Pub Date : 2021-08-16DOI: 10.31031/nacs.2021.06.000633
S. Sakhri
{"title":"Ovarian Cystadenocarcinoma with an Osteosarcoma Component","authors":"S. Sakhri","doi":"10.31031/nacs.2021.06.000633","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000633","url":null,"abstract":"","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44273304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-26DOI: 10.31031/nacs.2021.06.000632
Kameswari P
mucin accumulating in the duct, lobular acini or cavities associated with the lesion. These calcifications can appear in low to intermediate grade DCIS or benign conditions such as sclerosing adenosis and ductal hyperplasia. They take a round or hazy/amorphous shape with size of the calcification depending on the size of the duct. Calcifications within the ducts and lobules can also be formed by the calcium deposition within cell debris and Abstract Breast calcifications are the most common finding on mammograms and can show significant morphological variability. With the help of the BIRADS (Breast Imaging Reporting and Data System) lexicon they can be divided into benign and malignant types but there remains overlap between these two categories. Micro calcifications which fall in the ‘suspicious’ category can occur without the presence of an associated mass or architectural distortion. Micro- calcifications are also one of the first features to be seen on mammograms in DCIS (Ductal Carcinoma In Situ ), leading to early diagnosis and prompt treatment. With the advent of newer technologies in imaging, more information regarding the radiological extent of disease and cancer type associated with the calcification can be determined. This review aims to cover the BIRADS fifth edition descriptors and lexicons of breast calcifications on mammography. Calcifications are a common entity on mammograms, with most being benign. With the evolution in mammogram technology and screening programmes, microcalcifications have become easier to detect with reporting of DCIS increasing, thereby reducing patient mortality. With this review paper, we aim to review the imaging descriptors of benign and malignant calcifications seen on mammograms with a pictorial representation and brief literature review.
{"title":"Review Article: Breast Calcifications on Mammography","authors":"Kameswari P","doi":"10.31031/nacs.2021.06.000632","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000632","url":null,"abstract":"mucin accumulating in the duct, lobular acini or cavities associated with the lesion. These calcifications can appear in low to intermediate grade DCIS or benign conditions such as sclerosing adenosis and ductal hyperplasia. They take a round or hazy/amorphous shape with size of the calcification depending on the size of the duct. Calcifications within the ducts and lobules can also be formed by the calcium deposition within cell debris and Abstract Breast calcifications are the most common finding on mammograms and can show significant morphological variability. With the help of the BIRADS (Breast Imaging Reporting and Data System) lexicon they can be divided into benign and malignant types but there remains overlap between these two categories. Micro calcifications which fall in the ‘suspicious’ category can occur without the presence of an associated mass or architectural distortion. Micro- calcifications are also one of the first features to be seen on mammograms in DCIS (Ductal Carcinoma In Situ ), leading to early diagnosis and prompt treatment. With the advent of newer technologies in imaging, more information regarding the radiological extent of disease and cancer type associated with the calcification can be determined. This review aims to cover the BIRADS fifth edition descriptors and lexicons of breast calcifications on mammography. Calcifications are a common entity on mammograms, with most being benign. With the evolution in mammogram technology and screening programmes, microcalcifications have become easier to detect with reporting of DCIS increasing, thereby reducing patient mortality. With this review paper, we aim to review the imaging descriptors of benign and malignant calcifications seen on mammograms with a pictorial representation and brief literature review.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43527524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-09DOI: 10.31031/nacs.2021.06.000631
Daniel Borsch
A of the Potential Effects of Adiponectin in Major Abstract Adiponectin is a hormone-like cytokine (or adipokine) predominantly secreted from fat cells. Adiponectin has anti-inflammatory properties and inversely correlates with body fat mass, including visceral adiposity. This cytokine is present in different isoforms and may mediate its biological functions mainly through AdipoR1 and AdipoR2 receptors. It is thought that adiponectin has been associated with the pathological processes of diabetes, heart disease, and cancer. In our review of PubMed literature, we found interesting data regarding the effect of adiponectin levels on many types of cancer. Several studies have observed a protective role of adiponectin in some types of cancer. In endometrial, colon, kidney, postmenopausal breast cancer, and leukemia, there appears to be an inverse relationship between adiponectin levels and cancer. Understanding adiponectin’s biological connection with other hormones (e.g., insulin, insulin-like growth factors, leptin), as well as its modulation in pre-neoplastic states and malignancy to exploit its beneficial effects, could reveal potential new strategies for the management of certain types of cancer.
