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A Tribute to Franklin Shuler, M.D., Ph.D., C.I.M.E. (1967-2021) 向Franklin Shuler,医学博士,博士,C.I.M.E.致敬(1967-2021)
Pub Date : 2022-01-31 DOI: 10.33470/2379-9536.1360
Abigail Tolbert, Dipali Nemade
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引用次数: 0
A Rare Case of Right Lower Lobe Intralobar Pulmonary Sequestration in an Adult 一例罕见的成人右下叶肺内开窗术
Pub Date : 2021-10-28 DOI: 10.33470/2379-9536.1339
Andrew J. Weaver, Jenalee Corsello, P. Chirico, M. Cooper
Pulmonary sequestration is a rare congenital abnormality that is often diagnosed in childhood. There are two types of sequestration which are differentiated by the presence, or lack of, pleural lining dividing the aberrant lung tissue from the functional lung. Data for the management of this pathology in adults remains scarce. Here we present a case of intralobar pulmonary sequestration in an adult. The management of this patient comprised of surgical treatment involving lobectomy and ligation of the feeding vessel. The patient had an uneventful recovery, and the final pathology revealed a chronic infection in the sequestration.
肺隔离症是一种罕见的先天性异常,通常在儿童时期被诊断出来。有两种类型的隔离,其区别在于胸膜衬里的存在或缺乏,胸膜衬里将异常肺组织与功能性肺分开。成人这种病理学的管理数据仍然很少。本文报告一例成人肺叶内肺隔离症。该患者的治疗包括肺叶切除术和结扎喂养血管的手术治疗。患者恢复顺利,最终病理显示隔离区有慢性感染。
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引用次数: 0
Dysfunctional Voiding: Does a validated urine color scale correlate with dysfunctional voiding severity score? 功能障碍排尿:有效的尿色量表与功能障碍排尿严重程度评分相关吗?
Pub Date : 2021-10-28 DOI: 10.33470/2379-9536.1344
Katharina Mitchell, C. Crigger, Tyler L Overholt, T. Trump, J. Barnard, O. Al-Omar, Hilary Morley
Dysfunctional voiding (DV) affects approximately 40% of patients populating pediatric urology clinics. We administered the Dysfunctional Voiding Symptom Score [DVSS] survey and dehydration severity chart (Urine Color Chart [UCC]) to toilet trained pediatric patients and compared DV patients to patients presenting with non-urologic concerns. We compiled 29 DV patients (ages 3-15, 20 females, 9 males, 29 Caucasian) and 21 non-urologic patients (ages 2-17, 11 males, 10 females, 1 Hispanic, 1 African American, 20 Caucasian) from 2016 to 2018. The DV population had significantly higher scores in 7/ 10 items within the DVSS and overall scores compared to non-urologic patients p < 0.05, p = 0.0004 respectively. This suggests the DVSS results yield significantly different results among DV and non-DV patients.
功能性排尿困难(DV)影响了儿科泌尿外科诊所约40%的患者。我们对接受过如厕训练的儿科患者进行了功能障碍性排尿症状评分[DVSS]调查和脱水严重程度图(尿液颜色图[UCC]),并将DV患者与有非泌尿系统问题的患者进行了比较。我们收集了2016年至2018年的29名DV患者(年龄3-15岁,20名女性,9名男性,29名高加索人)和21名非泌尿系统患者(年龄2-17岁,11名男性,10名女性,1名西班牙裔,1名非裔美国人,20名高加索人)。与非泌尿科患者相比,DV人群在DVSS中的7/10项得分和总分显著较高,分别为p<0.05和p=0.0004。这表明DVSS结果在DV和非DV患者中产生显著不同的结果。
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引用次数: 0
Utility and yield of genetic testing leading to a definitive neuromuscular or neuropathic diagnosis at a rural outpatient neurology clinic affiliated with a university health center in West Virginia over 4 years. 在西弗吉尼亚州一所大学健康中心附属的农村门诊神经病学诊所,4年来基因检测的效用和产量导致了明确的神经肌肉或神经病变诊断。
Pub Date : 2021-10-28 DOI: 10.33470/2379-9536.1345
Holly Farkosh, Dominika Lozowska
Background: Clinicians are increasingly relying on genetic testing to pinpoint definite diagnoses. A more general diagnosis of neuropathy or neuromuscular disease like myopathy can be narrowed down substantially using genetic testing. Because carrier status is of utmost importance in reproductive matters, pathogenic results can prognosticate the future course of the illness and help plan ahead for treatment and social supports. Given the expense of genetic testing, it is important to assess the cost-benefit ratio to determine whether it is worthwhile to collect genetic samples. The purpose of the study was to