techniques have evolved in the last few decades from intracapsular cataract extraction through extracapsular cataract extraction, MSICS, Access this article online
背景:本研究旨在比较两种白内障摘除术对尼日利亚成人无并发症年龄相关性白内障患者角膜内皮细胞密度的影响,以期改善手术视力和生活质量。材料与方法:本研究为前瞻性随机非盲医院介入研究。269例符合条件的白内障患者277只眼随机分为手工小切口白内障手术(msic)和常规白内障囊外摘除(ECCE)两组。术前、术后1周、4周和12周用非接触式镜面显微镜(CSO sp02)测量内皮细胞密度(ECD)、变异系数(CV)和六边形(%)。统计分析-将获得的数据输入到microsoft Excel中,并使用SPSS version 16软件进行分析。结果:277只眼分析263只(94.9%)。mscs和ECCE患者的平均年龄分别为64.03岁(SD + 11.2,范围40 ~ 95岁)和62.69岁(SD +10.48,范围42 ~ 94岁)。在两个研究组中,男女比例为1.9:1。术前,角膜参数(平均ECD, CV和六角形细胞)在两个手术组之间相似。在研究人群中,术后白内障手术导致内皮细胞密度在1周时平均下降5.31%,4周时7.28%,12周时7.06%。mscs组和ECCE组平均内皮细胞密度损失无统计学差异。结论:mscs和ECCE在成人无并发症的年龄相关性白内障患者中诱导内皮细胞密度的中等可逆程度的损失。关键字;内皮细胞密度,ECCE, mscs,无并发症白内障。1 .贡贝联邦教学医院眼科;2 .卡杜纳国家眼科中心vitreoretina眼科;3 .阿联酋迪拜努尔迪拜基金会;4 .扎里亚Ahmadu Bello大学教学医院眼科。通讯作者Saudatu Umar Madaki博士,Gombe联邦教学医院眼科部,P M B 0037 Email addresssaudeumarmadaki@yahoo.com简介白内障是全球失明的主要原因,白内障手术是最常见的眼科手术1。近几十年来,从事白内障手术的眼科医生见证了新技术的成功应用,这些新技术提高了手术技术的效率,提高了护理标准,最重要的是,提高了患者的治疗效果。在过去的几十年里,手术技术从囊内白内障摘除到囊外白内障摘除,mscs,都在不断发展
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引用次数: 0
Fasting Blood Glucose Level Among Apparently Healthy Adults in Maiduguri North-Eastern Nigeria 尼日利亚东北部迈杜古里市表面健康成人的空腹血糖水平
Pub Date : 2019-06-01 DOI: 10.31173/BOMJ.BOMJ_139_16
M. Tukur, R. Gali, D. Mshelia, Ry Geresis, A. Numan, Jt Medugu
Background: For the past decades there has been an increase in type 2 diabetes mellitus worldwide including this environment, subsequently, baseline data is needed particularly in environment dependent on transferred reference values to access the level of fasting blood glucose. Objectives: This study was conducted to evaluate fasting blood glucose in apparently healthy adults in Maiduguri, Nigeria. Methodology: This is a cross-sectional study involving 308 participants: 258 apparently healthy non-pregnant adults, comprised of 162 males and 96 females and 50 pregnant women. A structured questionnaire was administered to those that consented and the subjects did overnight fast (between 10 and 12hours) before blood sampling. Blood glucose was measured using standard methods. Mean values of fasting blood glucose and body mass index were presented as mean ± standard deviation. Results: There was no significant difference in the fasting blood glucose of male (4.38±0.67 mmol/L) and female (4.38±0.60 mmol/L) subjects, (p = 0.93). The body mass index of female subjects 24.57±5.01 kg/m2 was significantly higher than their male counterparts 23.39±4.46 kg/m2 (p =0.05). There was an increasing trend of fasting blood glucose level (p = 0.85) and body mass index (p = 0.01) and also with increasing parity among the pregnant women. Conclusion: The fasting blood glucose level increases with weight, age, gestational age, and parity in pregnant women.
