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Symptomology Associated with in Utero Exposures to Polysubstance in an Appalachian Population. 阿巴拉契亚人群子宫内多物质暴露的相关症状
Pub Date : 2019-04-30 DOI: 10.33470/2379-9536.1212
W. Lester, L. Andrews, Emma M. Nellhaus, S. Murray, S. Loudin, T. Davies
Neonatal abstinence syndrome (NAS) is seen at a very high rate at our institution in Huntington, West Virginia, and the majority of exposures are polysubstance in nature. Polysubstance can have different meanings for different regions. At our institution, polysubstance is any combination of opioids, gabapentin, methamphetamine, cocaine, marijuana, benzodiazepines, nicotine or other neuroactive substances with three to four substances being the norm. Rapidly changing combinations of drug use and the lack of literature creates a difficult situation for clinicians who are often reliant on treatment recommendations that lack references or conclusive data supporting the clinical approaches. Elucidating withdrawal symptoms consistent with in utero exposures to particular drug combinations is difficult. Many substances induce similar withdrawal symptoms in neonates and the vast majority of cases present as polysubstance exposure. Standard methodology often leads to a research approach which isolates populations and substance of exposure to determine the individual effects on the neonate. In some drug combinations, like opioid and gabapentin exposure, the substances in concert create symptoms and complications that are not observed with either drug alone. The history of responses to substance use epidemics has been to handle each drug as a separate disease process; this is no longer a viable option. The following is a review of the literature available discussing individual substance withdrawal characteristics in neonates combined with the clinical insight gained at our hospital from treating such high rates of complex polysubstance exposure.
在我们位于西弗吉尼亚州亨廷顿的机构中,新生儿禁欲综合征(NAS)的发病率非常高,大多数暴露在自然界中是多物质的。多物质对于不同的区域可能具有不同的含义。在我们的机构中,多物质是阿片类药物、加巴喷丁、甲基苯丙胺、可卡因、大麻、苯二氮卓类药物、尼古丁或其他神经活性物质的任何组合,三到四种物质是常态。药物使用组合的快速变化和文献的缺乏给临床医生带来了困难,他们往往依赖缺乏支持临床方法的参考文献或结论性数据的治疗建议。很难阐明与子宫内接触特定药物组合一致的戒断症状。许多物质在新生儿中引起类似的戒断症状,绝大多数病例表现为多物质暴露。标准方法通常导致一种研究方法,该方法分离暴露的人群和物质,以确定对新生儿的个体影响。在一些药物组合中,如阿片类药物和加巴喷丁暴露,这些物质共同产生了单独使用任何一种药物都无法观察到的症状和并发症。对药物使用流行病的反应历史是将每种药物作为一个单独的疾病过程来处理;这不再是一个可行的选择。以下是对现有文献的综述,讨论新生儿的个体物质戒断特征,并结合我们医院从治疗如此高的复杂多物质暴露率中获得的临床见解。
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引用次数: 1
Surgery for Esophageal Adenocarcinoma: Three field open McKeown procedure has a role in assessment and treatment of extensive locally advanced esophageal adenocarcinoma with a favorable clinical and pathological outcome. 食管腺癌的手术治疗:三场开放McKeown手术在广泛的局部晚期食管腺癌的评估和治疗中具有良好的临床和病理结果。
Pub Date : 2019-04-30 DOI: 10.33470/2379-9536.1205
M. Cooper, Paul Bown, Toni O Pacioles
Esophageal adenocarcinoma has seen increased incidence due to gastroesophageal reflux disease, smoking, and obesity. There are no established guidelines for screening of esophageal cancer and many patients present late in their disease process. Most early stage adenocarcinoma of the esophagus is treated with neoadjuvant chemotherapy and radiation, followed by surgical resection. We describe a case of locally advanced esophageal cancer where the patient had a relatively insignificant response to neoadjuvant chemotherapy and radiation, who was then treated by open direct resection of the esophagus and proximal stomach (three field McKeown approach) with lymphadenectomy. There were no surgical complications such as anstomotic leak or chylothorax. Pathology showed T2N0 disease. The mainstay of esophageal resection continues to be minimally invasive procedures for early stage esophageal malignancy; however, locally advanced esophageal cancer in the mediastinum occasionally requires an open direct approach. We felt that this was a necessary procedure due to the large mass effect of the tumor, and a preoperative staging of T2N3. In this case, despite recent advancements, there was a limited response of the cancer to neoinduction therapy. Surgery was necessary to both assess and treat this cancer, proving that older, established therapy is still relevant.
