Mohamed Hammad, Nader Alwifati, Mohamed Ajala, Nour keshlaf, Dalia M.Khair, Marwan Alsari, Yousef M. Hasen, Ali Tumi, Mohamed Sultan
B ackground : While rapid on-site evaluation (ROSE) is considered to be an additional tool to optimize the yield of tissue acquisition during EUS-guided FNA of the gastrointestinal tract,1,2 it is not readily available at all times while performing these procedures. M ethods : We reviewed twenty-seven EUS-guided FNA procedures done at our institution in Tripoli central hospital with general working center restrictions due to local COVID-19 prevention protocols. This is a small-size retrospective chart review study to illustrate the optimal tissue adequacy during EUS-guided FNA of the upper gastrointestinal tract in a suboptimal hospital setting, lack of ROSE and merely utilizing visual inspection of those specimens by the performing physician and its effects on the diagnosis. r esults : Approximately 92.6 % of tissue adequacy was achieved despite the lack of ROSE which is comparable to ROSE-based tissue acquisition results. c onclusion : We concluded that our results of tissue acquisition and analysis with the standard (off-site) histopathology techniques are comparable to those in more developed centers where ROSE is readily available.
{"title":"Can the conventional cytology technique be sufficient in a center lacking ROSE?: Retrospective study during the COVID-19 pandemic","authors":"Mohamed Hammad, Nader Alwifati, Mohamed Ajala, Nour keshlaf, Dalia M.Khair, Marwan Alsari, Yousef M. Hasen, Ali Tumi, Mohamed Sultan","doi":"10.33470/2379-9536.1315","DOIUrl":"https://doi.org/10.33470/2379-9536.1315","url":null,"abstract":"B ackground : While rapid on-site evaluation (ROSE) is considered to be an additional tool to optimize the yield of tissue acquisition during EUS-guided FNA of the gastrointestinal tract,1,2 it is not readily available at all times while performing these procedures. M ethods : We reviewed twenty-seven EUS-guided FNA procedures done at our institution in Tripoli central hospital with general working center restrictions due to local COVID-19 prevention protocols. This is a small-size retrospective chart review study to illustrate the optimal tissue adequacy during EUS-guided FNA of the upper gastrointestinal tract in a suboptimal hospital setting, lack of ROSE and merely utilizing visual inspection of those specimens by the performing physician and its effects on the diagnosis. r esults : Approximately 92.6 % of tissue adequacy was achieved despite the lack of ROSE which is comparable to ROSE-based tissue acquisition results. c onclusion : We concluded that our results of tissue acquisition and analysis with the standard (off-site) histopathology techniques are comparable to those in more developed centers where ROSE is readily available.","PeriodicalId":93035,"journal":{"name":"Marshall journal of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49560196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"It Takes a Village: A Collaborative Approach to the COVID-19 Pandemic","authors":"D. Shah","doi":"10.33470/2379-9536.1337","DOIUrl":"https://doi.org/10.33470/2379-9536.1337","url":null,"abstract":"","PeriodicalId":93035,"journal":{"name":"Marshall journal of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43727619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Plavsic, V. Paton, Christiane R Herber-Valdez, Consuelo Rosales, Martín D. García, Z. Mulla
BACKGROUND The object of this study was to quantify the association between graduation from our annual comprehensive institutional faculty development course (IFDC) and being promoted from assisstant professor to associate professor at our health sciences center.
{"title":"Impact of a Faculty Development Course on Promotion at a Health Sciences Center","authors":"S. Plavsic, V. Paton, Christiane R Herber-Valdez, Consuelo Rosales, Martín D. García, Z. Mulla","doi":"10.33470/2379-9536.1327","DOIUrl":"https://doi.org/10.33470/2379-9536.1327","url":null,"abstract":"BACKGROUND The object of this study was to quantify the association between graduation from our annual comprehensive institutional faculty development course (IFDC) and being promoted from assisstant professor to associate professor at our health sciences center.","PeriodicalId":93035,"journal":{"name":"Marshall journal of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49265501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The development of an aorta-atrial fistula secondary to mechanical aortic valve infective endocarditis is a rare, serious complication. The fistula is an aberrant intra-cardiac shunt that occurs between the aorta and either the left or right atrium. An aorta-atrial fistula can be congenital or acquired. In the case of infective endocarditis, the infection’s expansion beyond the valvular structure may result in an aorto-cavitary fistula (ACF or AAF) with an estimated incidence of 1-2%. No clinical trials have been conducted for the best approach of management for this condition. Therefore, treatment strategies are applied on a case-by-case basis by expert opinion. Patients develop symptoms of heart failure secondary to AAF complications. The underlying cause of AAF needs to be identified with the use of imaging studies to determine the approach of optimal treatment. We are reporting a case of a 32-year-old male with a history of repaired congenital heart disease, who developed mechanical aortic valve infective endocarditis from intravenous drug use with subsequent development of an aorta-atrial fistula.