背景:在过去的几十年里,世界范围内2型糖尿病患者的增加,包括这种环境,因此需要基线数据,特别是在依赖于传递参考值的环境中,以获得空腹血糖水平。目的:本研究旨在评估尼日利亚迈杜古里表面健康成人的空腹血糖。方法:这是一项涉及308名参与者的横断面研究:258名明显健康的非怀孕成年人,包括162名男性、96名女性和50名孕妇。一份结构化的调查问卷被发给那些同意的人,受试者在抽血前禁食了一夜(10到12小时)。采用标准方法测量血糖。空腹血糖和体重指数的平均值以平均值±标准差表示。结果:男性受试者空腹血糖(4.38±0.67 mmol/L)与女性受试者空腹血糖(4.38±0.60 mmol/L)差异无统计学意义(p = 0.93)。女性受试者体重指数(24.57±5.01 kg/m2)显著高于男性受试者(23.39±4.46 kg/m2) (p =0.05)。孕妇空腹血糖水平(p = 0.85)和体重指数(p = 0.01)呈上升趋势,且随胎次的增加呈上升趋势。结论:孕妇空腹血糖水平随体重、年龄、胎次和胎次的增加而升高。
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引用次数: 0
Electrocardiographic changes in newly diagnosed hypertensive patients at Federal Teaching Hospital Gombe 冈贝联邦教学医院新诊断的高血压患者的心电图变化
Pub Date : 2019-06-01 DOI: 10.31173/BOMJ.BOMJ_141_16
Y. Ayoola, I. Ayanbisi, Adah Bonny Ejeh, Okezie Ejeagba, A. Adamu, H. Okolie
Background: Hypertension is an important public health problem globally with an increasing prevalence, severity and attendant complications on the heart and other internal organs. It was described as a silent killer due to its insidious onset and no obvious symptoms. Electrocardiogram (ECG) is a basic tool that can help determine some of the changes induced on the heart by systemic hypertension especially when it’s not diagnosed early. Objectives: To determine the pattern of ECG change in newly diagnosed hypertensives (HTN) at Federal Teaching Hospital, Gombe. Methods: The ECG results of 1015 newly diagnosed HTN patients referred for electrocardiographic study between Jan 2012 and Dec 2016 were retrieved and reviewed. All the patients had their basic anthropometric parameters, systolic and diastolic blood pressure (BP) recorded. Descriptive statistics was used in analyzing the different ECG findings. Results: The mean age of patients was 49.3±14.8 years. The mean BMI was 28.9±6.5 kg/m. The mean systolic and diastolic BP were 154.7±22.0 mmHg and 93.7±12.5 mmHg respectively. The mean ECG’s Heart Rate (HR), PR interval and QTc interval were; 85.9±16.8ms, 154.1± 23.9ms, and 433.5±32.5ms respectively. The commonest ECG abnormality was left ventricular hypertrophy (LVH) seen in 315(31.0%) of the patients. Some other abnormal ECG findings include; LAD (19.9%), LAE (18.7%), ST-T wave changes (14.1%), SB (1.8%), BBB (1.5%), AF (0.5%). Only 284(29%) of the patients had normal ECG. Conclusion: Most of the newly diagnosed hypertensives have already developed one or more cardiac related complications at the time of diagnosis. This further emphasizes the need for public enlightenment on regular BP check for early diagnosis and management of HTN.
背景:高血压是全球范围内一个重要的公共卫生问题,其患病率、严重程度和伴随的心脏和其他内脏器官并发症不断增加。它被描述为一个沉默的杀手,因为它的发病阴险,没有明显的症状。心电图(ECG)是一种基本的工具,可以帮助确定全身性高血压引起的心脏变化,特别是在没有早期诊断的情况下。目的:了解贡贝联邦教学医院新诊断的高血压患者(HTN)的心电图变化模式。方法:回顾性分析2012年1月至2016年12月1015例新诊断HTN患者的心电图结果。所有患者均记录了基本的人体测量参数,收缩压和舒张压(BP)。采用描述性统计分析不同心电图表现。结果:患者平均年龄49.3±14.8岁。平均BMI为28.9±6.5 kg/m。平均收缩压154.7±22.0 mmHg,舒张压93.7±12.5 mmHg。心电图平均心率(HR)、PR间期、QTc间期分别为;分别为85.9±16.8ms、154.1±23.9ms和433.5±32.5ms。最常见的心电图异常为左室肥厚(LVH), 315例(31.0%)。其他异常心电图表现包括:小伙子(19.9%)、莱城(18.7%)、ST-T波变化(14.1%),某人(1.8%)、BBB(1.5%)、AF(0.5%)。仅有284例(29%)患者心电图正常。结论:大多数新诊断的高血压患者在诊断时已出现一种或多种心脏相关并发症。这进一步强调了对HTN的早期诊断和治疗需要进行定期血压检查的公众启蒙。
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引用次数: 0
Superficial Femoral Artery Pseudoaneurysm Following Blast Injury in a Child: A Case Report 儿童爆炸伤后股浅动脉假性动脉瘤1例报告
Pub Date : 2019-06-01 DOI: 10.31173/BOMJ.BOMJ_136_16
U. Umar, Dm Yunusa, A. Farate, A. Bakare
Background: Pseudoaneurysms are vascular abnormalities due to disruption of the arterial wall. Pseudoaneurysm of the superficial femoral artery following bomb-blast injury is extremely rare. We report a case of 9-year-old girl who presented with one-month history of painful progressive swelling in the left thigh with previous history of improvised explosive device trauma. Doppler ultrasound scan confirmed the diagnosis of pseudoaneurysm of the superficial femoral artery and the patient had an uneventful surgical repair. High index of suspicion following penetrating trauma of the limb and Doppler ultrasound (US) scan are important for accurate diagnosis of pseudoaneurysm. Prompt treatment is also warranted to prevent life threatening complications such as rupture and thromboembolism. The classical findings of ‘ying-yang’ sign on colour Doppler US and ‘to and fro’ spectral waveform on pulse Doppler US for diagnosis of pseudoaneurysm were demonstrated.
