Journal of lung, pulmonary & respiratory research最新文献_第5页

Malignant pleural mesothelioma: current perspectives 恶性胸膜间皮瘤:目前的观点

Journal of lung, pulmonary & respiratory research

Pub Date : 2020-04-02 DOI: 10.15406/jlprr.2020.07.00226

A. Cheepsattayakorn, R. Cheepsattayakorn, Supawan Manosoontorn, Vijaya Bhakskara Reddy Mutha

The objectives of this study are to review epidemiology, novel methods of detection, novel diagnostics, and novel therapeutic options of malignant pleural mesothelioma (MPM) in the literature that were published between 1977 and 2019. Malignant pleural mesothelioma, associated with prolonged respirable-asbestos-fiber exposure is a rare cancer with constantly increasing incidence and poor prognosis due to lacking the effective treatment options. The median survival ranges from 8 to 14 months. Sarcomatoid histological subtype has the worst prognosis. Video-assisted thoracoscopy plus mediastinoscopy is the current gold standard for staging malignant pleural mesothelioma and is superior to computerized tomography of the chest for assessing the tumor size and suspected nodal metastases. Several circulating biomarkers are detected in MPM patients, such as mesothelin, osteopontin, fibulin-3, high mobility group B1, vascular endothelial growth factor, reactive oxygen species, reactive nitrogen species, micro-ribonucleic acids, tumor deoxyribonucleic acid, etc.Surgery is controversial and restricted to patients with early stage disease and good functional status. There is still no curative treatment whereas chemotherapy is the only treatment modality that improve patients’ survival. Radiotherapy is beneficial as a palliative treatment and an adjuvant to chemotherapy and surgery in the context of trimodality treatment. In conclusion, there is potential for the development of biomarkers and radiological imaging in the years to come. Several novel therapeutic options are under studied and it is likely to involve highly personalized treatment. Its incidenceis expected to decrease in the next decade.

本研究的目的是回顾1977年至2019年间发表的恶性胸膜间皮瘤(MPM)的流行病学、新检测方法、新诊断方法和新治疗方案。恶性胸膜间皮瘤是一种罕见的癌症，与长期呼吸石棉纤维接触有关，由于缺乏有效的治疗方案，发病率不断增加，预后差。中位生存期为8至14个月。肉瘤样组织学亚型预后最差。电视胸腔镜+纵隔镜检查是目前恶性胸膜间皮瘤分期的金标准，在评估肿瘤大小和疑似淋巴结转移方面优于胸部计算机断层扫描。在MPM患者中检测到多种循环生物标志物，如间皮素、骨桥蛋白、纤维蛋白-3、高迁移率组B1、血管内皮生长因子、活性氧、活性氮、微核糖核酸、肿瘤脱氧核糖核酸等。手术存在争议，仅限于疾病早期、功能状态良好的患者。目前还没有治愈的治疗方法，而化疗是唯一能提高患者生存率的治疗方式。在三重治疗的背景下，放疗作为一种姑息性治疗和辅助化疗和手术是有益的。总之，生物标志物和放射成像在未来几年有很大的发展潜力。一些新的治疗方案正在研究中，可能涉及高度个性化的治疗。预计其发病率将在未来十年下降。

{"title":"Malignant pleural mesothelioma: current perspectives","authors":"A. Cheepsattayakorn, R. Cheepsattayakorn, Supawan Manosoontorn, Vijaya Bhakskara Reddy Mutha","doi":"10.15406/jlprr.2020.07.00226","DOIUrl":"https://doi.org/10.15406/jlprr.2020.07.00226","url":null,"abstract":"The objectives of this study are to review epidemiology, novel methods of detection, novel diagnostics, and novel therapeutic options of malignant pleural mesothelioma (MPM) in the literature that were published between 1977 and 2019. Malignant pleural mesothelioma, associated with prolonged respirable-asbestos-fiber exposure is a rare cancer with constantly increasing incidence and poor prognosis due to lacking the effective treatment options. The median survival ranges from 8 to 14 months. Sarcomatoid histological subtype has the worst prognosis. Video-assisted thoracoscopy plus mediastinoscopy is the current gold standard for staging malignant pleural mesothelioma and is superior to computerized tomography of the chest for assessing the tumor size and suspected nodal metastases. Several circulating biomarkers are detected in MPM patients, such as mesothelin, osteopontin, fibulin-3, high mobility group B1, vascular endothelial growth factor, reactive oxygen species, reactive nitrogen species, micro-ribonucleic acids, tumor deoxyribonucleic acid, etc.Surgery is controversial and restricted to patients with early stage disease and good functional status. There is still no curative treatment whereas chemotherapy is the only treatment modality that improve patients’ survival. Radiotherapy is beneficial as a palliative treatment and an adjuvant to chemotherapy and surgery in the context of trimodality treatment. In conclusion, there is potential for the development of biomarkers and radiological imaging in the years to come. Several novel therapeutic options are under studied and it is likely to involve highly personalized treatment. Its incidenceis expected to decrease in the next decade.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"181 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85452666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophilic asthma: a complex phenotype of severe asthma 嗜中性粒细胞哮喘:严重哮喘的一种复杂表型

