Background:Azadirachta indica, an evergreen tree, is used by several folkloric practitioners to treat peptic ulcers in India. The present study was carried out to evaluate the antiulcer activity of the aqueous extract (AE) of the leaves of A. indica in Wistar rats. Methods: Gastric ulcerations were induced by pyloric ligation, aspirin, and cold restraint stress. AE was used in doses of 150, 300, and 600 mg/kg body weight per os. Distilled water served as the control and ranitidine 20 mg/kg body weight intraperitoneal as the reference standard. The ulcer index (UI) and percentage inhibition (PI) values were determined in each model. The volume of gastric contents, free acidity, total acidity, and pH were measured in the pyloric ligation-induced ulcer model. Results: AE showed a dose-dependent and significant (p < 0.05) decrease in the UI and an increase in the PI in all models employed compared to the control group. AE caused a dose-dependent decline in the gastric content volume, free acidity, and total acidity. Conclusion: The leaves of A. indica possess significant antiulcer activity and act via multiple mechanisms.
{"title":"Evaluation of the Antiulcer Activity of the Leaves of Azadirachta indica: An Experimental Study","authors":"P. Bhajoni, G. Meshram, M. Lahkar","doi":"10.1159/000442750","DOIUrl":"https://doi.org/10.1159/000442750","url":null,"abstract":"Background:Azadirachta indica, an evergreen tree, is used by several folkloric practitioners to treat peptic ulcers in India. The present study was carried out to evaluate the antiulcer activity of the aqueous extract (AE) of the leaves of A. indica in Wistar rats. Methods: Gastric ulcerations were induced by pyloric ligation, aspirin, and cold restraint stress. AE was used in doses of 150, 300, and 600 mg/kg body weight per os. Distilled water served as the control and ranitidine 20 mg/kg body weight intraperitoneal as the reference standard. The ulcer index (UI) and percentage inhibition (PI) values were determined in each model. The volume of gastric contents, free acidity, total acidity, and pH were measured in the pyloric ligation-induced ulcer model. Results: AE showed a dose-dependent and significant (p < 0.05) decrease in the UI and an increase in the PI in all models employed compared to the control group. AE caused a dose-dependent decline in the gastric content volume, free acidity, and total acidity. Conclusion: The leaves of A. indica possess significant antiulcer activity and act via multiple mechanisms.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"3 1","pages":"10 - 16"},"PeriodicalIF":0.0,"publicationDate":"2016-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000442750","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64985978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
For the first time in history, the Nobel Prize in Medicine 2015 was awarded to a researcher who is specialized in traditional Chinese medicine. The Chinese Tu Youyou received this highest award in medicine for her excellent work in malaria research. Tu Youyou and her team found out that artemisinin, the active ingredient of the medicinal herb ‘sweet wormwood', represents an effective malaria therapy. In the following article, the research that led to this Nobel Prize is introduced. In addition, the insidious tropical disease malaria will be explained briefly. Results of the research on moxibustion using Artemisia are also presented in this article; these studies were carried out at the TCM Research Center Graz, partly in close cooperation with the China Academy of Chinese Medical Sciences, the institution of the Nobel Prize winner.