背景:假性动脉瘤是由于动脉壁破裂引起的血管异常。股浅动脉假性动脉瘤是极为罕见的。我们报告一个9岁的女孩谁提出了一个月的历史疼痛进行性肿胀在左大腿与以前的简易爆炸装置创伤的历史。多普勒超声扫描证实了假性股浅动脉动脉瘤的诊断,患者进行了顺利的手术修复。肢体穿透伤后的高怀疑指数和多普勒超声(US)扫描对假性动脉瘤的准确诊断至关重要。及时治疗也是必要的,以防止危及生命的并发症,如破裂和血栓栓塞。彩色多普勒超声表现为“阴阳”征,脉冲多普勒超声表现为“来回”谱波形,是诊断假性动脉瘤的经典表现。
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引用次数: 0
Assessment of Family Functioning amongst Patients with Knee Osteoarthritis in Nigeria: A Multicentre Cross-Sectional Study 尼日利亚膝骨关节炎患者的家庭功能评估:一项多中心横断面研究
Pub Date : 2019-06-01 DOI: 10.31173/BOMJ.BOMJ_149_16
A. Yerima, R. Akintayo, A. Akpabio, H. Olaosebikan, C. Uhunmwangho
Background: Osteoarthritis (OA) is a leading cause of disability and reduced quality of life. The disability associated with OA depends on the cultural and socioeconomic context. Therefore, the role of family in the management of OA cannot be over emphasized. Objective: To determine the levels of family functioning and the predictors of poor family functioning amongst patients with knee OA. Method: A multicentre cross-sectional study involving 250 adults satisfying the American College of Rheumatology (ACR) clinical criteria for Knee OA were recruited over a period of 3 months after approval by the Ethical Review Committee of each of the study centres. Interviewer-administered questionnaire was used to obtained relevant demographic and clinical information. Family functioning was assessed using Family APGAR (Adaptation, Partnership, Growth, Affection, and Resolve) questionnaire. Other variables assessed were pain, functional class, Sleep Quality, depression and radiographs. Analysis was done using Statistical Package for Social Sciences (SPSS) version 21. Binary logistic regression was used to determine predictors of family functioning. A P value < 0.05 was considered significant. Results: The mean age was 59.9±10.62 and 209 (83.6%) were females. One hundred and ninety-nine (79.6%) reported a highly functional family, 40 (16.0%) and 11 (4.4%) had moderate and severely dysfunctional family respectively. APGAR scores were significantly associated with ethnicity (p=0.007) and functional class (p=0.020) and depression (p=0.013) and was best predicted by ethnicity (p=0.018, OR-1.360, CI [1.054 – 1.754]. Conclusion: Patients with knee OA seen in this study have a good level of family support. Ethnicity was the best predictor of dysfunctional family.
