K. Krylov, M. Petrova, A. Shestopalov, A. Yakovleva, A. Yakovlev
In the intensive care unit, along with other methods of intensive care, such as maintaining blood pressure, antibiotic therapy, mechanical ventilation (MV), vasopressors, clinical nutrition should always be present. Clinical nutrition is an integral part of the treatment process in the intensive care unit (ICU). There are a large number of publications concerning the prevention and treatment of intensive care outcome syndrome (ICU syndrome). One of the most important and low-cost strategies for preventing this condition is nutritional support for critically ill patients at all stages of curation, from the moment of admission to the ICU to the end of the rehabilitation course. With the correct appointment of nutritional support, taking into account the indications and contraindications for various nosological forms, the advantages are obvious in the form of: improved treatment outcomes. Proper organization of nutritional support in the hospital is the main key to success in early rehabilitation. From the understanding of nutritional support, its organization and mutual understanding between all links, its effectiveness will depend. Based on the experience of creating a laboratory for clinical nutrition and metabolism, it can be concluded that the creation of such a laboratory and the organization of clinical nutrition in a hospital can improve the results of treatment of even the most severe category of patients.
{"title":"Experience in organizing a clinical nutrition and metabolism laboratory and creating a nutritional support system in the icu and intensive care departments","authors":"K. Krylov, M. Petrova, A. Shestopalov, A. Yakovleva, A. Yakovlev","doi":"10.17816/clinutr109306","DOIUrl":"https://doi.org/10.17816/clinutr109306","url":null,"abstract":"In the intensive care unit, along with other methods of intensive care, such as maintaining blood pressure, antibiotic therapy, mechanical ventilation (MV), vasopressors, clinical nutrition should always be present. Clinical nutrition is an integral part of the treatment process in the intensive care unit (ICU). There are a large number of publications concerning the prevention and treatment of intensive care outcome syndrome (ICU syndrome). One of the most important and low-cost strategies for preventing this condition is nutritional support for critically ill patients at all stages of curation, from the moment of admission to the ICU to the end of the rehabilitation course. With the correct appointment of nutritional support, taking into account the indications and contraindications for various nosological forms, the advantages are obvious in the form of: improved treatment outcomes. Proper organization of nutritional support in the hospital is the main key to success in early rehabilitation. From the understanding of nutritional support, its organization and mutual understanding between all links, its effectiveness will depend. Based on the experience of creating a laboratory for clinical nutrition and metabolism, it can be concluded that the creation of such a laboratory and the organization of clinical nutrition in a hospital can improve the results of treatment of even the most severe category of patients.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78178929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical rehabilitation of spinal cord injured patients is an important medical and social problem associated with the high level of disability in this category of patients. The aim of the study was to improve the efficiency of medical rehabilitation of spinal cord injured patients based on a set of measures of nutritional support and raising the exercise tolerance. Materials and methods: seventy eight patients in the intermediate recovery period of spinal cord injury were monitored, the nutritional status was evaluated in the dynamics. In the 1st (main) group, a complex correction of the nutritional status with additional use of high protein hypercaloric mixtures for enteral nutrition was performed before and after handcycling. In the 2nd (control) group, - the rehabilitation techniques were carried out on the generally accepted basis. Results and discussion. As a result of the complex correction, the proportion of patients with mild and moderate malnutrition was significantly lower in the 1st (main) group than in the II (control) group (p = 0.05). Peak oxygen consumption increased in the 1st group of patients with mild malnutrition on 34.1% (p=0,019) and with moderate malnutrition on 23,6% (p=0,02) compared to the control group. All spinal cord injured patients of the 1st (main) group improved their motor and social activity according to the FIM scale compared to the control group (p0.001). Conclusions. The combination of adequate nutritional support and proper handcycling significantly contributes to reduce malnutrition in patients with spinal cord injury (p = 0.05). Tolerance to physical exercises during the complex correction of malnutrition significantly increased (p 0.01) as well as the motor and social activities and, therefore, quality of life (p 0.0001).
