L. Zarei, Raed Obaid Saleh, Ismael A. Arziev, M. Al-Gazally, Trias Mahmudiono, Negar Piri, S. Shokri, H. Huldani
Diabetes is one of the most common non-communicable diseases that have far-reaching economic and social consequences and threaten the national production and economy of countries. However, diabetes is a disease of self-control. Therefore, self-care strategies can maintain patients' independence while reducing the burden imposed on health care resources. This study aimed to investigate the factors affecting self-care behaviors in diabetic patients. This study is a systematic review; Google Scholar, SID, Scopus, PubMed, Science Direct, and ISI databases were used; 17,500 articles were found including the keywords "self-care", "diabetes" and "affecting factors" in the search process and all studies after 2010 were included. After reviewing the titles and abstracts, 51 studies were included. The studies' reports on self-care behaviors and their prevalence were very different depending on the tools used . The studies show the relationship between various factors including demographic, socio-economic, and psychological with self-care behaviors in patients with diabetes, which the most important variables included educational status, age, gender, marital status, BMI, occupational status, duration of illness, comorbidities, income, having glucometer, perceived severity of the disease and its complications, perceived barriers, diabetes distress, diabetes knowledge, perceived susceptibility, self-efficacy, social and family support, depression, anxiety. Due to the relationship of demographic, socio-economic, and psychological factors with self-care behaviors in patients with diabetes, it is suggested that a comprehensive program for the management of caring behaviors in diabetic patients should be designed to include all of the above.
{"title":"Investigating the factors affecting self-care behaviors in diabetic patients: A systematic review","authors":"L. Zarei, Raed Obaid Saleh, Ismael A. Arziev, M. Al-Gazally, Trias Mahmudiono, Negar Piri, S. Shokri, H. Huldani","doi":"10.4081/jbr.2022.10261","DOIUrl":"https://doi.org/10.4081/jbr.2022.10261","url":null,"abstract":"Diabetes is one of the most common non-communicable diseases that have far-reaching economic and social consequences and threaten the national production and economy of countries. However, diabetes is a disease of self-control. Therefore, self-care strategies can maintain patients' independence while reducing the burden imposed on health care resources. This study aimed to investigate the factors affecting self-care behaviors in diabetic patients. This study is a systematic review; Google Scholar, SID, Scopus, PubMed, Science Direct, and ISI databases were used; 17,500 articles were found including the keywords \"self-care\", \"diabetes\" and \"affecting factors\" in the search process and all studies after 2010 were included. After reviewing the titles and abstracts, 51 studies were included. The studies' reports on self-care behaviors and their prevalence were very different depending on the tools used . The studies show the relationship between various factors including demographic, socio-economic, and psychological with self-care behaviors in patients with diabetes, which the most important variables included educational status, age, gender, marital status, BMI, occupational status, duration of illness, comorbidities, income, having glucometer, perceived severity of the disease and its complications, perceived barriers, diabetes distress, diabetes knowledge, perceived susceptibility, self-efficacy, social and family support, depression, anxiety. Due to the relationship of demographic, socio-economic, and psychological factors with self-care behaviors in patients with diabetes, it is suggested that a comprehensive program for the management of caring behaviors in diabetic patients should be designed to include all of the above.","PeriodicalId":9116,"journal":{"name":"Bollettino della Societa italiana di biologia sperimentale","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79321483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Venturella, F. Mortillaro, G. Cancellieri, M. Giammanco, Irene Mistretta, A. Liga
Montanoa tomentosa is a shrub, belonging to the Asteraceae family, originally from Mexico and Central America known for its medicinal properties. The origins of its use in the field of herbal medicine can be traced back to the Mexican tradition. It was used for sexual dysfunctions. The extract of leaves was used in women to induce menstruation, abortion and labor, and also to reduce postpartum bleeding. The leaves are also used for their diuretic properties and the ground roots are used in the treatment of dysentery. Over time, studies have been conducted to identify the compounds responsible for the therapeutic activity and their mechanism of action. Two studies conducted in rats demonstrated the aphrodisiac properties of Montanoa tomentosa. This activity has been attributed to the presence of components that act as oxytocic agents. Furthermore, other studies have shown that Montanoa has anxiolytic properties. The mechanism underlying this action lies in the interaction with the GABAA receptor. However, it has been shown that the anxiolytic effect is influenced by the individual endocrine status: in conditions of low hormone levels the anxiolytic effect is more pronounced; in conditions of high hormonal levels, a state like anxiety is observed. Despite the multiple properties of Montanoa, today’s research is geared towards strengthening its clinical relevance as a natural antidepressant agent.
