Pub Date : 2020-10-09DOI: 10.31031/NACS.2020.05.000611
Raunak Varshney
One of the main reasons for focus on these particular cancer as prostate and breast cancers are the most common types cancer in men and women respectively. However small and non-small cell lung cancer are most frequent in both. The molecular basis for the utility of radiopeptides is due to their peptide receptor over expression by certain tumours [1]. Peptides are more important elements in fundamental biological processes due to their specificity for controlling various biological functions through their specific receptors naturally. The increased attention for peptides or their receptors for imaging cancer is due to their expression/over expression in many primary human cancers and their ability to target specific receptor. The clinical impact of radiolabelled peptides has been observed in theranostics by diagnosis of location of tumours and their metastases by receptor scintigraphy and by facilitating receptor radiotherapy of tumours for treatment. However, the research on peptide based radioligand seems to be slight aperture in the huge oncological area, but the receptor targeting by short peptide of over expressed receptors in tumours has become very important for cancer imaging [2].
{"title":"Targeting Bombesin Peptide Receptors for Cancer Imaging: Perspective in Prostate, Lung and Breast Cancer","authors":"Raunak Varshney","doi":"10.31031/NACS.2020.05.000611","DOIUrl":"https://doi.org/10.31031/NACS.2020.05.000611","url":null,"abstract":"One of the main reasons for focus on these particular cancer as prostate and breast cancers are the most common types cancer in men and women respectively. However small and non-small cell lung cancer are most frequent in both. The molecular basis for the utility of radiopeptides is due to their peptide receptor over expression by certain tumours [1]. Peptides are more important elements in fundamental biological processes due to their specificity for controlling various biological functions through their specific receptors naturally. The increased attention for peptides or their receptors for imaging cancer is due to their expression/over expression in many primary human cancers and their ability to target specific receptor. The clinical impact of radiolabelled peptides has been observed in theranostics by diagnosis of location of tumours and their metastases by receptor scintigraphy and by facilitating receptor radiotherapy of tumours for treatment. However, the research on peptide based radioligand seems to be slight aperture in the huge oncological area, but the receptor targeting by short peptide of over expressed receptors in tumours has become very important for cancer imaging [2].","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41918598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-30DOI: 10.31031/NACS.2020.05.000610
Savan Shah
The rise of SARS CoV-2, a respiratory disease known as COVID-19, presents unique care delivery challenges to cancer patients and their providers. An emerging theme is the significantly increased susceptibility of infection with COVID-19 among patients with cancer, as well as in those with hospital admission and recurrent hospital visits [1]. Early reports from China estimate that cancer patients incur a significantly increased risk of invasive ventilation, ICU admission or mortality compared to patients without cancer [2]. A New York hospital system documented 218 COVID-19 cancer patients from March 18 to April 8, 20203. Hospital system staff reported 28% of COVID-19 deaths in cancer patients, compared to 14% in the control group, suggesting a growing need for strategies to reduce exposure risk [3]. As hospitals became overburdened with COVID-19 patients, policies and procedures were created or modified and implemented swiftly (in response to local conditions or due to evolving State or County guidelines) to prevent increased exposure among these patients, ultimately interrupting routine cancer screenings and scheduled therapies.
{"title":"Interim Breast Cancer Care during the COVID-19 Pandemic","authors":"Savan Shah","doi":"10.31031/NACS.2020.05.000610","DOIUrl":"https://doi.org/10.31031/NACS.2020.05.000610","url":null,"abstract":"The rise of SARS CoV-2, a respiratory disease known as COVID-19, presents unique care delivery challenges to cancer patients and their providers. An emerging theme is the significantly increased susceptibility of infection with COVID-19 among patients with cancer, as well as in those with hospital admission and recurrent hospital visits [1]. Early reports from China estimate that cancer patients incur a significantly increased risk of invasive ventilation, ICU admission or mortality compared to patients without cancer [2]. A New York hospital system documented 218 COVID-19 cancer patients from March 18 to April 8, 20203. Hospital system staff reported 28% of COVID-19 deaths in cancer patients, compared to 14% in the control group, suggesting a growing need for strategies to reduce exposure risk [3]. As hospitals became overburdened with COVID-19 patients, policies and procedures were created or modified and implemented swiftly (in response to local conditions or due to evolving State or County guidelines) to prevent increased exposure among these patients, ultimately interrupting routine cancer screenings and scheduled therapies.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49386849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-28DOI: 10.31031/NACS.2020.05.000615
Zemskov Vm, R. ASh, Zemskov Am, V. Zoloedov, Chernitsyn, Zemskova Va, Peleshenko Ei, NeymannV, Pronko Kn
It is known that metabolic processes include free radical oxidations (ROS), which provide cells with energy to prepare plastic material, participate in the metabolism of carbohydrates, lipids, proteins, nucleic acids. ROS leads to the formation of primary (diene conjugate [DC], ketodienes [KD]) and secondary (malonic dialdehyde [MDA], bityrozine crosslinks [BC], Schiff ’s bases [SHB]) and other products that have a positive or negative effect on the biomembrane cells. For the leveling of ROS processes in the body, an endogenous antioxidant defense system (AOD) is developed, which consists of enzymatic and non-enzymatic links. The first group includes superoxide dismutase (SOD), catalase (C), peroxidase (P), glutathion peroxidase (GP), glutathione reductase (GR); to the second, glutathione (GL), alpha-tocopherol (vitamin E, VE), plasma antioxidant activity (AOA), total thiols, non-protein thiols, protein thiols (TT, NPT, PT), etc. [1,2]. It has been established that ROS products mainly implement a suppressive and AOD a modulating effect on the immune reactivity of patients [3]. At the same time, the direct link between immune-metabolic parameters, recognized by all authors is practically not documented [4-7].
