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Testicular Assessment of (Okra) Abelmoschus Esculentus Treated Wistar Rats 黄鼠草对Wistar大鼠睾丸的影响
Pub Date : 2022-06-16 DOI: 10.24966/tap-7752/100014
Obeten Ke
Results of the histology of the control group showed a normal histology of the seminiferous tubules (round cells), low dose showed seminiferous tubules with acute loss of Germinal cell area (G) and high dose showed testicular regression (loss of interstitial space, IT), tubular architecture and Germ layer (G).
对照组精小管(圆形细胞)组织学正常,低剂量组精小管伴急性生殖细胞面积丧失(G),高剂量组精小管伴睾丸间质间隙丧失(IT)、管状结构及生殖层(G)。
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引用次数: 0
A Palette of Adipose Tissue: Multiple Functionality and Extraordinary Plasticity 脂肪组织的调色板:多种功能和非凡的可塑性
Pub Date : 2021-02-17 DOI: 10.24966/tap-7752/100013
J. Pauli
After the knowledge of adipose tissue as an endocrine organ and its role as a regulator of metabolisms, studies have advanced on its biological function. Previously, only two adipose tissues were identified in mammals, white and brown adipose tissue. White adipocytes store lipids mainly with the function of energy reserve and brown for thermal homeostasis. Due to the plasticity of adipose tissue and its ability to proliferate and differentiate, the third type of adipocyte, beige, emerged. Beige adipocytes originate from white adipocytes that have acquired phenotypic brown characteristics in response to different stimuli, this process is known as browning. More recently, the plastic properties allowed the identification of the fourth type of adipose tissue, the pink.
在认识了脂肪组织作为内分泌器官和调节代谢的作用后,对其生物学功能的研究也有了新的进展。以前,在哺乳动物中只鉴定出两种脂肪组织,白色脂肪组织和棕色脂肪组织。白色脂肪细胞主要储存脂质,具有能量储备功能,棕色脂肪细胞主要保持热稳态。由于脂肪组织的可塑性及其增殖和分化的能力,出现了第三种类型的脂肪细胞,米黄色。米色脂肪细胞起源于白色脂肪细胞,在不同的刺激下获得了表型上的棕色特征,这一过程被称为褐变。最近,塑料特性使得第四种脂肪组织——粉色脂肪组织得以识别。
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引用次数: 1
Acknowledging Sex Differences in In vivo Experiments: Dilemma 承认体内实验中的性别差异:困境
Pub Date : 2021-02-17 DOI: 10.24966/tap-7752/100012
P. Švorc
The role of the Autonomic Nervous System (ANS) and its organ-specific functions are largely elucidated. Heart Rate Variability (HRV) analysis is a popular tool for the assessment of autonomic cardiac control. Heart rate and its changes are a sensitive indicator of ANS function, therefore cardiovascular autonomic regulation is considered to be the most reliable indicator of ANS activity and status. HRV refers to beat to beat variation in the heart rate that quantifies the interplay between sympathetic and parasympathetic activity of the ANS. Although patterns of HRV hold considerable promise for clarifying issues in clinical applications,
自主神经系统(ANS)的作用及其器官特异性功能在很大程度上被阐明。心率变异性(HRV)分析是评估自主心脏控制的常用工具。心率及其变化是反映ANS功能的敏感指标,因此心血管自主调节被认为是反映ANS活动和状态最可靠的指标。HRV是指心率的每拍变化,量化了ANS交感神经和副交感神经活动之间的相互作用。尽管HRV的模式在澄清临床应用中的问题方面有很大的希望,
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引用次数: 0
Telomeres Length Change in Peripheral Blood Lymphocytes of Psychotic Patients with Schizophrenia 精神分裂症患者外周血淋巴细胞端粒长度的变化
Pub Date : 2021-02-17 DOI: 10.24966/tap-7752/100011
Arkhipov Andrey Yurevich
In patients with schizophrenia life expectancy is shorter compared to the general population and the main causes of early mortality are somatic diseases. Schizophrenia is a complex disorder with a high risk of inheritance and is increasingly recognized as a systemic disorder, presumably having a common genetic basis with various somatic disorders. Modern research methods allow us to discover the mechanisms of etiology, pathogenesis and outcome of diseases. Changing the length of telomeres in the cells of organisms reflects the processes of development and degradation of cells, as well as the stages of its life cycle. The reduction in Telomere Length (TL) is considered one of the biological markers associated with age and can be accelerated by comorbid conditions in schizophrenia.
