I. E. Ridzwan, Maryam Saadah Suhaimi, Nur Syafinaz Wasli, A. Kasmuri, Marwan Saad Azzubaidi, R. Hashim, Q. Ahmed, L. Ming, Nornisah Mohamed, Syed Mohd Syhami
A Combination of 0.3mg/kg buprenorphine and 1.0 mg/kg naltrexone treatment shows a promising result due to its ability to attenuate reinstatement (relapse) in morphine/methamphetamine (polydrug)-dependent mice in a conditioned place preference (CPP) model. This prompted us to identify which opioid receptor that contributes to its anti-relapse activity. Using the same CPP model, 10 mg/kg nor- BNI (a selective kappa opioid receptor [KOR] antagonist) was used to evaluate the involvement of KOR in mediating relapse to polydrug dependence. By applying the immunohistochemistry (IHC) technique, the investigation was extended to the mice brain using KOR antibody (EPR18881), focusing on the brain regions that are abundant in KOR density. The results showed that nor-BNI alone failed to attenuate relapse to polydrug dependence. However, the IHC results proved that the number of KOR significantly increased in the striatum during reinstatement compared to post-conditioning (p <0.05). The KOR was significantly suppressed in the treatment group which strengthens the findings from previous studies proving that the KOR plays an important role in mediating relapse to polydrug dependence.
{"title":"The distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependence in mice","authors":"I. E. Ridzwan, Maryam Saadah Suhaimi, Nur Syafinaz Wasli, A. Kasmuri, Marwan Saad Azzubaidi, R. Hashim, Q. Ahmed, L. Ming, Nornisah Mohamed, Syed Mohd Syhami","doi":"10.5920/bjpharm.2017.20","DOIUrl":"https://doi.org/10.5920/bjpharm.2017.20","url":null,"abstract":"A Combination of 0.3mg/kg buprenorphine and 1.0 mg/kg naltrexone treatment shows a promising result due to its ability to attenuate reinstatement (relapse) in morphine/methamphetamine (polydrug)-dependent mice in a conditioned place preference (CPP) model. This prompted us to identify which opioid receptor that contributes to its anti-relapse activity. Using the same CPP model, 10 mg/kg nor- BNI (a selective kappa opioid receptor [KOR] antagonist) was used to evaluate the involvement of KOR in mediating relapse to polydrug dependence. By applying the immunohistochemistry (IHC) technique, the investigation was extended to the mice brain using KOR antibody (EPR18881), focusing on the brain regions that are abundant in KOR density. The results showed that nor-BNI alone failed to attenuate relapse to polydrug dependence. However, the IHC results proved that the number of KOR significantly increased in the striatum during reinstatement compared to post-conditioning (p <0.05). The KOR was significantly suppressed in the treatment group which strengthens the findings from previous studies proving that the KOR plays an important role in mediating relapse to polydrug dependence.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79362059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this study was to prepare a convenient formulation of garlic powder which has enhanced user compliance by suppressing its characteristic odour and masking the taste. Microcapsules of garlic powder were formulated by solvent evaporation method. Results show >80% yield, >70% drug loading efficiency and slow release profile (promising sustained action for more than 2hrs) and a significant reduction in the aromatic smell and taste evaluated through a single blind cross-over study conducted using ten healthy human volunteers.
{"title":"Microencapsulation: A taste and odour masking approach for garlic (Allium sativum) powder","authors":"S. Gondal, N. Abbas, A. Hussain","doi":"10.5920/BJPHARM.2017.19","DOIUrl":"https://doi.org/10.5920/BJPHARM.2017.19","url":null,"abstract":"The purpose of this study was to prepare a convenient formulation of garlic powder which has enhanced user compliance by suppressing its characteristic odour and masking the taste. Microcapsules of garlic powder were formulated by solvent evaporation method. Results show >80% yield, >70% drug loading efficiency and slow release profile (promising sustained action for more than 2hrs) and a significant reduction in the aromatic smell and taste evaluated through a single blind cross-over study conducted using ten healthy human volunteers.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87273380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abhishek Gupta, W. Low, S. Britland, I. Radecka, Claire Martin
The aim of this study was to characterise the physicochemical and biocompatibility properties of biosynthetic bacterial cellulose (BC) as a potential wound dressing material. The moisture content, water vapour transmission rate (WVTR), thermal stability, cyto- and haemo-compatibility of BC were investigated. Results indicated that the physicochemical properties of biosynthetic BC allow an optimum WVTR to be maintained for improved localised wound moisture levels, good thermal stability and excellent water imbibing capabilities. In vitro cytotoxicity and haemocompatibility confirmed the biocompatibility of BC and hence suitability of this material for further exploration into its’ application as a wound dressing material.