{"title":"Immune-Metabolic Stress in Purulent-Inflammatory Diseases of the Skin and Soft Tissues","authors":"Zemskov Vm, R. ASh, Zemskov Am, V. Zoloedov, Chernitsyn, Zemskova Va, Peleshenko Ei, NeymannV, Pronko Kn","doi":"10.31031/NACS.2020.05.000615","DOIUrl":"https://doi.org/10.31031/NACS.2020.05.000615","url":null,"abstract":"It is known that metabolic processes include free radical oxidations (ROS), which provide cells with energy to prepare plastic material, participate in the metabolism of carbohydrates, lipids, proteins, nucleic acids. ROS leads to the formation of primary (diene conjugate [DC], ketodienes [KD]) and secondary (malonic dialdehyde [MDA], bityrozine crosslinks [BC], Schiff ’s bases [SHB]) and other products that have a positive or negative effect on the biomembrane cells. For the leveling of ROS processes in the body, an endogenous antioxidant defense system (AOD) is developed, which consists of enzymatic and non-enzymatic links. The first group includes superoxide dismutase (SOD), catalase (C), peroxidase (P), glutathion peroxidase (GP), glutathione reductase (GR); to the second, glutathione (GL), alpha-tocopherol (vitamin E, VE), plasma antioxidant activity (AOA), total thiols, non-protein thiols, protein thiols (TT, NPT, PT), etc. [1,2]. It has been established that ROS products mainly implement a suppressive and AOD a modulating effect on the immune reactivity of patients [3]. At the same time, the direct link between immune-metabolic parameters, recognized by all authors is practically not documented [4-7].","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44809233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-16DOI: 10.31031/NACS.2020.05.000607
Shuyang Wang
Analysis of circulating tumor cells (CTC) has received enormous attentions for its potential to obtain diverse information of tumors dynamically. Nowadays fast-developing detection technologies facilitate its biological research of tumor dissemination and clinical implications. This review is going to discuss clinical applications of CTC including prognosis and prediction of metastatic progression, surveillance of therapeutic response and identification of therapeutic targets and resistance mechanisms and to further introduce present detection technologies of CTC.
{"title":"Current Clinical Applications and Challenges of Circulating Tumor Cells","authors":"Shuyang Wang","doi":"10.31031/NACS.2020.05.000607","DOIUrl":"https://doi.org/10.31031/NACS.2020.05.000607","url":null,"abstract":"Analysis of circulating tumor cells (CTC) has received enormous attentions for its potential to obtain diverse information of tumors dynamically. Nowadays fast-developing detection technologies facilitate its biological research of tumor dissemination and clinical implications. This review is going to discuss clinical applications of CTC including prognosis and prediction of metastatic progression, surveillance of therapeutic response and identification of therapeutic targets and resistance mechanisms and to further introduce present detection technologies of CTC.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42919309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-03DOI: 10.31031/NACS.2020.05.000606
Chengzu Li
{"title":"Virtual Reality Technology and 3D Reconstruction in Hepatectomy","authors":"Chengzu Li","doi":"10.31031/NACS.2020.05.000606","DOIUrl":"https://doi.org/10.31031/NACS.2020.05.000606","url":null,"abstract":"","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48485073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-28DOI: 10.31031/nacs.2020.05.000605
C. Ulloa
Breast cancer claims thousands of lives all over the world every year. A historical perspective on the social construction of breast cancer policy is presented. This mini review examines breast cancer through a historical lens to provide evidence of how, through a dynamic process of social construction, different social actors constructed breast cancer into a public health issue that merits policymakers’ attention.