{"title":"China's Tu Youyou, Nobel Laureate in Medicine 2015, and Relationships with the TCM Research Center Graz at the Medical University","authors":"D. Litscher, G. Litscher","doi":"10.1159/000442817","DOIUrl":"https://doi.org/10.1159/000442817","url":null,"abstract":"For the first time in history, the Nobel Prize in Medicine 2015 was awarded to a researcher who is specialized in traditional Chinese medicine. The Chinese Tu Youyou received this highest award in medicine for her excellent work in malaria research. Tu Youyou and her team found out that artemisinin, the active ingredient of the medicinal herb ‘sweet wormwood', represents an effective malaria therapy. In the following article, the research that led to this Nobel Prize is introduced. In addition, the insidious tropical disease malaria will be explained briefly. Results of the research on moxibustion using Artemisia are also presented in this article; these studies were carried out at the TCM Research Center Graz, partly in close cooperation with the China Academy of Chinese Medical Sciences, the institution of the Nobel Prize winner.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"3 1","pages":"1 - 9"},"PeriodicalIF":0.0,"publicationDate":"2015-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000442817","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64989998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aims: Vitiligo is a common disorder of depigmented skin. Traditional Chinese medicine (TCM) has been proved to be effective for the treatment of vitiligo, but the standard differential syndromes and effective formulas and herbs are still controversial. The aim of this study is to analyze the principles of differentiation and prescription in treating vitiligo in TCM based on a large-scale literature investigation. Methods: Articles about vitiligo treatment using TCM were searched in three databases, including China National Knowledge Infrastructure (1979-2014), China Science Periodical Database (1990-2014) and PubMed (1984-2014). The frequency of differential syndromes, formulas and herbs was analyzed using a metrological method and logistic multiple regression analysis. Results: Five syndromes account for the major differential categories in vitiligo: liver and kidney deficiency, Qi stagnation and blood stasis, liver depression and Qi stagnation, disharmony between Qi and blood, and blood conflicting with wind. The common formula prescriptions most frequently used were Tong-Qiao-Huo-Xue decoction, Xiao-Yao powder and Si-Wu decoction. The most frequently prescribed herbs were Angelica sinensis, Ligusticum wallichii, Tribulus terrestris, Polygonum multiflorum, Fructus psoraleae, Radix Paeoniae Rubra, Rehmannia glutinosa, Glossy Privet Fruit, Eclipta alba, Salvia miltiorrhiza, Liquorice, and Angelica dahurica, which shows that the treatment principles of vitiligo are tonifying the liver and kidney, activating blood and expelling wind. Conclusion: The most frequent syndromes of vitiligo are liver and kidney deficiency, Qi stagnation and blood stasis. Most TCM doctors prefer prescribing herbs with efficacy in tonifying the liver and kidney, activating blood and expelling wind in treating vitiligo.
{"title":"Principles of Differentiation and Prescription for Vitiligo in Traditional Chinese Medicine Based on a Literature Investigation","authors":"Chunjie Gao, Lili Yang, Mengjiao Chen, Huimin Zhang","doi":"10.1159/000441845","DOIUrl":"https://doi.org/10.1159/000441845","url":null,"abstract":"Background/Aims: Vitiligo is a common disorder of depigmented skin. Traditional Chinese medicine (TCM) has been proved to be effective for the treatment of vitiligo, but the standard differential syndromes and effective formulas and herbs are still controversial. The aim of this study is to analyze the principles of differentiation and prescription in treating vitiligo in TCM based on a large-scale literature investigation. Methods: Articles about vitiligo treatment using TCM were searched in three databases, including China National Knowledge Infrastructure (1979-2014), China Science Periodical Database (1990-2014) and PubMed (1984-2014). The frequency of differential syndromes, formulas and herbs was analyzed using a metrological method and logistic multiple regression analysis. Results: Five syndromes account for the major differential categories in vitiligo: liver and kidney deficiency, Qi stagnation and blood stasis, liver depression and Qi stagnation, disharmony between Qi and blood, and blood conflicting with wind. The common formula prescriptions most frequently used were Tong-Qiao-Huo-Xue decoction, Xiao-Yao powder and Si-Wu decoction. The most frequently prescribed herbs were Angelica sinensis, Ligusticum wallichii, Tribulus terrestris, Polygonum multiflorum, Fructus psoraleae, Radix Paeoniae Rubra, Rehmannia glutinosa, Glossy Privet Fruit, Eclipta alba, Salvia miltiorrhiza, Liquorice, and Angelica dahurica, which shows that the treatment principles of vitiligo are tonifying the liver and kidney, activating blood and expelling wind. Conclusion: The most frequent syndromes of vitiligo are liver and kidney deficiency, Qi stagnation and blood stasis. Most TCM doctors prefer prescribing herbs with efficacy in tonifying the liver and kidney, activating blood and expelling wind in treating vitiligo.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"149 - 156"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000441845","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64957055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diastolic heart failure (DHF) is a group of clinical syndromes related to the performance of the pulmonary circulation and systemic circulation, with normal left ventricular (LV) systolic function. The pathophysiology of diastolic dysfunction includes delayed relaxation, impaired LV filling, and/or increased stiffness. These conditions result in impaired LV diastolic relaxation ability and a decrease in myocardial compliance. In recent years, studies on the mechanisms of DHF have focused on the renin-angiotensin-aldosterone system, inflammatory cytokines, oxidative stress, the process of myocardial calcium cycling, and associated proteins. The pathomechanism has been proven to be due to a deficiency in ATP, and Ca2+ cannot be reduced by sarcoplasmic reticulum calcium pump (SERCA2a), which leads to myocardial diastolic dysfunction. The correlation between the degradation process of ATP and its metabolites and DHF has also been studied in recent years. This paper summarizes the views on the above and analyzes the correlations between the molecular mechanisms.
