Zhenxin Wang, Guoqing Zhang, Jin Li, Hongbo Ma, Ji Zhou, E. He, S. Skog
Elevated STK1p After the Second-Cycle-Chemotherapy Associated with Failure Poor Survival in I-II Stage of NSCLCsThree Cases Reports Zhenxin Wang1, Guoqing Zhang2, Jin Li3, Hongbo Ma3, Ji Zhou3, Ellen He3* and Sven Skog3 1Department of Oncology, Affiliated Hospital of Suzhou University, Shizi Street 188, Gusu District, Suzhou, China 2Department of Oncology, Peking 301 Chinese PLA General Hospital, Fuxing Road 28, Haidian District, Beijing 100853, China 3Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen 518057, China
{"title":"Elevated STK1p After the Second-Cycle-Chemotherapy Associated with Failure Poor Survival in I-II Stage of NSCLCs- Three Cases Reports","authors":"Zhenxin Wang, Guoqing Zhang, Jin Li, Hongbo Ma, Ji Zhou, E. He, S. Skog","doi":"10.47829/cos.2021.61002","DOIUrl":"https://doi.org/10.47829/cos.2021.61002","url":null,"abstract":"Elevated STK1p After the Second-Cycle-Chemotherapy Associated with Failure Poor Survival in I-II Stage of NSCLCsThree Cases Reports Zhenxin Wang1, Guoqing Zhang2, Jin Li3, Hongbo Ma3, Ji Zhou3, Ellen He3* and Sven Skog3 1Department of Oncology, Affiliated Hospital of Suzhou University, Shizi Street 188, Gusu District, Suzhou, China 2Department of Oncology, Peking 301 Chinese PLA General Hospital, Fuxing Road 28, Haidian District, Beijing 100853, China 3Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen 518057, China","PeriodicalId":92767,"journal":{"name":"Clinics of surgery","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77446393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. L., Z. Y., Z. M., Zhao J, Y. X, L. Y., Zhang J, Chen Y, Shang Y, Wang P, Yang Z, Zhou L, Chi Y, M. Z, L. J
Exploration of The Mechanism of Qianliexin Capsule Against Chronic Nonbacterial Prostatitis Using Metabolomicsv Zang L1, Zhang Y2, Zhang M1, Zhao J1, Yang X1, Li Y1, Zhang J1, Chen Y1, Shang Y1, Wang P1, Yang Z1, Zhou L1, Chi Y1, Meng Z2* and Lu J1* 1Institute of Life science and Bio-pharmaceuticals, Pharmaceutical College, Shenyang Pharmaceutical University, China 2Institute of traditional Chinese Medicine, Shandong Hongjitang Pharmaceutical Group Co., Ltd., China
{"title":"Exploration of The Mechanism of Qianliexin Capsule Against Chronic Nonbacterial Prostatitis Using Metabolomicsv","authors":"Z. L., Z. Y., Z. M., Zhao J, Y. X, L. Y., Zhang J, Chen Y, Shang Y, Wang P, Yang Z, Zhou L, Chi Y, M. Z, L. J","doi":"10.47829/cos.2021.6501","DOIUrl":"https://doi.org/10.47829/cos.2021.6501","url":null,"abstract":"Exploration of The Mechanism of Qianliexin Capsule Against Chronic Nonbacterial Prostatitis Using Metabolomicsv Zang L1, Zhang Y2, Zhang M1, Zhao J1, Yang X1, Li Y1, Zhang J1, Chen Y1, Shang Y1, Wang P1, Yang Z1, Zhou L1, Chi Y1, Meng Z2* and Lu J1* 1Institute of Life science and Bio-pharmaceuticals, Pharmaceutical College, Shenyang Pharmaceutical University, China 2Institute of traditional Chinese Medicine, Shandong Hongjitang Pharmaceutical Group Co., Ltd., China","PeriodicalId":92767,"journal":{"name":"Clinics of surgery","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77825888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lenjani B, R. P, Shabani G, D. A, Pelaj B, D. A, Sylaj R, Mulaj Ev, Lenjani D
{"title":"Emergency Medical Care and Management of Sports Injuries On the Football Court","authors":"Lenjani B, R. P, Shabani G, D. A, Pelaj B, D. A, Sylaj R, Mulaj Ev, Lenjani D","doi":"10.47829/cos.2021.4604","DOIUrl":"https://doi.org/10.47829/cos.2021.4604","url":null,"abstract":"","PeriodicalId":92767,"journal":{"name":"Clinics of surgery","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82409756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Importance of Micrornas in Human Cancer Development: A Molecular Analytical Approach Ahmed FE1*, Gouda MM2,3 and Ahmed NC4 1,4GEM Tox Labs, Institute for Research in Biotechnology, 2905 South Memorial Drive, Greenville, NC 27834, USA 2,3Egypt National Research Center, Giza, Dokki, Cairo, Egypt, and College of Biosystems Engineering and Food Science, Zhejang University, 866 Yuhangtang, Hangzhou, 310058, China
Micrornas在人类癌症发展中的重要性:分子分析方法Ahmed FE1*， Gouda MM2,3和Ahmed NC4 1,4GEM Tox实验室，生物技术研究所，2905 South Memorial Drive, Greenville, NC 27834, USA 2,3埃及国家研究中心，埃及开罗吉萨，Dokki，埃及，浙江大学生物系统工程与食品科学学院，杭州余杭汤866，中国，310058
{"title":"Importance of Micrornas in Human Cancer Development: A Molecular Analytical Approach","authors":"A. Fe, Gouda Mm, Ahmed Nc","doi":"10.47829/cos.2021.6401","DOIUrl":"https://doi.org/10.47829/cos.2021.6401","url":null,"abstract":"Importance of Micrornas in Human Cancer Development: A Molecular Analytical Approach Ahmed FE1*, Gouda MM2,3 and Ahmed NC4 1,4GEM Tox Labs, Institute for Research in Biotechnology, 2905 South Memorial Drive, Greenville, NC 27834, USA 2,3Egypt National Research Center, Giza, Dokki, Cairo, Egypt, and College of Biosystems Engineering and Food Science, Zhejang University, 866 Yuhangtang, Hangzhou, 310058, China","PeriodicalId":92767,"journal":{"name":"Clinics of surgery","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85538512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Njoku C, Ngene AH, Udeh K, Chukwuma UA, Oyeduntan EA
