Pub Date : 2019-01-01DOI: 10.4172/2376-0281.1000338
T. Oki
As we cannot stop disease progression of neurodegenerative diseases, we have to consider neurodegenerative diseases as life-threatening illnesses and the objects of palliative care. Neurodegenerative disease patients and their families usually do not have much information about their diseases and often cannot choose their treatment and care options on their own. Before applying the principles of palliative care to the patients and their families, we have to give appropriate information about their diseases to them. But there were few educational interventions in neurodegenerative disease patients and their families and also few studies investigating the knowledge they had. Moreover all but one was the educational interventions for demented patients. All reports about the educational interventions in neurodegenerative diseases showed that the simple educational interventions might not reduce the burdens on the families, and one report for extrapyramidal diseases and cerebellar degenerations moreover showed that the simple educational interventions could not change the courses of natural degradation of the diseases and might produce depressive reaction, to the patients. In order to reduce the burdens of the families we have to support the families with physically, and in order to encourage the patients to accept their diseases we have to control their depressions and approach to them with the principles of palliative care.
{"title":"Educational Programs for Neurodegenerative Diseases","authors":"T. Oki","doi":"10.4172/2376-0281.1000338","DOIUrl":"https://doi.org/10.4172/2376-0281.1000338","url":null,"abstract":"As we cannot stop disease progression of neurodegenerative diseases, we have to consider neurodegenerative diseases as life-threatening illnesses and the objects of palliative care. Neurodegenerative disease patients and their families usually do not have much information about their diseases and often cannot choose their treatment and care options on their own. Before applying the principles of palliative care to the patients and their families, we have to give appropriate information about their diseases to them. But there were few educational interventions in neurodegenerative disease patients and their families and also few studies investigating the knowledge they had. Moreover all but one was the educational interventions for demented patients. All reports about the educational interventions in neurodegenerative diseases showed that the simple educational interventions might not reduce the burdens on the families, and one report for extrapyramidal diseases and cerebellar degenerations moreover showed that the simple educational interventions could not change the courses of natural degradation of the diseases and might produce depressive reaction, to the patients. In order to reduce the burdens of the families we have to support the families with physically, and in order to encourage the patients to accept their diseases we have to control their depressions and approach to them with the principles of palliative care.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.4172/2376-0281.1000337
J. A. Santos, Alcino da Silva Carvalho
Physical training and sport conditioning depends on the correct conjugation of stimulus-load, resting and nutrition. Given that load and nutrition are adequate for training goals, rest handling is crucial for training control and posterior adaptation. Adequate resting between exercises, sets or workouts gives the direction for muscle/ body adaptation, allowing not only to achieve training goals but also to avoid situations of extreme fatigue whose deficient copping can induce non-physiological overreaching or pathological overtraining [1]. Thus, analysing optimal resting intervals is of surmount importance in the training process of different activities as high level sport training and rehabilitation.
{"title":"Recovery Interval during Physical Training Depends on both Neural and Energetic Constraints","authors":"J. A. Santos, Alcino da Silva Carvalho","doi":"10.4172/2376-0281.1000337","DOIUrl":"https://doi.org/10.4172/2376-0281.1000337","url":null,"abstract":"Physical training and sport conditioning depends on the correct conjugation of stimulus-load, resting and nutrition. Given that load and nutrition are adequate for training goals, rest handling is crucial for training control and posterior adaptation. Adequate resting between exercises, sets or workouts gives the direction for muscle/ body adaptation, allowing not only to achieve training goals but also to avoid situations of extreme fatigue whose deficient copping can induce non-physiological overreaching or pathological overtraining [1]. Thus, analysing optimal resting intervals is of surmount importance in the training process of different activities as high level sport training and rehabilitation.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.4172/2376-0281.1000342
M. Carmina
Stroke is a disabling global health-care problem, and rehabilitation is a major part of patient care. By 4 years after the event, more than 30% of stroke survivors report participation restrictions. Up to 70% of patients present fall during the first 6 months, the reason may be due to impairments in balance, gait, motor control, perception and vision contribute to an increment in fear of falling. This can lead to reduced levels of activity and loss of independence. Some of the affected areas include the balance, because of alteration of sensory and motor networks; this contributes to difficulty in activity daily living (ADLs). This is the reason of balance training must be performed. Another sequelae are loss or difficulty with ambulation, and restoration of gait is one of the primary goals in rehabilitation; limitation in gait is another factor that contributes to an increase in fall risk. Recurrence of stroke has been found to vary by sex: 24% of women and 42% of men experience a recurrence within 5 years of onset.