{"title":"Physicochemical characterisation of biosynthetic bacterial cellulose as a potential wound dressing material","authors":"Abhishek Gupta, W. Low, S. Britland, I. Radecka, Claire Martin","doi":"10.5920/BJPHARM.2017.27","DOIUrl":"https://doi.org/10.5920/BJPHARM.2017.27","url":null,"abstract":"The aim of this study was to characterise the physicochemical and biocompatibility properties of biosynthetic bacterial cellulose (BC) as a potential wound dressing material. The moisture content, water vapour transmission rate (WVTR), thermal stability, cyto- and haemo-compatibility of BC were investigated. Results indicated that the physicochemical properties of biosynthetic BC allow an optimum WVTR to be maintained for improved localised wound moisture levels, good thermal stability and excellent water imbibing capabilities. In vitro cytotoxicity and haemocompatibility confirmed the biocompatibility of BC and hence suitability of this material for further exploration into its’ application as a wound dressing material.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83901781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Twin-screw granulation has a significant advantage over traditional granulation methods leading to the possibility of continuous manufacturing. Although this technology has drawn attention in recent years, the general understanding of the process is limited. This study gives a brief overview of the most important process parameters and their influence on product quality. Experimental results from a benchtop granulator and an in-line particle size measurement have been analysed. From this basic study conclusions can be drawn how to tailor the particle size distribution in twin-screw granulation. The most crucial parameters are the liquid-to-solid ratio and the filling level of the screws.
{"title":"Twin-screw granulation – a systematic analysis of process parameters","authors":"M. Richter, W. Kaialy, H. Bello","doi":"10.5920/bjpharm.2017.26","DOIUrl":"https://doi.org/10.5920/bjpharm.2017.26","url":null,"abstract":"Twin-screw granulation has a significant advantage over traditional granulation methods leading to the possibility of continuous manufacturing. Although this technology has drawn attention in recent years, the general understanding of the process is limited. This study gives a brief overview of the most important process parameters and their influence on product quality. Experimental results from a benchtop granulator and an in-line particle size measurement have been analysed. From this basic study conclusions can be drawn how to tailor the particle size distribution in twin-screw granulation. The most crucial parameters are the liquid-to-solid ratio and the filling level of the screws.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82397207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this project is to develop an innovative analytical technique for the 3D chemical mapping of pharmaceutical dosage forms, via simultaneous topographic characterisation and dissolution analysis of solid drug delivery systems. The developed apparatus was optimised using the results obtained from the application of micro-photogrammetry to the analysis of commercial solid drug delivery systems. Results of the application of the developed method on the dissolution of a sugarcoated tablet sample are here presented.
{"title":"Micro-photogrammetry as a tool for characterisation of dissolution behaviour of pharmaceutical dosage forms","authors":"A. D’Angelo, M. Reading, Milan D Antonjievic","doi":"10.5920/bjpharm.2017.22","DOIUrl":"https://doi.org/10.5920/bjpharm.2017.22","url":null,"abstract":"The aim of this project is to develop an innovative analytical technique for the 3D \u0000chemical mapping of pharmaceutical dosage forms, via simultaneous topographic \u0000characterisation and dissolution analysis of solid drug delivery systems. The \u0000developed apparatus was optimised using the results obtained from the application \u0000of micro-photogrammetry to the analysis of commercial solid drug delivery systems. \u0000Results of the application of the developed method on the dissolution of a sugarcoated \u0000tablet sample are here presented.","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79870892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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