{"title":"The Molecular Mechanism of Diastolic Heart Failure","authors":"Jialin Gu, F. Zhao, Yuqi Wang, Junjie Gao, Xiaolong Wang, Jingui Xue, Hua Zhou","doi":"10.1159/000441223","DOIUrl":"https://doi.org/10.1159/000441223","url":null,"abstract":"Diastolic heart failure (DHF) is a group of clinical syndromes related to the performance of the pulmonary circulation and systemic circulation, with normal left ventricular (LV) systolic function. The pathophysiology of diastolic dysfunction includes delayed relaxation, impaired LV filling, and/or increased stiffness. These conditions result in impaired LV diastolic relaxation ability and a decrease in myocardial compliance. In recent years, studies on the mechanisms of DHF have focused on the renin-angiotensin-aldosterone system, inflammatory cytokines, oxidative stress, the process of myocardial calcium cycling, and associated proteins. The pathomechanism has been proven to be due to a deficiency in ATP, and Ca2+ cannot be reduced by sarcoplasmic reticulum calcium pump (SERCA2a), which leads to myocardial diastolic dysfunction. The correlation between the degradation process of ATP and its metabolites and DHF has also been studied in recent years. This paper summarizes the views on the above and analyzes the correlations between the molecular mechanisms.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"143 - 148"},"PeriodicalIF":0.0,"publicationDate":"2015-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000441223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64929108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prof. Wenjian Wang is currently a well-known Traditional Chinese Medicine (TCM) doctor and doctoral tutor of Fudan University. Leadership positions held by Prof. Wang include the presidency of the Integrative Medicine Institute and College of Integrative Medicine of Fudan University. He is also the vice chairman of the China Association of Integrated Traditional and Western Medicine, the president of the Shanghai Association of Chinese Integrative Medicine, and director of the major discipline of Integrative Medicine for the Chinese Ministry of Education. He is editor or associate editor of many journals, such as the Chinese Journal of Integrated Traditional and Western Medicine , Journal of Chinese Integrative Medicine , Chinese Patent Medicine , and Journal for Difficult Diseases , and serves as an editorial board member of many medical journals published in China and other countries. Prof. Wang is an internationally recognized integrative medicine expert of endocrine and metabolic diseases as well as cardiovascular and cerebral vascular diseases. In the late 2000s, Received: September 16, 2015 Accepted: September 17, 2015 Published online: October 15, 2015
{"title":"Integrative Medicine, the Direction of Future Medicine: An Interview with Prof. Wenjian Wang","authors":"Weidong Pan","doi":"10.1159/000441123","DOIUrl":"https://doi.org/10.1159/000441123","url":null,"abstract":"Prof. Wenjian Wang is currently a well-known Traditional Chinese Medicine (TCM) doctor and doctoral tutor of Fudan University. Leadership positions held by Prof. Wang include the presidency of the Integrative Medicine Institute and College of Integrative Medicine of Fudan University. He is also the vice chairman of the China Association of Integrated Traditional and Western Medicine, the president of the Shanghai Association of Chinese Integrative Medicine, and director of the major discipline of Integrative Medicine for the Chinese Ministry of Education. He is editor or associate editor of many journals, such as the Chinese Journal of Integrated Traditional and Western Medicine , Journal of Chinese Integrative Medicine , Chinese Patent Medicine , and Journal for Difficult Diseases , and serves as an editorial board member of many medical journals published in China and other countries. Prof. Wang is an internationally recognized integrative medicine expert of endocrine and metabolic diseases as well as cardiovascular and cerebral vascular diseases. In the late 2000s, Received: September 16, 2015 Accepted: September 17, 2015 Published online: October 15, 2015","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"139 - 142"},"PeriodicalIF":0.0,"publicationDate":"2015-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000441123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64926620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jingui Xue, Hua Zhou, Jialin Gu, F. Zhao, Yuqi Wang, Junjie Gao, Xiaolong Wang, P. Fsadni, F. Bezzina, N. Aquilina, C. Fsadni, S. Montefort, Huimin Zhang, Chunjie Gao, Lili Yang, Mengjiao Chen, Weidong Pan, Druckerei Stückle