determine the likelihood of obtaining a conclusive confirmatory diagnosis through genetic testing (measured as the percent of positive results obtained out of all the submitted samples). Methods: A single clinician’s record of genetic test outcomes was reviewed spanning four years from July 2015 to June 2019 to identify those who had submitted genetic samples to Invitae, a commercial lab in California that offers affordable genetic testing. All patients were evaluated for complaints of neuromuscular and neuropathic nature using the standard of care workup that included a physical exam, lab tests, nerve conduction study (NCS), electromyography (EMG), and/or muscle biopsy before sending out for genetic testing. The positive, negative, and indeterminate genetic diagnoses were tabulated, and the individual disease entities’ prevalence was determined. results: Of the patients who participated in genetic testing, 96 were diagnosed with neuropathic conditions and 59 with neuromuscular conditions. The patients’ health records did not have to be mined for results because the clinician’s Invitae account contained de-identified requisition numbers linked to their results. The patients in the neuromuscular group had twice as many positive results as those in the neuropathic group. There were about three times as many normal results in the neuropathic group compared to the neuromuscular group. Around half of all test samples showed indeterminate results containing variants of unknown significance (VOUS), which were not indicative of any pathology and were considered inconclusive. conclusion: Based on the study findings, there were 17.7% and 35.6% positive (meaning pathogenic) results, respectively, among neuropathic and neuromuscular cases sent off for genetic analysis. While 38 out of 155 total cases makes up a small, 24.5% yield of abnormal results, genetic studies are still a worthwhile addition to investigating neuropathic and neuromuscular cases.
背景:临床医生越来越依赖基因检测来确定诊断。神经病变或神经肌肉疾病(如肌病)的更通用诊断可以通过基因检测大幅缩小范围。由于携带者状态在生殖问题上至关重要,致病结果可以预测疾病的未来进程,并有助于提前计划治疗和社会支持。考虑到基因检测的费用,评估成本效益比以确定是否值得收集基因样本是很重要的。该研究的目的是确定通过基因检测(以在所有提交的样本中获得阳性结果的百分比衡量)获得结论性确诊的可能性。方法:从2015年7月到2019年6月,对一名临床医生的基因检测结果记录进行了为期四年的审查,以确定那些向Invitae提交基因样本的人。Invitae是一家位于加利福尼亚州的商业实验室,提供负担得起的基因检测。使用标准护理检查评估所有患者的神经肌肉和神经病理性投诉,包括体检、实验室测试、神经传导研究(NCS)、肌电图(EMG)和/或肌肉活检,然后再进行基因检测。将阳性、阴性和不确定的基因诊断制成表格,并确定单个疾病实体的患病率。结果:在参与基因检测的患者中,96人被诊断为神经性疾病,59人被诊断患有神经肌肉疾病。患者的健康记录不必进行结果挖掘,因为临床医生的Invitae账户包含与他们的结果相关的未识别请购单编号。神经肌肉组患者的阳性结果是神经性组患者的两倍。与神经肌肉组相比,神经病理性组的正常结果大约是神经肌肉组的三倍。大约一半的测试样本显示出不确定的结果,其中包含未知意义的变体(VOUS),这些变体不表明任何病理学,被认为是不确定的。结论:根据研究结果,在被送往基因分析的神经性和神经肌肉性病例中,阳性(即致病性)结果分别为17.7%和35.6%。虽然155例病例中有38例占异常结果的24.5%,但遗传学研究仍然是研究神经病理性和神经肌肉病例的一个有价值的补充。
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引用次数: 0
How One NYC Hospital Handled the Covid-19 Pandemic- The Chief Residents’ Perspective 纽约一家医院如何应对新冠肺炎大流行-首席居民的观点
Pub Date : 2021-10-28 DOI: 10.33470/2379-9536.1353
S. Arora, Krystyna Bronchard, M. Murphy, Stephen J. Peterson
In March of 2020, life as we knew it changed in a series of seemingly insurmountable challenges. The inpatient medicine ward of New York-Presbyterian Brooklyn Methodist Hospital (NYPBMH), a large Weill Cornell Medicine university hospital located in Park Slope, New York, is a high volume and high acuity institution. On March 5th, 2020, the hospital confirmed its first case of Covid-19 pneumonia. From that day on, the number of Covid-19 hospitalizations grew exponentially, and by mid-April, the hospital peaked at 403 admitted positive patients with nearly 110 on mechanical ventilation. We completed 356 COVID swabs in March with 207 positive results, a 58% positivity rate. In April, we completed 468 swabs with 232 positive results, a 49% positivity rate. This number fell to 10% in May as individuals isolated.