与一般人群相比,精神分裂症患者的预期寿命较短,早期死亡的主要原因是躯体疾病。精神分裂症是一种具有高遗传风险的复杂疾病,并且越来越被认为是一种全身性疾病,可能与各种躯体疾病具有共同的遗传基础。现代研究方法使我们能够发现疾病的病因、发病机制和预后。生物细胞中端粒长度的变化反映了细胞的发育和降解过程,也反映了细胞生命周期的各个阶段。端粒长度(TL)的减少被认为是与年龄相关的生物学标记之一,并且可以被精神分裂症的合并症加速。
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引用次数: 0
Diabetics-Related Foot Deformity: Prevalence, Risk Factors, Knowledge and Practice 糖尿病相关足部畸形:患病率、危险因素、知识和实践
Pub Date : 2021-02-17 DOI: 10.24966/tap-7752/100010
Amenu T Wirtu
Neuromusculoskeletal functions interplay in maintaining normal gait patterns. Changes in foot posture and architecture are results of diseases. For Instance, diabetes impacts human biomechanics of running and weight bearing of the foot. We conducted a prospective cross sectional study to assess the risk factors of anatomical foot changes in patients with Type-2 diabetes mellitus. It was carried out in normal 196 subjects at Mizan-Tepi University teaching hospital, Bench-Sheko zone, South-West, Ethiopia. Data were collected using a well-structured questionnaires and diabetic foot assessment checklists. Data analysis was done using SPSS, version 24. Whereas, randomly selected associated risk factors were assessed using multivariate linear regression model. Our results
神经肌肉骨骼功能在维持正常步态模式中相互作用。足部姿势和结构的改变是疾病的结果。例如,糖尿病会影响人体跑步和足部负重的生物力学。我们进行了一项前瞻性横断面研究,以评估2型糖尿病患者足部解剖改变的危险因素。在埃塞俄比亚西南部Bench-Sheko区的Mizan-Tepi大学教学医院对196名正常受试者进行了这项研究。使用结构良好的问卷调查和糖尿病足评估清单收集数据。数据分析使用SPSS,版本24。而随机选择的相关危险因素采用多元线性回归模型进行评估。我们的研究结果
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引用次数: 1
Time of Reaction in Using the Pushing of Button in Exper- iment of Evoked Cognitive Potentials (R300) 诱发认知电位实验中使用按钮的反应时间(R300)
Pub Date : 2019-05-22 DOI: 10.24966/tap-7752/100009
Klochkova Oi
Background Evoked cognitive potentials are a promising experimental technique that can be useful in diagnosis of various cognitive disorders, especially connected to the various memory impairments. Of particular interest to researchers is the study of the cognitive evoked potentials’ latency when recognition of various stimuli is involved. Objective The method of Luria was used to determine the volume of verbal memory. To study the physiological nature and functional role of evoked cognitive potentials observed during the reaction to stimuli, and to determine the degree of conscious control involved in this reaction. To do so the experimental data were statistically analyzed to determine the numerical correlation between the working memory capacity and the cognitive potential’s latency. Design The cognitive Eps were measured for 166 healthy subjects and 63 others that had some pathological brain condition (circulatory encephalopathy and other brain circulatory disorders), varied by the age and gender. Measurements were done with the Neurosoft Neuro-MVP 4 computerized encephalography system, which implemented the standard method of large latency neural response measurement for P300 waves. Measurements were done in the setup where the subject had to recognize the significant stimuli and react to them by pressing a button. The significant stimulus was represented by a 2 kHz tone, while the insignificant stimuli were the frequently repeated 1 kHz tones. The brainwaves were registered in Cz-M1 and Cz-M2 outputs. This method allowed detection and latency measurements of the main response components N2, P3a and N3. Working memory capacity was determined by the number of words from a 10-15 word sets correctly reproduced shortly after exposures, as outlined by Luria. Results A statistically significant non-linear correlation was observed between the memory capacity and the EP’s latency, which was fitted by a modified hyperbolic function. Additionally, greater latencies were observed for subjects suffering from the memory disorders, and much shorter latencies were in general noted for the male subjects as opposed to the female ones. One more interesting observation was that in many cases the absolute reaction time was less than the cognitive potential peak taken as a conscious decision, suggesting that it is in many cases an automatic reaction. Conclusions: This cognitive potentials measurement, being an instrumental method, allows a clinical psychologist much greater flexibility in his diagnostic repertory, as it can be used even in the cases where word tests cannot. Also, the reaction time shorter than the latency of conscious reaction to stimuli adds weight to the simultaneous codes theory of automatic reactions.