{"title":"BIT's 2nd Annual World Congress of High-Tech Acupuncture and Integrative Medicine Hangzhou, May 2015: Abstracts","authors":"Jingui Xue, Hua Zhou, Jialin Gu, F. Zhao, Yuqi Wang, Junjie Gao, Xiaolong Wang, P. Fsadni, F. Bezzina, N. Aquilina, C. Fsadni, S. Montefort, Huimin Zhang, Chunjie Gao, Lili Yang, Mengjiao Chen, Weidong Pan, Druckerei Stückle","doi":"10.1159/000441070","DOIUrl":"https://doi.org/10.1159/000441070","url":null,"abstract":"","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"90 - 128"},"PeriodicalIF":0.0,"publicationDate":"2015-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000441070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64926089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Litscher, Lequan Min, C. Passegger, D. Litscher, Min Li, Mian Wang, Nassim Ghaffari-Tabrizi-Wizsy, Ingeborg Stelzer, G. Feigl, Ingrid Gaischek, Guangjun Wang, A. Sadjak, F. Bahr
Background: The use of transcranial laser or light-emitting diode (LED) therapy in the treatment of different neurological diseases is attracting increasing attention. The main goal of this study was to investigate different kinds of scientifically and commercially available laser (yellow, red, and infrared) and LED stimulation systems for the first time using a chick embryo model under a fixed human cadaver (scalp and/or skull) and without this anatomical preparation. Methods: In the present study, the extra-embryonic vasculature of a 1-week-old chick embryo chorioallantoic membrane (CAM) was investigated. For stimulation, four different systems were used (infrared LED and yellow, red, and infrared laser). Four measurement periods were compared: before stimulation, immediately after stimulation onset, immediately after the 10-min stimulation was turned off, and 6 min after stimulation had ended. Special image processing programs developed at the Beijing University of Science and Technology were used for data analysis. Results: The different kinds of laser induced different effects, e.g. the direct stimulation with yellow laser led to initial vasoconstriction (-17%), whereas yellow laser stimulation through a human skull resulted in an increase in blood volume. These effects could only be observed after mathematical processing of the images. Conclusion: After intensive basic research (e.g. CAM model), transcranial laser stimulation may open up new therapies for lifestyle-related diseases such as stroke, dementia, Alzheimer's or possibly Parkinson's disease.
{"title":"Transcranial Yellow, Red, and Infrared Laser and LED Stimulation: Changes of Vascular Parameters in a Chick Embryo Model","authors":"G. Litscher, Lequan Min, C. Passegger, D. Litscher, Min Li, Mian Wang, Nassim Ghaffari-Tabrizi-Wizsy, Ingeborg Stelzer, G. Feigl, Ingrid Gaischek, Guangjun Wang, A. Sadjak, F. Bahr","doi":"10.1159/000431176","DOIUrl":"https://doi.org/10.1159/000431176","url":null,"abstract":"Background: The use of transcranial laser or light-emitting diode (LED) therapy in the treatment of different neurological diseases is attracting increasing attention. The main goal of this study was to investigate different kinds of scientifically and commercially available laser (yellow, red, and infrared) and LED stimulation systems for the first time using a chick embryo model under a fixed human cadaver (scalp and/or skull) and without this anatomical preparation. Methods: In the present study, the extra-embryonic vasculature of a 1-week-old chick embryo chorioallantoic membrane (CAM) was investigated. For stimulation, four different systems were used (infrared LED and yellow, red, and infrared laser). Four measurement periods were compared: before stimulation, immediately after stimulation onset, immediately after the 10-min stimulation was turned off, and 6 min after stimulation had ended. Special image processing programs developed at the Beijing University of Science and Technology were used for data analysis. Results: The different kinds of laser induced different effects, e.g. the direct stimulation with yellow laser led to initial vasoconstriction (-17%), whereas yellow laser stimulation through a human skull resulted in an increase in blood volume. These effects could only be observed after mathematical processing of the images. Conclusion: After intensive basic research (e.g. CAM model), transcranial laser stimulation may open up new therapies for lifestyle-related diseases such as stroke, dementia, Alzheimer's or possibly Parkinson's disease.