Journal of lung, pulmonary & respiratory research

Pub Date : 2020-03-20 DOI: 10.15406/jlprr.2020.07.00223

N. Syabbalo

Asthma is a common chronic airway disease affecting about 334 million people worldwide, and an estimated 7 million children globally. Approximately 10% of patients with asthma have severe refractory disease, which is difficult to control on high doses of inhaled corticosteroids and other modifiers. Among these, are patients with severe neutrophilic asthma. Neutrophilic asthma is a phenotype of asthma that is very severe and persistent, with frequent exacerbations, and characterized by fixed airway obstruction. It is associated with comorbidities such as respiratory infections, obesity, gastroeosophageal reflux disease, and obstructive sleep apnoea. Immunopathologically, it is characterized by the presence of high levels of neutrophils in the lungs and airways. Neutrophils and the interleukin-17 family of cytokines play a pivotal role in the pathogenesis of severe neutrophilic asthma. Most patients with the disease do not achieve control with high dose inhaled corticosteroids, and probably to novel IgE, interleukin and interleukin monoclonal antibodies.

哮喘是一种常见的慢性气道疾病，影响全球约3.34亿人，全球估计有700万儿童。大约10%的哮喘患者患有严重的难治性疾病，通过高剂量吸入皮质类固醇和其他调节剂难以控制。其中，有严重的嗜中性粒细胞哮喘患者。中性粒细胞哮喘是一种非常严重和持续的哮喘表型，经常发作，以固定气道阻塞为特征。它与呼吸道感染、肥胖、胃食管反流病和阻塞性睡眠呼吸暂停等合并症有关。在免疫病理学上，它的特点是在肺和气道中存在高水平的中性粒细胞。中性粒细胞和白细胞介素-17家族细胞因子在严重中性粒细胞性哮喘的发病机制中起关键作用。大多数患者不能通过大剂量吸入皮质类固醇获得控制，可能需要新的IgE、白细胞介素和白细胞介素单克隆抗体。

引用次数: 3

Andrographis paniculata(Green chiretta) may combat COVID-19

Journal of lung, pulmonary & respiratory research

Pub Date : 2020-03-02 DOI: 10.15406/JLPRR.2020.07.00224

A. Cheepsattayakorn, R. Cheepsattayakorn

symptoms, such as human immunodeficiency-virus infection (HIV)/ acquired immunodeficiency syndrome (AIDS), infections, parasitic infestations, sinus infections, cancer, rheumatoid arthritis, hepatic problems, cardiac diseases, anorexia, allergies, ulcers, and skin diseases. Nevertheless, there is not enough scientific evidence to support the use of Andrographis paniculata for most of these health benefits. Some preliminary studies demonstrated that Andrographis paniculata may offer the health benefits, such as upper respiratory tract infections and ulcerative colitis.

症状，如人类免疫缺陷病毒感染(HIV)/获得性免疫缺陷综合征(AIDS)、感染、寄生虫感染、鼻窦感染、癌症、类风湿关节炎、肝脏问题、心脏病、厌食症、过敏、溃疡和皮肤病。然而，没有足够的科学证据支持穿心莲对这些健康的益处。一些初步研究表明穿心莲可能对上呼吸道感染和溃疡性结肠炎有一定的保健作用。

引用次数: 2

Oxygen injury in neonates: which is worse? hyperoxia, hypoxia, or alternating hyperoxia/hypoxia 新生儿氧损伤:哪个更严重?高氧、低氧或交替高氧/低氧

