The majority of pharmaceutical and polymer powders are insulating materials that have the propensity to attain and then retain triboelectric charge. This phenomenon can potentially give rise to issues during handling and processing of materials. A comprehensive understanding of the mechanisms controlling charging behaviour can inform effective control of the process and potentially enhance the final product quality and performance. Therefore, the objective of this review article is to summarise the principles of triboelectric charging and to understand the various contributing factors. It is intuitively expected that the acquired understanding can be helpful in improving the efficiency, quality, performance and safety of powder processing phenomena and final products.
{"title":"Triboelectrification of Pharmaceutical powders: A critical review","authors":"B. Conway, M. U. Ghori","doi":"10.5920/BJPHARM.2018.08","DOIUrl":"https://doi.org/10.5920/BJPHARM.2018.08","url":null,"abstract":"The majority of pharmaceutical and polymer powders are insulating materials that have the propensity to attain and then retain triboelectric charge. This phenomenon can potentially give rise to issues during handling and processing of materials. A comprehensive understanding of the mechanisms controlling charging behaviour can inform effective control of the process and potentially enhance the final product quality and performance. Therefore, the objective of this review article is to summarise the principles of triboelectric charging and to understand the various contributing factors. It is intuitively expected that the acquired understanding can be helpful in improving the efficiency, quality, performance and safety of powder processing phenomena and final products.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85641052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seham Shaboun, E. Nep, N. Ngwuluka, A. Adebisi, B. Conway, Alan M. Smith, K. Asare-Addo
The search for non-toxic and cost effective carriers for solid dispersion formulations has increased the focus of researchers on renewable resources. In this study, gum was extracted from the leaves of Sesamum radiatum (SRG) and its role in solid dispersion formulations of Ibuprofen (IBU) investigated. Physical mixing and comilling using different ratios of IBU to SRG (4:1, 1:1, 1:4) and milling times of 1 min, 5 min, and 10 min was employed. Solid state of these formulations was characterized using DSC, FT-IR and XRPD. The effect of the co-milling ratio and time on drug dissolution was also studied. Solid state characterization showed that SRG does not interact with IBU in the solid dispersion formulations. However, SRG retarded the release of IBU from all the formulations. Although the co-milled solid dispersions gave a higher dissolution than the physical mixes (PM), with the dissolution rate increasing as the ratio of SRG decreases, the technique did not result in appreciable improvement in the dissolution of IBU. The gel layer that surrounded the formulations suggest SRG may prove useful as a hydrophilic carrier in matrices for extended release and perhaps a modified form of the gum could be used in solid dispersions.
{"title":"Solid state and dissolution behaviour of a low melting point drug in co-milled mixtures of Sesamum radiatum gum","authors":"Seham Shaboun, E. Nep, N. Ngwuluka, A. Adebisi, B. Conway, Alan M. Smith, K. Asare-Addo","doi":"10.5920/BJPHARM.2018.07","DOIUrl":"https://doi.org/10.5920/BJPHARM.2018.07","url":null,"abstract":"The search for non-toxic and cost effective carriers for solid dispersion formulations has increased the focus of researchers on renewable resources. In this study, gum was extracted from the leaves of Sesamum radiatum (SRG) and its role in solid dispersion formulations of Ibuprofen (IBU) investigated. Physical mixing and comilling using different ratios of IBU to SRG (4:1, 1:1, 1:4) and milling times of 1 min, 5 min, and 10 min was employed. Solid state of these formulations was characterized using DSC, FT-IR and XRPD. The effect of the co-milling ratio and time on drug dissolution was also studied. Solid state characterization showed that SRG does not interact with IBU in the solid dispersion formulations. However, SRG retarded the release of IBU from all the formulations. Although the co-milled solid dispersions gave a higher dissolution than the physical mixes (PM), with the dissolution rate increasing as the ratio of SRG decreases, the technique did not result in appreciable improvement in the dissolution of IBU. The gel layer that surrounded the formulations suggest SRG may prove useful as a hydrophilic carrier in matrices for extended release and perhaps a modified form of the gum could be used in solid dispersions.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"148 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77791193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anil R Gadhe, Bipin D Pustake, M. Shinde, R. Korhale, V. Gharge
Orally disintegrating tablet (ODT) has number of advantages like faster onset of action, ease of administration, rapid disintegration and dissolution etc. A novel attempt has been made to develop orally disintegrating tablets of Ondansetron by using two approaches, one is soluble hydrophilic matrix by superdisintegrant and other is effect of sweetener on the formulation. Direct compression method was employed for making orally disintegrating tablets. The formulated orally disintegrating tablets have rapid disintegration property for better patient compliance. Formulated tablets were evaluated for physical parameters along with wetting time, disintegration time, drug content and “in vitro” dissolution. In first approach it was found that batch F7 containing Crospovidone (Polyplasdone XL 10) 10 mg showed minimum disintegration time (i.e. approx. 7.00 seconds) with maximum drug release. Wetting time for batch F7 was found to beminimum (i.e. 12 seconds). In second approach of selection of sweetener batch F 10 containing Sodium saccharin was found better in terms of Impurity study (Relative Substances study).Impurity was found within the specified limit compared to other two sweeteners. Stability study was carried out on optimized formulation. Overall batch containing 10 mg Crospovidone (Polyplasdone XL 10) along with Sodium Saccharin was foundstable both physically and chemically.