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"80 - 89"},"PeriodicalIF":0.0,"publicationDate":"2015-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000431176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64875067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aim: The mechanisms and processes of amyloid beta (Aβ)1-42/Aβ1-40 degeneration and deposition of neuron damage are still not clear. The long noncoding RNA (lncRNA) is one of the members of the noncoding RNA family. In this study, we aimed to investigate whether Aβ1-42 inhibited SH-SY5Y cells in vitro through modulating Meg3 lncRNA. Methods: The Alzheimer's disease (AD) senile plaque cell model was generated using synthetic Aβ1-42-treated SH-SY5Y cells. MTT assays were used to determine the proliferation of SH-SY5Y cells. Quantitative (q)RT-PCR and Western blot analyses were used to test the expression levels of mRNA and protein. Northern blot analysis was used to confirm Meg3 lncRNA expression. Results: The MTT assays showed that exogenous Aβ1-42 suppressed SH-SY5Y cells. The qRT-PCR and Western blot analyses revealed that the expression of p53 mRNA and protein was significantly increased in the AD model group, with a marked decrease in MDM2 and Ki-67 expression on day 7. Moreover, the qRT-PCR and Northern blot analyses confirmed that exogenous Aβ1-42 promoted the expression of Meg3 lncRNA. There was a downregulation of Meg3 lncRNA expression in SH-SY5Y cells by siRNA, which could promote of the ability of MDM2 to degrade p53 protein on the ubiquitin pathway and delay SH-SY5Y apoptosis. Conclusion: Meg3 lncRNA is implicated as an important factor in the formation of mature Aβ peptides.
{"title":"Amyloid Beta Peptide 1-42 Induces SH-SY5Y Cell Apoptosis via the Promotion of Meg3 Long Noncoding RNA Expression","authors":"Yongyi Huang, Te Liu","doi":"10.1159/000438702","DOIUrl":"https://doi.org/10.1159/000438702","url":null,"abstract":"Background/Aim: The mechanisms and processes of amyloid beta (Aβ)1-42/Aβ1-40 degeneration and deposition of neuron damage are still not clear. The long noncoding RNA (lncRNA) is one of the members of the noncoding RNA family. In this study, we aimed to investigate whether Aβ1-42 inhibited SH-SY5Y cells in vitro through modulating Meg3 lncRNA. Methods: The Alzheimer's disease (AD) senile plaque cell model was generated using synthetic Aβ1-42-treated SH-SY5Y cells. MTT assays were used to determine the proliferation of SH-SY5Y cells. Quantitative (q)RT-PCR and Western blot analyses were used to test the expression levels of mRNA and protein. Northern blot analysis was used to confirm Meg3 lncRNA expression. Results: The MTT assays showed that exogenous Aβ1-42 suppressed SH-SY5Y cells. The qRT-PCR and Western blot analyses revealed that the expression of p53 mRNA and protein was significantly increased in the AD model group, with a marked decrease in MDM2 and Ki-67 expression on day 7. Moreover, the qRT-PCR and Northern blot analyses confirmed that exogenous Aβ1-42 promoted the expression of Meg3 lncRNA. There was a downregulation of Meg3 lncRNA expression in SH-SY5Y cells by siRNA, which could promote of the ability of MDM2 to degrade p53 protein on the ubiquitin pathway and delay SH-SY5Y apoptosis. Conclusion: Meg3 lncRNA is implicated as an important factor in the formation of mature Aβ peptides.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"73 - 79"},"PeriodicalIF":0.0,"publicationDate":"2015-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000438702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64896104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alzheimer's disease (AD) is the most common neurodegenerative disease, and its mechanisms have not been clearly elucidated. A large percentage (more than 95%) of cases are late-onset AD without familial traits. Although some genes have been implicated in the pathogenesis and the risk of developing sporadic AD, they only account for the minority of late-onset AD. Recently, accumulating data have suggested a potential role for epigenetic mechanisms in neurodegenerative processes leading to dementia. Alterations in the epigenetic machinery cause aberrant DNA methylation and histone acetylation. Therefore, these changes trigger alterations on the transcriptional level of genes involved in the pathogenesis of AD. In this review, we summarize recent advances in research on AD caused by common epigenetic modification and the potential treatment strategies targeting the epigenetic machinery.