{"title":"Antigravity Treadmill for Rehabilitation of Stroke Survivors","authors":"M. Carmina","doi":"10.4172/2376-0281.1000342","DOIUrl":"https://doi.org/10.4172/2376-0281.1000342","url":null,"abstract":"Stroke is a disabling global health-care problem, and rehabilitation is a major part of patient care. By 4 years after the event, more than 30% of stroke survivors report participation restrictions. Up to 70% of patients present fall during the first 6 months, the reason may be due to impairments in balance, gait, motor control, perception and vision contribute to an increment in fear of falling. This can lead to reduced levels of activity and loss of independence. Some of the affected areas include the balance, because of alteration of sensory and motor networks; this contributes to difficulty in activity daily living (ADLs). This is the reason of balance training must be performed. Another sequelae are loss or difficulty with ambulation, and restoration of gait is one of the primary goals in rehabilitation; limitation in gait is another factor that contributes to an increase in fall risk. Recurrence of stroke has been found to vary by sex: 24% of women and 42% of men experience a recurrence within 5 years of onset.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"6 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01Epub Date: 2019-01-12DOI: 10.4172/2376-0281.1000336
David R Dolbow, Daniel P Credeur, Jennifer L Lemacks, Mujtaba Rahimi, Dobrivoje S Stokic
Introduction: Various therapies have been utilized to improve cardiometabolic health after spinal cord injury (SCI), including Functional Electrical Stimulation (FES) cycling. Typically, FES is used in SCI cases resulting from Upper Motor Neuron Injury (UMN-SCI). However, it has been reported that FES may improve muscle torque and functional mobility in individuals with Lower Motor Neuron Injuries (LMN-SCI) but potential effects on cardiometabolic health have not been studied before. Thus, this study examined the cardiometabolic health response to FES cycling combined with nutritional counseling in two individuals with chronic SCI; one person with LMN-SCI and one with UMN-SCI.
Case presentation: Body composition, vascular stiffness, and glucose deposition were assessed before and after participation in the FES cycling and nutritional counseling program. Despite the decrease in body mass in the case of LMN-SCI but not UMN-SCI, the fat mass-to-lean mass ratio in the lower limbs and trunk increased +4% and +8% respectively, in the former and decreased -10% and -8% respectively in the latter. Both subjects decreased markers of central vascular stiffness (AIx@75, reflection magnitude) as well as blood glucose and HbA1c levels, however, the changes were greater in the case of UMN-SCI.
Discussion: This dual case study provides only a partial support for the use of FES cycling alone or in combination with nutritional counseling for improving cardio metabolic health in LMN-SCI, however modest decreases in glucose and vascular stiffness warrant further investigations.
{"title":"The Effect of Electrically Induced Cycling and Nutritional Counseling on Cardiometabolic Health in Upper and Lower Motor Neuron Chronic Spinal Cord Injury: Dual Case Report.","authors":"David R Dolbow, Daniel P Credeur, Jennifer L Lemacks, Mujtaba Rahimi, Dobrivoje S Stokic","doi":"10.4172/2376-0281.1000336","DOIUrl":"https://doi.org/10.4172/2376-0281.1000336","url":null,"abstract":"<p><strong>Introduction: </strong>Various therapies have been utilized to improve cardiometabolic health after spinal cord injury (SCI), including Functional Electrical Stimulation (FES) cycling. Typically, FES is used in SCI cases resulting from Upper Motor Neuron Injury (UMN-SCI). However, it has been reported that FES may improve muscle torque and functional mobility in individuals with Lower Motor Neuron Injuries (LMN-SCI) but potential effects on cardiometabolic health have not been studied before. Thus, this study examined the cardiometabolic health response to FES cycling combined with nutritional counseling in two individuals with chronic SCI; one person with LMN-SCI and one with UMN-SCI.</p><p><strong>Case presentation: </strong>Body composition, vascular stiffness, and glucose deposition were assessed before and after participation in the FES cycling and nutritional counseling program. Despite the decrease in body mass in the case of LMN-SCI but not UMN-SCI, the fat mass-to-lean mass ratio in the lower limbs and trunk increased +4% and +8% respectively, in the former and decreased -10% and -8% respectively in the latter. Both subjects decreased markers of central vascular stiffness (AIx@75, reflection magnitude) as well as blood glucose and HbA1c levels, however, the changes were greater in the case of UMN-SCI.</p><p><strong>Discussion: </strong>This dual case study provides only a partial support for the use of FES cycling alone or in combination with nutritional counseling for improving cardio metabolic health in LMN-SCI, however modest decreases in glucose and vascular stiffness warrant further investigations.</p>","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000336","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37717919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.4172/2376-0281.1000344
Belenichev Igor Fedorovich, D. Voitenko, N. Bukhtiayrova
Our study experimentally provides promising opportunities for further clinical use of a combination of the essential amino acid L-arginine with a thiotriazoline in placental insufficiency (PI). The biological functions of L-arginine are substantiated by the fact that it is a precursor to the synthesis of nitric oxide (NO). Tiotriazolin is able to act as a tansport molecule NO, forming nitrosothiols. The pharmacological effect of the combination is due to the mutual potentiality of thiotriazoline and arginine on the synthesis, transport and bioavailability of NO and the physiological functions of this molecular messenger.