Journal of lung, pulmonary & respiratory research

Pub Date : 2020-01-09 DOI: 10.15406/jlprr.2018.05.00221

B. Uhal

Premature birth results in an increased risk of respiratory distress and often requires oxygen therapy. While the supplemental oxygen has been implicated as a cause of bronchopulmonary dysplasia (BPD), in clinical practice this supplementation usually only occurs after the patient’s oxygen saturation levels have dropped. The effect of hyperoxia on neonates has been extensively studied. However, there is an unanswered fundamental question: which has the most impact-hyperoxia, hypoxia or fluctuating oxygen levels? In this review, we will summarize the reported effect of hypoxia, hyperoxia or a fluctuation of oxygen levels (hypoxia/hyperoxia cycling) in preterm neonates, with special emphasis on the lungs.

早产会增加呼吸窘迫的风险，通常需要吸氧治疗。虽然补充氧被认为是支气管肺发育不良(BPD)的一个原因，但在临床实践中，这种补充通常只在患者氧饱和度下降后才发生。高氧对新生儿的影响已被广泛研究。然而，有一个没有答案的基本问题:高氧、低氧和波动的氧水平，哪个影响最大?在这篇综述中，我们将总结报道的缺氧、高氧或氧水平波动(缺氧/高氧循环)对早产儿的影响，特别强调对肺部的影响。

引用次数: 12

Spontaneous pneumothorax in a newborn case report: original image, treatment process and follow-up 新生儿自发性气胸1例:原始影像、治疗过程及随访

Journal of lung, pulmonary & respiratory research

Pub Date : 2020-01-02 DOI: 10.15406/jlprr.2020.07.00220

Muhammet Mesut Nezir Engin, Gülden Ak, Önder Kılıçaslan

Pneumothorax is a condition where there is free air between the parietal and visceral pleural leaves within the thoracic cavity. She was born with a cesarean section of 2780grams in 38th gestational week. As the patient had tachypnea and intercostal retractions, he was hospitalized in another hospital and started treatment. On the second day of hospitalization, pneumothorax was seen on the posterior anterior chest radiograph and he was referred to us. When the patient came to our clinic, his general condition was poor, tachypnea, intercostal withdrawal and groan breathing were present. When the patient had low saturation, he was intubated and connected to a mechanical ventilator. The chest tube was placement and free drainage was performed. She was discharged on the 9th day of his hospitalization because of his good general condition, improved laboratory findings and no additional difficulties. Spontaneous pneumothorax should be considered in the presence of sudden respiratory distress in the newborn period. Patients diagnosed with pneumothorax should be immediately chest tube placement, patients with respiratory distress should be evaluated and given supportive treatment.

气胸是一种胸腔内胸膜壁叶和内脏叶之间存在自由空气的情况。她在妊娠第38周通过剖宫产出生，体重为2780克。由于患者有呼吸急促和肋间挛缩，在另一家医院住院并开始治疗。在住院的第二天，他在胸片上发现了气胸，并被转介到我们这里。患者来门诊时，一般情况较差，有呼吸急促、肋间抽脱、呻吟呼吸。当患者饱和度低时，插管并连接机械呼吸机。置胸管，行自由引流。由于他的一般情况良好，实验室检查结果有所改善，没有其他困难，她于住院第9天出院。在新生儿期出现突发性呼吸窘迫时应考虑自发性气胸。诊断为气胸的患者应立即置管，有呼吸窘迫的患者应评估并给予支持治疗。

{"title":"Spontaneous pneumothorax in a newborn case report: original image, treatment process and follow-up","authors":"Muhammet Mesut Nezir Engin, Gülden Ak, Önder Kılıçaslan","doi":"10.15406/jlprr.2020.07.00220","DOIUrl":"https://doi.org/10.15406/jlprr.2020.07.00220","url":null,"abstract":"Pneumothorax is a condition where there is free air between the parietal and visceral pleural leaves within the thoracic cavity. She was born with a cesarean section of 2780grams in 38th gestational week. As the patient had tachypnea and intercostal retractions, he was hospitalized in another hospital and started treatment. On the second day of hospitalization, pneumothorax was seen on the posterior anterior chest radiograph and he was referred to us. When the patient came to our clinic, his general condition was poor, tachypnea, intercostal withdrawal and groan breathing were present. When the patient had low saturation, he was intubated and connected to a mechanical ventilator. The chest tube was placement and free drainage was performed. She was discharged on the 9th day of his hospitalization because of his good general condition, improved laboratory findings and no additional difficulties. Spontaneous pneumothorax should be considered in the presence of sudden respiratory distress in the newborn period. Patients diagnosed with pneumothorax should be immediately chest tube placement, patients with respiratory distress should be evaluated and given supportive treatment.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78592809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Simple classification of COVID-19 patients COVID-19患者简单分类

