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Evaluation of Movements in Tapping and Tremor from the Viewpoint of the Theory of Chaos and Self-Organization 从混沌和自组织理论的角度评价敲击和震颤的运动
Pub Date : 2016-08-12 DOI: 10.1159/000446281
A. Khadartsev, V. Eskov, Weidong Pan
Chaos in the organization of any human or animal movement has its own parameters in the form of quasi-attractors, and these parameters (quasi-attractors) have a diagnostically significant value. Motor activity of any biological entity in biomechanics consists of a real superposition of voluntary acts (i.e., having a goal and the mechanisms of its implementation) and an obligatory element of chaos when the arbitrary motor activity cannot really be implemented arbitrarily. This paper presents examples of the practical implementation of the parameters of chaos in clinical medicine and their diagnostic value.
任何人类或动物运动组织中的混沌都有自己的准吸引子形式的参数,这些参数(准吸引子)具有诊断意义。在生物力学中,任何生物实体的运动活动都是由自愿行为(即具有目标及其实现机制)的真实叠加和当任意运动活动无法真正任意执行时的强制性混乱元素组成的。本文介绍了混沌参数在临床医学中的应用实例及其诊断价值。
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引用次数: 0
Clinical Effects of a 6-Month Treatment Course of Ibandronate, Vitamin D, and Calcium in Postmenopausal Women from Central America: Results of a Multinational, Prospective Pilot Study 6个月伊班膦酸盐、维生素D和钙治疗中美洲绝经后妇女的临床效果:一项多国前瞻性试点研究的结果
Pub Date : 2016-08-04 DOI: 10.1159/000448478
C. Gutierrez, Helga Codina, Cesar Benjamin Matamoros Pinel, Edin Hidalgo, Arturo Arellano, M. V. Rey, S. Pérez-Lloret
Background/Aims: To explore the effects of ibandronate plus a supplementation of vitamin D and calcium on bone mineral density (BMD) and health-related quality of life (HRQoL) in a sample of postmenopausal women from Central America. Secondarily, factors related to the magnitude of improvements in BMD after treatment were investigated. Methods: Postmenopausal women with idiopathic osteoporosis or at risk of developing it, who were going to start treatment with ibandronate 150 mg once a month plus daily supplementation with vitamin D 400-800 IU and calcium 500-1,000 mg, were followed up for 6 months. BMD, HRQoL (mini-Osteoporosis Quality of Life Questionnaire), and treatment adherence (Morisky scale) were studied before and after treatment. Results: Four hundred and twenty-five women were assessed at baseline, and 308 (72%) were reassessed at month 6. Lumbar spine, proximal femur, and hip BMD increased by 3.35 ± 0.75, 1.88 ± 0.50, and 2.75 ± 0.32%, respectively (p < 0.001 for all). HRQoL total score and emotional functioning, symptoms, physical function, and leisure subscores improved by 26-49% (p < 0.01 in all cases). Lower body mass index, younger age at menopause, use of corticoids, and higher adherence were significantly and independently associated with a greater improvement in lumbar spine BMD (logistic regression). Conclusion: Improvements in BMD and HRQoL after ibandronate, vitamin D, and calcium were observed in patients from Central America, which should be confirmed by double-blind, randomized, controlled trials. Lack of adherence to ibandronate was related to worse outcomes, thus highlighting the need for work on this issue with patients on treatment.
背景/目的:探讨伊班膦酸盐加补充维生素D和钙对中美洲绝经后妇女骨密度(BMD)和健康相关生活质量(HRQoL)的影响。其次,研究了治疗后骨密度改善程度的相关因素。方法:绝经后特发性骨质疏松症或有发生骨质疏松症危险的妇女,开始使用伊班膦酸酯150 mg,每月1次,每日补充维生素D 400-800 IU和钙500- 1000 mg,随访6个月。研究治疗前后BMD、HRQoL (mini-骨质疏松症生活质量问卷)、治疗依从性(Morisky量表)。结果:425名妇女在基线时接受了评估,308名(72%)在第6个月时重新接受了评估。腰椎、股骨近端和髋部骨密度分别增加3.35±0.75、1.88±0.50和2.75±0.32%(均p < 0.001)。HRQoL总分和情绪功能、症状、身体功能、休闲评分改善26-49% (p < 0.01)。较低的身体质量指数、较年轻的绝经年龄、皮质激素的使用和较高的依从性与腰椎骨密度的改善显著且独立相关(logistic回归)。结论:中美洲患者在服用依班膦酸盐、维生素D和钙后,骨密度和HRQoL均有改善,有待于双盲、随机、对照试验证实。缺乏对依班膦酸盐的依从性与较差的结果有关,因此强调需要对正在接受治疗的患者进行这一问题的研究。
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引用次数: 0
A Laser Watch for Simultaneous Laser Blood Irradiation and Laser Acupuncture at the Wrist 一种腕部激光血液照射和激光针灸同时使用的激光手表
Pub Date : 2016-07-23 DOI: 10.1159/000448099
G. Litscher, D. Litscher
Background: Laser medicine in general has experienced enormous progress over the last years. The latest innovation is a so-called laser watch, a system only slightly larger than a wrist watch. Methods: The laser watch is applied to the wrist, where simultaneous and continuous acupuncture point or blood irradiation using laser light can be performed. Results: This results in new and promising therapeutic approaches for different diseases. This article introduces and briefly discusses the first pilot measurements with regard to the laser watch. Conclusion: The laser watch is practicable; however, further research is absolutely necessary before the laser watch is widely used.