The effective communication of risks involved in anti-malaria dosage information dissemination is fundamental in health education and advocacies. Although there is no known pattern of communication perspective regarding numerous health risks involved in self-medication of anti-malaria drugs in Nigeria setting especially as more than half of the entire population relay on self-medication because of poor healthcare system. This paper reviews and evaluates the relative merits of two approaches to health risk communication of anti-malaria drugs on patients in Nigeria. One approach relies on the presentation of numerical information regarding the probability of a health problem occurring annually despite the claim of malaria eradication, whereas the other relies on the presentation of information about the antecedents and consequences of a health problem. Because people have considerable difficulty understanding and using quantitative information on the anti-malaria leaflets, the effectiveness of interventions that rely solely on numerical probability information has been limited. Interventions that provide people with a broader informational context to think about a health problem have had greater success systematically influencing perceptions of personal risk but have several important limitations. However, before any final conclusions can be drawn regarding the relative merits of different health risk communication strategies, investigators must agree on the specific criteria that should be used to identify an effective intervention. The finding pre-supposes a recurring pattern of approach to health risk information based on the peculiarity of recent interventions in the health sector
{"title":"Communicating Anti-Malaria Drugs Amongst ‘A’ Group Gynotype Groups in South East Nigeria","authors":"Njoku C, Ngene AH, Udeh K, Chukwuma UA, Oyeduntan EA","doi":"10.47829/cos.2021.61105","DOIUrl":"https://doi.org/10.47829/cos.2021.61105","url":null,"abstract":"The effective communication of risks involved in anti-malaria dosage information dissemination is fundamental in health education and advocacies. Although there is no known pattern of communication perspective regarding numerous health risks involved in self-medication of anti-malaria drugs in Nigeria setting especially as more than half of the entire population relay on self-medication because of poor healthcare system. This paper reviews and evaluates the relative merits of two approaches to health risk communication of anti-malaria drugs on patients in Nigeria. One approach relies on the presentation of numerical information regarding the probability of a health problem occurring annually despite the claim of malaria eradication, whereas the other relies on the presentation of information about the antecedents and consequences of a health problem. Because people have considerable difficulty understanding and using quantitative information on the anti-malaria leaflets, the effectiveness of interventions that rely solely on numerical probability information has been limited. Interventions that provide people with a broader informational context to think about a health problem have had greater success systematically influencing perceptions of personal risk but have several important limitations. However, before any final conclusions can be drawn regarding the relative merits of different health risk communication strategies, investigators must agree on the specific criteria that should be used to identify an effective intervention. The finding pre-supposes a recurring pattern of approach to health risk information based on the peculiarity of recent interventions in the health sector","PeriodicalId":92767,"journal":{"name":"Clinics of surgery","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88736163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case Report: COVID Vaccine-Induced Immune Thrombocytopenia","authors":"Lwin Zaw Thant, N. Phyu","doi":"10.47829/cos.2021.51201","DOIUrl":"https://doi.org/10.47829/cos.2021.51201","url":null,"abstract":"","PeriodicalId":92767,"journal":{"name":"Clinics of surgery","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74352961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Intravenous fluids are commonly prescribed, but uncertainty remains about how to assess when fluids are required and how much to give [1]. Two recent guidelines have acknowledged a limited evidence base to guide fluid assessment. A recommended means to assess hypovolaemia includes assessment of fluid responsiveness. Fluid responsiveness is a rise in stroke volume following an increase in preload, achieved using a fluid challenge or a passive leg raise. However, the means of defining fluid responsiveness and its ability to identify patients who would benefit from fluid resuscitation is currently unclear.