2020年3月,我们所知道的生活在一系列看似无法克服的挑战中发生了变化。纽约长老会布鲁克林卫理公会医院(NYPBMH)的住院病房是位于纽约公园坡的大型威尔康奈尔医学院医院,是一个高容量和高敏锐度的机构。2020年3月5日,该院确诊首例新冠肺炎病例。从那天起,新冠肺炎住院人数呈指数级增长,到4月中旬,医院收治的阳性患者达到403人,其中近110人使用机械通气。3月份完成356例COVID拭子检测,阳性结果207例,阳性率58%。4月,我们完成了468次拭子取样,其中232次为阳性,阳性率为49%。随着个体被隔离,这一数字在5月份降至10%。
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引用次数: 0
Alpha-Gal Allergy: a new threat to Appalachia α - gal过敏:阿巴拉契亚的新威胁
Pub Date : 2021-10-28 DOI: 10.33470/2379-9536.1348
A. Franks, Makala Murphy, Madison Griffis, Rebekah Franks, Colin M. Franks, G. Petty
Alpha-gal allergy, or mammalian meat allergy, is described as the development of IgE antibodies to the oligosaccharide galactose-a-1,3-galactose following a bite from the tick species Amblyomma americanum (Lone Star tick) or Dermacentor variabilis (Wood tick). Dermatologic or gastrointestinal symptoms are usually delayed by four to six hours after exposure, making the diagnosis difficult. Due to the use of mammalian proteins in many common medications, surgical equipment, and prosthesis, unexpected reactions can occur. In the United States, this pathology is predominately seen in the southeast but has been associated with other tick species on every continent except Antarctica. As the habitat for Amblyomma and Dermacentor continues to move further north due to changing patterns in deer population and weather, the incidence of alpha-gal syndrome has increased in the states outside its normal southeastern locale, especially in people with occupations and hobbies that require time outdoors in wooded areas.
α-半乳糖过敏,或称哺乳动物肉类过敏,是指在被蜱类美洲安氏蜱(Lone Star tick)或可变皮蜱(Dermacentor variabilis)叮咬后,产生针对低聚糖半乳糖-1,3-半乳糖的IgE抗体。皮肤病或胃肠道症状通常在暴露后延迟四至六小时,使诊断变得困难。由于哺乳动物蛋白质在许多常见的药物、手术设备和假体中的使用,可能会发生意想不到的反应。在美国,这种疾病主要发生在东南部,但除南极洲外,其他大陆的蜱虫物种都与这种疾病有关。由于鹿的种群和天气模式的变化,Amblyomma和Dermacentor的栖息地继续向北移动,在东南部正常地区以外的州,阿尔法-加尔综合征的发病率有所增加,尤其是那些有职业和爱好的人,需要在林区户外活动。
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引用次数: 0
COVID-19 Disease and Viral Characteristics in a Long-Term Care Facility 长期护理机构中的新冠肺炎疾病和病毒特征
Pub Date : 2021-10-28 DOI: 10.33470/2379-9536.1341
Shauna Assadzandi, E. Crocetti, Courtney S. Pilkerton, A. Ashcraft, C. Shrader
B ackground : Due to the combination of age, comorbidities, and close living quarters, residents at long-term care facilities (LTCFs) are at particularly high risk of severe symptoms and death due to COVID-19. M ethods : This cross-sectional study examines the relationship between demographic characteristics, symptom severity, and length of viral shedding in 49 residents testing positive for SARS-CoV-2 at a LTCF in West Virginia (WV). r esults : Over half of the residents were asymptomatic, while nearly a quarter experienced severe symptoms. Women were more likely to be asymptomatic, and age was not associated with symptom severity. While no specific medical condition was associated with symptom severity, having more chronic illnesses was associated. The length of time from initially positive to PCR negative ranged from 2 to 63 days, with an average of 29 days. c onclusion : Given the variability in PCR testing reliability, 30 days of isolation and two consecutive negative PCR tests are recommended before reintegrating residents.
B背景:由于年龄、合并症和封闭的居住环境等因素,长期护理机构(ltcf)的居民因COVID-19出现严重症状和死亡的风险特别高。方法:本横断面研究探讨了西弗吉尼亚州(WV) LTCF中49名SARS-CoV-2检测阳性居民的人口统计学特征、症状严重程度和病毒脱落长度之间的关系。结果:超过一半的居民无症状,而近四分之一的居民出现严重症状。女性更有可能无症状,年龄与症状严重程度无关。虽然没有特定的医疗条件与症状的严重程度有关,但患有更多的慢性疾病是相关的。从最初阳性到PCR阴性的时间长度为2 ~ 63天,平均为29天。c结论:考虑到PCR检测可靠性的差异,建议在居民重新融入前进行30天的隔离和连续两次PCR阴性检测。
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引用次数: 0
Hospitalists Stare down the COVID-19 Pandemic 医护人员警惕新冠肺炎疫情
Pub Date : 2021-07-30 DOI: 10.33470/2379-9536.1349
Sutoidem Akpanudo
Hospital medicine is the country’s fastest growing medical specialty. The role of hospitalists has evolved greatly in the past few decades. Hospitalists have become the quarterbacks in the effort to fight against the COVID-19 pandemic. The pandemic has brought about a transformational change to the practice of Hospital Medicine.
