首页 > 最新文献

Journal of clinical nutrition and metabolism最新文献

英文 中文
Nutritional support as part of the basic therapy of a patient in the acute period of ischemic stroke in the intensive care unit 营养支持作为重症监护病房缺血性脑卒中急性期患者基本治疗的一部分
Pub Date : 2023-01-24 DOI: 10.17816/clinutr119857
K. Krylov, Sergey V. Sviridov, I. Vedenina, R. Yagubyan
Ischemic stroke remains the predominant cause of disability in the population (3.2 per 1000 population). Only 8% of surviving after ischemic stroke patients can return to their previous work. An integral part of the treatment of ischemic stroke in the intensive care unit is nutritional support. Nutritional support is an integral part of a multidisciplinary approach to the treatment of a patient with ischemic stroke, both during the acute period of the disease and in the rehabilitation phase, since brain damage always has metabolic consequences for the patient's body, and both premorbid malnutrition and malnutrition after stroke, significantly impact to outcome of the disease. The prevalence of malnutrition in patients with ischemic stroke varies widely. According to various sources, it ranges from 6.1% to 62%, depending on the method for determining protein-energy malnutrition. Despite the relevance of the problem of nutritional support for patients with ischemic stroke, there are few specific recommendations in the literature for this category of patients. This review focuses on nutritional support for patients who require mechanical ventilation or stay in the intensive care unit for more than 48 hours.
缺血性中风仍然是人口致残的主要原因(每1000人中有3.2人)。只有8%的缺血性中风患者能够恢复他们以前的工作。在重症监护病房治疗缺血性中风的一个组成部分是营养支持。营养支持是缺血性中风患者治疗的多学科方法的一个组成部分,无论是在疾病的急性期还是在康复阶段,因为脑损伤总是对患者的身体产生代谢后果,而且病前营养不良和卒中后营养不良都对疾病的结局产生重大影响。缺血性脑卒中患者营养不良的发生率差别很大。根据各种来源,它的范围从6.1%到62%,这取决于确定蛋白质能量营养不良的方法。尽管缺血性脑卒中患者的营养支持问题具有相关性,但文献中很少有针对这类患者的具体建议。本综述的重点是需要机械通气或在重症监护病房停留超过48小时的患者的营养支持。
{"title":"Nutritional support as part of the basic therapy of a patient in the acute period of ischemic stroke in the intensive care unit","authors":"K. Krylov, Sergey V. Sviridov, I. Vedenina, R. Yagubyan","doi":"10.17816/clinutr119857","DOIUrl":"https://doi.org/10.17816/clinutr119857","url":null,"abstract":"Ischemic stroke remains the predominant cause of disability in the population (3.2 per 1000 population). Only 8% of surviving after ischemic stroke patients can return to their previous work. An integral part of the treatment of ischemic stroke in the intensive care unit is nutritional support. Nutritional support is an integral part of a multidisciplinary approach to the treatment of a patient with ischemic stroke, both during the acute period of the disease and in the rehabilitation phase, since brain damage always has metabolic consequences for the patient's body, and both premorbid malnutrition and malnutrition after stroke, significantly impact to outcome of the disease. The prevalence of malnutrition in patients with ischemic stroke varies widely. According to various sources, it ranges from 6.1% to 62%, depending on the method for determining protein-energy malnutrition. Despite the relevance of the problem of nutritional support for patients with ischemic stroke, there are few specific recommendations in the literature for this category of patients. This review focuses on nutritional support for patients who require mechanical ventilation or stay in the intensive care unit for more than 48 hours.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85048099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Problematic issues of diagnostics and treatment of vitamin D deficiency in elderly patients 老年患者维生素D缺乏症的诊断和治疗问题
Pub Date : 2023-01-19 DOI: 10.17816/clinutr115028
Anastasya S. Podkhvatilina, I. Nikitin, L. Brutskaya, N. A. Gultyaeva
This article is about vitamin D in elderly patients. We review a data about matabolism, diagnostic and treatment
这篇文章是关于老年患者的维生素D。我们回顾了有关代谢、诊断和治疗的资料
{"title":"Problematic issues of diagnostics and treatment of vitamin D deficiency in elderly patients","authors":"Anastasya S. Podkhvatilina, I. Nikitin, L. Brutskaya, N. A. Gultyaeva","doi":"10.17816/clinutr115028","DOIUrl":"https://doi.org/10.17816/clinutr115028","url":null,"abstract":"This article is about vitamin D in elderly patients. We review a data about matabolism, diagnostic and treatment","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75740337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Nutritional support in patients with abdominal surgical pathology. The view of a surgeon and an anesthesiologist: opponents or allies? 腹部外科病理患者的营养支持。外科医生和麻醉师的观点:对手还是盟友?