Journal of lung, pulmonary & respiratory research

Pub Date : 2020-01-01 DOI: 10.15406/jlprr.2020.07.00230

A. Gülşen

The research that has been reported in the literature compares patients as follows: (a) nonsevere/ severe; (b) non-intensive care unit (ICU)/ICU; (c) improvement/progression; (d) general/refractory; (e) common type/severe; (f) noninvasive mechanical ventilation (IMV)/ IMV; (g) good/poor outcomes; and (h) survivors/non-survivors. Although classifications are recommended based on radiological imaging, also clinical classification is urgently needed.5 Therefore, a uniform stratification of COVID-19 patients is necessary to standardize the future research studies and to enable meta-analyses that can more appropriately evaluate the data.

文献中报道的研究对患者的比较如下:(a)非严重/严重;(b)非重症监护病房(ICU)/ICU;(c)改进/进展;(d)一般/耐火材料;(e)普通型/重度;无创机械通气(IMV)/ IMV;(g)良好/不良的结果;(h)幸存者/非幸存者。虽然推荐基于放射影像学的分类，但迫切需要临床分类因此，对COVID-19患者进行统一分层是必要的，以使未来的研究标准化，并使荟萃分析能够更恰当地评估数据。

引用次数: 8

Mas Receptor Agonist AVE0991 increases surfactant protein expression under hyperoxic conditions in human lung epithelial cells. Mas 受体激动剂 AVE0991 可增加高氧条件下人肺上皮细胞中表面活性物质蛋白的表达。

Journal of lung, pulmonary & respiratory research

Pub Date : 2020-01-01 Epub Date: 2020-11-17

Ranga Prasanth Thiruvenkataramani, Amal Abdul-Hafez, Ira Gewolb, Bruce Uhal

Background: Hyperoxia in pre-term neonates is a known risk factor of bronchopulmonary dysplasia (BPD). Hyperoxia is known to cause oxidative stress, inflammatory changes that leads to surfactant deactivation, and decreased surfactant expression. The previous research has shown short term exposure to hyperoxia increases surfactant protein expression but decreased expression in long term exposure. Local tissue renin-angiotensin system (RAS) is associated with tissue injury and repair and it may play a role in BPD. Endogenous peptide angiotensin 1-7 acts on the MAS receptor. The activation of the MAS receptor was previously shown to have protective pulmonary responses. However, the effect of MAS receptor activation on surfactant proteins in hyperoxic conditions has not been tested.

Objective: To determine the effects of hyperoxia with or without MAS receptor activation on Surfactant proteins.

Methods: Human epithelial cell line A549 and human primary alveolar epithelial cells (AECs) were cultured to sub-confluence (60-75%) and treated with hyperoxia (95% oxygen) and normoxia (21% oxygen) for 72 hours with or without the MAS receptor agonist (AVE0991) in serum-free F-12 nutrient media. Cells were lysed and cell lysates were collected for western blot. The statistical analysis was done using Student-Newman-Keuls Multiple comparison test.

Results: Surfactant protein concentration increased in AVE treated group under the hyperoxic condition when compared to the control group in both A549 cells and human primary AECs. Surfactant protein was in higher concentration in AVE0991 treated cells in both hyperoxic and normoxic conditions when compared to the non-treated control group.

Conclusions: MAS receptor activation via AVE0991 causes an increase in Surfactant protein concentration in both hyperoxic and normoxic conditions. As per our experiments, hyperoxic conditions decrease the production of surfactant protein when compared to normoxic conditions. These results may reveal a novel potential drug for BPD treatment and decrease its severity.