背景:在过去的几年里,激光医学总体上经历了巨大的进步。最新的创新是所谓的激光手表,这个系统只比手表大一点。方法:将激光手表贴在手腕上,用激光同时连续照射穴位或血液。结果:这为不同的疾病带来了新的和有希望的治疗方法。本文介绍并简要讨论了激光手表的首次先导测量。结论:激光手表是可行的;然而,在激光手表被广泛应用之前,进一步的研究是绝对必要的。
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引用次数: 15
Advancing the Adoption of Integrative Medicine: A Quick Guide to Publishing Research in Integrative Medicine International 推进整合医学的采用:国际整合医学出版研究快速指南
Pub Date : 2016-07-21 DOI: 10.1159/000448037
Weidong Pan, C. Jones
Researchers and clinicians in integrative medicine (IM) are well aware that the research and reporting methods they use should be as scientifically rigorous as those used in conventional medicine. To establish the scientific evidence needed to promote the further adoption of traditional medicine (TM) and complementary and alternative medicine (CAM) into healthcare systems worldwide, it is important that doctors of IM publish their findings in English. The English-language, cross-disciplinary journal Integrative Medicine International aims to publish such work, by focusing on reporting ‘new methods in [TM/CAM] research and therapy to complement and extend the methods of Western medicine'. The journal acts as a portal for the latest innovations, developments, trends, opinions, and achievements in TM. The purpose of this editorial is to encourage and support authors across a wide range of disciplines to report their research and clinical findings in IM. The article starts by explaining the process of preparing a suitable manuscript for the journal and then describes the general process of manuscript preparation, peer review, and publication that is common to many international journals. Some advices are also given to authors who are nonnative speakers to help them submit manuscripts of sufficient quality of English for review and in accordance with ethical publishing standards.
综合医学(IM)的研究人员和临床医生很清楚,他们使用的研究和报告方法应该像传统医学中使用的方法一样在科学上严格。为了建立促进传统医学(TM)和补充和替代医学(CAM)进一步进入全球卫生保健系统所需的科学证据,IM医生用英语发表他们的发现是很重要的。英文、跨学科期刊《国际中西医结合》(Integrative Medicine International)的目标是发表这样的研究成果,重点报道“[TM/CAM]研究和治疗中的新方法,以补充和扩展西方医学的方法”。该杂志是TM领域最新创新、发展、趋势、观点和成就的门户。这篇社论的目的是鼓励和支持各个学科的作者在IM杂志上报告他们的研究和临床发现。这篇文章首先解释了为期刊准备一份合适的手稿的过程,然后描述了许多国际期刊共同的手稿准备、同行评审和出版的一般过程。对于非英语为母语的作者,也给出了一些建议,帮助他们提交足够质量的英文稿件供评审,并符合道德出版标准。
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引用次数: 0
Kidneys in Oriental and Occidental Medicine 肾在东方和西方医学
Pub Date : 2016-07-15 DOI: 10.1159/000447491
T. Kondo
Background: Oriental medicine is based on the 5-phase theory, in which the balance among the 5 viscera - the liver, the heart, the spleen, the lung and the kidney - is important. It is confusing that the viscera in Oriental and Occidental medicine have the same name. Out of the 5 viscera in Oriental medicine, it is the spleen that differs most from that in Occidental medicine. It mainly corresponds to the digestive organs and pancreas and has no relation to the spleen in Occidental medicine, a kind of lymph tissue. On the other hand, the concept of each of the other Oriental viscera includes the corresponding viscus in Occidental medicine. Key Messages: The 11 aspects of the kidney in Oriental medicine correspond to three kinds of endocrine and metabolic systems, all of which are associated with aging.