Pub Date : 2023-01-19 DOI: 10.17816/clinutr110892
N. Shen, Svetlana Yurievna Mukhacheva
BACKGROUND: Nutritional support in abdominal surgery is a complex section of intensive care with many contradictions, both in the available recommendations and in relation to interdisciplinary interaction. The issues of assessing nutritional status, timing of the start and methods of clinical nutrition are far from being resolved. The analysis made it possible not so much to explain who and how to feed in the intensive care unit, to prove the need for an early start of enteral nutrition, as to assess the "scale of the disaster" in the form of a lack of unity of views and low adherence to clinical recommendations. AIMS: to analyze the effectiveness of early enteral nutrition in achieving optimal results in the treatment of patients with abdominal surgical pathology, to assess the depth of knowledge and adherence to clinical recommendations of specialists providing care to this cohort of patients. MATERIALS AND METHODS: The study included 50 patients, 32 of whom started early enteral nutrition, and 18 later enteral nutrition. A survey of 41 specialists (surgeons and intensivist) from three leading hospitals in Tyumen was also conducted. The main set of clinical material was conducted on the basis of the Regional Clinical Hospital No. 1. RESULTS: The study demonstrated the advantages of early enteral nutrition over delayed nutrition by an average of 48 hours in the form of reducing the duration of hospitalization, resuscitation stage of treatment and minimizing pulmonary complications. At the same time, a survey of specialists providing assistance to this cohort of patients showed a lack of unity in tactical approaches and insufficient adherence to the existing clinical recommendations on clinical nutrition in patients with abdominal surgical pathology. CONCLUSIONS: Further research in the field of nutritional support in patients with abdominal surgical pathology should be aimed at reducing the decision-making time in favor of an earlier and combined method of nutritional support, which can be facilitated by increasing literacy and adherence to clinical recommendations of specialists at the interdisciplinary level.
背景:腹部外科的营养支持是重症监护的一个复杂部分,既有现有的建议,也有跨学科的相互作用。评估营养状况、开始时间和临床营养的方法等问题远未得到解决。这一分析不仅解释了在重症监护室里给谁喂食以及如何喂食,也证明了早期开始肠内营养的必要性,而且由于缺乏统一的观点和对临床建议的遵守程度较低,因此有可能评估“灾难的规模”。目的:分析早期肠内营养在腹部外科病理患者治疗中获得最佳效果的有效性,评估为该队列患者提供护理的专家的知识深度和对临床建议的依从性。材料与方法:本研究纳入50例患者,其中32例早期开始肠内营养,18例后期开始肠内营养。还对秋明三家主要医院的41名专家(外科医生和重症监护医师)进行了调查。主要临床资料以区域第一临床医院为基础进行。结果:研究表明早期肠内营养在缩短住院时间、治疗复苏阶段和减少肺部并发症方面比延迟营养平均多48小时的优势。与此同时,对为这组患者提供帮助的专家进行的一项调查显示,在战术方法上缺乏统一,对腹部外科病理患者临床营养的现有临床建议的依从性不足。结论:在腹部外科病理患者的营养支持领域的进一步研究应旨在减少决策时间,支持早期和联合的营养支持方法,这可以通过提高跨学科水平的专家的读写能力和依从临床建议来促进。
{"title":"Nutritional support in patients with abdominal surgical pathology. The view of a surgeon and an anesthesiologist: opponents or allies?","authors":"N. Shen, Svetlana Yurievna Mukhacheva","doi":"10.17816/clinutr110892","DOIUrl":"https://doi.org/10.17816/clinutr110892","url":null,"abstract":"BACKGROUND: Nutritional support in abdominal surgery is a complex section of intensive care with many contradictions, both in the available recommendations and in relation to interdisciplinary interaction. The issues of assessing nutritional status, timing of the start and methods of clinical nutrition are far from being resolved. The analysis made it possible not so much to explain who and how to feed in the intensive care unit, to prove the need for an early start of enteral nutrition, as to assess the \"scale of the disaster\" in the form of a lack of unity of views and low adherence to clinical recommendations. \u0000AIMS: to analyze the effectiveness of early enteral nutrition in achieving optimal results in the treatment of patients with abdominal surgical pathology, to assess the depth of knowledge and adherence to clinical recommendations of specialists providing care to this cohort of patients. \u0000MATERIALS AND METHODS: The study included 50 patients, 32 of whom started early enteral nutrition, and 18 later enteral nutrition. A survey of 41 specialists (surgeons and intensivist) from three leading hospitals in Tyumen was also conducted. The main set of clinical material was conducted on the basis of the Regional Clinical Hospital No. 1. \u0000RESULTS: The study demonstrated the advantages of early enteral nutrition over delayed nutrition by an average of 48 hours in the form of reducing the duration of hospitalization, resuscitation stage of treatment and minimizing pulmonary complications. At the same time, a survey of specialists providing assistance to this cohort of patients showed a lack of unity in tactical approaches and insufficient adherence to the existing clinical recommendations on clinical nutrition in patients with abdominal surgical pathology. \u0000CONCLUSIONS: Further research in the field of nutritional support in patients with abdominal surgical pathology should be aimed at reducing the decision-making time in favor of an earlier and combined method of nutritional support, which can be facilitated by increasing literacy and adherence to clinical recommendations of specialists at the interdisciplinary level.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88225030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional therapy for protein-energy malnutrition in sepsis in children 儿童败血症中蛋白质-能量营养不良的营养治疗
Pub Date : 2023-01-11 DOI: 10.17816/clinutr111170
Elmira Samatovna Satvaldieva
ABSTRACT. The article is devoted to the most difficult problem of intensive care - sepsis. The issues of the pathogenesis of the development of metabolic disorders, the significance of the syndrome of intestinal insufficiency in the formation of endogenous intoxication and multiple organ failure in sepsis are outlined. The review highlights the analysis of publications on the correction of protein-energy malnutrition in critical conditions. Currently, there are no targeted randomized clinical trials to assess the nutritional status and the adequacy of artificial therapeutic nutrition in children diagnosed with sepsis.