{"title":"Рossibilities of comprehensive correction of malnutrition in spinal cord injured patients.","authors":"L. Gumarova, R. A. Bodrova, G. Z. Akhmetzyanova","doi":"10.17816/clinutr108613","DOIUrl":"https://doi.org/10.17816/clinutr108613","url":null,"abstract":"Medical rehabilitation of spinal cord injured patients is an important medical and social problem associated with the high level of disability in this category of patients. The aim of the study was to improve the efficiency of medical rehabilitation of spinal cord injured patients based on a set of measures of nutritional support and raising the exercise tolerance. Materials and methods: seventy eight patients in the intermediate recovery period of spinal cord injury were monitored, the nutritional status was evaluated in the dynamics. In the 1st (main) group, a complex correction of the nutritional status with additional use of high protein hypercaloric mixtures for enteral nutrition was performed before and after handcycling. In the 2nd (control) group, - the rehabilitation techniques were carried out on the generally accepted basis. Results and discussion. As a result of the complex correction, the proportion of patients with mild and moderate malnutrition was significantly lower in the 1st (main) group than in the II (control) group (p = 0.05). Peak oxygen consumption increased in the 1st group of patients with mild malnutrition on 34.1% (p=0,019) and with moderate malnutrition on 23,6% (p=0,02) compared to the control group. All spinal cord injured patients of the 1st (main) group improved their motor and social activity according to the FIM scale compared to the control group (p0.001). Conclusions. The combination of adequate nutritional support and proper handcycling significantly contributes to reduce malnutrition in patients with spinal cord injury (p = 0.05). Tolerance to physical exercises during the complex correction of malnutrition significantly increased (p 0.01) as well as the motor and social activities and, therefore, quality of life (p 0.0001).","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80912580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Shestopalov, A. Zholinsky, T. Pushkina, Zh. V. Grishina, M. Ogannisyan, V. Feshchenko, I. Dolgov, Elena Razumec, S. Barshak
Purpose of the study: the study of the intestinal microbiome of high-class athletes and the effect of restoring the balance of intestinal microflora on indicators of their physical and psychophysiological state. Materials and methods: A single-center prospective study was performed on professional athletes in the conditions of training camps. Fifty-one high-class athletes (women - 37, men - 14) aged from 18 to 32 years took part. Athletes were divided into 3 groups: Group 1 (basketball) - 16 female athletes, Group 2 (biathlon, ski racing) - 19 athletes (14 men and 5 women), Group 3 (water polo) - 16 female athletes. Stool was analyzed for the composition of microflora. Depending on the results of the analysis, the sportsmen were recommended to use one of the programs, including prebiotic, probiotic, metabiotic, or their combination. Results and conclusions: gut dysbacteriosis and gastrointestinal dysfunctions are frequent in highly qualified athletes. A combined use of prebiotic and probiotic or prebiotic and metabiotic has an effective effect on restoring the gut microbiome and the functional state of the gastrointestinal tract. This normalization has a direct positive effect on the gut-microbiota-brain axis, thereby improving the functional and psychoemotional state of high-class athletes in general
{"title":"Improving the physical performance and psychophysiological state of highly qualified athletes by normalizing the interaction of the intestinal microbiome and central nervous system","authors":"A. Shestopalov, A. Zholinsky, T. Pushkina, Zh. V. Grishina, M. Ogannisyan, V. Feshchenko, I. Dolgov, Elena Razumec, S. Barshak","doi":"10.17816/clinutr106582","DOIUrl":"https://doi.org/10.17816/clinutr106582","url":null,"abstract":"Purpose of the study: the study of the intestinal microbiome of high-class athletes and the effect of restoring the balance of intestinal microflora on indicators of their physical and psychophysiological state. Materials and methods: A single-center prospective study was performed on professional athletes in the conditions of training camps. Fifty-one high-class athletes (women - 37, men - 14) aged from 18 to 32 years took part. Athletes were divided into 3 groups: Group 1 (basketball) - 16 female athletes, Group 2 (biathlon, ski racing) - 19 athletes (14 men and 5 women), Group 3 (water polo) - 16 female athletes. Stool was analyzed for the composition of microflora. Depending on the results of the analysis, the sportsmen were recommended to use one of the programs, including prebiotic, probiotic, metabiotic, or their combination. Results and conclusions: gut dysbacteriosis and gastrointestinal dysfunctions are frequent in highly qualified athletes. A combined use of prebiotic and probiotic or prebiotic and metabiotic has an effective effect on restoring the gut microbiome and the functional state of the gastrointestinal tract. This normalization has a direct positive effect on the gut-microbiota-brain axis, thereby improving the functional and psychoemotional state of high-class athletes in general","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"190 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77239754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Martyushev-Poklad, D. Yankevich, M. Petrova, Nataliya G. Savitskaya