背景:骨关节炎(OA)是导致残疾和生活质量下降的主要原因。与OA相关的残疾取决于文化和社会经济背景。因此,家庭在OA管理中的作用再怎么强调也不为过。目的:确定膝关节炎患者的家庭功能水平和家庭功能不良的预测因素。方法:在每个研究中心的伦理审查委员会批准后,一项多中心横断面研究招募了250名满足美国风湿病学会(ACR)膝关节OA临床标准的成年人,为期3个月。采用访谈者填写的调查问卷获得相关的人口学和临床信息。采用家庭APGAR(适应、伙伴关系、成长、情感和决心)问卷评估家庭功能。评估的其他变量包括疼痛、功能等级、睡眠质量、抑郁和x光片。分析使用社会科学统计软件包(SPSS)版本21。采用二元逻辑回归确定家庭功能的预测因子。P值< 0.05为显著性。结果:平均年龄59.9±10.62岁,女性209例(83.6%)。高度功能失调家庭199例(79.6%),中度功能失调家庭40例(16.0%),重度功能失调家庭11例(4.4%)。APGAR评分与种族(p=0.007)、功能类别(p=0.020)和抑郁(p=0.013)显著相关,以种族为预测标准(p=0.018, or = 1.360, CI[1.054 - 1.754])。结论:本研究中发现的膝关节炎患者有良好的家庭支持水平。种族是家庭功能失调的最佳预测因素。
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引用次数: 0
Inter-relationship between type-2 diabetes mellitus, obesity and Hypertension in Nigeria 尼日利亚2型糖尿病、肥胖和高血压的相互关系
Pub Date : 2019-06-01 DOI: 10.31173/BOMJ.BOMJ_145_16
Musa Muhammad Babandina, I. Abdullahi, A. Emeribe, H. Shuwa, L. Olayemi, P. Musa
Background: The trio; hypertension, obesity and type-2 diabetes mellitus (T2DM) share similar risk factors and frequently co-exist. This hospital-based case-control study investigated the relationship between high blood pressure, body mass index and plasma glucose concentration among persons attending Nigeria National hospital, Abuja. Materials and methods: After ethical approval, 45 case subjects (known T2DM) and 45 controls (non-diabetics) within the age range of 25-60 years were enrolled and their body mass index and blood pressure (BP) measured. Furthermore, the case group were subdivided into 15 Diabetic patients ≤ 5 years on treatment (group 1), 15 Diabetic patients with cardiovascular disease (group 2), 15 Diabetic patients with nephropathy (group 3) and the control group subdivided into 15 apparently healthy subjects (control 1), 15 Non-diabetic patients with cardiovascular disease (control 2), and 15 Non-diabetic patients with nephropathy (control 3). Results: Seventy-five (83.3 %) of both the subject and control had no family history of diabetes while only 15 (16.7 %) were reported to have family history of diabetes. There was significant association between family history of diabetes with the presence of T2DM among participants (p = 0.001). Forty-one (45.5 %) of the subjects had normal BMI as against 49 (54.4 %) that were obese. Forty-four (48.8 %) of all groups were normotensive while 46 (51.1%) had high blood pressure (> 140/100 mmHg). Similarly, 41 (45.5 %) of the subjects had normal BMI as against 49 (54.4 %). There was significant difference in the proportions of overweight among the different study groups (p =0.007). High BMI occurred mostly in diabetic subjects with nephropathy. The diabetic subjects with nephropathy and apparently health non-diabetic subjects had the most cases of high BP. There is significant difference in blood pressure among the study groups (p=0.002). Conclusion: Findings from this study revealed that obesity and a family history of diabetes are important risk factors for T2DM. Hence, early BP management and body weight regulation are needed to prevent DM and its complications.
背景:三人组;高血压、肥胖和2型糖尿病(T2DM)具有相似的危险因素,并且经常共存。本以医院为基础的病例对照研究调查了在阿布贾尼日利亚国立医院就诊的人的高血压、体重指数和血糖浓度之间的关系。材料与方法:经伦理批准,入选年龄25-60岁的T2DM患者45例,对照组45例,测量体重指数和血压。病例组再细分为治疗≤5年的糖尿病患者15例(1组)、糖尿病合并心血管疾病患者15例(2组)、糖尿病合并肾病患者15例(3组),对照组再细分为表面健康者15例(对照1)、非糖尿病合并心血管疾病患者15例(对照2)、非糖尿病合并肾病患者15例(对照3)。75人(83.3%)无糖尿病家族史,仅有15人(16.7%)有糖尿病家族史。糖尿病家族史与2型糖尿病存在显著相关性(p = 0.001)。41人(45.5%)BMI正常,49人(54.4%)肥胖。血压正常者44例(48.8%),高血压者46例(51.1%)。同样,41人(45.5%)BMI正常,49人(54.4%)BMI正常。各研究组超重比例差异有统计学意义(p =0.007)。高BMI多见于糖尿病肾病患者。伴有肾病的糖尿病患者和明显健康的非糖尿病患者血压升高最多。各研究组血压差异有统计学意义(p=0.002)。结论:本研究结果表明,肥胖和糖尿病家族史是2型糖尿病的重要危险因素。因此,早期血压管理和体重调节是预防糖尿病及其并发症的必要措施。
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