摘要这篇文章致力于重症监护中最困难的问题——败血症。综述了代谢性疾病发展的发病机制、肠道功能不全综合征在内源性中毒形成中的意义以及脓毒症中的多器官衰竭等问题。该综述重点分析了危重状态下蛋白质-能量营养不良纠正的出版物。目前,还没有针对性的随机临床试验来评估诊断为败血症的儿童的营养状况和人工治疗性营养的充分性。
{"title":"Nutritional therapy for protein-energy malnutrition \u0000in sepsis in children","authors":"Elmira Samatovna Satvaldieva","doi":"10.17816/clinutr111170","DOIUrl":"https://doi.org/10.17816/clinutr111170","url":null,"abstract":"ABSTRACT. \u0000 The article is devoted to the most difficult problem of intensive care - sepsis. The issues of the pathogenesis of the development of metabolic disorders, the significance of the syndrome of intestinal insufficiency in the formation of endogenous intoxication and multiple organ failure in sepsis are outlined. The review highlights the analysis of publications on the correction of protein-energy malnutrition in critical conditions. Currently, there are no targeted randomized clinical trials to assess the nutritional status and the adequacy of artificial therapeutic nutrition in children diagnosed with sepsis.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87714538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review of ESPEN-2021 Practice Guidelines for Cancer Patients (part two) -- interventions relevant to specific patient categories. 对espen2021癌症患者实践指南(第二部分)的审查-与特定患者类别相关的干预措施。
Pub Date : 2023-01-11 DOI: 10.17816/clinutr119059
O. Obukhova, A. S. Ivanova, I. Kurmukov, Larisa Ya. Volf
Introduction. In the presented work, the discussion of the 2021 ESPEN practical recommendations for nutritional support in oncology is continued. Methods: The updated version of the 2021 ESPEN practice guidelines differs slightly from the 2017 version and contains flowcharts to facilitate the use of the guidelines in clinical practice, which is also relevant for domestic healthcare. ESPEN-2021 Clinical Guidelines, which offer practical solutions in all areas of oncology, are of particular interest to both oncologists and allied specialists working in oncology. Results. The second part of the review discusses particular issues of nutritional support for cancer patients, and also analyzes the domestic experience of their use. The review provides the main protocols for artificial nutrition in surgery, during irradiation, drug therapy, in patients in remission and at the palliative stage, and also proves the need to maintain physical activity in cancer patients. Conclusion: The presented practical guidance allows organizing an adequate supply of nutrient substrates to cancer patients receiving various types of anticancer treatment, in remission and at the stage of palliative care.