{"title":"Development and Evaluation of Ondansetron Orally Disintegrating Tablets","authors":"Anil R Gadhe, Bipin D Pustake, M. Shinde, R. Korhale, V. Gharge","doi":"10.5920/bjpharm.2018.06","DOIUrl":"https://doi.org/10.5920/bjpharm.2018.06","url":null,"abstract":"Orally disintegrating tablet (ODT) has number of advantages like faster onset of action, ease of administration, rapid disintegration and dissolution etc. A novel attempt has been made to develop orally disintegrating tablets of Ondansetron by using two approaches, one is soluble hydrophilic matrix by superdisintegrant and other is effect of sweetener on the formulation. Direct compression method was employed for making orally disintegrating tablets. The formulated orally disintegrating tablets have rapid disintegration property for better patient compliance. Formulated tablets were evaluated for physical parameters along with wetting time, disintegration time, drug content and “in vitro” dissolution. In first approach it was found that batch F7 containing Crospovidone (Polyplasdone XL 10) 10 mg showed minimum disintegration time (i.e. approx. 7.00 seconds) with maximum drug release. Wetting time for batch F7 was found to beminimum (i.e. 12 seconds). In second approach of selection of sweetener batch F 10 containing Sodium saccharin was found better in terms of Impurity study (Relative Substances study).Impurity was found within the specified limit compared to other two sweeteners. Stability study was carried out on optimized formulation. Overall batch containing 10 mg Crospovidone (Polyplasdone XL 10) along with Sodium Saccharin was foundstable both physically and chemically.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91160952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I spend quite a bit of time collating information from pharmaceutical company press releases and news feeds to compile review articles describing the latest advances in therapeutic approaches (novel targets, growth in options for treatment of rare diseases, emerging modalities such as CAR-T, new drug delivery technologies, etc.). Based on what I have seen over the last few years, looking at the evolution in this space, I sense there may be potential impacts for pharmacy we ought to consider, if we are not already doing so, for the profession and the science of pharmacy and in the education and training of future pharmacists and pharmaceutical scientists. My most recent review of information showed that a significant amount of new research collaborations involving pharmaceutical companies and of early phase clinical research highlighted gene delivery, oligonucleotide therapeutics, CAR-T therapeutics, and novel treatments for rare diseases.
