Journal of lung, pulmonary & respiratory research最新文献

{"title":"Re-expansion pulmonary edema after large left pleural effusion","authors":"Bilal Chaudhry, MD, Kirill Alekseyev, MD, MBA, Lidiya Didenko MS, Nikita Donti, DO","doi":"10.15406/jlprr.2021.08.00245","DOIUrl":"https://doi.org/10.15406/jlprr.2021.08.00245","url":null,"abstract":"Background: Reexpansion pulmonary edema (REPE) is a complication that arises from a precipitous or rapid expansion of a collapsed lung. This rare complication is thought to arise after using an intercostal drainage tube in patients with a tension pneumothorax, those with large pleural effusions, and occasionally when used therapeutically in thoracentesis. There are a multitude of risk factors, and it usually self-limiting, with the mainstay of treatment being supportive with oxygen. It is believed that 20% of cases are fatal. Case report: A 60-year-old male was treated with a 28 French tube for a large left pleural effusion. He developed REPE shortly after and developed severe shortness of breath, for which he required high flow oxygen. He was managed in the Intermediate Care Unit (IMCU) and shortly after was discharged home.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84494592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antisynthetase Syndrome associated with mycobacterium tuberculosis infection, presenting as an acute respiratory failure","authors":"A. B. Mansour, S. Ben Saad, S. Yaâlaoui, H. Bellali, H. Daghfous, F. Tritar","doi":"10.15406/jlprr.2021.08.00243","DOIUrl":"https://doi.org/10.15406/jlprr.2021.08.00243","url":null,"abstract":"Antisynthetase syndrome (ASS) is characterized by myositis, interstitial lung disease, Raynaud’s phenomenon, fever and mechanics hands. Diagnosis is confirmed with the detection of an antibody directed against anti–aminoacyl–transfer–RNA synthetases (ARS). The most common anti–ARS antibody is anti–Jo–1. Opportunistic infections are common causes of mortality in patients with autoimmune diseases. Immunosuppressive treatment further contributes to the risk of infection. We report a rare case of a 68 year–old man diagnosed with antisynthetase syndrome associated to a pulmonary tuberculosis infection, revealed with an acute respiratory failure. The diagnosis of this rare combination of a connective tissue disease and tuberculosis revealed with an acute respiratory failure is difficult in a previously asymptomatic patient. Early diagnosis and immunosuppressive therapy associated to antituberculosis treatment started precociously prevented the disease progression and resulted in a good outcome.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87671999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Children: their role in the face of the pandemic in mexico","authors":"MD. José de Jesús Coria Lorenzo, MD. Jorge Field Cortazares, Dr. Lauta Erika Garcia Carrillo","doi":"10.15406/jlprr.2021.08.00241","DOIUrl":"https://doi.org/10.15406/jlprr.2021.08.00241","url":null,"abstract":"","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80330039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrapulmonary mature teratoma: case report of an exceptional entity","authors":"Najat Id el haj, S. Boubia, M. Ridai","doi":"10.15406/jlprr.2021.08.00240","DOIUrl":"https://doi.org/10.15406/jlprr.2021.08.00240","url":null,"abstract":"Teratomas are tumors consisting of tissues derived from more than one germ cell line. Criteria for pulmonary origin are exclusion of a gonadal or other extra-gonadal primary site and origin entirely within the lung. The intrapulmonary teratoma (IPT) is a rare type of teratoma extra-gonadal which often presents with nonspecific symptoms and wrongly can be diagnosed as other diseases. Here we report a patient with IPT who was initially misdiagnosed as pulmonary aspergilloma. We report a case of mature pulmonary teratoma in a 22-year-old male with no toxic habits, treated in 2007 for smear-positive pulmonary tuberculosis, presenting progressively for 1 year, with a left chest pain, intermittent episodes of cough and hemoptysis, and dyspnea. A computed tomography (CT) chest scan showed a heterogeneous tumor with cavitary lesion in the left upper lobe. The patient had a left upper lobectomy with complete resection of the mediastinal mass. The patient is currently in good general condition, and does not present any complications or recurrence and thyroid function was normal during the long term follow up. Preoperative diagnosis of IPT is not always possible and is usually misdiagnosed early on due to its rarity, nonspecific and vague symptoms, normal lab results, and indistinguishable chest x-ray results. We report a case of intrapulmonary teratoma in a 22-year-old man and review the relevant literature.