Background: The current dietary advice for the elderly are not in line with contemporary understanding of the effects that nutrition produces on the universal mechanisms of age-related diseases (ARD). The review is aimed at filling this gap, with special focus on prevention of frailty and sarcopenia, the key factors of longevity and health quality. Methods: Search in Google Scholar, PubMed for reviews and clinical trials with key words nutrition, frailty, and sarcopenia. Results: Frailty is affected by several biopsychosocial factors, with paramount role of nutrition. It dominates the onset and progression of the key mechanisms of accelerated aging: most importantly, chronic systemic inflammation, insulin resistance, and gut dysbiosis. There is strong evidence that frailty is promoted by malnutrition (insufficiency of energy and nutrients), obesity (insulin resistance), protein deficit, high dietary inflammatory index, easily digested carbohydrates (including fructose and starch), highly processed food, trans-fats, and indirectly by gluten. Frailty and sarcopenia can be prevented through consumption of high quality (animal) protein, vegetables and fruit (the source of dietary fiber, vitamins, minerals, and phytonutrients), fats, nutrients with antioxidant properties (including vitamins A and E, zinc, selenium, omega-3 fatty acids), correction of vitamin D status, support of gut microbial diversity, correction of hyperinsulinemia and increased intestinal permeability. Conclusion: The dietary advice for the elderly requires revision in line with the contemporary understanding of ARD mechanisms and the recent evidence base. The review covers the basics of nutrition essential to prevent frailty and sarcopenia.
{"title":"Novel approaches to optimize nutrition in the elderly patients","authors":"A. Martyushev-Poklad, D. Yankevich, M. Petrova, Nataliya G. Savitskaya","doi":"10.17816/clinutr108594","DOIUrl":"https://doi.org/10.17816/clinutr108594","url":null,"abstract":"Background: The current dietary advice for the elderly are not in line with contemporary understanding of the effects that nutrition produces on the universal mechanisms of age-related diseases (ARD). The review is aimed at filling this gap, with special focus on prevention of frailty and sarcopenia, the key factors of longevity and health quality. \u0000Methods: Search in Google Scholar, PubMed for reviews and clinical trials with key words nutrition, frailty, and sarcopenia. \u0000Results: Frailty is affected by several biopsychosocial factors, with paramount role of nutrition. It dominates the onset and progression of the key mechanisms of accelerated aging: most importantly, chronic systemic inflammation, insulin resistance, and gut dysbiosis. There is strong evidence that frailty is promoted by malnutrition (insufficiency of energy and nutrients), obesity (insulin resistance), protein deficit, high dietary inflammatory index, easily digested carbohydrates (including fructose and starch), highly processed food, trans-fats, and indirectly by gluten. \u0000Frailty and sarcopenia can be prevented through consumption of high quality (animal) protein, vegetables and fruit (the source of dietary fiber, vitamins, minerals, and phytonutrients), fats, nutrients with antioxidant properties (including vitamins A and E, zinc, selenium, omega-3 fatty acids), correction of vitamin D status, support of gut microbial diversity, correction of hyperinsulinemia and increased intestinal permeability. \u0000Conclusion: The dietary advice for the elderly requires revision in line with the contemporary understanding of ARD mechanisms and the recent evidence base. The review covers the basics of nutrition essential to prevent frailty and sarcopenia.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87549157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rybakova.poly@yandex.ru D. Rybakova, A. Miroshnikov, A. Smolensky
Effective nutritional-metabolic support strategies are of interest to athletes, coaches, and physicians prescribing various supplements. Dietary deficiencies in macronutrients, vitamins, and minerals of the right type can interfere with training adaptation, while in athletes who eat a balanced diet, physiological training adaptation can be enhanced. Therefore, in the event of a lack of specific nutrients, athletes are forced to use various supplements, but will individual combinations of them be safe for the body as a whole and effective for improving athletic performance? The paper analyzes and summarizes studies on the compatibility of some supplements and the safety and efficacy of such combinations in sports, in particular: the compatibility of vitamins E and C, vitamin D and calcium, creatine and caffeine, branched chain amino acids (isoleucine, leucine and valine).