{"title":"Acquired Aorto-Atrial Fistula from Intravenous Drug Use with Underlying Congenital Heart Disease.","authors":"M. Tashani, L. Given, E. Karem, Mahmoud Abualayem","doi":"10.33470/2379-9536.1304","DOIUrl":"https://doi.org/10.33470/2379-9536.1304","url":null,"abstract":"The development of an aorta-atrial fistula secondary to mechanical aortic valve infective endocarditis is a rare, serious complication. The fistula is an aberrant intra-cardiac shunt that occurs between the aorta and either the left or right atrium. An aorta-atrial fistula can be congenital or acquired. In the case of infective endocarditis, the infection’s expansion beyond the valvular structure may result in an aorto-cavitary fistula (ACF or AAF) with an estimated incidence of 1-2%. No clinical trials have been conducted for the best approach of management for this condition. Therefore, treatment strategies are applied on a case-by-case basis by expert opinion. Patients develop symptoms of heart failure secondary to AAF complications. The underlying cause of AAF needs to be identified with the use of imaging studies to determine the approach of optimal treatment. We are reporting a case of a 32-year-old male with a history of repaired congenital heart disease, who developed mechanical aortic valve infective endocarditis from intravenous drug use with subsequent development of an aorta-atrial fistula.","PeriodicalId":93035,"journal":{"name":"Marshall journal of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45611215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer M. Hawkins, R. Russell, Logan Lawrence, A. Valluri, Jessica C. Wellman, K. Denning
Translational cancer research relies on the availability of human patient tissue demonstrating the specific disease process under investigation. Biobanks of human tissue have historically been and remain to date the primary access point for cancer research samples. Biorepositories routinely supply researchers with varying sample types for use in biomedical studies, most commonly formalin-fixed and paraffin-embedded (FFPE) tissue or fresh snap-frozen tissue. In conjunction with preserved tissue samples, viable tumor cell lines derived from patient tissue have emerged to be a new gold standard in cancer research, particularly in drug discovery and functional prognostic assays. Tissue banks providing these samples are being termed “nextgeneration” and are adapting to directly assist researchers by performing high throughout technical studies, such as routine histology and immunostaining of donor tissue. These highquality, next-generation biorepositories are a relatively scarce resource in the broader research community in the United States and have traditionally been associated with large centralized and very well-established university medical centers. This article describes the next-generation resources now available at the Edwards Comprehensive Cancer Center with its association with the Marshall University Joan C. Edwards School of Medicine in Huntington, West Virginia. This manuscript details the procedures, protocols, and success rates of the Tissue Procurement Program (TPP) to generate a growing cohort of viable primary human tumor cell lines representing varying malignancies to be used in conjunction with matched formalin-fixed and paraffin-embedded (FFPE) and snap-frozen tissue samples for comprehensive translational research.
{"title":"Non-selective Primary Human Tumor Cell Line Generation from Surgical Resections to be Paired With Flash Frozen and Paraffin Embedded Tissue: Advancements in Democratizing Translational Research Materials to Rural Institutions","authors":"Jennifer M. Hawkins, R. Russell, Logan Lawrence, A. Valluri, Jessica C. Wellman, K. Denning","doi":"10.33470/2379-9536.1325","DOIUrl":"https://doi.org/10.33470/2379-9536.1325","url":null,"abstract":"Translational cancer research relies on the availability of human patient tissue demonstrating the specific disease process under investigation. Biobanks of human tissue have historically been and remain to date the primary access point for cancer research samples. Biorepositories routinely supply researchers with varying sample types for use in biomedical studies, most commonly formalin-fixed and paraffin-embedded (FFPE) tissue or fresh snap-frozen tissue. In conjunction with preserved tissue samples, viable tumor cell lines derived from patient tissue have emerged to be a new gold standard in cancer research, particularly in drug discovery and functional prognostic assays. Tissue banks providing these samples are being termed “nextgeneration” and are adapting to directly assist researchers by performing high throughout technical studies, such as routine histology and immunostaining of donor tissue. These highquality, next-generation biorepositories are a relatively scarce resource in the broader research community in the United States and have traditionally been associated with large centralized and very well-established university medical centers. This article describes the next-generation resources now available at the Edwards Comprehensive Cancer Center with its association with the Marshall University Joan C. Edwards School of Medicine in Huntington, West Virginia. This manuscript details the procedures, protocols, and success rates of the Tissue Procurement Program (TPP) to generate a growing cohort of viable primary human tumor cell lines representing varying malignancies to be used in conjunction with matched formalin-fixed and paraffin-embedded (FFPE) and snap-frozen tissue samples for comprehensive translational research.","PeriodicalId":93035,"journal":{"name":"Marshall journal of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42421833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyle B Smith, C. Kiefer, E. Shaver, K. Quedado, T. Marshall, Jerome Kerwin, Christopher S Goode
Resident physicians and advanced practice providers (APPs) both have roles in providing care within emergency departments (ED). While both bring unique skill sets and capabilities to the health care team, little is known about the comparative financial impact of APPs and residents in a community ED. The objective of this study was to compare direct staffing costs per relative value unit (RVU) generated of emergency medicine (EM) residents and APPs in a community ED setting.