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83264268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in research.","authors":"Amal Abdul-Hafez,&nbsp;Tarek Mohamed,&nbsp;Bruce D Uhal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Coronavirus Disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Like the 2002-2003 epidemic severe acute respiratory syndrome coronavirus (SARS-CoV), angiotensin converting enzyme-2 (ACE-2) has been identified as the SARS-CoV-2 receptor.^1-3 The virus docks into host cell via its spike protein binding to ACE-2 and undergoes proteolytic cleavage by TMPRSS2 protease to facilitate membrane fusion. The spike protein binding to ACE-2 has been shown to be stronger in the novel SARS-CoV-2 virus.¹ This review will present an overview of ACE-2 biology.</p>","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"8 2","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39328472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of ACE-2 enzyme by hyperoxia in lung epithelial cells by post-translational modification.","authors":"Tarek Mohamed,&nbsp;Amal Abdul-Hafez,&nbsp;Bruce D Uhal","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Bronchopulmonary Dysplasia (BPD) occurs in premature neonates with respiratory distress who require supplemental oxygen in the first days after birth. BPD involves uniform arrest of alveolar development and variable interstitial cellularity and/or fibroproliferation. Previous studies by our lab showed that the enzyme, angiotensin converting enzyme-2 (ACE-2) and its product Ang1-7 exerting action on the receptor Mas oncogene in what is known as ACE-2/Mas axis is protective to lung cells. We also showed that ACE-2 is expressed in fetal human lung fibroblasts but is significantly decreased by hyperoxic gas lung injury, an effect caused by ACE-2 enzyme shedding mediated by TNF-alpha-converting enzyme (TACE/ADAM17). However, no reports yet exist about the regulation of ACE-2 in the alveolar epithelia in hyperoxic lung injury.</p><p><strong>Objective: </strong>In this study we aim to define the effects of hyperoxic lung injury on the protective ACE-2 enzyme in the human lung alveolar epithelial cell line A549.</p><p><strong>Design/methods: </strong>Cultured A549 cells were exposed to hyperoxia (95% O2) or normoxia (21% O2) for 3 or 7 days in serum-free nutrient media. Cells were lysed and culture media were collected to test for cellular ACE-2 enzymatic activity and for ACE-2, Mas receptor, TACE/ADAM17, and ubiquitin proteins abundance by immunoblotting. Cells were harvested in Trizol for RNA extraction and ACE-2 qRT-PCR. Whole cell extracts of A549 cell line was used for ACE-2 immunoprecipitation and subsequent ubiquitin immunoblotting.</p><p><strong>Results: </strong>Total ubiquitinated proteins were increased by hyperoxia treatment, while ACE-2 and Mas receptor proteins abundance and ACE-2 enzymatic activity were decreased significantly in A549 cells exposed to hyperoxia relative to the normoxia controls. The percent decrease in ACE-2 activity corresponded with increased time of hyperoxic gas exposure. However, in contrast to our data from lung fibroblasts, no significant change was noted in ACE-2 protein released into the media or in ACE-2 mRNA levels by the hyperoxic treatment. Ubiquitin immunoreactive bands were detectable in the ACE-2 immunoprecipitate.</p><p><strong>Conclusions: </strong>These data suggest that hyperoxic exposure of the lung epithelial cells decreases the protective enzyme ACE-2 by cell type specific mechanisms independent of shedding by TACE/ADAM17. The data also suggest a regulatory level of ACE-2 downstream of transcription may involve ACE-2 ubiquitination and targeting for degradation.</p>","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"8 ","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39913275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of pulmonary rehabilitation for everyone","authors":"K. McCain","doi":"10.15406/jlprr.2021.08.00244","DOIUrl":"https://doi.org/10.15406/jlprr.2021.08.00244","url":null,"abstract":"Knowledge and therapy for patients with respiratory illnesses has been ongoing in the medical world. Assisting with the patient’s quality of life and possible recovery is a type of rehab that includes education as well as monitored exercise. This rehab notably labeled Pulmonary Rehab is managed by healthcare workers with the intent on assisting the patient to not only get up and move, but to remain social. Quarantine and the threat of being infected with Covid-19 put a halt to programs like this. As people were searching for ways to see their physicians for appointments and telehealth was approved for most, it was not for Pulmonary Rehab. These patients that had been placed in a program to ensure they would have interaction, were now just shut in their homes. Pulmonary Rehab should be open to all not being approved now because of insurance or other details such as financial or telehealth issues.