{"title":"Montanoa tomentosa. A review of the new scientific evidence on pharmacological properties","authors":"F. Venturella, F. Mortillaro, G. Cancellieri, M. Giammanco, Irene Mistretta, A. Liga","doi":"10.4081/jbr.2022.9399","DOIUrl":"https://doi.org/10.4081/jbr.2022.9399","url":null,"abstract":"Montanoa tomentosa is a shrub, belonging to the Asteraceae family, originally from Mexico and Central America known for its medicinal properties. The origins of its use in the field of herbal medicine can be traced back to the Mexican tradition. It was used for sexual dysfunctions. The extract of leaves was used in women to induce menstruation, abortion and labor, and also to reduce postpartum bleeding. The leaves are also used for their diuretic properties and the ground roots are used in the treatment of dysentery. Over time, studies have been conducted to identify the compounds responsible for the therapeutic activity and their mechanism of action. Two studies conducted in rats demonstrated the aphrodisiac properties of Montanoa tomentosa. This activity has been attributed to the presence of components that act as oxytocic agents. Furthermore, other studies have shown that Montanoa has anxiolytic properties. The mechanism underlying this action lies in the interaction with the GABAA receptor. However, it has been shown that the anxiolytic effect is influenced by the individual endocrine status: in conditions of low hormone levels the anxiolytic effect is more pronounced; in conditions of high hormonal levels, a state like anxiety is observed. Despite the multiple properties of Montanoa, today’s research is geared towards strengthening its clinical relevance as a natural antidepressant agent.","PeriodicalId":9116,"journal":{"name":"Bollettino della Societa italiana di biologia sperimentale","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79666206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The dramatic changes brought by the relationship between humans and their natural environments by different human activities such as the exploitation of natural resources and use of fossil fuels threatens humanity at large. Beside considerable disagreements on when Anthropocene began, it is considered an epochal transformation linked to deterioration of global ecologies, loss of biodiversity and environmental degradation. Environmental anthropologists are contributing both theoretically and by important ethnographic insights in analyzing and understanding the consequences of climate changes in socio-ecological systems worldwide. In this article we provide an overview of main theoretical contributions during the development of environmental anthropology as a discipline. In addition, we highlight the possible Cultural Evolution theory (CE) contribution in climate changes consequences to a socio-ecological system.
{"title":"From nature to man: Environmental anthropology in the Anthropocene","authors":"Ani Bajrami","doi":"10.4081/jbr.2022.10377","DOIUrl":"https://doi.org/10.4081/jbr.2022.10377","url":null,"abstract":"The dramatic changes brought by the relationship between humans and their natural environments by different human activities such as the exploitation of natural resources and use of fossil fuels threatens humanity at large. Beside considerable disagreements on when Anthropocene began, it is considered an epochal transformation linked to deterioration of global ecologies, loss of biodiversity and environmental degradation. Environmental anthropologists are contributing both theoretically and by important ethnographic insights in analyzing and understanding the consequences of climate changes in socio-ecological systems worldwide. In this article we provide an overview of main theoretical contributions during the development of environmental anthropology as a discipline. In addition, we highlight the possible Cultural Evolution theory (CE) contribution in climate changes consequences to a socio-ecological system.","PeriodicalId":9116,"journal":{"name":"Bollettino della Societa italiana di biologia sperimentale","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76738646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This abstract book contains the abstracts presented at the 94th National Congress of the Italian Society for Experimental Biology, Torino, Italy, 6-9 April 2022.