背景:东方医学是以五相学说为基础的,五脏——肝、心、脾、肺和肾——之间的平衡很重要。东西方医学的脏器名称相同,令人困惑。在东方医学的五脏中,与西方医学区别最大的是脾。它在西方医学中主要与消化器官和胰腺相对应,与脾无关,是一种淋巴组织。另一方面,其他东方脏腑的概念在西方医学中包括相应的脏腑。东方医学中肾的11个方面对应着三种内分泌和代谢系统,它们都与衰老有关。
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引用次数: 2
Immune Responses Mediated by Th17 Cells in Helicobacter pylori Infection 幽门螺杆菌感染中Th17细胞介导的免疫应答
Pub Date : 2016-07-09 DOI: 10.1159/000446317
Chang Liu, Zhengli Zhang, Meiping Zhu
T helper 17 (Th17) cells are one of the CD4+ T-cell subsets which induce a variety of diseases by secreting IL-17 and other inflammatory factors. After Helicobacter pylori (Hp) infection, cytotoxin-associated gene A and urease subunit B regulate the number of Th17 cells via induction of cell differentiation by infected macrophages, activation of MyD88 and other pathways, and by driving chemokines, which upregulates the number of both Th17 cells and regulatory T cells (Tregs) and switches towards a Treg-type immune response. Meanwhile, Th17 cells also play important roles in the response to Hp infection, participating in the clearance of Hp by recruiting neutrophils and expanding inflammatory response, causing mucosal damage and even inducing cancer. Thereby, Th17 cells participate in the occurrence and development of Hp-related diseases, such as gastritis, peptic ulcer disease and gastric cancer.
T辅助17 (Th17)细胞是CD4+ T细胞亚群之一,通过分泌IL-17等炎症因子诱导多种疾病。幽门螺杆菌(Hp)感染后,细胞毒素相关基因A和脲酶亚基B通过被感染的巨噬细胞诱导细胞分化、MyD88的激活等途径,以及驱动趋化因子调控Th17细胞和调节性T细胞(treg)的数量,并转向treg型免疫应答。同时,Th17细胞在Hp感染应答中也发挥着重要作用,通过募集中性粒细胞参与Hp的清除,扩大炎症反应,引起粘膜损伤,甚至诱发癌症。由此可见,Th17细胞参与了胃炎、消化性溃疡疾病、胃癌等hp相关疾病的发生发展。
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引用次数: 6
Herbal Medicine-Induced Liver Injury in China 中国草药性肝损伤的研究
Pub Date : 2016-05-14 DOI: 10.1159/000444485
Xin Sun, Tao Yang, Chunwu Zhu, Hai-nan Wang, Cheng-hai Liu
Herbal medicine (HM) has been widely used to prevent and treat diseases for thousands of years. However, recent increasing evidence shows that HM-induced liver injury (HILI) is not something to be ignored. In fact, herbal toxicity has always been recognized and emphasized in the long history of Traditional Chinese Medicine. In this article, we analyzed the situation of HILI in China and its risk factors in detail. In addition, the legal regime of the HM industry in contemporary China is introduced. Recently, the mechanisms of HILI have been widely studied, and epidemiological investigations into HILI have been conducted. In the future, a comprehensive platform for research and communication could help facilitate the development of strategies to predict and prevent HILI.
几千年来,草药一直被广泛用于预防和治疗疾病。然而,最近越来越多的证据表明,hm诱导的肝损伤(HILI)是不可忽视的。事实上,在漫长的中医历史中,草药的毒性一直受到人们的认可和重视。在本文中,我们详细分析了HILI在中国的情况及其危险因素。此外,还介绍了当代中国HM行业的法律制度。近年来,人们对HILI的发病机制进行了广泛的研究,并开展了HILI的流行病学调查。在未来,一个全面的研究和交流平台可以帮助制定预测和预防HILI的策略。
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引用次数: 1
Targeting ONOO-/HMGB1/MMP-9 Signaling Cascades: Potential for Drug Development from Chinese Medicine to Attenuate Ischemic Brain Injury and Hemorrhagic Transformation Induced by Thrombolytic Treatment 靶向ONOO-/HMGB1/MMP-9信号级联:中药药物开发减轻缺血性脑损伤和溶栓治疗引起的出血转化的潜力
Pub Date : 2016-02-03 DOI: 10.1159/000442468
Hansen Chen, Binghe Guan, Jiangang Shen
Stroke is the leading cause of death and disability worldwide, and ischemic stroke accounts for more than 85% of the stroke incidence. Tissue plasminogen activator (t-PA) is the only FDA-approved drug for ischemic stroke treatment with a narrow treatment time window of 4.5 h. Hemorrhagic transformation (HT) is a severe complication of delayed t-PA treatment in ischemic stroke. Thus, it is critically important to develop combination therapies to reduce HT and extend the therapeutic time window of t-PA. Current progress suggests that peroxynitrite (ONOO-)/high-mobility group box 1 protein (HMGB1)/matrix metalloproteinase-9 (MMP-9) signaling cascades could be important for attenuating HT during thrombolytic treatment for acute ischemic stroke. Recently, important progress has been made in seeking for natural compounds from Chinese medicine for reducing ischemic stroke injury, with some of them targeting ONOO-/HMGB1/MMP-9 signaling cascades. Herein, we analyze the roles and interactions of these three targets in mediating HT; subsequently, we summarize the potential compounds from Chinese herbal medicine for attenuating HT and analyze the related targets. Finally, we raise the potential issues to be addressed in further development of these compounds as combination therapy.