{"title":"A Review of the Potential Preventive Effects of Adiponectin in Major Cancers","authors":"Daniel Borsch","doi":"10.31031/nacs.2021.06.000631","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000631","url":null,"abstract":"A of the Potential Effects of Adiponectin in Major Abstract Adiponectin is a hormone-like cytokine (or adipokine) predominantly secreted from fat cells. Adiponectin has anti-inflammatory properties and inversely correlates with body fat mass, including visceral adiposity. This cytokine is present in different isoforms and may mediate its biological functions mainly through AdipoR1 and AdipoR2 receptors. It is thought that adiponectin has been associated with the pathological processes of diabetes, heart disease, and cancer. In our review of PubMed literature, we found interesting data regarding the effect of adiponectin levels on many types of cancer. Several studies have observed a protective role of adiponectin in some types of cancer. In endometrial, colon, kidney, postmenopausal breast cancer, and leukemia, there appears to be an inverse relationship between adiponectin levels and cancer. Understanding adiponectin’s biological connection with other hormones (e.g., insulin, insulin-like growth factors, leptin), as well as its modulation in pre-neoplastic states and malignancy to exploit its beneficial effects, could reveal potential new strategies for the management of certain types of cancer.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":"32 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41303253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-07DOI: 10.31031/nacs.2021.06.000630
Kessel Boris
The future belongs to technologies. It is certainly true in medicine, but particularly in clinical oncology. Immense improvements and advancements in many fields of medicine have already resulted in overall prolongation of life and improvement in its quality. However, there are still many aggressive, rapidly progressing malignant diseases that are associated with a short median survival time, despite all advances and development of high-resolution technologies, new drugs, and various treatment policies. In this work, we want to present, describe, and discuss the most promising, molecular advances in cancer research in our opinion that we believe would soon change the face of modern oncology.
{"title":"Tumor-Agnostic Indications: Which Direction are We Going?","authors":"Kessel Boris","doi":"10.31031/nacs.2021.06.000630","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000630","url":null,"abstract":"The future belongs to technologies. It is certainly true in medicine, but particularly in clinical oncology. Immense improvements and advancements in many fields of medicine have already resulted in overall prolongation of life and improvement in its quality. However, there are still many aggressive, rapidly progressing malignant diseases that are associated with a short median survival time, despite all advances and development of high-resolution technologies, new drugs, and various treatment policies. In this work, we want to present, describe, and discuss the most promising, molecular advances in cancer research in our opinion that we believe would soon change the face of modern oncology.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46353998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-06DOI: 10.31031/nacs.2021.06.000629
Alcántara-Quintana Luz Eugenia
Introduction: Cervical cancer is the fourth leading cause of death in the world. This poor prognosis is due to the fact that in two out of three cases the disease is diagnosed in advanced stages. Consequently, advances in detection methods can lead to early diagnosis of the disease and consequently to an improved prognosis. Methods based on serum-based tumor markers are a promising tool for early diagnosis and in general for biochemical screening of cancer patients. They also offer the added value of being non-invasive methods. Evidence has been found for the release of cellular DNA into the blood, so its quantification has the potential to serve as a tumor marker. If this DNA is detected in serum, it can reflect tumor size, viral load and response to treatment. Objective: To determine the amount of circulating DNA in serum of patients with precancerous lesions. Methods: The study was carried out with 40 healthy women and 120 women with precancerous lesions, who attended gynecological-obstetric care. Of the 120, 60 had low-grade lesions and 60 had high-grade lesions. All participants had a blood sample taken for determination of circulating DNA in serum. Specific oligonucleotides were used to determine not only the amount of circulating DNA in the patient, but also the amount of viral DNA. Papillomavirus detection/genotyping was performed by qPCR. One third of the patients showed at least one high-risk genotype. Conclusion: In this study, differential quantification of both patient and viral circulating DNA was observed.