{"title":"94th National Congress of the Italian Society for Experimental Biology | Torino, Italy, 6-9 April 2022","authors":"The editors","doi":"10.4081/jbr.2022.10494","DOIUrl":"https://doi.org/10.4081/jbr.2022.10494","url":null,"abstract":"This abstract book contains the abstracts presented at the 94th National Congress of the Italian Society for Experimental Biology, Torino, Italy, 6-9 April 2022.","PeriodicalId":9116,"journal":{"name":"Bollettino della Societa italiana di biologia sperimentale","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87888440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Shafighi, M. Teymoori, M. Ardakani, A. S. Shirani Rad, M. Alavifazel, F. Rafiei
Climate change and water scarcity are among the significant limited factors to constrain the production and development of oilseed crops, especially rapeseed (Brassica napus L.), in arid and semi-arid areas. The effects of drought stress and late-sowing on the grain yield and oil quality of rapeseed were studied by conducting a factorial split-plot experiment as a randomized complete block design with three replications for two years (2015-2017) in Karaj, Iran. Irrigation and sowing date treatments were considered in the main plots as factorial, and cultivars were placed in subplots. Two sowing dates were the regular date (October 7th) and the late-sowing date (November 6th). Irrigation was also carried out at two levels of normal irrigation and irrigation interruption from the flowering stage onwards. Experimental cultivars included ES Hydromel, ES Alonso, ES Darko, ES Lauren, and Ahmadi. The highest grain yield (4505.6 kg ha-1) was obtained on the regular date, and the normal irrigation. ES Hydromel had the best quality of oil and grain meal due to the highest percentage of palmitic acid (4.44%) under late cultivation and drought stress and the lowest glucosinolates (23.19 µmol g-1 DW) content under late cultivation. Therefore, the ES Hydromel hybrid cultivar was more successful in optimal use of water resources in the face of water scarcity and late-planting in arid and semi-arid regions.
气候变化和水资源短缺是制约干旱和半干旱地区油料作物特别是油菜生产和发展的重要限制因素。在伊朗卡拉伊，采用3个重复的因子分割区试验(2015-2017)，研究了干旱胁迫和晚播对油菜籽籽粒产量和油质的影响。灌水和播期处理作为因子在主区，品种在子区。两个播期分别为常规播期(10月7日)和晚播期(11月6日)。从开花期开始分正常灌溉和中断灌溉两个阶段进行灌溉。试验品种包括ES Hydromel、ES Alonso、ES Darko、ES Lauren和Ahmadi。常规灌水条件下籽粒产量最高(4505.6 kg hm -1)。在栽培后期和干旱胁迫下，棕榈酸含量最高(4.44%)，硫代葡萄糖苷含量最低(23.19µmol g-1 DW)。因此，在干旱半干旱区面临缺水和晚播的情况下，ES水蜜杂交品种更能成功地优化利用水资源。
{"title":"Evaluation of the oil quality properties of Rapeseed genotypes contributed to drought stress at the flowering stage in semi-arid conditions","authors":"A. Shafighi, M. Teymoori, M. Ardakani, A. S. Shirani Rad, M. Alavifazel, F. Rafiei","doi":"10.4081/jbr.2022.10297","DOIUrl":"https://doi.org/10.4081/jbr.2022.10297","url":null,"abstract":"Climate change and water scarcity are among the significant limited factors to constrain the production and development of oilseed crops, especially rapeseed (Brassica napus L.), in arid and semi-arid areas. The effects of drought stress and late-sowing on the grain yield and oil quality of rapeseed were studied by conducting a factorial split-plot experiment as a randomized complete block design with three replications for two years (2015-2017) in Karaj, Iran. Irrigation and sowing date treatments were considered in the main plots as factorial, and cultivars were placed in subplots. Two sowing dates were the regular date (October 7th) and the late-sowing date (November 6th). Irrigation was also carried out at two levels of normal irrigation and irrigation interruption from the flowering stage onwards. Experimental cultivars included ES Hydromel, ES Alonso, ES Darko, ES Lauren, and Ahmadi. The highest grain yield (4505.6 kg ha-1) was obtained on the regular date, and the normal irrigation. ES Hydromel had the best quality of oil and grain meal due to the highest percentage of palmitic acid (4.44%) under late cultivation and drought stress and the lowest glucosinolates (23.19 µmol g-1 DW) content under late cultivation. Therefore, the ES Hydromel hybrid cultivar was more successful in optimal use of water resources in the face of water scarcity and late-planting in arid and semi-arid regions.","PeriodicalId":9116,"journal":{"name":"Bollettino della Societa italiana di biologia sperimentale","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87628105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Organizations urgently need evaluation in order to be aware of the desirability and quality of their activities, especially in complex and dynamic environments. The aim of this study was to determine the effective factors on the performance evaluation of Iranian health centers in 2020. This study was a cross-sectional study conducted on 88 