{"title":"Reduce the Neuroapoptosis in the Brain of Rats Born to Mothers with Experimental Placental Insufficiency by Combination of Thiotriazoline with L-Arginine and Thiotriazolin with Piracetam","authors":"Belenichev Igor Fedorovich, D. Voitenko, N. Bukhtiayrova","doi":"10.4172/2376-0281.1000344","DOIUrl":"https://doi.org/10.4172/2376-0281.1000344","url":null,"abstract":"Our study experimentally provides promising opportunities for further clinical use of a combination of the essential amino acid L-arginine with a thiotriazoline in placental insufficiency (PI). The biological functions of L-arginine are substantiated by the fact that it is a precursor to the synthesis of nitric oxide (NO). Tiotriazolin is able to act as a tansport molecule NO, forming nitrosothiols. The pharmacological effect of the combination is due to the mutual potentiality of thiotriazoline and arginine on the synthesis, transport and bioavailability of NO and the physiological functions of this molecular messenger.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"6 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.4172/2376-0281.1000346
V. Golubkova
Introduction: Myasthenia Gravis (MG) is characterized by muscle weakness that may be exacerbated with exercise. Research on safety of exercise in MG is scarce. Patients are frequently discouraged from participation. At the same time, exercise-based cardiac rehabilitation is a class I recommendation for patients recovering from Myocardial Infarction (MI) and Percutaneous Coronary Intervention (PCI). Rehabilitation of cardiac patients suffering from MG presents a unique challenge for clinicians. Methods: We describe a cardiac rehabilitation (CR) program in a patient status post STEMI (ST-Elevation Myocardial Infarction) and PCI with a fifteen-year history of MG. Results: The patient was able to successfully complete a 36-session program consisting of aerobic, strength and flexibility training, showing marked improvements in aerobic capacity, endurance, and field exercise tests results. No significant adverse events were noted. Conclusion: aerobic and resistance exercise programs are feasible and may be beneficial in cardiac patients with comorbid MG.
{"title":"Cardiac Rehabilitation in Myasthenia Gravis","authors":"V. Golubkova","doi":"10.4172/2376-0281.1000346","DOIUrl":"https://doi.org/10.4172/2376-0281.1000346","url":null,"abstract":"Introduction: Myasthenia Gravis (MG) is characterized by muscle weakness that may be exacerbated with exercise. Research on safety of exercise in MG is scarce. Patients are frequently discouraged from participation. At the same time, exercise-based cardiac rehabilitation is a class I recommendation for patients recovering from Myocardial Infarction (MI) and Percutaneous Coronary Intervention (PCI). Rehabilitation of cardiac patients suffering from MG presents a unique challenge for clinicians. Methods: We describe a cardiac rehabilitation (CR) program in a patient status post STEMI (ST-Elevation Myocardial Infarction) and PCI with a fifteen-year history of MG. Results: The patient was able to successfully complete a 36-session program consisting of aerobic, strength and flexibility training, showing marked improvements in aerobic capacity, endurance, and field exercise tests results. No significant adverse events were noted. Conclusion: aerobic and resistance exercise programs are feasible and may be beneficial in cardiac patients with comorbid MG.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"6 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-05-23DOI: 10.4172/2376-0281.1000320
H. Bando
As to metabolic syndrome (Met-S), the frequency of hypertension and diabetes increases with the progress of arteriosclerosis. Its pathophysiological mechanism also involves the control of the nervous system. In other words, regarding the adjustment of blood pressure in humans, the blood pressure will fluctuate by adjusting mechanism of the nervous system, corresponding to the body position, movement, exercise and psycho-psychiatric changes in various situations. There is no problem in normal persons concerning these regulatory mechanisms. However, in the patients associated with hypertension or previous stroke, the mechanism for instantaneously regulating blood pressure has been impaired. Therefore, blood pressure may rise or fall suddenly in such patients.