中风是世界范围内导致死亡和残疾的主要原因,缺血性中风占中风发病率的85%以上。组织纤溶酶原激活剂(Tissue plasminogen activator, t-PA)是fda唯一批准的用于缺血性卒中治疗的药物,治疗时间窗较窄,仅为4.5小时。出血转化(Hemorrhagic transformation, HT)是延迟t-PA治疗缺血性卒中的严重并发症。因此,开发联合疗法以减少HT和延长t-PA的治疗时间窗至关重要。目前的进展表明,过氧亚硝酸盐(ONOO-)/高迁移率组盒1蛋白(HMGB1)/基质金属蛋白酶-9 (MMP-9)信号级联可能对急性缺血性卒中溶栓治疗期间减轻HT很重要。近年来,从中药中寻找减轻缺血性脑卒中损伤的天然化合物取得了重要进展,其中一些靶向ONOO-/HMGB1/MMP-9信号级联。在此,我们分析了这三个靶点在介导HT中的作用和相互作用;随后,我们总结了中草药中可能具有减毒作用的化合物,并分析了相关靶点。最后,我们提出了在进一步开发这些化合物作为联合治疗中需要解决的潜在问题。
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引用次数: 8
Application of Laser Phoresis in Complicated Postmenopausal Osteoporosis 激光电泳在绝经后复杂骨质疏松症中的应用
Pub Date : 2016-01-15 DOI: 10.1159/000442669
E. Belyaeva, A. Khadartsev, I. Fedorischev, A. S. Sazonov
This study presents postmenopausal osteoporosis as a feature of metabolic systemic diseases of the skeleton, with abnormalities of the bone microarchitecture and reduction in bone mineral density, leading to an increased risk of fractures with a low level of trauma. The neurological manifestations of such fractures are uncharacteristic, representing a differential diagnostic indication. There is a change of posture in the form of hyperkyphosis of the thoracic spine and loss of height due to the increase in the number of modified vertebrae. The age of these patients is between 66 and 68 years, which limits the use of traditional analgesic preparations. The ionized gel ‘Giasulf' was applied in 29 cases according to the developed technology. The description of the composition of the gel that provides maximum analgesic effect, reinforced by the influence of laser radiation on the cell membranes, is presented. A significant antinociceptive effect was obtained.
本研究表明,绝经后骨质疏松症是骨骼代谢性全身性疾病的一个特征,伴有骨微结构异常和骨矿物质密度降低,导致低水平创伤的骨折风险增加。这类骨折的神经学表现是非特征性的,是一种鉴别诊断指征。姿势的改变表现为胸椎后凸过度以及由于椎体数目的增加而造成的高度损失。这些患者的年龄在66岁至68岁之间,这限制了传统镇痛制剂的使用。根据所开发的技术,将离子凝胶“Giasulf”应用于29例病例。描述了凝胶的组成,提供了最大的镇痛效果,加强了激光辐射对细胞膜的影响,被提出。具有明显的抗伤害感受作用。
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引用次数: 1
SCN's 1st Annual Congress of Neuroendocrinology, Neuroimmunology and Chinese Integrative Medicine, and Gongji Stroke Forum. Shanghai General Hospital. Shanghai, China, November 19-20, 2015: Abstracts 第一届神经内分泌学、神经免疫学与中西医结合学术年会暨工机卒中学术论坛。上海总医院。中国,上海,2015年11月19-20日:摘要
Pub Date : 2016-01-15 DOI: 10.1159/000443318
Helga Codina, C. Gutierrez, C. Pinel, Edin Hidalgo, Arturo Arellano, M. V. Rey, S. Pérez-Lloret, G. Meshram, P. Bhajoni, M. Lahkar, Jiangang Shen, Hansen Chen, Binghe Guan, Weidong Pan, C. Jones, A. Khadartsev, E. Belyaeva, I. Fedorischev, A. S. Sazonov, T. Kondo, Chang Liu, Zhengli Zhang, Meiping Zhu, D. Litscher, G. Litscher, Xin Sun, Hai-nan Wang, Tao Yang, Chunwu Zhu, Cheng-hai Liu, V. Eskov, Druckerei Stückle
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引用次数: 0
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Integrative medicine international
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