诱发认知电位是一种很有前途的实验技术,可用于诊断各种认知障碍,特别是与各种记忆障碍有关的认知障碍。研究人员特别感兴趣的是认知诱发电位的潜伏期,当涉及到各种刺激的识别。目的采用Luria法测定非文字记忆容量。研究在刺激反应中观察到的诱发认知电位的生理性质和功能作用,并确定该反应中涉及的意识控制程度。为此,对实验数据进行统计分析,以确定工作记忆容量与认知电位潜伏期之间的数值相关性。设计对166名健康受试者和63名患有脑病理性疾病(循环性脑病和其他脑循环疾病)的受试者进行认知Eps测量,这些受试者因年龄和性别而异。测量采用Neurosoft neuromvp - 4计算机脑电图系统,该系统采用测量P300波大潜伏期神经反应的标准方法。测量是在设置中完成的,受试者必须识别重要的刺激,并通过按下按钮对它们做出反应。显著的刺激用2 kHz的音调表示,而不显著的刺激用频繁重复的1 kHz的音调表示。脑电波记录在Cz-M1和Cz-M2输出。该方法可以检测N2、P3a和N3的主要响应成分并测量其潜伏期。根据Luria的概述,工作记忆容量是由暴露后不久正确复制的10-15个单词集中的单词数量决定的。结果记忆容量与脑电位潜伏期之间存在显著的非线性关系,并采用修正双曲函数拟合。此外,患有记忆障碍的受试者观察到更大的潜伏期,而男性受试者的潜伏期通常比女性受试者短得多。一个更有趣的观察是,在许多情况下,绝对反应时间小于作为有意识决定的认知潜在峰值,这表明它在许多情况下是一种自动反应。结论:这种认知潜能测量,作为一种工具方法,允许临床心理学家在他的诊断库中有更大的灵活性,因为它甚至可以在单词测试不能使用的情况下使用。同时,对刺激的反应时间比有意识反应的潜伏期短,也为自动反应的同时编码理论增加了分量。
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引用次数: 0
Time Of Reaction In Using The Pushing Of Button In Experiment Of Evoked Cognitive Potentials (R300) 诱发认知电位实验中使用按钮的反应时间(R300)
Pub Date : 2019-04-29 DOI: 10.24966/tap-7752/100008
Klochkova Oi
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引用次数: 0
New Research In The Anatomy Of The Myocardium 心肌解剖的新研究
Pub Date : 2019-04-29 DOI: 10.24966/tap-7752/100007
Trainini Jc
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引用次数: 1
Contribution of Three-Dimensional Reconstructions from CT-Scan for Assessing the Factors Associated with Blunt Splenic Injury Severity ct三维重建对评估钝性脾损伤严重程度相关因素的贡献
Pub Date : 2018-11-23 DOI: 10.24966/TAP-7752/100004
A. Studer, C. J. Kahn, A. Loundou, K. Chaumoitre, S. Berdah, R. Denis, C. Brunet, T. Bège
Purpose Analysis of influence of anthropomorphometry, splenic variability and crash’s circumstances on the severity of splenic injury. Methods Seventy-seven patients with blunt splenic trauma had a tomodensitometry at time of admission. Localisation, type, and lesion’s severity (AAST classification), were determined. Severe splenic lesion was defined by: Grade 4 or 5, lesion of entire parenchyma, or fracture. Three-dimensional splenic segmentation allowed calculation of volume, orientation (colatitude and azimuth), morphometry, morphology and span of hilar vessels. Anthropometric parameters were: Age, gender, BMI, and morphotype. Relationships between spleen, stomach, liver and 10th left rib were detailed. Results In univariate analysis, splenic parameters for a severer lesion were: Orientation of hilar side turned towards vertebral column (azimuth, p=0.05), spread conformation of hilar vessels (p=0.10), and high splenic volume (p=0.06). The younger the patient, the more severe was the splenic lesion (p=0.07). A full stomach and a left liver overflowing in the left hypochondrium, were associated with low gravity splenic lesion, (p=0.02 and p=0.03). In multivariable analysis, injured patients whose hilar area was vertically oriented, were more at risk of severe splenic lesion (OR=0.92, 95% CI (0.85-0.99), p=0.02). An abdominal-shaped liver was associated with low gravity splenic lesion (OR= 0.13, 95% CI (0.02-0.93), p=0.04). Conclusions Topographic and morphologic variability of the spleen condition its vulnerability in trauma cases. Using this analysis and the biomechanical behaviour of splenic tissue will allow for the creation of a splenic numerical model, and its integration in the virtual human scientific application of modern traumatology.
目的分析人体形态、脾脏变异性及碰撞情况对脾损伤严重程度的影响。方法对77例钝性脾外伤患者在入院时进行断层密度测定。确定定位、类型和病变严重程度(AAST分级)。脾严重病变的定义为:4级或5级,整个实质病变或骨折。脾三维分割可以计算脾门血管的体积、方位(经度和方位角)、形态、形态和跨度。人体测量参数为:年龄、性别、BMI和形态。详细分析了脾、胃、肝与左第10肋的关系。结果在单因素分析中,严重病变的脾参数为:门侧朝向脊柱方向(方位角,p=0.05),门侧血管展布构象(p=0.10),脾体积高(p=0.06)。患者年龄越小,脾损害越严重(p=0.07)。胃满和左肝在左肋部溢满与低重量性脾损害相关(p=0.02和p=0.03)。在多变量分析中,门区垂直方向的损伤患者发生严重脾损害的风险更高(OR=0.92, 95% CI (0.85 ~ 0.99), p=0.02)。腹部型肝与低重量性脾损害相关(OR= 0.13, 95% CI (0.02-0.93), p=0.04)。结论脾脏的地形和形态变化决定了其在创伤病例中的易损性。利用这种分析和脾脏组织的生物力学行为将允许创建脾脏数值模型,并将其整合到现代创伤学的虚拟人体科学应用中。
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引用次数: 0
Detrimental Effects of Formaldehyde on Health and Counteracting Beneficial Effects of Melatonin and Nigella sativa 甲醛对健康的有害影响和抵消褪黑素和黑草的有益作用
Pub Date : 2018-11-23 DOI: 10.24966/TAP-7752/100006
M. Sarsılmaz
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引用次数: 1
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HSOA trends in anatomy and physiology
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