{"title":"The New Scientific Foundation of Fluid Therapy in Shock Management","authors":"Ahmed Nasr M Ghanem","doi":"10.47829/cos.2021.61301","DOIUrl":"https://doi.org/10.47829/cos.2021.61301","url":null,"abstract":"Intravenous fluids are commonly prescribed, but uncertainty remains about how to assess when fluids are required and how much to give [1]. Two recent guidelines have acknowledged a limited evidence base to guide fluid assessment. A recommended means to assess hypovolaemia includes assessment of fluid responsiveness. Fluid responsiveness is a rise in stroke volume following an increase in preload, achieved using a fluid challenge or a passive leg raise. However, the means of defining fluid responsiveness and its ability to identify patients who would benefit from fluid resuscitation is currently unclear.","PeriodicalId":92767,"journal":{"name":"Clinics of surgery","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80781486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhifeng Y, Yongjing L, Z. K, Xuejie D, S. R., Z. W
Combined Detection of Preoperative Neutrophil to Lymphocyte Ratio and Interleukin-6 as an Independent Prognostic Factor for Patients with Non-Metastatic Colorectal Cancer Zhifeng Y1, Yongjing L1, Zhang K1, Xuejie D2, Shikuo R3,* and Zhen W2* 1Department of Laboratory, Liaocheng Maternal and Child Health Hospital, Shandong, China 2Department of Gastroenterology, Leshan People’s Hospital, Sichuan, China 3Department of general surgery, Chengdu Second People’s Hospital, Chengdu, Sichuan, China
{"title":"Combined Detection of Preoperative Neutrophil to Lymphocyte Ratio and Interleukin-6 as an Independent Prognostic Factor for Patients with Non-Metastatic Colorectal Cancer","authors":"Zhifeng Y, Yongjing L, Z. K, Xuejie D, S. R., Z. W","doi":"10.47829/cos.2021.6203","DOIUrl":"https://doi.org/10.47829/cos.2021.6203","url":null,"abstract":"Combined Detection of Preoperative Neutrophil to Lymphocyte Ratio and Interleukin-6 as an Independent Prognostic Factor for Patients with Non-Metastatic Colorectal Cancer Zhifeng Y1, Yongjing L1, Zhang K1, Xuejie D2, Shikuo R3,* and Zhen W2* 1Department of Laboratory, Liaocheng Maternal and Child Health Hospital, Shandong, China 2Department of Gastroenterology, Leshan People’s Hospital, Sichuan, China 3Department of general surgery, Chengdu Second People’s Hospital, Chengdu, Sichuan, China","PeriodicalId":92767,"journal":{"name":"Clinics of surgery","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85482628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qinghua He, Qifan Zhang, Jian-ping Qian, Sheng Yu, Leyi Liao, Qingping Li, P. Huang, Hanbiao Liang, Z. Han, Qingyan Li, Xianbin Li, Yiran Wei, Bili Zhu, Jie Zhou, Liu Chuanjiang, Kai Wang
Background: This study investigated the incidence of post-hepatectomy hypoalbuminemia and the necessity of Intravenous Albumin (ALB) supplement for hypoalbuminemia after Laparoscopic Hepatectomy (LH). Methods: Nine hundred and eighty patients with Open Hepatectomy (OH) and 198 patients with LH were matched on the propensity score by 2:1. The incidences of postoperative hypoalbuminemia and the usage of ALB injection on different Postoperative Days (POD) were compared. Preventive and risk factors of hypoalbuminemia were screened by logistic regression. Receiver Operator Characteristic (ROC) curve and nomogram were established to predict postoperative hypoalbuminemia. Result: 175 patients of LH and 296 patients of OH were matched. The usage of ALB injection was significantly lower in the LH group than those in the OH group (60.0 vs. 75.3%, P=0.000; 6.71 ± 6.99 vs. 8.62 ± 7.18 g, P=0.005). The incidences of postoperative hypoalbuminemia in the LH group were significantly lower than those in the OH group (62.3 vs. 78.4% (P=0.000) on POD 1, 51.4 vs. 71.6% (P=0.000) on POD 3, 37.1 vs. 51.4% (P=0.003) on POD 5, and 27.4 vs. 39.9% (P=0.006) on POD 7). Preoperative serum ALB level and Serum Alanine Aminotransferase (ALT) level was identified as independent protective and risk factor of hypoalbuminemia after LH, respectively. Preoperative serum ALB level below 42.95 g/L and serum ALT level above 28.50 U/L were identified as the reliable cut-off value to predict postoperative hypoalbuminemia after LH. A nomogram for predicting the probability of hypoalbuminemia after LH was established. Conclusion: LH with a reduced intravenous ALB supplement was still associated with a lower incidence of postoperative hypoalbuminemia.