managers, deputies, physicians, and experts working in the headquarters of health deputy and health centers of the township in Ahvaz (Khuzistan province, Southwest of Iran), Lorestan, and Ilam (West of Iran) provinces. We used two questionnaires to collect data. The first included demographic variables and the second was a researcher-designed questionnaire to determine the effective factors on the performance evaluation of health centers. Finally, Univariate and Multivariable Linear Regression model was used for data analysis by SPSS 24 software. The number of men was 50%. The most people were in the age group of 41-45 and 46-50 years with 23.9% and 30.7%, respectively, and the factors of planning was β= 0.122. Resource management β=0.119, combined index (β=0.200), information technology (β=0.132), customer satisfaction (β=0.327), education and empowerment (β=0.191), dealing with the crisis (β=0.344), committees, working groups (β=0.223), research and creativity (β=0.216) were in order the most important predictors of performance evaluation in Iranian health centers. All of the above factors are important predictors for performance evaluation in health centers. Therefore, paying attention to these factors in the performance evaluation of Iranian health centers seems to be necessary.
{"title":"Study of factors affecting the performance evaluation of Iranian health centers","authors":"Firouz Amrai, S. Mahfoozpour, S. Vahdat, S. Hesam","doi":"10.4081/jbr.2022.10302","DOIUrl":"https://doi.org/10.4081/jbr.2022.10302","url":null,"abstract":"Organizations urgently need evaluation in order to be aware of the desirability and quality of their activities, especially in complex and dynamic environments. The aim of this study was to determine the effective factors on the performance evaluation of Iranian health centers in 2020. This study was a cross-sectional study conducted on 88 managers, deputies, physicians, and experts working in the headquarters of health deputy and health centers of the township in Ahvaz (Khuzistan province, Southwest of Iran), Lorestan, and Ilam (West of Iran) provinces. We used two questionnaires to collect data. The first included demographic variables and the second was a researcher-designed questionnaire to determine the effective factors on the performance evaluation of health centers. Finally, Univariate and Multivariable Linear Regression model was used for data analysis by SPSS 24 software. The number of men was 50%. The most people were in the age group of 41-45 and 46-50 years with 23.9% and 30.7%, respectively, and the factors of planning was β= 0.122. Resource management β=0.119, combined index (β=0.200), information technology (β=0.132), customer satisfaction (β=0.327), education and empowerment (β=0.191), dealing with the crisis (β=0.344), committees, working groups (β=0.223), research and creativity (β=0.216) were in order the most important predictors of performance evaluation in Iranian health centers. All of the above factors are important predictors for performance evaluation in health centers. Therefore, paying attention to these factors in the performance evaluation of Iranian health centers seems to be necessary.","PeriodicalId":9116,"journal":{"name":"Bollettino della Societa italiana di biologia sperimentale","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75621794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Marynenko, T. Halenova, N. Raksha, T. Vovk, Y. Tyravska, O. Savchuk, L. Ostapchenko
Coronary artery disease (CAD) is a major public health problem all over the world, and although diagnostic and treatment approaches are improving, the majority of individuals who suffer CAD will not survive. Therefore, it is a clinical demand to find out new biomarkers for identification of CAD in the earlier stage. The purpose of this study was to determine whether qualitative and quantitative alterations of plasma soluble fibrin monomer complexes (SFMCs) are associated with cardiovascular events. Additionally, some other well-known biomarkers of hypercoagulation state, such as fibrinogen, and prothrombin were analyzed in plasma of patients with different coronary artery pathologies. We found that plasma SFMC concentrations were remarkably increased in all tested CAD groups. Moreover, the development of CAD was accompanied by the changes in both quantity and quality of SFMC composition compared to that of healthy subjects. Our results also demonstrated the elevated level of high molecular weight vitamin K-dependent protein (VKDP) complexes in plasma of CAD patients which could be used as a potential biomarker of hypercoagulation state. More studies are clearly needed to investigate whether SFMCs or abnormal forms of VKDPs affect cardiovascular events under CAD development and progression.