{"title":"Circulating DNA in Serum as a Tumor Marker in Precancerous Lesions of the Cervix in Mexican Women","authors":"Alcántara-Quintana Luz Eugenia","doi":"10.31031/nacs.2021.06.000629","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000629","url":null,"abstract":"Introduction: Cervical cancer is the fourth leading cause of death in the world. This poor prognosis is due to the fact that in two out of three cases the disease is diagnosed in advanced stages. Consequently, advances in detection methods can lead to early diagnosis of the disease and consequently to an improved prognosis. Methods based on serum-based tumor markers are a promising tool for early diagnosis and in general for biochemical screening of cancer patients. They also offer the added value of being non-invasive methods. Evidence has been found for the release of cellular DNA into the blood, so its quantification has the potential to serve as a tumor marker. If this DNA is detected in serum, it can reflect tumor size, viral load and response to treatment. Objective: To determine the amount of circulating DNA in serum of patients with precancerous lesions. Methods: The study was carried out with 40 healthy women and 120 women with precancerous lesions, who attended gynecological-obstetric care. Of the 120, 60 had low-grade lesions and 60 had high-grade lesions. All participants had a blood sample taken for determination of circulating DNA in serum. Specific oligonucleotides were used to determine not only the amount of circulating DNA in the patient, but also the amount of viral DNA. Papillomavirus detection/genotyping was performed by qPCR. One third of the patients showed at least one high-risk genotype. Conclusion: In this study, differential quantification of both patient and viral circulating DNA was observed.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47152769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-29DOI: 10.31031/nacs.2021.06.000628
Wehrmann S
Histiocytic and dendritic cell neoplasms are rare but extremely aggressive tumors that represent less than 1% of all neoplasms arising in lymph nodes or soft tissues. Often the tumor is detected lately, and diagnosis is challenging both for pathologists and for clinicians. Based on the multiplicity of resembling tumors a final diagnosis is often difficult to find. Furthermore, structured therapy algorithms do not exist. Here we show our experience in diagnostics and treatment of these tumors.
{"title":"Multimodal Approach in Histiocytic and Dendritic Cell Neoplasms","authors":"Wehrmann S","doi":"10.31031/nacs.2021.06.000628","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000628","url":null,"abstract":"Histiocytic and dendritic cell neoplasms are rare but extremely aggressive tumors that represent less than 1% of all neoplasms arising in lymph nodes or soft tissues. Often the tumor is detected lately, and diagnosis is challenging both for pathologists and for clinicians. Based on the multiplicity of resembling tumors a final diagnosis is often difficult to find. Furthermore, structured therapy algorithms do not exist. Here we show our experience in diagnostics and treatment of these tumors.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48701200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-24DOI: 10.31031/nacs.2021.06.000627
Murad Abdul Raheem Younis
Women with breast cancer face challenges in different aspects of their lives, as the drastic changes in their psychological needs can be distressful. With the intention of helping these women to cope after the diagnosis, there has been an emphasis in providing psychological support and interventions to enhance Quality of Life (QOL) and survival rate. It is imperative to investigate the psychological and psychosocial factors interrupting the quality of life and wellbeing in female cancer patients with the intention of providing them with proper treatment and therapeutic intervention. Psycho-education is a form of therapeutic intervention for patients and their families. One of the most operative psycho-social approaches to cancer patients is psycho-education Dastan [1], Younis et al. [2]. Psycho-education is important as it is a process that provides education and information to individuals who seek or receive mental health services, such as individuals that are seriously or terminally ill and also their family members. The program normally includes health education, stress management, coping skills, and psychological support.