背景:本研究探讨腹腔镜肝切除术(LH)术后低白蛋白血症的发生率及静脉补充白蛋白(ALB)的必要性。方法:90例开放式肝切除术(OH)患者和198例LH患者的倾向性评分按2:1匹配。比较两组患者术后不同天数(POD)低白蛋白血症发生率及ALB注射液使用情况。采用logistic回归方法筛选低白蛋白血症的预防和危险因素。建立受试者操作特征(ROC)曲线和nomogram预测术后低白蛋白血症。结果:LH 175例，OH 296例。LH组ALB注射液使用率明显低于OH组(60.0 vs. 75.3%， P=0.000;(6.71±6.99 g vs. 8.62±7.18 g, P=0.005)。LH组术后低白蛋白血症发生率明显低于OH组(POD 1组62.3比78.4% (P=0.000)， POD 3组51.4比71.6% (P=0.000)， POD 5组37.1比51.4% (P=0.003)， POD 7组27.4比39.9% (P=0.006))。术前血清ALB水平和血清丙氨酸转氨酶(ALT)水平分别被确定为LH术后低白蛋白血症的独立保护因素和危险因素。术前血清ALB水平低于42.95 g/L，血清ALT水平高于28.50 U/L被确定为预测LH术后低白蛋白血症的可靠临界值。建立了预测LH后低白蛋白血症概率的nomogram。结论:LH与静脉白蛋白补充减少仍然与术后低白蛋白血症发生率较低相关。
{"title":"Laparoscopic Hepatectomy Reduces the Incidence of Postoperative Hypoalbuminemia: A Propensity Score Matching Analysis with Open Hepatectomy","authors":"Qinghua He, Qifan Zhang, Jian-ping Qian, Sheng Yu, Leyi Liao, Qingping Li, P. Huang, Hanbiao Liang, Z. Han, Qingyan Li, Xianbin Li, Yiran Wei, Bili Zhu, Jie Zhou, Liu Chuanjiang, Kai Wang","doi":"10.47829/cos.2021.61001","DOIUrl":"https://doi.org/10.47829/cos.2021.61001","url":null,"abstract":"Background: This study investigated the incidence of post-hepatectomy hypoalbuminemia and the necessity of Intravenous Albumin (ALB) supplement for hypoalbuminemia after Laparoscopic Hepatectomy (LH). Methods: Nine hundred and eighty patients with Open Hepatectomy (OH) and 198 patients with LH were matched on the propensity score by 2:1. The incidences of postoperative hypoalbuminemia and the usage of ALB injection on different Postoperative Days (POD) were compared. Preventive and risk factors of hypoalbuminemia were screened by logistic regression. Receiver Operator Characteristic (ROC) curve and nomogram were established to predict postoperative hypoalbuminemia. Result: 175 patients of LH and 296 patients of OH were matched. The usage of ALB injection was significantly lower in the LH group than those in the OH group (60.0 vs. 75.3%, P=0.000; 6.71 ± 6.99 vs. 8.62 ± 7.18 g, P=0.005). The incidences of postoperative hypoalbuminemia in the LH group were significantly lower than those in the OH group (62.3 vs. 78.4% (P=0.000) on POD 1, 51.4 vs. 71.6% (P=0.000) on POD 3, 37.1 vs. 51.4% (P=0.003) on POD 5, and 27.4 vs. 39.9% (P=0.006) on POD 7). Preoperative serum ALB level and Serum Alanine Aminotransferase (ALT) level was identified as independent protective and risk factor of hypoalbuminemia after LH, respectively. Preoperative serum ALB level below 42.95 g/L and serum ALT level above 28.50 U/L were identified as the reliable cut-off value to predict postoperative hypoalbuminemia after LH. A nomogram for predicting the probability of hypoalbuminemia after LH was established. Conclusion: LH with a reduced intravenous ALB supplement was still associated with a lower incidence of postoperative hypoalbuminemia.","PeriodicalId":92767,"journal":{"name":"Clinics of surgery","volume":"991 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77133279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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