医院医学是该国发展最快的医学专业。在过去的几十年里,住院医生的角色发生了很大的变化。在抗击新冠肺炎疫情的努力中,住院医生已成为四分卫。新冠疫情给医院医学带来了变革。
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引用次数: 1
Recurrent Spontaneous Pneumothorax During Pregnancy; A Case Report 妊娠期复发性自发性胸腔积液;案例报告
Pub Date : 2021-04-30 DOI: 10.33470/2379-9536.1312
Andrew J. Weaver, Wai-kin Hau, M. Cooper
Spontaneous pneumothorax is a rare but potentially life-threatening condition during pregnancy. We discuss a case of recurrent spontaneous pneumothorax during a single pregnancy. The pneumothorax occurred twice during the pregnancy in the second and third trimesters. Both pneumothoraxes were managed conservatively as due to the low prevalence of this condition, management guidelines are few. We report our management of recurrent spontaneous pneumothorax during pregnancy to support the literature and current guidelines.
自发性肺气肿是一种罕见但可能危及生命的妊娠期疾病。我们讨论了一例在单次妊娠期间复发的自发性肺气肿。在妊娠中期和晚期,发生了两次肺气肿。由于这种情况的发生率较低,因此对两种胸肺切除术都进行了保守治疗,管理指南很少。我们报告了我们对妊娠期复发性自发性肺气肿的处理,以支持文献和当前指南。
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引用次数: 0
Mr. Watson, come here-I want to see you: One rural residency program’s rapid pivot to telemedicine during the pandemic 沃森先生,过来,我要见你:一个农村住院医师项目在疫情期间迅速转向远程医疗
Pub Date : 2021-04-30 DOI: 10.33470/2379-9536.1314
W. Crump, Diana M Nims, D. Hatler
Telemedicine has been used for over a generation, but application has been limited in rural areas due to lack of payment, licensure issues, cumbersome video equipment, and challenges with digital communications. Early in the COVID-19 pandemic, our rural family medicine residency made a rapid shift to all telemedicine services for our patients. We collected data over a four-week period in April 2020 as we transitioned to 100% telemedicine consultations. We compare that to a four-week period prior to mid-March when COVID-related shutdowns began. We collected detailed visit summaries, patient feedback, and physician feedback to compare these two periods. Early in the pandemic, telemedicine visits increased for those with chronic respiratory and cardiovascular issues, anxiety, and depression. Patient and physician feedback was positive, and time required averaged 12 to 18 minutes. The cost savings from the 15% of telemedicine patients who would have otherwise sought urgent or emergency care is significant, and almost 45% would have still made an appointment later, further risking exposure and increasing outpatient volume. In this sense, telemedicine could be considered to have “flattened the curve” for potentially overwhelmed outpatient facilities just as mitigation interventions were implemented to do the same for acute inpatient beds. We share our experience for consideration by those who will implement a similar transition and those who choose to advocate for continuing payment and platform flexibility. We also hope that residency training requirements can adapt to consider a telemedicine visit comparable to one completed in-person.
远程医疗已经使用了一代多人,但由于缺乏支付、许可证问题、笨重的视频设备以及数字通信的挑战,远程医疗在农村地区的应用受到限制。在新冠肺炎大流行初期,我们的农村家庭医学住院医生迅速转向为患者提供所有远程医疗服务。2020年4月,当我们过渡到100%远程医疗咨询时,我们收集了四周的数据。我们将其与3月中旬新冠肺炎相关停工开始前的四周时间进行了比较。我们收集了详细的就诊总结、患者反馈和医生反馈,以比较这两个时期。在疫情早期,那些患有慢性呼吸和心血管问题、焦虑和抑郁的人的远程医疗就诊次数增加了。患者和医生的反馈是积极的,所需时间平均为12-18分钟。15%的远程医疗患者原本会寻求紧急或紧急护理,这节省了大量成本,近45%的患者稍后仍会预约,这进一步增加了暴露风险并增加了门诊量。从这个意义上说,远程医疗可以被认为已经为可能不堪重负的门诊设施“拉平了曲线”,就像对急性住院病床实施缓解干预一样。我们分享我们的经验,供那些将实施类似过渡的人和那些选择倡导持续支付和平台灵活性的人考虑。我们还希望住院医师培训要求能够进行调整,以考虑与亲自完成的远程医疗访问类似的远程医疗。
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引用次数: 0
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Marshall journal of medicine
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