介绍。在目前的工作中,继续讨论2021年ESPEN关于肿瘤学营养支持的实用建议。方法:2021年版ESPEN实践指南与2017年版略有不同,并包含流程图,便于临床实践使用,这也与国内医疗保健相关。espen2021临床指南为肿瘤学的所有领域提供了实用的解决方案,是肿瘤学家和肿瘤学相关专家特别感兴趣的。结果。第二部分综述了癌症患者营养支持的具体问题,并分析了其国内使用经验。这篇综述提供了手术、放疗、药物治疗、缓解期和姑息期患者人工营养的主要方案,并证明了癌症患者保持身体活动的必要性。结论:提出的实用指南可以为接受各种类型抗癌治疗、缓解期和姑息治疗阶段的癌症患者组织足够的营养基质供应。
{"title":"Review of ESPEN-2021 Practice Guidelines for Cancer Patients (part two) -- interventions relevant to specific patient categories.","authors":"O. Obukhova, A. S. Ivanova, I. Kurmukov, Larisa Ya. Volf","doi":"10.17816/clinutr119059","DOIUrl":"https://doi.org/10.17816/clinutr119059","url":null,"abstract":"Introduction. In the presented work, the discussion of the 2021 ESPEN practical recommendations for nutritional support in oncology is continued. \u0000Methods: The updated version of the 2021 ESPEN practice guidelines differs slightly from the 2017 version and contains flowcharts to facilitate the use of the guidelines in clinical practice, which is also relevant for domestic healthcare. ESPEN-2021 Clinical Guidelines, which offer practical solutions in all areas of oncology, are of particular interest to both oncologists and allied specialists working in oncology. \u0000Results. The second part of the review discusses particular issues of nutritional support for cancer patients, and also analyzes the domestic experience of their use. The review provides the main protocols for artificial nutrition in surgery, during irradiation, drug therapy, in patients in remission and at the palliative stage, and also proves the need to maintain physical activity in cancer patients. \u0000Conclusion: The presented practical guidance allows organizing an adequate supply of nutrient substrates to cancer patients receiving various types of anticancer treatment, in remission and at the stage of palliative care.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88329629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Calcium and vitamin D supplements for treatment ana prevention of osteoporosis. Should it be widely used? 钙和维生素D补充剂用于治疗和预防骨质疏松症。它应该被广泛使用吗?
Pub Date : 2022-12-05 DOI: 10.17816/clinutr112300
Y. A. Kaminarskaya
Osteoporosis is the most common age-related skeletal disease, which characterized by rapid loss of bone mineral density and increased risk of fragility fractures. The social significance of the disease is caused by its complications, which increase disability and mortality rates mostly among elderly people. Inadequate dietary calcium intake and vitamin D deficiency are well-known risk factors for osteoporosis. That is why for many years calcium and vitamin D have been considered crucial in the prevention and treatment of osteoporosis. However, in recent years, the efficacy and safety of calcium and vitamin D has been questioned. Since some conducted randomized clinical trials have reported only a week positive effect of calcium with or without vitamin in reducing fragility fracture risk. On the other hand, besides the gastrointestinal side effects of calcium supplements and the risk of kidney stones related to use of co-administered calcium and vitamin D supplements, other recent data suggested potential adverse cardiovascular effects from calcium supplementation. This article is focused on the evidence regarding both the possible usefulness for bone health and the potential harmful effects of calcium and/or calcium with vitamin D supplementation.
骨质疏松症是最常见的与年龄相关的骨骼疾病,其特征是骨矿物质密度的迅速丧失和脆性骨折的风险增加。该病的社会意义在于其并发症,这些并发症增加了残疾和死亡率,主要发生在老年人中。膳食钙摄入不足和维生素D缺乏是众所周知的骨质疏松症的危险因素。这就是为什么多年来钙和维生素D一直被认为是预防和治疗骨质疏松症的关键。然而,近年来,钙和维生素D的有效性和安全性受到质疑。由于一些随机临床试验报告了只有一周的积极作用,钙与维生素或不维生素降低脆性骨折的风险。另一方面,除了钙补充剂的胃肠道副作用和与同时服用钙和维生素D补充剂相关的肾结石风险外,最近的其他数据表明,钙补充剂可能对心血管产生不利影响。这篇文章的重点是关于钙和/或钙与维生素D补充可能对骨骼健康有益和潜在有害影响的证据。
{"title":"Calcium and vitamin D supplements for treatment ana prevention of osteoporosis. Should it be widely used?","authors":"Y. A. Kaminarskaya","doi":"10.17816/clinutr112300","DOIUrl":"https://doi.org/10.17816/clinutr112300","url":null,"abstract":"Osteoporosis is the most common age-related skeletal disease, which characterized by rapid loss of bone mineral density and increased risk of fragility fractures. The social significance of the disease is caused by its complications, which increase disability and mortality rates mostly among elderly people. Inadequate dietary calcium intake and vitamin D deficiency are well-known risk factors for osteoporosis. That is why for many years calcium and vitamin D have been considered crucial in the prevention and treatment of osteoporosis. However, in recent years, the efficacy and safety of calcium and vitamin D has been questioned. Since some conducted randomized clinical trials have reported only a week positive effect of calcium with or without vitamin in reducing fragility fracture risk. On the other hand, besides the gastrointestinal side effects of calcium supplements and the risk of kidney stones related to use of co-administered calcium and vitamin D supplements, other recent data suggested potential adverse cardiovascular effects from calcium supplementation. This article is focused on the evidence regarding both the possible usefulness for bone health and the potential harmful effects of calcium and/or calcium with vitamin D supplementation.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78146660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of intestinal lavage in the normalization of the functions of the gastrointestinal tract in patients in chronic critical condition. 肠灌洗在慢性危重症患者胃肠道功能正常化中的作用。