{"title":"Coagulation markers in patients with coronary artery disease","authors":"T. Marynenko, T. Halenova, N. Raksha, T. Vovk, Y. Tyravska, O. Savchuk, L. Ostapchenko","doi":"10.4081/jbr.2022.10259","DOIUrl":"https://doi.org/10.4081/jbr.2022.10259","url":null,"abstract":"Coronary artery disease (CAD) is a major public health problem all over the world, and although diagnostic and treatment approaches are improving, the majority of individuals who suffer CAD will not survive. Therefore, it is a clinical demand to find out new biomarkers for identification of CAD in the earlier stage. The purpose of this study was to determine whether qualitative and quantitative alterations of plasma soluble fibrin monomer complexes (SFMCs) are associated with cardiovascular events. Additionally, some other well-known biomarkers of hypercoagulation state, such as fibrinogen, and prothrombin were analyzed in plasma of patients with different coronary artery pathologies. We found that plasma SFMC concentrations were remarkably increased in all tested CAD groups. Moreover, the development of CAD was accompanied by the changes in both quantity and quality of SFMC composition compared to that of healthy subjects. Our results also demonstrated the elevated level of high molecular weight vitamin K-dependent protein (VKDP) complexes in plasma of CAD patients which could be used as a potential biomarker of hypercoagulation state. More studies are clearly needed to investigate whether SFMCs or abnormal forms of VKDPs affect cardiovascular events under CAD development and progression.","PeriodicalId":9116,"journal":{"name":"Bollettino della Societa italiana di biologia sperimentale","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85143315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The authors report about the association of progressive external ophthalmoplegia, atypical pigmentary retinopathy, ataxia phenotype with onset in first months of life (Kearns-Sayre syndrome) and with optic nerve atrophy and deafness. The localization of retinal lesions was coincident with that reported by multifunctional electroretinogram (mfERG) in OPA 1 mutation. The authors hypothesize that Kearns-Sayre mitochondrial mutation may be associated with OPA 1 missense mutation, with worsening of symptomatology, as occurs in the reported case. The prolonged rehabilitation and treatment with coenzyme Q10 for many years gave positive results, with amelioration of ophthalmoplegia, stopping of aggravation of retinal damage and optic nerve atrophy, maintaining of vision some meters away, possibility of socialization and proprioceptive ability amelioration.
{"title":"Kearns-Sayre syndrome with optic nerve atrophy phenotype: A possible biological and clinical concurrence of two mutations?","authors":"A. Berio, G. Mariottini, M. Frascio, A. Piazzi","doi":"10.4081/jbr.2022.10308","DOIUrl":"https://doi.org/10.4081/jbr.2022.10308","url":null,"abstract":"The authors report about the association of progressive external ophthalmoplegia, atypical pigmentary retinopathy, ataxia phenotype with onset in first months of life (Kearns-Sayre syndrome) and with optic nerve atrophy and deafness. The localization of retinal lesions was coincident with that reported by multifunctional electroretinogram (mfERG) in OPA 1 mutation. The authors hypothesize that Kearns-Sayre mitochondrial mutation may be associated with OPA 1 missense mutation, with worsening of symptomatology, as occurs in the reported case. The prolonged rehabilitation and treatment with coenzyme Q10 for many years gave positive results, with amelioration of ophthalmoplegia, stopping of aggravation of retinal damage and optic nerve atrophy, maintaining of vision some meters away, possibility of socialization and proprioceptive ability amelioration.","PeriodicalId":9116,"journal":{"name":"Bollettino della Societa italiana di biologia sperimentale","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74921999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yayuk Fatmawati, Sophi Sandrina, Richca Nur Aina, E. Narulita
Enhalus acoroides have potential to inhibit the α-glucosidase enzyme and as an antidiabetic drug. Twenty-seven phytochemical compounds of seagrass (E. acoroides) were analyzed by molecular docking method. All possible candidatecompounds predicted ADME pharmacokinetic properties using the swissADME website. A molecular docking analysis was carried out using the PyRx 0.8 Autodock Vina software. Furthermore, the interaction analysis between molecules was carried out using PyMOL software and the Discovery Studio Visualizer BIOVIA.There were 17 of the27 compounds which had the best potency as oral antidiabeticdrug candidates. The validation results showed that all ligands had aroot mean score deviation(RMSD) value <2Å with the best value of 0.0. The binding affinity with the strongest bond value was -9.2 (kcal/mol) on the NAMPT bond with tannin, while the weakest value was 40.01 at 3l4y (α-glucosidase) with 3-methyl. The 2h6d receptor can bind to all ligands, and the α-glucosidase receptor can bind to two test ligands.The docking method used in this study was valid, and the phytochemical compounds of seagrass have the potential to be an alternative to antidiabetic drugs.