{"title":"THE PROBLEM OF COMPATIBILITY OF DIFFERENT SUPPLEMENTS IN SPORTS","authors":"Rybakova.poly@yandex.ru D. Rybakova, A. Miroshnikov, A. Smolensky","doi":"10.17816/clinutr106711","DOIUrl":"https://doi.org/10.17816/clinutr106711","url":null,"abstract":"Effective nutritional-metabolic support strategies are of interest to athletes, coaches, and physicians prescribing various supplements. Dietary deficiencies in macronutrients, vitamins, and minerals of the right type can interfere with training adaptation, while in athletes who eat a balanced diet, physiological training adaptation can be enhanced. Therefore, in the event of a lack of specific nutrients, athletes are forced to use various supplements, but will individual combinations of them be safe for the body as a whole and effective for improving athletic performance? The paper analyzes and summarizes studies on the compatibility of some supplements and the safety and efficacy of such combinations in sports, in particular: the compatibility of vitamins E and C, vitamin D and calcium, creatine and caffeine, branched chain amino acids (isoleucine, leucine and valine).","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"4657 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83994118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Shestopalov, A. Yakovleva, Oleg B. Lukyanec, M. Petrova
Due to the modern level of development of medicine, more and more patients survive after severe acute diseases. However, some of the patients remain dependent on life support systems. Therefore, a chronic critical condition is an urgent problem for patients in the intensive care unit. The main syndrome of this complex is maladaptive response to long-term existing stress factors. This review examines the main pathophysiological mechanisms of chronic critical illness, as well as the resulting metabolic disorders. Emphasis is placed on the systemic inflammatory reaction, the reaction of hypermetabolism - hypercatabolism, disorders of carbohydrate, protein and fat metabolism, the development of secondary sarcopenia. In conclusion, the volume of metabolic control and intensive nutritional and metabolic support, which are an important component of a comprehensive approach to the treatment of chronic critical illness, are also considered.
{"title":"Metabolic predictors of life-threatening conditions in patients in chronic critical condition (review)","authors":"A. Shestopalov, A. Yakovleva, Oleg B. Lukyanec, M. Petrova","doi":"10.17816/clinutr105625","DOIUrl":"https://doi.org/10.17816/clinutr105625","url":null,"abstract":"Due to the modern level of development of medicine, more and more patients survive after severe acute diseases. However, some of the patients remain dependent on life support systems. Therefore, a chronic critical condition is an urgent problem for patients in the intensive care unit. The main syndrome of this complex is maladaptive response to long-term existing stress factors. This review examines the main pathophysiological mechanisms of chronic critical illness, as well as the resulting metabolic disorders. Emphasis is placed on the systemic inflammatory reaction, the reaction of hypermetabolism - hypercatabolism, disorders of carbohydrate, protein and fat metabolism, the development of secondary sarcopenia. In conclusion, the volume of metabolic control and intensive nutritional and metabolic support, which are an important component of a comprehensive approach to the treatment of chronic critical illness, are also considered.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75110219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Grishina, A. Shestopalov, E. Lomazova, Andrey Kalinin, V. Feshchenko, A. Zholinsky
Purpose of the study: to evaluate the effect of consumption of beet juice, as a source of nitrates, on the performance of biathletes. Materials and methods: 40 male biathletes aged from 18 to 22 years took part in the study. The study took place under the conditions of a training camp in the summer of 2017, the athletes were divided into 2 groups: experimental and control. The experimental group was given a preparation containing beet juice of a special variety 2 times a day after each training session, the athletes of the control group did not take anything after training sessions. Before the experiment and after 20 days of taking the preparation load testing before work refusal was carried out, as well as biochemical and general blood analysis. Results and conclusions: in the athletes of the experimental group against the background of taking beet juice there was a decrease in oxygen uptake per kg of body weight and an increase in heart rate at the moment of anaerobic threshold, as well as an increase in load time, which indicates an increase in endurance during anaerobic exercise. This parameter is one of the limiting factors of performance in cyclic sports. In addition, an increase in blood iron content, % transferrin saturation, hemoglobin concentration, and average erythrocyte volume was observed against the background of the beet juice preparation. These changes in the indicators of the oxygen-transport system of the blood may be one of the mechanisms through which exogenous nitrates realize their effect in increasing performance in the anaerobic phase.
