{"title":"Integration of Ki67 and Pan-Immune-Inflammation Value (PIV) into a predictive nomogram for pathologic complete response in triple-negative breast cancer : (Ki67 and inflammation in triple-negative breast cancer).","authors":"Taliha Guclu, Ozgur Tanriverdi, Ismail Bayrakci, Bilgin Demir, Gokhan Colak, Sait Kitaplı, Ali Alkan, Gamze Gokoz-Doğu, Sernaz Topaloglu, Sabri Barutca","doi":"10.1186/s12885-026-15842-5","DOIUrl":"https://doi.org/10.1186/s12885-026-15842-5","url":null,"abstract":"","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Relationships between BMI and breast cancer risk have been widely reported in previous Mendelian randomization (MR) studies, but the underlying molecular mechanisms remain unclear. We conducted this comprehensive two-sample MR to investigate the mediating role of 8 circulating biomarkers linking genetically predicted BMI to breast cancer risk both individually and simultaneously.
Methods: A total of 281 BMI-associated single-nucleotide polymorphisms (SNPs) were used to estimate the associations of BMI with biomarker levels and breast cancer susceptibility. Instruments involving 8 ~ 364 SNPs were used to proxy 8 circulating biomarkers related to adipocytokine imbalance, chronic low-grade inflammation and insulin/insulin-like growth factor (IGF) axis dysregulation. Two-step MR mediation analyses were conducted to evaluate the indirect effects of a single biomarker in the relationship between genetically predicted BMI and breast cancer risk, and stepwise MR mediation analyses were employed to identify potential pathways involving multiple mediators.
Results: Genetically predicted BMI was positively correlated with genetically predicted circulating leptin (LEP), insulin (INS), and C-reactive protein (CRP) levels, with β values ranging from 0.166 to 0.453, and negatively correlated with IGF-1 levels (β=-0.118), whereas no statistically significant associations were found for adiponectin, resistin, soluble leptin receptor or insulin-like growth factor binding protein-3 levels. Two-step MR mediation analyses showed that in the association between genetically predicted BMI and breast cancer susceptibility (OR: 0.894; 95%CI: 0.832, 0.960; P = 2.06 × 10- 3), the indirect effect mediated by CRP was statistically significant (OR: 1.046; 95%CI: 1.014, 1.079; P = 4.83 × 10- 3), while no statistically significant indirect effects were detected for LEP, INS or IGF-1. Furthermore, stepwise MR mediation analyses with multiple mediators revealed that both the indirect effect mediated by CRP alone (OR: 1.040; 95%CI: 1.012, 1.070; P = 5.73 × 10- 3) and by the sequential combination of IGF-1 and CRP (OR: 1.003; 95%CI: 1.000, 1.005; P = 2.38 × 10- 2) were statistically significant.
Conclusions: Chronic low-grade inflammation is a vital pathway linking genetically predicted BMI to breast cancer risk. Genetically predicted BMI is associated with higher genetically predicted CRP levels, potentially through a pathway involving reduced IGF-1 levels, which may attenuate the inverse association between genetically predicted BMI and breast cancer risk.