{"title":"Comparison of Direct Staffing Costs of Advanced Practice Providers and Residents in a High Acuity Area of a Community Emergency Department","authors":"Kyle B Smith, C. Kiefer, E. Shaver, K. Quedado, T. Marshall, Jerome Kerwin, Christopher S Goode","doi":"10.33470/2379-9536.1318","DOIUrl":"https://doi.org/10.33470/2379-9536.1318","url":null,"abstract":"Resident physicians and advanced practice providers (APPs) both have roles in providing care within emergency departments (ED). While both bring unique skill sets and capabilities to the health care team, little is known about the comparative financial impact of APPs and residents in a community ED. The objective of this study was to compare direct staffing costs per relative value unit (RVU) generated of emergency medicine (EM) residents and APPs in a community ED setting.","PeriodicalId":93035,"journal":{"name":"Marshall journal of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48906150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Like all viruses, the SARS-CoV-2 virus mutates over time, creating new viral variants that have the potential to transmit more rapidly, cause more severe disease, or avoid treatment and prevention strategies. A critical component of the public health response to COVID-19 is identifying and tracking the emergenc of SARS-CoV-2 variants. In West Virginia, this effort is coordinated via a public-private-academic collaboration.
{"title":"Leveraging a Public-Private-Academic Collaborative Partnership to confront challenges in the COVID-19 pandemic.","authors":"J. Denvir","doi":"10.33470/2379-9536.1335","DOIUrl":"https://doi.org/10.33470/2379-9536.1335","url":null,"abstract":"Like all viruses, the SARS-CoV-2 virus mutates over time, creating new viral variants that have the potential to transmit more rapidly, cause more severe disease, or avoid treatment and prevention strategies. A critical component of the public health response to COVID-19 is identifying and tracking the emergenc of SARS-CoV-2 variants. In West Virginia, this effort is coordinated via a public-private-academic collaboration.","PeriodicalId":93035,"journal":{"name":"Marshall journal of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45018525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A retrospective review of salient features of the early-to-mid phases of the COVID-19 pandemic is provided from the perspective of the clinical laboratory. Lessons learned and possible improvements are opined. These include the importance of maintaining a robust laboratory infrastructure, increased public health funding, the partnership between public health and hospital/commercial laboratories, and the critical importance of sound, scientific assessment, even during a pandemic crisis.
{"title":"Confronting the COVID-19 Pandemic: A View from the Laboratory","authors":"G. Procop","doi":"10.33470/2379-9536.1322","DOIUrl":"https://doi.org/10.33470/2379-9536.1322","url":null,"abstract":"A retrospective review of salient features of the early-to-mid phases of the COVID-19 pandemic is provided from the perspective of the clinical laboratory. Lessons learned and possible improvements are opined. These include the importance of maintaining a robust laboratory infrastructure, increased public health funding, the partnership between public health and hospital/commercial laboratories, and the critical importance of sound, scientific assessment, even during a pandemic crisis.","PeriodicalId":93035,"journal":{"name":"Marshall journal of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43692692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coronaviruses have caused at least three large scale epidemics/pandemics in humans over the past twenty years – severe acute respiratory syndrome (SARS) in 2003; the Middle East respiratory syndrome (MERS) in 2012; novel coronavirus disease (COVID-19) in 2019 – taking many lives all over the world. World Health Organization (WHO) named the new virus responsible for COVID-19 as SARS-CoV-2.
{"title":"Blocking serine protease (TMPRSS2) by Bromhexine; looking at potential treatment to prevent COVID-19 infection","authors":"R. Tolouian, Audrey Tolouian, M. Ardalan","doi":"10.33470/2379-9536.1286","DOIUrl":"https://doi.org/10.33470/2379-9536.1286","url":null,"abstract":"Coronaviruses have caused at least three large scale epidemics/pandemics in humans over the past twenty years – severe acute respiratory syndrome (SARS) in 2003; the Middle East respiratory syndrome (MERS) in 2012; novel coronavirus disease (COVID-19) in 2019 – taking many lives all over the world. World Health Organization (WHO) named the new virus responsible for COVID-19 as SARS-CoV-2.","PeriodicalId":93035,"journal":{"name":"Marshall journal of medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43162091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The novel coronavirus (COVID-19) pandemic is placing unique demands on America’s entire health care system. It is causing a humanitarian crisis of global proportions, with hundreds of thousands of lives disrupted. Alongside these gloomy sentiments, however, images of solidarity have emerged.
{"title":"The COVID-19 crisis: How rural Appalachia is handling the pandemic?","authors":"Shah, T. Darshana","doi":"10.33470/2379-9536.1287","DOIUrl":"https://doi.org/10.33470/2379-9536.1287","url":null,"abstract":"The novel coronavirus (COVID-19) pandemic is placing unique demands on America’s entire health care system. It is causing a humanitarian crisis of global proportions, with hundreds of thousands of lives disrupted. Alongside these gloomy sentiments, however, images of solidarity have emerged.","PeriodicalId":93035,"journal":{"name":"Marshall journal of medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69500717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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