{"title":"THE EFFECT OF BEET JUICE-BASED FOODS ON PERFORMANCE OF ATHLETES IN CYCLIC SPORTS","authors":"Z. Grishina, A. Shestopalov, E. Lomazova, Andrey Kalinin, V. Feshchenko, A. Zholinsky","doi":"10.17816/clinutr105659","DOIUrl":"https://doi.org/10.17816/clinutr105659","url":null,"abstract":"Purpose of the study: to evaluate the effect of consumption of beet juice, as a source of nitrates, on the performance of biathletes. Materials and methods: 40 male biathletes aged from 18 to 22 years took part in the study. The study took place under the conditions of a training camp in the summer of 2017, the athletes were divided into 2 groups: experimental and control. The experimental group was given a preparation containing beet juice of a special variety 2 times a day after each training session, the athletes of the control group did not take anything after training sessions. Before the experiment and after 20 days of taking the preparation load testing before work refusal was carried out, as well as biochemical and general blood analysis. Results and conclusions: in the athletes of the experimental group against the background of taking beet juice there was a decrease in oxygen uptake per kg of body weight and an increase in heart rate at the moment of anaerobic threshold, as well as an increase in load time, which indicates an increase in endurance during anaerobic exercise. This parameter is one of the limiting factors of performance in cyclic sports. In addition, an increase in blood iron content, % transferrin saturation, hemoglobin concentration, and average erythrocyte volume was observed against the background of the beet juice preparation. These changes in the indicators of the oxygen-transport system of the blood may be one of the mechanisms through which exogenous nitrates realize their effect in increasing performance in the anaerobic phase.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90456844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In order to describe the necessity and safety of nutritional therapy in patients with non-small cell lung cancer, an analysis of publications on the topic was carried out with a preliminarysearch in the medical databases PubMed and Medline. Based on the data obtained, it has beenconvincingly shown that patients with non-small cell lung cancer often have anorexia-cachexiasyndrome. In the perioperative period nutritional support for non-small cell lung cancer improvesthe immediate and long-term results of surgical treatment. Currently, nutritional therapy should be considered as an integral component of any anticancer treatment, contributing to theimprovement of the results of the therapy.
{"title":"The role of nutritional support in non-small cell lung cancer treatment","authors":"Aleksandra D. Sergienko, O. Obukhova, P. Kononets","doi":"10.17816/clinutr101394","DOIUrl":"https://doi.org/10.17816/clinutr101394","url":null,"abstract":"In order to describe the necessity and safety of nutritional therapy in patients with non-small cell lung cancer, an analysis of publications on the topic was carried out with a preliminarysearch in the medical databases PubMed and Medline. Based on the data obtained, it has beenconvincingly shown that patients with non-small cell lung cancer often have anorexia-cachexiasyndrome. In the perioperative period nutritional support for non-small cell lung cancer improvesthe immediate and long-term results of surgical treatment. Currently, nutritional therapy should \u0000be considered as an integral component of any anticancer treatment, contributing to theimprovement of the results of the therapy.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73097769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gestational diabetes mellitus (GDM) is a disease, which is characterized by glucose intolerance first recognized during pregnancy, but which does not meet criteria of overt diabetes. GDM is a major medico-social problem, because is associated with adverse pregnancy outcomes. The main method of GDM treatment is nutrition therapy, which can be supplemented with anti-hyperglycemic agents. Lifestyle modification has shown to be effective in preventing the complications of GDM. Despite this fact, there is no consensus on which dietary recommendations should be recommended in case of glucose intolerance during pregnancy. Most of current guideline recommendations suggest to control carbohydrate or calorie intake, diet with low glycemic index, Mediterranean or DASH diet. Another essential aspect of nutrition therapy in GDM is a safety of a diet outcomes for both mothers and their offspring. The purpose of this review is to evaluate current recommendations for GDM nutrition management and their supporting evidence. Along with this the goal is to the review common and uncommon proposed GDM diets, and ultimately and to provide an analysis of their safety and efficacy, the possibility of application in clinical practice for the treatment of patients with GDM.