{"title":"Molecular docking analysis of seagrass (Enhalus acoroides) phytochemical compounds as an antidiabetic","authors":"Yayuk Fatmawati, Sophi Sandrina, Richca Nur Aina, E. Narulita","doi":"10.4081/jbr.2022.10224","DOIUrl":"https://doi.org/10.4081/jbr.2022.10224","url":null,"abstract":"Enhalus acoroides have potential to inhibit the α-glucosidase enzyme and as an antidiabetic drug. Twenty-seven phytochemical compounds of seagrass (E. acoroides) were analyzed by molecular docking method. All possible candidatecompounds predicted ADME pharmacokinetic properties using the swissADME website. A molecular docking analysis was carried out using the PyRx 0.8 Autodock Vina software. Furthermore, the interaction analysis between molecules was carried out using PyMOL software and the Discovery Studio Visualizer BIOVIA.There were 17 of the27 compounds which had the best potency as oral antidiabeticdrug candidates. The validation results showed that all ligands had aroot mean score deviation(RMSD) value <2Å with the best value of 0.0. The binding affinity with the strongest bond value was -9.2 (kcal/mol) on the NAMPT bond with tannin, while the weakest value was 40.01 at 3l4y (α-glucosidase) with 3-methyl. The 2h6d receptor can bind to all ligands, and the α-glucosidase receptor can bind to two test ligands.The docking method used in this study was valid, and the phytochemical compounds of seagrass have the potential to be an alternative to antidiabetic drugs.","PeriodicalId":9116,"journal":{"name":"Bollettino della Societa italiana di biologia sperimentale","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89009945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Giammanco, F. Plescia, M. Giammanco, G. Leto, C. Gentile
Citrus fruits are the main fruits of the Mediterranean diet and have been long recognized for their beneficial effects on human health. Observational studies have shown a significant association between dietary flavo-noid intake and reduced risk of cardiovascular and malignant diseases. The beneficial effects of citrus fruits on human health appear to be due to their high content in vitamins, minerals and fibers. In particular, the an-tioxidant and anti-inflammatory activities have been indicated as some of the mechanisms through which citrus fruits may thwarts the development of chronic degenerative diseases such as atherosclerosis and can-cer. This review would critically examine the results from numerous studies carried out in order assess the contribute of citrus flavonoids to the prevention of chronic pathological conditions including athero-sclerosis and cancer.
{"title":"Bioactive effects of citrus flavonoids and role in the prevention of atherosclerosis and cancer","authors":"M. Giammanco, F. Plescia, M. Giammanco, G. Leto, C. Gentile","doi":"10.4081/jbr.2022.10313","DOIUrl":"https://doi.org/10.4081/jbr.2022.10313","url":null,"abstract":"Citrus fruits are the main fruits of the Mediterranean diet and have been long recognized for their beneficial effects on human health. Observational studies have shown a significant association between dietary flavo-noid intake and reduced risk of cardiovascular and malignant diseases. The beneficial effects of citrus fruits on human health appear to be due to their high content in vitamins, minerals and fibers. In particular, the an-tioxidant and anti-inflammatory activities have been indicated as some of the mechanisms through which citrus fruits may thwarts the development of chronic degenerative diseases such as atherosclerosis and can-cer. This review would critically examine the results from numerous studies carried out in order assess the contribute of citrus flavonoids to the prevention of chronic pathological conditions including athero-sclerosis and cancer.","PeriodicalId":9116,"journal":{"name":"Bollettino della Societa italiana di biologia sperimentale","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89725217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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