由于胃食管反流病、吸烟和肥胖,食管腺癌的发病率增加。目前还没有确定的癌症筛查指南,许多患者在疾病过程后期出现。大多数早期食管腺癌采用新辅助化疗和放疗,然后进行手术切除。我们描述了一例局部晚期癌症食管癌,患者对新辅助化疗和放疗的反应相对不明显,然后通过食管和胃近端开放直接切除术(三视野麦基翁入路)和淋巴结切除术进行治疗。没有出现诸如肛门镜渗漏或乳糜胸等手术并发症。病理显示T2N0病变。食管切除术的主要内容仍然是早期食管恶性肿瘤的微创手术;然而,纵隔局部晚期食管癌症偶尔需要直接开放入路。我们认为这是一个必要的手术,因为肿瘤的巨大质量效应,以及T2N3的术前分期。在这种情况下,尽管最近取得了进展,但癌症对新诱导治疗的反应有限。手术对于评估和治疗这种癌症是必要的,这证明了较老的、既定的治疗仍然是相关的。
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引用次数: 0
Advancing Science through Diversity Begins with Cultural Immersion in Science Education 多元推进科学始于科学教育的文化渗透
Pub Date : 2019-04-30 DOI: 10.33470/2379-9536.1224
D. Shah
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引用次数: 1
Bilateral foot drop linked to rapid intentional weight loss and long distance walking. 双足下垂与快速有意减肥和长距离步行有关。
Pub Date : 2019-04-30 DOI: 10.33470/2379-9536.1207
Morgan Aguirre, J. Gibson, Dominika Lozowska
There are many causes of acute onset foot drop ranging from deep fibular nerve or sciatic nerve injury caused by trauma or a compressive mass such as a neuroma, to spinal cord disorders like disc herniation causing L4-5 radiculopathy. Even brain disorders like MS, stroke or ALS can result in foot drop and various muscular dystrophies affecting the tibialis anterior muscle responsible for foot dorsiflexion and eversion. We present a case of bilateral foot drop as a complication of rapid 70 lb weight loss which was described in literature previously as “slimmer’s palsy”.
急性起脚跌落的原因有很多,从创伤或压迫性肿块(如神经瘤)引起的腓深神经或坐骨神经损伤,到导致L4-5神经根病的椎间盘突出等脊髓疾病。即使是MS、中风或ALS等脑部疾病也会导致足部下垂和各种肌肉营养不良,影响负责足部背屈和外翻的胫骨前肌。我们报告了一例双侧足下垂,这是70磅体重快速减轻的并发症,在以前的文献中被描述为“苗条的麻痹”。
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引用次数: 2
On Watson, Racism, and Standardized Tests 论Watson、种族主义与标准化考试
Pub Date : 2019-04-30 DOI: 10.33470/2379-9536.1219
Joseph I Shapiro
2019 On Watson, Racism, and Standardized Tests Joseph I. Shapiro Author Affiliations Joseph I. Shapiro MD (Marshall University Joan C. Edwards School of Medicine, Huntington, West Virginia) The author has no financial disclosures to declare and no conflicts of interest to report. Corresponding Author Joseph I. Shapiro MD (Marshall University Joan C. Edwards School of Medicine, Huntington, West Virginia)
约瑟夫·i·夏皮罗医学博士(马歇尔大学琼·c·爱德华兹医学院,西弗吉尼亚州亨廷顿)作者没有财务披露要申报,也没有利益冲突要报告。通讯作者Joseph I. Shapiro医学博士(马歇尔大学Joan C. Edwards医学院,西弗吉尼亚州亨廷顿)
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引用次数: 0
Rare Sarcomatoid Carcinoma of the Liver in a patient with no history of Hepatocellular Carcinoma: A Case Report 无肝细胞癌病史的罕见肝肉瘤样癌1例报告