背景：早产新生儿高氧是支气管肺发育不良（BPD）的一个已知风险因素。众所周知，高氧会导致氧化应激、炎症变化，从而导致表面活性物质失活和表面活性物质表达减少。先前的研究表明，短期暴露于高氧环境会增加表面活性物质蛋白的表达，但长期暴露于高氧环境则会降低表面活性物质蛋白的表达。局部组织的肾素-血管紧张素系统（RAS）与组织损伤和修复有关，可能在 BPD 中发挥作用。内源性肽血管紧张素 1-7 作用于 MAS 受体。以前的研究表明，激活 MAS 受体可产生保护性肺部反应。然而，在高氧条件下，MAS 受体激活对表面活性蛋白的影响尚未得到测试：方法：将人上皮细胞系 A549 和人原代肺泡上皮细胞（AECs）培养至亚融合状态（60-75%），并在无血清 F-12 营养培养基中用高氧（95% 氧气）和常氧（21% 氧气）处理 72 小时，无论是否使用 MAS 受体激动剂（AVE0991）。裂解细胞并收集细胞裂解液进行 Western 印迹。采用Student-Newman-Keuls多重比较试验进行统计分析：结果：在高氧条件下，AVE 处理组与对照组相比，A549 细胞和人原代 AECs 的表面活性物质蛋白浓度均有所增加。与未处理的对照组相比，高氧和常氧条件下 AVE0991 处理组细胞的表面活性物质蛋白浓度更高：结论：在高氧和常氧条件下，通过 AVE0991 激活 MAS 受体都会导致表面活性物质蛋白浓度增加。根据我们的实验，与常氧条件相比，高氧条件会减少表面活性物质蛋白的产生。这些结果可能揭示了一种治疗 BPD 并减轻其严重程度的新型潜在药物。

{"title":"Mas Receptor Agonist AVE0991 increases surfactant protein expression under hyperoxic conditions in human lung epithelial cells.","authors":"Ranga Prasanth Thiruvenkataramani, Amal Abdul-Hafez, Ira Gewolb, Bruce Uhal","doi":"","DOIUrl":"","url":null,"abstract":"Background: Hyperoxia in pre-term neonates is a known risk factor of bronchopulmonary dysplasia (BPD). Hyperoxia is known to cause oxidative stress, inflammatory changes that leads to surfactant deactivation, and decreased surfactant expression. The previous research has shown short term exposure to hyperoxia increases surfactant protein expression but decreased expression in long term exposure. Local tissue renin-angiotensin system (RAS) is associated with tissue injury and repair and it may play a role in BPD. Endogenous peptide angiotensin 1-7 acts on the MAS receptor. The activation of the MAS receptor was previously shown to have protective pulmonary responses. However, the effect of MAS receptor activation on surfactant proteins in hyperoxic conditions has not been tested.Objective: To determine the effects of hyperoxia with or without MAS receptor activation on Surfactant proteins.Methods: Human epithelial cell line A549 and human primary alveolar epithelial cells (AECs) were cultured to sub-confluence (60-75%) and treated with hyperoxia (95% oxygen) and normoxia (21% oxygen) for 72 hours with or without the MAS receptor agonist (AVE0991) in serum-free F-12 nutrient media. Cells were lysed and cell lysates were collected for western blot. The statistical analysis was done using Student-Newman-Keuls Multiple comparison test.Results: Surfactant protein concentration increased in AVE treated group under the hyperoxic condition when compared to the control group in both A549 cells and human primary AECs. Surfactant protein was in higher concentration in AVE0991 treated cells in both hyperoxic and normoxic conditions when compared to the non-treated control group.Conclusions: MAS receptor activation via AVE0991 causes an increase in Surfactant protein concentration in both hyperoxic and normoxic conditions. As per our experiments, hyperoxic conditions decrease the production of surfactant protein when compared to normoxic conditions. These results may reveal a novel potential drug for BPD treatment and decrease its severity.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"7 4","pages":"85-91"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39328537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxygen injury in neonates: which is worse? hyperoxia, hypoxia, or alternating hyperoxia/hypoxia. 新生儿氧损伤:哪个更严重?高氧、低氧或交替高氧/低氧。

Journal of lung, pulmonary & respiratory research

Pub Date : 2020-01-01 Epub Date: 2020-01-29

Tarek Mohamed, Amal Abdul-Hafez, Ira H Gewolb, Bruce D Uhal

Premature birth results in an increased risk of respiratory distress and often requires oxygen therapy. While the supplemental oxygen has been implicated as a cause of bronchopulmonary dysplasia (BPD), in clinical practice this supplementation usually only occurs after the patient's oxygen saturation levels have dropped. The effect of hyperoxia on neonates has been extensively studied. However, there is an unanswered fundamental question: which has the most impact-hyperoxia, hypoxia or fluctuating oxygen levels? In this review, we will summarize the reported effect of hypoxia, hyperoxia or a fluctuation of oxygen levels (hypoxia/hyperoxia cycling) in preterm neonates, with special emphasis on the lungs.