{"title":"Psycho-Education Intervantion Program Among Women with Breast Cancer","authors":"Murad Abdul Raheem Younis","doi":"10.31031/nacs.2021.06.000627","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000627","url":null,"abstract":"Women with breast cancer face challenges in different aspects of their lives, as the drastic changes in their psychological needs can be distressful. With the intention of helping these women to cope after the diagnosis, there has been an emphasis in providing psychological support and interventions to enhance Quality of Life (QOL) and survival rate. It is imperative to investigate the psychological and psychosocial factors interrupting the quality of life and wellbeing in female cancer patients with the intention of providing them with proper treatment and therapeutic intervention. Psycho-education is a form of therapeutic intervention for patients and their families. One of the most operative psycho-social approaches to cancer patients is psycho-education Dastan [1], Younis et al. [2]. Psycho-education is important as it is a process that provides education and information to individuals who seek or receive mental health services, such as individuals that are seriously or terminally ill and also their family members. The program normally includes health education, stress management, coping skills, and psychological support.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49473474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-18DOI: 10.31031/nacs.2021.06.000626
D. Ali
Radiation therapy for advanced head and neck cancer has developed from the Three-Dimensional Conformal Radiotherapy 3DCRT to intensity modulated radiation therapy IMRT and Volumetric Modulated Arc Therapy VMAT. Remaining Volume at Risk RVR is clinically important in plan evaluating process. RVR is useful for assisting and estimating the risk of late effects. Aim: The aim of the present work is to compare dosimetric evaluation factors and dosimetric data remaining volume at risk for both IMRT and VMAT in the treatment of large volume head and neck cancer patients. methods: Eleven retrospective patients with advanced head and neck tumors were selected for the planning study. The patients’ treatments are planned by using the two different techniques (IMRT and VMAT) and optimized to evaluate highly conformal target coverage and sparing organs at risk OAR. Standard fractionation is 33 fractions with 5 fractions weekly, the prescribed doses 70Gy, 59.4Gy and 54Gy for the high, intermediate, and low risk targets by simultaneous integrated boost. Results: The study showed that VMAT and IMRT are comparable in target volumes homogeneity index HI, while VMAT is more superior (0.76, 44.4and 589) and (0.68, 55.6 and 1989) in conformity number CN, gradient index GI and Monitor Units (MU), respectively. Furthermore, VMAT has an advantage over IMRT in RVR volumes that received 15Gy, 10Gy and 5Gy, which are (4327, 5281 and 6703cc) and a 1019cGy mean dose in the VMAT technique, while in IMRT are (4435, 5311 and 6543cc) and a 1051cGy mean dose. Conclusion: The results of comparing dosimetric evaluation factors of both techniques showed that VMAT had a priority over IMRT in 3 factors of RVR evaluation parameters. Additionally, to other comparison points, especially the time on the machine, makes VMAT a first choice in the treatment plan selection.
{"title":"Comparison Between VMAT and IMRT in Remaining Volume at Risk for Large Volume Head and Neck Cancer Patients","authors":"D. Ali","doi":"10.31031/nacs.2021.06.000626","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000626","url":null,"abstract":"Radiation therapy for advanced head and neck cancer has developed from the Three-Dimensional Conformal Radiotherapy 3DCRT to intensity modulated radiation therapy IMRT and Volumetric Modulated Arc Therapy VMAT. Remaining Volume at Risk RVR is clinically important in plan evaluating process. RVR is useful for assisting and estimating the risk of late effects. Aim: The aim of the present work is to compare dosimetric evaluation factors and dosimetric data remaining volume at risk for both IMRT and VMAT in the treatment of large volume head and neck cancer patients. methods: Eleven retrospective patients with advanced head and neck tumors were selected for the planning study. The patients’ treatments are planned by using the two different techniques (IMRT and VMAT) and optimized to evaluate highly conformal target coverage and sparing organs at risk OAR. Standard fractionation is 33 fractions with 5 fractions weekly, the prescribed doses 70Gy, 59.4Gy and 54Gy for the high, intermediate, and low risk targets by simultaneous integrated boost. Results: The study showed that VMAT and IMRT are comparable in target volumes homogeneity index HI, while VMAT is more superior (0.76, 44.4and 589) and (0.68, 55.6 and 1989) in conformity number CN, gradient index GI and Monitor Units (MU), respectively. Furthermore, VMAT has an advantage over IMRT in RVR volumes that received 15Gy, 10Gy and 5Gy, which are (4327, 5281 and 6703cc) and a 1019cGy mean dose in the VMAT technique, while in IMRT are (4435, 5311 and 6543cc) and a 1051cGy mean dose. Conclusion: The results of comparing dosimetric evaluation factors of both techniques showed that VMAT had a priority over IMRT in 3 factors of RVR evaluation parameters. Additionally, to other comparison points, especially the time on the machine, makes VMAT a first choice in the treatment plan selection.