Pub Date : 2022-12-01 DOI: 10.17816/clinutr111148
O. B. Lukyanets, M. Petrova, A. Yakovleva, A. Shestopalov
BACKGROUND: The resolution of intestinal insufficiency syndrome remains one of the urgent problems of nutritional support for patients in chronic critical condition. Purpose of the study. To determine the effectiveness of intestinal lavage in restoring the basic functions of the gastrointestinal tract and microbiocenosis in patients in chronic critical condition. Materials and methods. A prospective, randomized, single-center study was performed. The study was performed in 56 affected men with TBI of various etiologies in a chronic critical condition. At the beginning of treatment and on the 10th day, the effectiveness of gastrointestinal lavage was evaluated in the complex intensive therapy of intestinal insufficiency syndrome. Results. Patients were randomized into two groups depending on the conduct of intestinal lavage. In the 1st group (27 patients), enteral tube feeding was performed according to the standard method. In the 2nd group (29 patients), intestinal lavage was additionally performed with the addition of an enterosorbent to the saline enterosorbent solution, 3 procedures with an interval of 3 days. In the 2nd group (main), there was a significant positive dynamics of carbohydrate and protein metabolism, restoration by the 10th day of the barrier function of the intestine, motility of the gastrointestinal tract, microbiocenosis compared with patients in the control (group 1). Conclusion. The inclusion of gastrointestinal lavage in the complex intensive therapy of SCI in patients in a chronic critical condition in a short time helps to resolve the main pathogenetic links of SCI - restoration of the barrier function of the intestine, digestive-transport, motor-evacuation processes in the gastrointestinal tract, normalization of microbiocenosis, metabolic parameters and nutritional status.
背景:肠功能不全综合征的解决仍然是慢性危重症患者营养支持的迫切问题之一。研究目的:目的探讨肠灌洗对恢复慢性危重症患者胃肠道基本功能和微生物病的疗效。材料和方法。进行了一项前瞻性、随机、单中心研究。该研究在56名慢性危重症的不同病因的TBI患者中进行。在治疗开始和第10天,评估胃肠灌洗在肠功能不全综合征综合强化治疗中的效果。结果。根据洗肠情况将患者随机分为两组。第一组(27例)按标准方法进行肠内管喂养。第二组(29例)在生理盐水肠吸收液基础上加肠吸收剂进行肠灌洗,共3次,间隔3天。在第二组(主要)中,与对照组(1组)患者相比,碳水化合物和蛋白质代谢、第10天肠道屏障功能恢复、胃肠道运动、微生物病均有显著的正动态变化。将胃肠灌洗纳入慢性危重期脊髓损伤的综合强化治疗中,有助于解决脊髓损伤的主要发病环节——肠道屏障功能的恢复、胃肠道消化运输、运动排泄过程的恢复、微生物群落、代谢参数和营养状况的正常化。
{"title":"The role of intestinal lavage in the normalization of the functions of the gastrointestinal tract in patients in chronic critical condition.","authors":"O. B. Lukyanets, M. Petrova, A. Yakovleva, A. Shestopalov","doi":"10.17816/clinutr111148","DOIUrl":"https://doi.org/10.17816/clinutr111148","url":null,"abstract":"BACKGROUND: The resolution of intestinal insufficiency syndrome remains one of the urgent problems of nutritional support for patients in chronic critical condition. \u0000Purpose of the study. To determine the effectiveness of intestinal lavage in restoring the basic functions of the gastrointestinal tract and microbiocenosis in patients in chronic critical condition. \u0000Materials and methods. A prospective, randomized, single-center study was performed. The study was performed in 56 affected men with TBI of various etiologies in a chronic critical condition. At the beginning of treatment and on the 10th day, the effectiveness of gastrointestinal lavage was evaluated in the complex intensive therapy of intestinal insufficiency syndrome. \u0000Results. Patients were randomized into two groups depending on the conduct of intestinal lavage. In the 1st group (27 patients), enteral tube feeding was performed according to the standard method. In the 2nd group (29 patients), intestinal lavage was additionally performed with the addition of an enterosorbent to the saline enterosorbent solution, 3 procedures with an interval of 3 days. In the 2nd group (main), there was a significant positive dynamics of carbohydrate and protein metabolism, restoration by the 10th day of the barrier function of the intestine, motility of the gastrointestinal tract, microbiocenosis compared with patients in the control (group 1). \u0000Conclusion. The inclusion of gastrointestinal lavage in the complex intensive therapy of SCI in patients in a chronic critical condition in a short time helps to resolve the main pathogenetic links of SCI - restoration of the barrier function of the intestine, digestive-transport, motor-evacuation processes in the gastrointestinal tract, normalization of microbiocenosis, metabolic parameters and nutritional status.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82489637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distribution of water sectors in patients in chronic critical illness (early rehabilitation stage). 慢性危重症患者(早期康复阶段)的供水部门分布。