Pub Date : 2019-04-30 DOI: 10.33470/2379-9536.1215
K. B. Patel, Rita H Hawarny, E. Saunders, M. Hettlinger, N. Nahar
Sarcomatoid carcinoma is a rare malignant tumor of unknown pathogenesis characterized by poorly differentiated carcinoma tissue containing sarcoma-like differentiation of either spindle or giant cell and rarely occurs in the gastrointestinal tract and hepatobiliary-pancreatic system. Primary hepatic sarcomatoid carcinoma accounts for only 0.2 % of primary malignant liver tumors, and 1.8% of all surgically resected hepatocellular carcinomas. The majority of hepatic sarcomatoid carcinoma cases appear to occur simultaneously with hepatocellular or cholangiocellular carcinoma. The preferred treatment for hepatic sarcomatoid carcinoma is surgical resection and the overall prognosis is poor. This case depicts a 62-year-old female who underwent initial resection of a cavernous hemangioma in 2010. Seven years after her initial diagnosis, she developed what was initially felt to be local recurrence of the hemangioma but additional diagnostic workup with a liver biopsy confirmed primary hepatic sarcomatoid carcinoma.
肉瘤样癌是一种罕见的恶性肿瘤,其发病机制尚不清楚,以低分化癌组织为特征,癌组织中含有梭形细胞或巨细胞样肉瘤样分化,很少发生于胃肠道和肝胆胰系统。原发性肝肉瘤样癌仅占原发性恶性肝肿瘤的0.2%,占所有手术切除的肝细胞癌的1.8%。大多数肝肉瘤样癌似乎与肝细胞癌或胆管细胞癌同时发生。肝肉瘤样癌的首选治疗方法是手术切除,但总体预后较差。本病例描述了一位62岁的女性,她在2010年接受了海绵状血管瘤的初步切除术。在最初诊断7年后,她出现了最初认为是局部血管瘤复发的症状,但肝脏活检证实了原发性肝肉瘤样癌。
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引用次数: 0
Angiogram negative subarachnoid hemorrhage in the setting of sexual intercourse and chronic cannabis use 性交和长期使用大麻情况下血管造影阴性蛛网膜下腔出血
Pub Date : 2019-04-30 DOI: 10.33470/2379-9536.1211
D. May, Dominika Lozowska
Etiology of unprovoked subarachnoid hemorrhage (SAH) is predominantly from cerebral aneurysm rupture and manifests classically as a thunderclap headache. Orgasmic cephalgia may herald SAH given that 4-12% of SAH sufferers were found to have engaged in prior sexual activity. Precipitating causes of SAH leading to aneurysmal rupture may be the rise in blood pressure caused by physical activity. A CT angiogram (CTA) is used to reveal a source of the bleed but occasionally this is normal, and is labelled angiogramnegative SAH or non-aneurysmal SAH. In those cases digital subtraction imaging (DSA, conventional angiogram) is needed for verification. Herein we discuss an instance of angiogram negative SAH which occurred after sexual activity in a young male with a chronic cannabis habit.