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87408584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardio-Respiratory tolerability of perfluoropropaneEnhanced MRI of pulmonary ventilation","authors":"Joseph Mammarappallil, MD, PhD, Richard E. Moon MD, Neil R. MacIntyre MD, W. M. Foster PhD, Samantha J. Womack MS, Maureen D. Ainslie MS RT(R)MR, H. P. McAdams, MD, Ahmed F. Halaweish PhD, Kingshuk Choudury PhD, H. C. Charles PhD","doi":"10.15406/jlprr.2020.07.00239","DOIUrl":"https://doi.org/10.15406/jlprr.2020.07.00239","url":null,"abstract":"Rationale: Recent advances in perfluoropropane magnetic resonance imaging of the lung have provided the means to assess pulmonary ventilation and gas distribution throughout the pulmonary airways and acini in a non-invasive manner. Objectives: The increased density of the inhaled PFP/O2 gas mixture generates longer wash-in times compared to wash-out while breathing room air and leads to slight increases in airway resistance (Raw) and respiratory effort by the subject during imaging. As a consequence of these gas-related effects, we sought to evaluate the cardio-respiratory tolerability of the PFP/O2 gas mixtures in our sequential breath-hold imaging protocol in normal subjects and subjects with obstructive lung disease. Methods: Tolerability was determined by evaluation of changes in vital signs (Heart Rate, Systolic and Diastolic Blood Pressure, Respiratory Rate and Temperature (otic)) at 3 time points (screening, pre-imaging and post-imaging) Measurements and Main Results: Assessment of vital signs before and after the administration of perfluoropropane gas mixture by matched pair analysis demonstrated statistically different values for Heart rate (Mean Difference =-2.417 bpm), Systolic BP (Mean Difference=6.95 mmHg), Diastolic BP (Mean Difference=3.86 mmHg) and SpO2 (Mean Difference=0.56%) even though these do not represent physiologically significant differences compared to activities of daily living such as climbing a flight of stairs. Conclusions: Our data demonstrate no negative outcomes in using PFP gas to image pulmonary ventilation. The PFP gas mixture is safe, well tolerated, and provides a three dimensional ‘picture’ (representation) of inhaled gas distribution for subject cohorts of normal and obstructive lung disease.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"2004 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89518120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airway epithelial dysfunction contributes to the pathogenesis of asthma","authors":"N. Syabbalo","doi":"10.15406/jlprr.2020.07.00238","DOIUrl":"https://doi.org/10.15406/jlprr.2020.07.00238","url":null,"abstract":"growth factor (VEGF), angiopoietin, and angiogenin in the airways, which promote neovascularization, expansion of the airway vascular bed, oedema, and airway narrowing. 19 These changes are inevitably associated with thickening and shedding of the airway epithelium in both atopic and non-atopic asthmatic patients. 20,21 Additionally, there is goblet cell, and submucous gland hyperplasia resulting in mucus hypersecretion. 22 This is accompanied by hyperplasia and hypertrophy of ASM cells, which acquire a highly proliferative, secretory, and contractile phenotype. 15,18,22 These structural changes are associated with more severe fixed airflow obstruction, which may be unresponsive to high dose inhaled corticosteroids (ICS), and to","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87611307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung sensors in pulmonary diseases","authors":"Jerome Walker, Jerry Yu","doi":"10.15406/jlprr.2020.07.00237","DOIUrl":"https://doi.org/10.15406/jlprr.2020.07.00237","url":null,"abstract":"Sensory information in the lung is mainly generated by airway sensors carried by the vagus nerves, yielding multiple reflex responses essential for breathing control and lung defense. When these sensors are activated in lung disease, they produce clinical signs, including cough, bronchoconstriction and mucus secretion, and alter disease course by reflexes and neuroimmune interaction.","PeriodicalId":91750,"journal":{"name":"Journal of lung, pulmonary & respiratory research","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88258031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}