早产会增加呼吸窘迫的风险，通常需要吸氧治疗。虽然补充氧被认为是支气管肺发育不良(BPD)的一个原因，但在临床实践中，这种补充通常只在患者氧饱和度下降后才发生。高氧对新生儿的影响已被广泛研究。然而，有一个没有答案的基本问题:高氧、低氧和波动的氧水平，哪个影响最大?在这篇综述中，我们将总结报道的缺氧、高氧或氧水平波动(缺氧/高氧循环)对早产儿的影响，特别强调对肺部的影响。

引用次数: 0

Effects of dexamethasone, cyclosporine and betamethasone on inflammatory cell recruitment in mice infected with Strongyloides venezuelensis 地塞米松、环孢素和倍他米松对委内瑞拉圆线虫感染小鼠炎症细胞募集的影响

Journal of lung, pulmonary & respiratory research

Pub Date : 2019-12-26 DOI: 10.15406/jlprr.2019.06.00219

E. Machado, M. Ueta, R. M. Rodrigues, S. Ramos, V. Vilhena, Anna Maly de Leão e Neves Eduardo, Leandro Junio Barreto dos Reis, Raphael da Silva Affonso, L. Faccioli

The objective of this study was verified effect of immunosuppressant activities of Dexametasone (Dexa), Cyclosporine (CsA) and Betamethasone (Beta) in the synhteses of inflammatory cell and dissemination of Strongyloides venezuelensis. S. venezuelensis- infected mice increased total leucocytes (TL), eosinophil (EO), mononuclear cells (MC), and neutrophil (NE) numbers in the blood. The infection induced recruitment of TL, EO and MC to peritoneal cavity (PCF) and space bronchoalveolar (BALF), exception for NE. Dexa, CsA and Beta treatments inhibited TL, EO and MC production. However, Dexa treatment was associated with NE accumulation in the blood. Dexa and Beta tratments reductions migration of inflammatory cells from the blood to PCF and BALF. Infected mice and treated with Dexa and Beta worm parasites, eggs/g/feces and larvae recovered were higher than CsA. The results showed that glucocorticoid treatment may induce strongyloidiasis dissemination while CsA induced mice protection against S. venezuelensis infection.

本研究的目的是验证地塞米松(Dexa)、环孢素(CsA)和倍他米松(Beta)的免疫抑制活性对委内瑞拉圆线虫炎症细胞合成和传播的影响。感染委内瑞拉葡萄球菌的小鼠血液中白细胞(TL)、嗜酸性粒细胞(EO)、单核细胞(MC)和中性粒细胞(NE)总数增加。感染诱导TL、EO和MC向腹膜腔(PCF)和间隙支气管肺泡(BALF)募集，NE除外。Dexa、CsA和β处理抑制了TL、EO和MC的生成。然而，Dexa治疗与血液中NE积聚有关。Dexa和β治疗可减少炎症细胞从血液向PCF和BALF的迁移。经Dexa和β虫寄生虫处理的感染小鼠，虫卵/克/粪便和幼虫恢复率均高于CsA。结果表明糖皮质激素可诱导圆线虫病传播，而CsA可诱导小鼠抗委内瑞拉葡萄球菌感染。