非诱发性蛛网膜下腔出血(SAH)的病因主要是脑动脉瘤破裂,典型表现为雷击性头痛。性高潮性头痛症可能预示着SAH,因为4-12%的SAH患者被发现有过性行为。导致动脉瘤破裂的SAH的促发原因可能是体力活动引起的血压升高。CT血管造影(CTA)用于显示出血来源,但偶尔这是正常的,并标记为血管造影阴性SAH或非动脉瘤性SAH。在这些情况下,需要数字减影成像(DSA,传统血管造影)进行验证。在这里,我们讨论血管造影阴性SAH的一个实例,发生在性行为后的年轻男性与慢性大麻习惯。
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引用次数: 0
Kounis Syndrome: A simple MRI with contrast turned into a life threatening condition Kounis综合征:一个带有造影剂的简单MRI变成了一种危及生命的情况
Pub Date : 2019-04-30 DOI: 10.33470/2379-9536.1217
A. Amro, Kanaan Mansoor, M. Amro, A. Sobeih, Mehiar El-Hamdani
Kounis syndrome (KS) is a hypersensitivity coronary disorder induced by various allergens. It is a rare condition which has been reported in every age group (2-90 years) and in every race and geographic location. Its incidence has been reported to range from 7.9 to 19.4 per 100,000. The presentation of the detrimental effects of KS on coronary arteries ranges from vasospastic angina to allergic myocardial infarction. Drugs are the major iatrogenic cause of KS, but virtually everything in the environment around us can cause KS. In recent years contrast mediums used in the radiologic investigation have come forth as a leading cause of anaphylaxis. Gadolinium is a rare earth metal that is used in contrast mediums for magnetic resonance imaging and is generally considered to be safe. This is a case of 52-year-old female who developed KS after receiving gadobenate dimeglumine, a gadolinium based contrast medium (GBCM) for MRI of the brain as a work up for metastatic renal cell carcinoma. Her EKG was remarkable for ST elevations in the inferior leads. Cardiac catheterization was preformed which did not reveal any significant obstructive coronary artery disease. Patient was treated with anti-histamines, corticosteroids and norepinephrine after which she recovered and discharged home stable. GBCM induced KS is very rare and to our knowledge this is the third case of Kounis syndrome reported in association with gadobenate dimeglumine.
库尼斯综合征是一种由多种过敏原引起的超敏性冠状动脉疾病。这是一种罕见的情况,在每个年龄组(2-90岁)、每个种族和地理位置都有报道。据报道,其发病率为每100000人7.9至19.4人。KS对冠状动脉有害影响的表现从血管痉挛性心绞痛到过敏性心肌梗死。药物是KS的主要医源性原因,但实际上我们周围环境中的一切都会导致KS。近年来,放射学研究中使用的造影剂已成为过敏反应的主要原因。钆是一种稀土金属,用于磁共振成像的造影剂,通常被认为是安全的。这是一例52岁的女性患者,在接受钆基造影剂(GBCM)治疗转移性肾细胞癌后出现KS。她的心电图在下导联ST段抬高方面非常显著。心导管插入术未发现任何严重的阻塞性冠状动脉疾病。患者接受了抗组胺药、皮质类固醇和去甲肾上腺素治疗,之后康复出院,病情稳定。GBCM诱导的KS非常罕见,据我们所知,这是报告的第三例与加多酚酸酯-二甲葡胺相关的Kounis综合征。
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引用次数: 0
Trans-radial coronary intervention (TCI) using 5-Fr versus 6-Fr guiding catheters in the setting of acute coronary syndrome (ACS). 在急性冠状动脉综合征(ACS)中使用5-Fr与6-Fr引导导管的经桡动脉介入治疗(TCI)。
Pub Date : 2019-04-30 DOI: 10.33470/2379-9536.1210
A. Amro, M. Amro, A. Sobeih, Obadah Aqtash, H. Hirzallah, M. Kanbour, A. Elhamdani, Alaa Gabi, Yazan Numan, M. Studeny, Mehiar El-Hamdani