{"title":"Editorial: New Generation Therapeutic Modalities the importance of pharmacy and pharmaceutical science","authors":"P. Timmins","doi":"10.5920/BJPHARM.2018.05","DOIUrl":"https://doi.org/10.5920/BJPHARM.2018.05","url":null,"abstract":"I spend quite a bit of time collating information from pharmaceutical company press releases and news feeds to compile review articles describing the latest advances in therapeutic approaches (novel targets, growth in options for treatment of rare diseases, emerging modalities such as CAR-T, new drug delivery technologies, etc.). Based on what I have seen over the last few years, looking at the evolution in this space, I sense there may be potential impacts for pharmacy we ought to consider, if we are not already doing so, for the profession and the science of pharmacy and in the education and training of future pharmacists and pharmaceutical scientists. My most recent review of information showed that a significant amount of new research collaborations involving pharmaceutical companies and of early phase clinical research highlighted gene delivery, oligonucleotide therapeutics, CAR-T therapeutics, and novel treatments for rare diseases.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78573672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Three Dimensional (3D) printing within the pharmaceutical industry is rapidly developing and current trends within drug development include the 3D printing of oral dosage forms, implants, hydrogels and topical drug delivery systems. 3D printed dosage forms can be used to treat a range of conditions varying from cardiovascular disease to recovery from orthopaedic surgery and the prevention of infection. Compared to traditional manufacturing methods, 3D printing allows the precise spatial control and deposition of material as layers. This results in a large degree of printing flexibility and means that a variety of complex designs can be printed accurately. By controlling factors such as the type of polymer, drug load and surface area a variety of controlled release dosage formulations can be produced and application in personalised medicine holds promise. Multiple release oral dosage forms can also be printed as well as those containing more than one Active Pharmaceutical Ingredient (API) which addresses polypharmacy and should aid medical treatment. This review studies recent trends in 3D printing and drug development, and current drawbacks are examined to evaluate the future potential to manufacture dosage forms.
{"title":"Mapping current trends in 3D printing and the impact on the recent landscape of drug development research","authors":"Craig A. Russell, Harriet Hampshire","doi":"10.5920/BJPHARM.2018.01","DOIUrl":"https://doi.org/10.5920/BJPHARM.2018.01","url":null,"abstract":"Three Dimensional (3D) printing within the pharmaceutical industry is rapidly developing and current trends within drug development include the 3D printing of oral dosage forms, implants, hydrogels and topical drug delivery systems. 3D printed dosage forms can be used to treat a range of conditions varying from cardiovascular disease to recovery from orthopaedic surgery and the prevention of infection. Compared to traditional manufacturing methods, 3D printing allows the precise spatial control and deposition of material as layers. This results in a large degree of printing flexibility and means that a variety of complex designs can be printed accurately. By controlling factors such as the type of polymer, drug load and surface area a variety of controlled release dosage formulations can be produced and application in personalised medicine holds promise. Multiple release oral dosage forms can also be printed as well as those containing more than one Active Pharmaceutical Ingredient (API) which addresses polypharmacy and should aid medical treatment. This review studies recent trends in 3D printing and drug development, and current drawbacks are examined to evaluate the future potential to manufacture dosage forms.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88011586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. S. Ali, A. Al-Qahtani, Saqib Nabi, K. Altaf, Gomand Beekho Sonekhi, Javed Ahmed, Farhan Ali Solangi, Kiran Shoukat Ali, Arzoo Ajaz
Antimicrobial resistant organisms are associated with significant morbidity and mortality and have considerable burden on healthcare costs. Antimicrobial discovery was a major breakthrough in the field of infectious diseases and drug discovery until the unexpected rise of antimicrobial resistance which is now a public health threat. Imprudent use of antimicrobials have led to the emergence of microbial resistance strains and favoured microorganisms to successfully exploit every possible resistance mechanisms which includes, but not limited to, genetic mutations, gene pickup, horizontal gene transfer and heterologous expression. They have extended themselves to community settings highlighting the importance of reservoirs of antibiotic resistant microbes in environment. The antimicrobial therapeutic repertoire is also shrinking on a steady pace for present or impossible to treat multidrug resistant infections. This short review briefly discusses the different molecular mechanisms of antibiotic resistance which allow microbes to exhibit multidrug resistance trait. Prompt actions to limit the emergence and dissemination of multi-drug resistant superbugs through novel therapeutic approaches should be designed.