Pub Date : 2022-11-18 DOI: 10.17816/clinutr110984
A. Yakovleva, Zinaida M. Orehova, A. Shestopalov, M. Petrova
BACKGROUND: Fluid therapy in the intensive care unit is one of the most common components of therapy, but at the same time one of the most controversial and widely discussed. The choice of volume and type of infusion is a multifactorial issue. Currently, the search continues for a convenient non-invasive method, which can be used to assess the water composition of the patient's body. AIMS: analysis of the distribution of fluid sectors in patients in chronic critical illness using the bioimpedance with standard fluid therapy. MATERIALS AND METHODS: The study included 63 patients in CCI after brain damage, 28 men, 35 women, the average age 54 19 years. According to nosology: ischemic stroke 22, traumatic brain injury 17, hemorrhagic stroke 14, condition after brain surgery 7, post-hypoxic conditions 2. The study was carried out in the morning before breakfast using the analyzer of bioimpedance metabolic processes and body composition ABC-02 "Medass". A total of 140 measurements were conducted. RESULTS: It drew attention to the fact that in most cases the volume of the total body water (TBW) in patients was within the age and sex norm (78.6%), however, the volume of extracellular water (ECW) reached normal values ​​only in 45.7%. Moreover, both indicators were simultaneously within the normal range only in 44.3%. Then we found that TBW and ECW did not coincide at 35.7%. The most common option for this was an increase in ECW while maintaining a normal TBW (24.3%). When conducting a correlation analysis of TBW and ECW indicators with biochemical blood test data (a decrease in the total protein level, a decrease in the albumin level), the strength of the relationship between the correlation coefficients of the samples on the Chaddock scale turned out to be very weak for all the options considered. CONCLUSIONS: In patients in CCI after brain damage, in more than 50%, there may be an accumulation of water in the extracellular space without visible edema, while in 24.3% the total body water indicator is within the age and sex norm. This indicator doesnt depend on either the level of hypoproteinemia or hypoalbuminemia.
背景:重症监护病房的液体疗法是最常见的疗法之一,但同时也是最具争议和广泛讨论的疗法之一。输注量和输注类型的选择是一个多因素问题。目前,仍在继续寻找一种方便的非侵入性方法,可用于评估患者体内的水成分。目的:应用生物阻抗法和标准液体疗法分析慢性危重症患者体液区分布。材料与方法:本研究纳入63例脑损伤后CCI患者,男性28例,女性35例,平均年龄54 - 19岁。根据疾病分类:缺血性中风22例,外伤性脑损伤17例,出血性中风14例,脑部手术后情况7例,缺氧后情况2例。研究在早餐前进行,使用生物阻抗代谢过程和身体成分分析仪ABC-02“Medass”。总共进行了140次测量。结果:值得注意的是,大多数患者的总水量(TBW)在年龄和性别标准范围内(78.6%),而细胞外水量(ECW)达到正常值的仅占45.7%。两项指标同时处于正常范围的仅占44.3%。然后我们发现TBW和ECW不一致,为35.7%。最常见的选择是在维持正常TBW的同时增加ECW(24.3%)。当对TBW和ECW指标与血液生化检测数据(总蛋白水平降低,白蛋白水平降低)进行相关性分析时,在所有考虑的选项中,Chaddock量表上样品的相关系数之间的关系强度非常弱。结论:在脑损伤后CCI患者中,超过50%的患者可能存在细胞外空间积水,但未见明显水肿,24.3%的患者全身水分指标在年龄和性别正常值范围内。该指标既不取决于低蛋白血症水平,也不取决于低白蛋白血症水平。
{"title":"Distribution of water sectors in patients in chronic critical illness (early rehabilitation stage).","authors":"A. Yakovleva, Zinaida M. Orehova, A. Shestopalov, M. Petrova","doi":"10.17816/clinutr110984","DOIUrl":"https://doi.org/10.17816/clinutr110984","url":null,"abstract":"BACKGROUND: Fluid therapy in the intensive care unit is one of the most common components of therapy, but at the same time one of the most controversial and widely discussed. The choice of volume and type of infusion is a multifactorial issue. Currently, the search continues for a convenient non-invasive method, which can be used to assess the water composition of the patient's body. \u0000AIMS: analysis of the distribution of fluid sectors in patients in chronic critical illness using the bioimpedance with standard fluid therapy. \u0000MATERIALS AND METHODS: The study included 63 patients in CCI after brain damage, 28 men, 35 women, the average age 54 19 years. According to nosology: ischemic stroke 22, traumatic brain injury 17, hemorrhagic stroke 14, condition after brain surgery 7, post-hypoxic conditions 2. The study was carried out in the morning before breakfast using the analyzer of bioimpedance metabolic processes and body composition ABC-02 \"Medass\". A total of 140 measurements were conducted. \u0000RESULTS: It drew attention to the fact that in most cases the volume of the total body water (TBW) in patients was within the age and