{"title":"Genetic evidence for potential molecular mediators underlying the causal relationship between obesity and breast cancer: a two-step, two-sample Mendelian randomization study.","authors":"Yu Hao, Xia Jiang, Jinyu Xiao, Mengyu Fan, Xueyao Wu, Jiaqiang Liao, Xunying Zhao, Wanting Feng, Hongbo Qi, Jiayuan Li","doi":"10.1186/s12885-026-15744-6","DOIUrl":"https://doi.org/10.1186/s12885-026-15744-6","url":null,"abstract":"<p><strong>Background: </strong>Relationships between BMI and breast cancer risk have been widely reported in previous Mendelian randomization (MR) studies, but the underlying molecular mechanisms remain unclear. We conducted this comprehensive two-sample MR to investigate the mediating role of 8 circulating biomarkers linking genetically predicted BMI to breast cancer risk both individually and simultaneously.</p><p><strong>Methods: </strong>A total of 281 BMI-associated single-nucleotide polymorphisms (SNPs) were used to estimate the associations of BMI with biomarker levels and breast cancer susceptibility. Instruments involving 8 ~ 364 SNPs were used to proxy 8 circulating biomarkers related to adipocytokine imbalance, chronic low-grade inflammation and insulin/insulin-like growth factor (IGF) axis dysregulation. Two-step MR mediation analyses were conducted to evaluate the indirect effects of a single biomarker in the relationship between genetically predicted BMI and breast cancer risk, and stepwise MR mediation analyses were employed to identify potential pathways involving multiple mediators.</p><p><strong>Results: </strong>Genetically predicted BMI was positively correlated with genetically predicted circulating leptin (LEP), insulin (INS), and C-reactive protein (CRP) levels, with β values ranging from 0.166 to 0.453, and negatively correlated with IGF-1 levels (β=-0.118), whereas no statistically significant associations were found for adiponectin, resistin, soluble leptin receptor or insulin-like growth factor binding protein-3 levels. Two-step MR mediation analyses showed that in the association between genetically predicted BMI and breast cancer susceptibility (OR: 0.894; 95%CI: 0.832, 0.960; P = 2.06 × 10<sup>- 3</sup>), the indirect effect mediated by CRP was statistically significant (OR: 1.046; 95%CI: 1.014, 1.079; P = 4.83 × 10<sup>- 3</sup>), while no statistically significant indirect effects were detected for LEP, INS or IGF-1. Furthermore, stepwise MR mediation analyses with multiple mediators revealed that both the indirect effect mediated by CRP alone (OR: 1.040; 95%CI: 1.012, 1.070; P = 5.73 × 10<sup>- 3</sup>) and by the sequential combination of IGF-1 and CRP (OR: 1.003; 95%CI: 1.000, 1.005; P = 2.38 × 10<sup>- 2</sup>) were statistically significant.</p><p><strong>Conclusions: </strong>Chronic low-grade inflammation is a vital pathway linking genetically predicted BMI to breast cancer risk. Genetically predicted BMI is associated with higher genetically predicted CRP levels, potentially through a pathway involving reduced IGF-1 levels, which may attenuate the inverse association between genetically predicted BMI and breast cancer risk.</p>","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Experiences of swallowing and communication after nasopharyngeal cancer in Malaysian men: a qualitative study.","authors":"Giuditta Smith, Ting Ying Boey, Shin Ying Chu, Caryn Mei Hsien Chan, Siti Fathiah Masre, Fuad Ismail, Maria Garraffa, Deborah Hersh","doi":"10.1186/s12885-026-15606-1","DOIUrl":"https://doi.org/10.1186/s12885-026-15606-1","url":null,"abstract":"","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1186/s12885-026-15839-0
Jianxi Guo, Honggui Tang, Tao Xu, Yucong Zhang, Jian Kong, Sina Zhang
{"title":"Development and validation of a SHAP-explainable preoperative predictive model for microvascular invasion in hepatocellular carcinoma.","authors":"Jianxi Guo, Honggui Tang, Tao Xu, Yucong Zhang, Jian Kong, Sina Zhang","doi":"10.1186/s12885-026-15839-0","DOIUrl":"https://doi.org/10.1186/s12885-026-15839-0","url":null,"abstract":"","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1186/s12885-026-15570-w
Guanzhi Zhou, Nanna M Sijtsema, Yan Li, Tiantian Zhai, Lihong Xi, Jun Li, Arjen van der Schaaf, Lisanne V van Dijk, Yingrui Shi, Pei Yang, Johannes A Langendijk
{"title":"Prediction of treatment outcome in nasopharyngeal carcinoma patients.","authors":"Guanzhi Zhou, Nanna M Sijtsema, Yan Li, Tiantian Zhai, Lihong Xi, Jun Li, Arjen van der Schaaf, Lisanne V van Dijk, Yingrui Shi, Pei Yang, Johannes A Langendijk","doi":"10.1186/s12885-026-15570-w","DOIUrl":"https://doi.org/10.1186/s12885-026-15570-w","url":null,"abstract":"","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1186/s12885-026-15813-w
Brian O Ayara, Samuel G Mukono, Rodney D Adam, Shahin Sayed
{"title":"Ten-year pathology-based cancer registry at a tertiary referral hospital in Kenya (2015-2024): distribution of cancers and completeness of pathology reporting.","authors":"Brian O Ayara, Samuel G Mukono, Rodney D Adam, Shahin Sayed","doi":"10.1186/s12885-026-15813-w","DOIUrl":"https://doi.org/10.1186/s12885-026-15813-w","url":null,"abstract":"","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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