{"title":"Nutritional therapy for gestational diabetes mellitus: what does the evidence say?","authors":"Y. A. Kaminarskaya","doi":"10.17816/clinutr105653","DOIUrl":"https://doi.org/10.17816/clinutr105653","url":null,"abstract":"Gestational diabetes mellitus (GDM) is a disease, which is characterized by glucose intolerance first recognized during pregnancy, but which does not meet criteria of overt diabetes. GDM is a major medico-social problem, because is associated with adverse pregnancy outcomes. The main method of GDM treatment is nutrition therapy, which can be supplemented with anti-hyperglycemic agents. Lifestyle modification has shown to be effective in preventing the complications of GDM. Despite this fact, there is no consensus on which dietary recommendations should be recommended in case of glucose intolerance during pregnancy. Most of current guideline recommendations suggest to control carbohydrate or calorie intake, diet with low glycemic index, Mediterranean or DASH diet. Another essential aspect of nutrition therapy in GDM is a safety of a diet outcomes for both mothers and their offspring. The purpose of this review is to evaluate current recommendations for GDM nutrition management and their supporting evidence. Along with this the goal is to the review common and uncommon proposed GDM diets, and ultimately and to provide an analysis of their safety and efficacy, the possibility of application in clinical practice for the treatment of patients with GDM.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78361429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rationale. Malnutrition is a common problem among cancer patients, due to the direct influence of the tumor and the consequences of specific therapy, negatively affects the quality of life and worsens the results of anticancer treatment. Nutritional support (NS) plays an important role in systemic drug anticancer therapy, however, malnutrition that develops against the background of malignant neoplasms (MN) remains underestimated and receives little attention in clinical practice. Purpose: to assess the need for and safety of NS against the background of systemic drug antitumor treatment of malignant neoplasms. Materials and methods: an analysis of publications in the medical databases e-Library, PubMed, Medline was performed with an emphasis on assessing the safety and efficacy of NP against the background of systemic drug antitumor treatment. Results: based on the data obtained, it was shown that patients with cancer have an anorexia-cachexia syndrome, leading to the development of sarcopenia, which negatively affects the results of specific therapy. Timely appointment of NS significantly improves the results of treatment, quality of life, and also increases the survival rate in patients receiving non-surgical anticancer therapy. Conclusions: Nutritional support, carried out in parallel with anticancer drug treatment, improves its results.
{"title":"The effect of nutritional support on nutritional status, quality of life and survival in cancer patients receiving systemic anticancer therapy: a literature review.","authors":"O. Obukhova, I. Kurmukov, Alla Aleksandrovna Ryk","doi":"10.17816/clinutr104771","DOIUrl":"https://doi.org/10.17816/clinutr104771","url":null,"abstract":"Rationale. Malnutrition is a common problem among cancer patients, due to the direct influence of the tumor and the consequences of specific therapy, negatively affects the quality of life and worsens the results of anticancer treatment. Nutritional support (NS) plays an important role in systemic drug anticancer therapy, however, malnutrition that develops against the background of malignant neoplasms (MN) remains underestimated and receives little attention in clinical practice. \u0000Purpose: to assess the need for and safety of NS against the background of systemic drug antitumor treatment of malignant neoplasms. \u0000Materials and methods: an analysis of publications in the medical databases e-Library, PubMed, Medline was performed with an emphasis on assessing the safety and efficacy of NP against the background of systemic drug antitumor treatment. \u0000Results: based on the data obtained, it was shown that patients with cancer have an anorexia-cachexia syndrome, leading to the development of sarcopenia, which negatively affects the results of specific therapy. Timely appointment of NS significantly improves the results of treatment, quality of life, and also increases the survival rate in patients receiving non-surgical anticancer therapy. \u0000Conclusions: Nutritional support, carried out in parallel with anticancer drug treatment, improves its results.","PeriodicalId":92235,"journal":{"name":"Journal of clinical nutrition and metabolism","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82586072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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