sex norm (78.6%), however, the volume of extracellular water (ECW) reached normal values ​​only in 45.7%. Moreover, both indicators were simultaneously within the normal range only in 44.3%. Then we found that TBW and ECW did not coincide at 35.7%. The most common option for this was an increase in ECW while maintaining a normal TBW (24.3%). When conducting a correlation analysis of TBW and ECW indicators with biochemical blood test data (a decrease in the total protein level, a decrease in the albumin level), the strength of the relationship between the correlation coefficients of the samples on the Chaddock scale turned out to be very weak for all the options considered. \u0000CONCLUSIONS: In patients in CCI after brain damage, in more than 50%, there may be an accumulation of water in the extracellular space without visible edema, while in 24.3% the total body water indicator is within the age and sex norm. This indicator doesnt depend on either the level of hypoproteinemia or hypoalbuminemia.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82441674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review of ESPEN-2021 Practice Guidelines for Cancer Patients. Part one. 癌症患者ESPEN-2021实践指南审查第一部分。
Pub Date : 2022-11-15 DOI: 10.17816/clinutr111900
O. Obukhova, A. Ivanova, I. Kurmukov, L. Volf
Introduction. This paper discusses the 2021 ESPEN Practical Guidelines for Nutritional Support in Oncology. Methods: The updated version of the 2021 ESPEN practice guidelines differs slightly from the 2017 version and contains flowcharts to facilitate the use of the guidelines in clinical practice, which is also relevant for domestic healthcare. ESPEN-2021 Clinical Guidelines, which offer practical solutions in all areas of oncology, are of particular interest to both oncologists and allied specialists working in oncology. Results. The first part of the review discusses general recommendations for nutritional support for cancer patients and the possibility of their use in our country: screening of nutritional status at the initial visit, indications for prescribing additional nutrition, the benefits of one or another type of nutritional support in various situations, norms for providing macronutrients, vitamins and minerals, and also substantiates the need for physical activity. Conclusion: This practical guide forms an algorithm of actions to ensure optimal nutrition for a cancer patient. The general principles of nutritional therapy applicable to all cancer patients are based on timely screening for nutritional deficiencies, adherence to proper nutritional support of patients, which can be achieved by modifying the diet or prescribing additional nutrition, mainly enteral.
介绍。本文讨论了2021年ESPEN肿瘤营养支持实用指南。方法:2021年版ESPEN实践指南与2017年版略有不同,并包含流程图,便于临床实践使用,这也与国内医疗保健相关。espen2021临床指南为肿瘤学的所有领域提供了实用的解决方案,是肿瘤学家和肿瘤学相关专家特别感兴趣的。结果。审查的第一部分讨论了对癌症患者的营养支持的一般建议及其在我国使用的可能性:筛查初次就诊时的营养状况,处方额外营养的适应症,在各种情况下一种或另一种营养支持的益处,提供宏量营养素,维生素和矿物质的规范,并证实需要进行身体活动。结论:本实用指南形成了确保癌症患者最佳营养的行动算法。适用于所有癌症患者的营养治疗的一般原则是基于及时筛查营养缺乏,坚持适当的患者营养支持,这可以通过改变饮食或开额外的营养来实现,主要是肠内营养。
{"title":"Review of ESPEN-2021 Practice Guidelines for Cancer Patients. Part one.","authors":"O. Obukhova, A. Ivanova, I. Kurmukov, L. Volf","doi":"10.17816/clinutr111900","DOIUrl":"https://doi.org/10.17816/clinutr111900","url":null,"abstract":"Introduction. This paper discusses the 2021 ESPEN Practical Guidelines for Nutritional Support in Oncology. \u0000Methods: The updated version of the 2021 ESPEN practice guidelines differs slightly from the 2017 version and contains flowcharts to facilitate the use of the guidelines in clinical practice, which is also relevant for domestic healthcare. ESPEN-2021 Clinical Guidelines, which offer practical solutions in all areas of oncology, are of particular interest to both oncologists and allied specialists working in oncology. \u0000Results. The first part of the review discusses general recommendations for nutritional support for cancer patients and the possibility of their use in our country: screening of nutritional status at the initial visit, indications for prescribing additional nutrition, the benefits of one or another type of nutritional support in various situations, norms for providing macronutrients, vitamins and minerals, and also substantiates the need for physical activity. \u0000Conclusion: This practical guide forms an algorithm of actions to ensure optimal nutrition for a cancer patient. The general principles of nutritional therapy applicable to all cancer patients are based on timely screening for nutritional deficiencies, adherence to proper nutritional support of patients, which can be achieved by modifying the diet or prescribing additional nutrition, mainly enteral.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74383204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Nutritional interventions in the framework of a person-centered model of health care and geroprotection 在以人为本的保健和老年保护模式框架内的营养干预措施