Ahmed Amro, Mohammad Amro, Amal Sobeih, Obadah Aqtash, Hisham Hirzallah, Majd Kanbour, Adee El-Hamdani, Alaa Gabi, Yazan Numan, Mark Studeny, and Mehiar El-Hamdani Author Affiliations Ahmed Amro (Marshall University Joan C. Edwards School of Medicine) Mohammad Amro (Misr University for Science and Technology) Amal Sobeih (Al-Najah University School of Medicine, Nablus, Palestine) Obadah Aqtash (Marshall University Joan C. Edwards School of Medicine, Huntington, West Virginia) Hisham Hirzallah ((Marshall University Joan C. Edwards School of Medicine, Huntington, West Virginia) Majd Kanbour (Marshall University Joan C. Edwards School of Medicine, Huntington, West Virginia) Adee El-Hamdani (Marshall University Joan C. Edwards School of Medicine, Huntington, West Virginia) Alaa Gabi (Marshall University Joan C. Edwards School of Medicine, Huntington, West Virginia) Yazan Numan (Marshall University Joan C. Edwards School of Medicine, Huntington, West Virginia) Mark Studeny (Marshall University) Mehiar El-Hamdani (Marshall University Joan C. Edwards School of Medicine)
Ahmed Amro、Mohammad Amro、Amal Sobeih、Obadah Aqtash、Hisham Hirzallah、Majd Kanbour、Adee El Hamdani、Alaa Gabi、Yazan Numan、Mark Studeny和Mehiar El Hamdany作者关系Ahmed Amro[马歇尔大学Joan C。Edwards医学院)Mohammad Amro(米斯尔科技大学)Amal Sobeih(巴勒斯坦纳布卢斯Al-Najah大学医学院)Obadah Aqutash(西弗吉尼亚州亨廷顿马歇尔大学Joan C.Edwards医学学院)Hisham Hirzallah。西弗吉尼亚州亨廷顿爱德华医学院)Majd Kanbour。爱德华医学院,西弗吉尼亚州亨廷顿)Mark Studeny(马歇尔大学)Mehiar El Hamdani(马歇尔大学Joan C.Edwards医学院)
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引用次数: 0
The use of Dermoscopy Following a one-day Workshop Among Family Medicine Residents 在为期一天的家庭医学住院医师研讨会后使用皮肤镜
Pub Date : 2019-01-30 DOI: 10.33470/2379-9536.1196
Dylan Maldonado, K. O'Hanlon
Skin cancer is the most common form of cancer in the United States. The purpose of this study is to determine if a single grand rounds workshop impacts the use of dermoscopy in a family medicine residency training program. Dermoscopy is a non-invasive tool to allow for higher magnification of skin lesions thereby increasing the ability to assess qualities which are unable to be seen by the naked eye. This study utilized a preand post-workshop survey questionnaire to assess participant practices in evaluation, diagnosis, and management of skin lesions. Eighteen residents completed the survey prior to the grand rounds workshop. Nine residents completed the follow-up survey three-months post-workshop. The results showed that the frequency of dermoscopy use increased post-workshop (Pearson’s Chi Square=8.83, p=0.012; Fischer’s Exact=0.008) and residents felt dermoscopy decreased the need to refer skin lesions (Pearson’s Chi Square=9.11, p=0.028; Fischer’s Exact=0.023). However, there was no significant change in resident comfort level when using dermoscopy post-educational workshop (Pearson’s Chi Square=5.34, p=0.255; Fischer’s Exact=0.272).
癌症是美国最常见的癌症。本研究的目的是确定一次大型研讨会是否会影响皮肤镜检查在家庭医学住院培训项目中的使用。皮肤镜是一种非侵入性工具,可以对皮肤损伤进行更高的放大,从而提高评估肉眼无法看到的质量的能力。这项研究使用了研讨会前后的调查问卷来评估参与者在评估、诊断和管理皮肤损伤方面的做法。18名居民在大圆桌研讨会之前完成了调查。9名居民在研讨会后三个月完成了后续调查。结果显示,工作后使用皮肤镜检查的频率增加(Pearson’s Chi Square=8.83,p=0.012;Fischer’s Exact=0.008),居民认为皮肤镜检查减少了提及皮肤病变的需要(Pearson's Chi Square=9.11,p=0.028;Fischer‘s Exact=0.023)。然而,在使用皮肤镜检查的教育后研讨会时,住院医师的舒适度没有显著变化(Pearson’s Chi Square=5.34,p=0.255;Fischer’s Exact=0.272)。
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引用次数: 0
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Marshall journal of medicine
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