{"title":"Epigenetic Modification and Its Role in Alzheimer's Disease","authors":"Yiping Zhu, Ya Feng, Te Liu, Yun-Cheng Wu","doi":"10.1159/000437329","DOIUrl":"https://doi.org/10.1159/000437329","url":null,"abstract":"Alzheimer's disease (AD) is the most common neurodegenerative disease, and its mechanisms have not been clearly elucidated. A large percentage (more than 95%) of cases are late-onset AD without familial traits. Although some genes have been implicated in the pathogenesis and the risk of developing sporadic AD, they only account for the minority of late-onset AD. Recently, accumulating data have suggested a potential role for epigenetic mechanisms in neurodegenerative processes leading to dementia. Alterations in the epigenetic machinery cause aberrant DNA methylation and histone acetylation. Therefore, these changes trigger alterations on the transcriptional level of genes involved in the pathogenesis of AD. In this review, we summarize recent advances in research on AD caused by common epigenetic modification and the potential treatment strategies targeting the epigenetic machinery.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"63 - 72"},"PeriodicalIF":0.0,"publicationDate":"2015-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000437329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64887501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weidong Pan, Jun Liu, Xiangjun Chen, Qiudong Wang, Yuncheng Wu, Yu Bai, Yi Liu, Wentao Li, Wenwei Li, Can-Xing Yuan, Weiguo Hou, Xiaoying Bi, J. Zhuang, Qin Dong, Dingfang Cai
Integrative medicine, including traditional Chinese medicine (TCM), is a new concept in clinical practice for the treatment of neurodegenerative and most chronic diseases. However, integrative consensus or a guideline for the management of patients with Parkinson's disease (PD) is still lacking. The aim of this paper is to provide a review of experiences in clinical practice from Chinese neurologists and physicians (including TCM doctors) in Shanghai, China, and try to provide a clinical guideline for the treatment of the complex and progressive disease of PD with integrative medicine. We included the following treatments: common Western medication, surgery, TCM decoction and patent medicines, acupuncture and Tui na, Yoga, Tai chi chuan, hyperbaric oxygenation, rehabilitation, and other complementary and alternative medicines for the integrative management of the disease. Neurologists and physicians in Shanghai, China, and all over the world should pay attention to integrative medicine, which may be a good choice of treatment for PD.
{"title":"A Practical Consensus Guideline for the Integrative Treatment of Parkinson's Disease in Shanghai, China","authors":"Weidong Pan, Jun Liu, Xiangjun Chen, Qiudong Wang, Yuncheng Wu, Yu Bai, Yi Liu, Wentao Li, Wenwei Li, Can-Xing Yuan, Weiguo Hou, Xiaoying Bi, J. Zhuang, Qin Dong, Dingfang Cai","doi":"10.1159/000435813","DOIUrl":"https://doi.org/10.1159/000435813","url":null,"abstract":"Integrative medicine, including traditional Chinese medicine (TCM), is a new concept in clinical practice for the treatment of neurodegenerative and most chronic diseases. However, integrative consensus or a guideline for the management of patients with Parkinson's disease (PD) is still lacking. The aim of this paper is to provide a review of experiences in clinical practice from Chinese neurologists and physicians (including TCM doctors) in Shanghai, China, and try to provide a clinical guideline for the treatment of the complex and progressive disease of PD with integrative medicine. We included the following treatments: common Western medication, surgery, TCM decoction and patent medicines, acupuncture and Tui na, Yoga, Tai chi chuan, hyperbaric oxygenation, rehabilitation, and other complementary and alternative medicines for the integrative management of the disease. Neurologists and physicians in Shanghai, China, and all over the world should pay attention to integrative medicine, which may be a good choice of treatment for PD.","PeriodicalId":91502,"journal":{"name":"Integrative medicine international","volume":"2 1","pages":"56 - 62"},"PeriodicalIF":0.0,"publicationDate":"2015-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000435813","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64880995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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