{"title":"Diabetes May Influence Blood Pressure on Antihypertensive Drug","authors":"H. Bando","doi":"10.4172/2376-0281.1000320","DOIUrl":"https://doi.org/10.4172/2376-0281.1000320","url":null,"abstract":"As to metabolic syndrome (Met-S), the frequency of hypertension and diabetes increases with the progress of arteriosclerosis. Its pathophysiological mechanism also involves the control of the nervous system. In other words, regarding the adjustment of blood pressure in humans, the blood pressure will fluctuate by adjusting mechanism of the nervous system, corresponding to the body position, movement, exercise and psycho-psychiatric changes in various situations. There is no problem in normal persons concerning these regulatory mechanisms. However, in the patients associated with hypertension or previous stroke, the mechanism for instantaneously regulating blood pressure has been impaired. Therefore, blood pressure may rise or fall suddenly in such patients.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"5 1","pages":"320"},"PeriodicalIF":0.0,"publicationDate":"2018-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47451877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-02-02DOI: 10.4172/2376-0281.1000e130
R. Perna
{"title":"Clinical Communication with People who have Stroke Related Hemiplegia","authors":"R. Perna","doi":"10.4172/2376-0281.1000e130","DOIUrl":"https://doi.org/10.4172/2376-0281.1000e130","url":null,"abstract":"","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":" ","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000e130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48238797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-25DOI: 10.4172/2376-0281.1000304
S. Manzoor
Stroke is the major cause of long term disability and increase economic burden. Hypertension and cardiac diseases are the major contributing risk factor. Stroke is the major reason for long term dependence due to decline in cognitive function. Almost more than 60% of stroke survivors suffer from moderate motor and sensory impairment that can be treated with physical therapy intervention.
{"title":"Stroke Rehabilitation and Physical Therapy Interventions: A Short Commentary","authors":"S. Manzoor","doi":"10.4172/2376-0281.1000304","DOIUrl":"https://doi.org/10.4172/2376-0281.1000304","url":null,"abstract":"Stroke is the major cause of long term disability and increase economic burden. Hypertension and cardiac diseases are the major contributing risk factor. Stroke is the major reason for long term dependence due to decline in cognitive function. Almost more than 60% of stroke survivors suffer from moderate motor and sensory impairment that can be treated with physical therapy intervention.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"5 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44378048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.4172/2376-0281.1000325
E. Katada
Posterior Reversible Encephalopathy Syndrome (PRES) is characterized by neurologic symptoms with hyperintense lesions on magnetic resonance imaging and it presents signs including a sudden onset headache, hypertension, and fever. The pathophysiology underlying PRES have been postulated to be severe hypertension leading to failed cerebral vascular auto-regulation and endothelial injury/vasogenic edema, vasoconstriction leading to brain ischemic and subsequent vasogenic edema. PRES may be associated with recent chemotherapy agents, in particular, bevacizumab which is a recombinant, humanized, monoclonal IgG1 antibody that binds and inhibits vascular endothelial growth factor. We experienced the case of PRES associated with Reversible Cerebral Vasoconstriction Syndrome (RCVS) 15 months later after a variety of combined chemotherapies containing bevacizumab for metastatic colon cancer. PRES and RCVS are frequently associated like this case and have overlapping or similar pathophysiological mechanism. We speculated that bevacizumab may have induced vasospasm coupled with hypertension and/or endothelial dysfunction due to bevacizumab has been shown able to affect the regulation of the cerebral arterial tone and trigger vasoconstriction with subsequent hypoperfusion, breakdown of the blood-brain barrier, and vasogenic edema, and which led to PRES. It is important to come to mind PRES early in the clinical course when the patient treated with bevacizumab shows the sign and symptoms resembling the cerebrovasucular disease.
{"title":"Posterior Reversible Encephalopathy Syndrome Associated with Bevacizumab","authors":"E. Katada","doi":"10.4172/2376-0281.1000325","DOIUrl":"https://doi.org/10.4172/2376-0281.1000325","url":null,"abstract":"Posterior Reversible Encephalopathy Syndrome (PRES) is characterized by neurologic symptoms with hyperintense lesions on magnetic resonance imaging and it presents signs including a sudden onset headache, hypertension, and fever. The pathophysiology underlying PRES have been postulated to be severe hypertension leading to failed cerebral vascular auto-regulation and endothelial injury/vasogenic edema, vasoconstriction leading to brain ischemic and subsequent vasogenic edema. PRES may be associated with recent chemotherapy agents, in particular, bevacizumab which is a recombinant, humanized, monoclonal IgG1 antibody that binds and inhibits vascular endothelial growth factor. We experienced the case of PRES associated with Reversible Cerebral Vasoconstriction Syndrome (RCVS) 15 months later after a variety of combined chemotherapies containing bevacizumab for metastatic colon cancer. PRES and RCVS are frequently associated like this case and have overlapping or similar pathophysiological mechanism. We speculated that bevacizumab may have induced vasospasm coupled with hypertension and/or endothelial dysfunction due to bevacizumab has been shown able to affect the regulation of the cerebral arterial tone and trigger vasoconstriction with subsequent hypoperfusion, breakdown of the blood-brain barrier, and vasogenic edema, and which led to PRES. It is important to come to mind PRES early in the clinical course when the patient treated with bevacizumab shows the sign and symptoms resembling the cerebrovasucular disease.","PeriodicalId":91292,"journal":{"name":"International journal of neurorehabilitation","volume":"5 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2376-0281.1000325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70303087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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