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43129091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-14DOI: 10.31031/nacs.2021.05.000625
V. Niculescu
In the last decade, more and more researchers believe that cancer is caused by a progressive weakening of a multicellular cell, leading to a loss of function and a switch to a unicellular life cycle. Lineweaver et al. [1] consider cancer as “a dysregulation and degeneration of recently evolved genes and the upregulation of complementary ancient genes.” This also applies to DNA repair genes. Multicellular cells have differentially dysfunctional DNA repair systems [2]; second, more evolved repair genes (evolutionary younger genes) become dysfunctional more rapidly than older genes. Also of particular interest is the consideration by Lineweaver et al. [1] that cancer “can only revert to phenotypes compatible with cellular survival in a human” [3]. This fits with the analogy described between the dual cell systems of cancer and intestinal parasitic amoebae [4-9].
{"title":"Is an Ancient Genome Repair Mechanism the Trojan Horse of Cancer?","authors":"V. Niculescu","doi":"10.31031/nacs.2021.05.000625","DOIUrl":"https://doi.org/10.31031/nacs.2021.05.000625","url":null,"abstract":"In the last decade, more and more researchers believe that cancer is caused by a progressive weakening of a multicellular cell, leading to a loss of function and a switch to a unicellular life cycle. Lineweaver et al. [1] consider cancer as “a dysregulation and degeneration of recently evolved genes and the upregulation of complementary ancient genes.” This also applies to DNA repair genes. Multicellular cells have differentially dysfunctional DNA repair systems [2]; second, more evolved repair genes (evolutionary younger genes) become dysfunctional more rapidly than older genes. Also of particular interest is the consideration by Lineweaver et al. [1] that cancer “can only revert to phenotypes compatible with cellular survival in a human” [3]. This fits with the analogy described between the dual cell systems of cancer and intestinal parasitic amoebae [4-9].","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42038159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-25DOI: 10.31031/nacs.2021.05.000624
Jun Shen
Brachyury is essential to maintain notochord cell fate and function [1]. Chordoma is a rare malignant tumor originated from notochordal cell rests. Chordoma patients with higher Brachyury expression showed significantly shorter progression-free survival. Brachyury was suggested as a prognostic biomarker in chordoma. Further Brachyury was found to promote chordoma cell growth via PI3K/Akt signaling [2]. The origin of intervertebral disc cells is always considered to be associated with notochord cells. Brachyury was found to have the capability of reprogramming degenerative human intervertebral disc cells to a healthy phenotype [3]. Our research has also found that Brachyury can protect the intervertebral disc cells from degeneration.
{"title":"Many Roles of Transcriptional Factor Brachyury","authors":"Jun Shen","doi":"10.31031/nacs.2021.05.000624","DOIUrl":"https://doi.org/10.31031/nacs.2021.05.000624","url":null,"abstract":"Brachyury is essential to maintain notochord cell fate and function [1]. Chordoma is a rare malignant tumor originated from notochordal cell rests. Chordoma patients with higher Brachyury expression showed significantly shorter progression-free survival. Brachyury was suggested as a prognostic biomarker in chordoma. Further Brachyury was found to promote chordoma cell growth via PI3K/Akt signaling [2]. The origin of intervertebral disc cells is always considered to be associated with notochord cells. Brachyury was found to have the capability of reprogramming degenerative human intervertebral disc cells to a healthy phenotype [3]. Our research has also found that Brachyury can protect the intervertebral disc cells from degeneration.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41394455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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