Pub Date : 2022-11-08 DOI: 10.17816/clinutr110996
A. Martyushev-Poklad, D. Yankevich, Nataliya G. Savitskaya, M. Petrova
The existing system of prevention of age-related diseases focused on cohort-based risk factors shows insufficient effectiveness, and hence there is a need in practicable methodology of health promotion compliant with the principles of P4 medicine, with a special focus on nutritional interventions. The paper outlines an algorithm of nutritional interventions designed in accordance with the principles of person-centered organizational model of health care. The algorithm is based on the modern concept of exposome and its influence on the key mechanisms of accelerated aging and pathogenesis of age-related diseases. The proposed approach to personalized nutritional interventions is implemented in 3 steps: (1) the need in nutritional intervention is identified through evaluation of the signs and symptoms of health impairment and accelerated aging that have very probable association with suboptimal nutrition; (2) factors of individual exposome are evaluated as potential sources of health problems; (3) first line nutritional interventions are selected and implemented. The algorithm is focused on eliminating the shortcomings of the diagnosis-centered organizational model of healthcare prevailing worldwide: to enable early detection of distress, the use of the most effective and affordable interventions (diet and nutrition), maximum involvement of the patient in the management of ones health. The algorithm bears a good potential of automation in the form of decision support for the patient regarding his health. The use of original questionnaires and patient-centered data reduces the cost and expands the possibilities of scaling the algorithms of intervention. The algorithm can become the basis for wide introduction of the principles of predictive, personalized and participatory prevention of age-related diseases.
现有的年龄相关疾病预防系统侧重于基于队列的风险因素,其有效性不足,因此需要采用符合P4医学原则的切实可行的健康促进方法,并特别注重营养干预。本文提出了一种按照以人为本的卫生保健组织模式原则设计的营养干预算法。该算法基于现代暴露体概念及其对加速衰老关键机制和年龄相关疾病发病机制的影响。提出的个性化营养干预方法分三个步骤实施:(1)通过评估与营养不良极有可能相关的健康损害和加速衰老的体征和症状来确定营养干预的必要性;(2)评估个人暴露因素作为健康问题的潜在来源;(3)选择并实施一线营养干预措施。该算法的重点是消除世界范围内普遍存在的以诊断为中心的医疗保健组织模式的缺点:能够早期发现痛苦,使用最有效和负担得起的干预措施(饮食和营养),最大限度地让患者参与管理自己的健康。该算法具有很好的自动化潜力,可以为患者的健康提供决策支持。使用原始问卷和以患者为中心的数据降低了成本,扩大了扩展干预算法的可能性。该算法可以成为广泛引入预测、个性化和参与式预防老年性疾病原则的基础。
{"title":"Nutritional interventions in the framework of a person-centered model of health care and geroprotection","authors":"A. Martyushev-Poklad, D. Yankevich, Nataliya G. Savitskaya, M. Petrova","doi":"10.17816/clinutr110996","DOIUrl":"https://doi.org/10.17816/clinutr110996","url":null,"abstract":"The existing system of prevention of age-related diseases focused on cohort-based risk factors shows insufficient effectiveness, and hence there is a need in practicable methodology of health promotion compliant with the principles of P4 medicine, with a special focus on nutritional interventions. \u0000The paper outlines an algorithm of nutritional interventions designed in accordance with the principles of person-centered organizational model of health care. The algorithm is based on the modern concept of exposome and its influence on the key mechanisms of accelerated aging and pathogenesis of age-related diseases. \u0000The proposed approach to personalized nutritional interventions is implemented in 3 steps: \u0000(1) the need in nutritional intervention is identified through evaluation of the signs and symptoms of health impairment and accelerated aging that have very probable association with suboptimal nutrition; \u0000(2) factors of individual exposome are evaluated as potential sources of health problems; \u0000(3) first line nutritional interventions are selected and implemented. \u0000The algorithm is focused on eliminating the shortcomings of the diagnosis-centered organizational model of healthcare prevailing worldwide: to enable early detection of distress, the use of the most effective and affordable interventions (diet and nutrition), maximum involvement of the patient in the management of ones health. The algorithm bears a good potential of automation in the form of decision support for the patient regarding his health. The use of original questionnaires and patient-centered data reduces the cost and expands the possibilities of scaling the algorithms of intervention. \u0000The algorithm can become the basis for wide introduction of the principles of predictive, personalized and participatory prevention of age-related diseases.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76965454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of clinical nutrition and metabolism
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1