{"title":"A Short Review on Antibiotics and Ever-Changing Microbial Resistance Mechanisms","authors":"A. S. Ali, A. Al-Qahtani, Saqib Nabi, K. Altaf, Gomand Beekho Sonekhi, Javed Ahmed, Farhan Ali Solangi, Kiran Shoukat Ali, Arzoo Ajaz","doi":"10.5920/BJPHARM.2018.04","DOIUrl":"https://doi.org/10.5920/BJPHARM.2018.04","url":null,"abstract":"Antimicrobial resistant organisms are associated with significant morbidity and \u0000mortality and have considerable burden on healthcare costs. Antimicrobial \u0000discovery was a major breakthrough in the field of infectious diseases and drug \u0000discovery until the unexpected rise of antimicrobial resistance which is now a \u0000public health threat. Imprudent use of antimicrobials have led to the emergence of \u0000microbial resistance strains and favoured microorganisms to successfully exploit \u0000every possible resistance mechanisms which includes, but not limited to, genetic \u0000mutations, gene pickup, horizontal gene transfer and heterologous expression. \u0000They have extended themselves to community settings highlighting the \u0000importance of reservoirs of antibiotic resistant microbes in environment. The \u0000antimicrobial therapeutic repertoire is also shrinking on a steady pace for present \u0000or impossible to treat multidrug resistant infections. This short review briefly \u0000discusses the different molecular mechanisms of antibiotic resistance which allow \u0000microbes to exhibit multidrug resistance trait. Prompt actions to limit the \u0000emergence and dissemination of multi-drug resistant superbugs through novel \u0000therapeutic approaches should be designed.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"85 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72632647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Over the past decade, the pharmacists’ role has been revolutionised utilising and incorporating expert clinical skills and knowledge. In doing so, a pharmacist’s performance is underpinned by competence and must be assessed in a valid and reliable manner throughout the undergraduate degree and preregistration year prior to becoming a responsible practitioner. The Observed Structured Clinical Examination (OSCE) is a practical assessment method evaluating student application of knowledge and understanding of the content in a simulated real-life environment. ‘Pharmacy OSCEs and competency-based assessments’ by Haughey and O’Hare is a novel book which endeavours to enhance the use of this method of assessment in pharmacy education.
{"title":"Pharmacy OSCEs and Competency-Based Assessments by Sharon Haughey and Roisin O'Hare Book review","authors":"Saima Afzal","doi":"10.5920/BJPHARM.2018.02","DOIUrl":"https://doi.org/10.5920/BJPHARM.2018.02","url":null,"abstract":"Over the past decade, the pharmacists’ role has been revolutionised utilising and incorporating expert clinical skills and knowledge. In doing so, a pharmacist’s performance is underpinned by competence and must be assessed in a valid and reliable manner throughout the undergraduate degree and preregistration year prior to becoming a responsible practitioner. The Observed Structured Clinical Examination (OSCE) is a practical assessment method evaluating student application of knowledge and understanding of the content in a simulated real-life environment. ‘Pharmacy OSCEs and competency-based assessments’ by Haughey and O’Hare is a novel book which endeavours to enhance the use of this method of assessment in pharmacy education.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78864781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilyasu Salim, Olowosulu Adeniji Kehinde, A. Abdulsamad, G. M. Khalid, M. Gwarzo
The goal of this research was to provide critical evaluation of the physicomechanical performance of Starch-MCC-Povidone (SMP) composites engineered via co-processing strategy. Aqueous dispersions of the primary excipients at predetermined combination levels were subjected to physical agglomeration at controlled subgelatinization (55 °C) temperature followed by drying at 60 °C for 48 h. Under scanning electron microscope, the materials appeared as enlarged porous composites of starch-MCC bound by solid bridges of povidone. Powder fluidity indicators suggested acceptable flow properties (Angle of repose 5 gs-1). Compact weight variation studies revealed reproducible volumetric die filling capacity. Analysis of powder compaction indices shows appreciable densification and total volume reduction in both Heckel and Kawakita models. The dilution capacity of the composites was up to 40% using L-ascorbic acid as the model drug. Analysis of post compression tablet properties indicated extensive elastic recovery at low MCC content. All the novel composites were characterised by rapid in-vitro disintegration and efficient in-vitro drug release (t50% <1 min; t80% < 2 min). In comparison to Ludipress® and Prosolv®, moderate to high MCC containing Starch-MCC-Povidone composites (SMP3 and SMP5) could be employed as alternative cost effective direct compression diluents in tablet formulation.