{"title":"Effects of dexamethasone, cyclosporine and betamethasone on inflammatory cell recruitment in mice infected with Strongyloides venezuelensis","authors":"E. Machado, M. Ueta, R. M. Rodrigues, S. Ramos, V. Vilhena, Anna Maly de Leão e Neves Eduardo, Leandro Junio Barreto dos Reis, Raphael da Silva Affonso, L. Faccioli","doi":"10.15406/jlprr.2019.06.00219","DOIUrl":"https://doi.org/10.15406/jlprr.2019.06.00219","url":null,"abstract":"The objective of this study was verified effect of immunosuppressant activities of Dexametasone (Dexa), Cyclosporine (CsA) and Betamethasone (Beta) in the synhteses of inflammatory cell and dissemination of Strongyloides venezuelensis. S. venezuelensis- infected mice increased total leucocytes (TL), eosinophil (EO), mononuclear cells (MC), and neutrophil (NE) numbers in the blood. The infection induced recruitment of TL, EO and MC to peritoneal cavity (PCF) and space bronchoalveolar (BALF), exception for NE. Dexa, CsA and Beta treatments inhibited TL, EO and MC production. However, Dexa treatment was associated with NE accumulation in the blood. Dexa and Beta tratments reductions migration of inflammatory cells from the blood to PCF and BALF. Infected mice and treated with Dexa and Beta worm parasites, eggs/g/feces and larvae recovered were higher than CsA. The results showed that glucocorticoid treatment may induce strongyloidiasis dissemination while CsA induced mice protection against S. venezuelensis infection.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73365174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SABA over-reliance; time for a change 萨巴的过度依赖;是时候改变了

Journal of lung, pulmonary & respiratory research

Pub Date : 2019-12-09 DOI: 10.15406/jlprr.2019.06.00217

A. Kaplan

areas. SABAs are given as the first line therapy, despite the fact that most asthma is related to Th2, often eosinophilic, inflammation that requires an anti-inflammatory such as inhaled corticosteroids (ICS)I to improve it.II The patients rely on their SABA often to the exclusion of the ICS, perceiving it as the medication giving them benefit. This leads to the paradox regarding the issue of patient autonomy. As patients control their own disease, in their mind, using SABA as they feel necessary, they then follow up with the clinician who recognizes that SABA use is a marker of disease activity and inflammation, so then changes the therapy, adding an anti-inflammatory to reduce the inflammation. These medications, however, are to be taken as per the clinician instructions and therefore all patient autonomy is removed from the decision process. Patients have clearly demonstrated that they want control over their own disease,III so this is going to be an issue for many. There is also often a disconnect between the patients understanding of asthma control, often feeling that means relief of their symptoms when they have them compared with the clinicians view on asthma control which means preventing symptoms, disability and exacerbations.

区域。尽管大多数哮喘与Th2有关，通常是嗜酸性粒细胞性炎症，需要吸入性皮质类固醇(ICS)I等抗炎药物来改善，但仍将SABAs作为一线治疗。II患者依赖SABA而排斥ICS，认为这是给他们带来好处的药物。这就导致了关于病人自主权问题的悖论。当病人控制自己的疾病时，在他们的脑海中，使用SABA，因为他们觉得有必要，然后他们跟进临床医生认识到SABA的使用是疾病活动和炎症的标志，所以改变治疗，添加抗炎药来减少炎症。然而，这些药物必须按照临床医生的指示服用，因此所有患者的自主权都被排除在决策过程之外。病人已经清楚地表明，他们想要控制自己的疾病，所以这将是许多人面临的一个问题。患者对哮喘控制的理解也经常存在脱节，他们通常认为这意味着缓解他们的症状，而临床医生对哮喘控制的看法是预防症状，残疾和恶化。

{"title":"SABA over-reliance; time for a change","authors":"A. Kaplan","doi":"10.15406/jlprr.2019.06.00217","DOIUrl":"https://doi.org/10.15406/jlprr.2019.06.00217","url":null,"abstract":"areas. SABAs are given as the first line therapy, despite the fact that most asthma is related to Th2, often eosinophilic, inflammation that requires an anti-inflammatory such as inhaled corticosteroids (ICS)I to improve it.II The patients rely on their SABA often to the exclusion of the ICS, perceiving it as the medication giving them benefit. This leads to the paradox regarding the issue of patient autonomy. As patients control their own disease, in their mind, using SABA as they feel necessary, they then follow up with the clinician who recognizes that SABA use is a marker of disease activity and inflammation, so then changes the therapy, adding an anti-inflammatory to reduce the inflammation. These medications, however, are to be taken as per the clinician instructions and therefore all patient autonomy is removed from the decision process. Patients have clearly demonstrated that they want control over their own disease,III so this is going to be an issue for many. There is also often a disconnect between the patients understanding of asthma control, often feeling that means relief of their symptoms when they have them compared with the clinicians view on asthma control which means preventing symptoms, disability and exacerbations.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86346195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2