{"title":"Physicomechanical Behaviour of Novel Directly Compressible Starch-MCC-Povidone Composites and their Application in Ascorbic Acid Tablet Formulation","authors":"Ilyasu Salim, Olowosulu Adeniji Kehinde, A. Abdulsamad, G. M. Khalid, M. Gwarzo","doi":"10.5920/BJPHARM.2018.03","DOIUrl":"https://doi.org/10.5920/BJPHARM.2018.03","url":null,"abstract":"The goal of this research was to provide critical evaluation of the physicomechanical performance of Starch-MCC-Povidone (SMP) composites engineered via co-processing strategy. Aqueous dispersions of the primary excipients at predetermined combination levels were subjected to physical agglomeration at controlled subgelatinization (55 °C) temperature followed by drying at 60 °C for 48 h. Under scanning electron microscope, the materials appeared as enlarged porous composites of starch-MCC bound by solid bridges of povidone. Powder fluidity indicators suggested acceptable flow properties (Angle of repose 5 gs-1). Compact weight variation studies revealed reproducible volumetric die filling capacity. Analysis of powder compaction indices shows appreciable densification and total volume reduction in both Heckel and Kawakita models. The dilution capacity of the composites was up to 40% using L-ascorbic acid as the model drug. Analysis of post compression tablet properties indicated extensive elastic recovery at low MCC content. All the novel composites were characterised by rapid in-vitro disintegration and efficient in-vitro drug release (t50% <1 min; t80% < 2 min). In comparison to Ludipress® and Prosolv®, moderate to high MCC containing Starch-MCC-Povidone composites (SMP3 and SMP5) could be employed as alternative cost effective direct compression diluents in tablet formulation.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81990815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gareth C. Gilvary, A. Almajaan, Shu Li, Zoe Senta Loys, Yiwei Tian, Jeremiah Kelleher, A. Madi, A. Healy, David S. Jones, G. Andrews
This work focused on the development of a concentric multi-layered fixed-dose combination via an advanced manufacturing technique, hot-melt co-extrusion. The dosage form was designed to offer differing release behaviour; immediate and sustained release from the coat and core, respectively. Hydrochlorothiazide and losartan potassium were incorporated as anti-hypertensive drugs. Solid-state characterisation revealed that both were transformed into their amorphous forms. In-vitro dissolution testing showed desired release performances offering both immediate and modified release.
{"title":"Hot-melt co-extrusion technology as a manufacturing platform for anti-hypertensive fixed-dose combinations","authors":"Gareth C. Gilvary, A. Almajaan, Shu Li, Zoe Senta Loys, Yiwei Tian, Jeremiah Kelleher, A. Madi, A. Healy, David S. Jones, G. Andrews","doi":"10.5920/BJPHARM.596","DOIUrl":"https://doi.org/10.5920/BJPHARM.596","url":null,"abstract":"This work focused on the development of a concentric multi-layered fixed-dose combination via an advanced manufacturing technique, hot-melt co-extrusion. The dosage form was designed to offer differing release behaviour; immediate and sustained release from the coat and core, respectively. Hydrochlorothiazide and losartan potassium were incorporated as anti-hypertensive drugs. Solid-state characterisation revealed that both were transformed into their amorphous forms. In-vitro dissolution testing showed desired release performances offering both immediate and modified release.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"240 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74487742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah A. Stewart, R. Donnelly, Eneko Larraneta Landa
Despite being apopular and convenient route of drug delivery, the oral route has a number ofdisadvantages. Polymeric sub-dermal implants offer an alternative deliveryroute that may circumvent many of these challenges. In this study, implantswere designed using computer-aided design (CAD) software and fabricated using3D printing. The impact of implant design on the rate of drug release wasinvestigated using methylene blue as a model. It was found that drug releasecould be extended from 2 days to over 40 days as a result of changing implantdesign. Future work will focus on optimisation of implant design with the aimof producing degrading polymeric rate‑controlling membranes to further controldrug release and to conduct further invitro investigation with a drug compound.
{"title":"Development of Implants for Prolonged Drug delivery","authors":"Sarah A. Stewart, R. Donnelly, Eneko Larraneta Landa","doi":"10.5920/BJPHARM.595","DOIUrl":"https://doi.org/10.5920/BJPHARM.595","url":null,"abstract":"Despite being apopular and convenient route of drug delivery, the oral route has a number ofdisadvantages. Polymeric sub-dermal implants offer an alternative deliveryroute that may circumvent many of these challenges. In this study, implantswere designed using computer-aided design (CAD) software and fabricated using3D printing. The impact of implant design on the rate of drug release wasinvestigated using methylene blue as a model. It was found that drug releasecould be extended from 2 days to over 40 days as a result of changing implantdesign. Future work will focus on optimisation of implant design with the aimof producing degrading polymeric rate‑controlling membranes to further controldrug release and to conduct further invitro investigation with a drug compound.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90437377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：