{"title":"Breast Cancer: A Public Health Issue that is also Subject of Social Construction","authors":"C. Ulloa","doi":"10.31031/nacs.2020.05.000605","DOIUrl":"https://doi.org/10.31031/nacs.2020.05.000605","url":null,"abstract":"Breast cancer claims thousands of lives all over the world every year. A historical perspective on the social construction of breast cancer policy is presented. This mini review examines breast cancer through a historical lens to provide evidence of how, through a dynamic process of social construction, different social actors constructed breast cancer into a public health issue that merits policymakers’ attention.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41944203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-04DOI: 10.31031/nacs.2020.05.000603
M. Porcelli
Laryngeal squamous cell carcinoma (LSCC), an epithelial tumor that originates from larynx, is highly aggressive and more than 150.000 new cases are diagnosed each year [1,2]. Alcohol consumption, tobacco use and human papilloma virus (HPV) infections are the main risk factors for these types of cancer [3,4]. The main treatment options are surgery, radiotherapy, targeted therapy, and chemotherapy [1,2]. Despite significant progress in finding potential therapeutic targets to improve survival, mortality is still high. Several studies have focused on the discovery of new molecules, obtained from natural compounds, that demonstrate anticancer and anti-proliferation effect and can be used in combination with conventional chemotherapy agents for LSCC treatment. Among natural compounds, our research group focused its interest on S-adenosyl-L-methionine (AdoMet), a naturally occurring sulfur-containing nucleoside found ubiquitously in all living cells where it functions as the main biological methyl donor. The role of AdoMet in various cellular processes, such as proliferation, differentiation, cell cycle regulation, cell migration and apoptosis has been Abstract
{"title":"AdoMet Synergistically Enhances the Chemotherapeutic Action of Cisplatin and Improves Drug Efficacy in JHU-SCC-011 Laryngeal Squamous Cell Carcinoma","authors":"M. Porcelli","doi":"10.31031/nacs.2020.05.000603","DOIUrl":"https://doi.org/10.31031/nacs.2020.05.000603","url":null,"abstract":"Laryngeal squamous cell carcinoma (LSCC), an epithelial tumor that originates from larynx, is highly aggressive and more than 150.000 new cases are diagnosed each year [1,2]. Alcohol consumption, tobacco use and human papilloma virus (HPV) infections are the main risk factors for these types of cancer [3,4]. The main treatment options are surgery, radiotherapy, targeted therapy, and chemotherapy [1,2]. Despite significant progress in finding potential therapeutic targets to improve survival, mortality is still high. Several studies have focused on the discovery of new molecules, obtained from natural compounds, that demonstrate anticancer and anti-proliferation effect and can be used in combination with conventional chemotherapy agents for LSCC treatment. Among natural compounds, our research group focused its interest on S-adenosyl-L-methionine (AdoMet), a naturally occurring sulfur-containing nucleoside found ubiquitously in all living cells where it functions as the main biological methyl donor. The role of AdoMet in various cellular processes, such as proliferation, differentiation, cell cycle regulation, cell migration and apoptosis has been Abstract","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42594418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-20DOI: 10.31031/nacs.2020.05.000602
Xiaolong Li
TFF1, one member of the trefoil factor family (TFFs), is an antiproteinolytic peptide. Abnormal TFF1 expression is associated with carcinogenesis. In order to investigate the expression of TFF1 in esophageal carcinoma and its potential gene regulatory network. We used sequencing data from the Cancer Genome Atlas database and Gene Expression Omnibus, analyzed TFF1 expression and gene regulation networks in esophageal carcinoma (ESCA). TFF1 expression profiling was analyzed using Oncomine TM, while TFF1 mutation and related functional networks were identified using cBioPortal. Linked Omics was used to identify differential gene expression with TFF1 and to analyze Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. We found that TFF1 is overexpressed in ESCA, and deletion is the most common TFF1 mutation type in ESCA, and TFF1 gene mutation may also significantly affect the prognosis of ESCA patients. Functional network analysis showed that TFF1 may play a role in ESCA by participating in NF-κB signaling pathway and Hippo signaling pathway. Our results demonstrate that data mining efficiently reveals information about TFF1 expression and potential regulatory networks in ESCA, laying a foundation for further study of the role of TFF1 in carcinogenesis.
{"title":"Expression and Gene Regulation Network of TFF1 in Esophageal Carcinoma","authors":"Xiaolong Li","doi":"10.31031/nacs.2020.05.000602","DOIUrl":"https://doi.org/10.31031/nacs.2020.05.000602","url":null,"abstract":"TFF1, one member of the trefoil factor family (TFFs), is an antiproteinolytic peptide. Abnormal TFF1 expression is associated with carcinogenesis. In order to investigate the expression of TFF1 in esophageal carcinoma and its potential gene regulatory network. We used sequencing data from the Cancer Genome Atlas database and Gene Expression Omnibus, analyzed TFF1 expression and gene regulation networks in esophageal carcinoma (ESCA). TFF1 expression profiling was analyzed using Oncomine TM, while TFF1 mutation and related functional networks were identified using cBioPortal. Linked Omics was used to identify differential gene expression with TFF1 and to analyze Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. We found that TFF1 is overexpressed in ESCA, and deletion is the most common TFF1 mutation type in ESCA, and TFF1 gene mutation may also significantly affect the prognosis of ESCA patients. Functional network analysis showed that TFF1 may play a role in ESCA by participating in NF-κB signaling pathway and Hippo signaling pathway. Our results demonstrate that data mining efficiently reveals information about TFF1 expression and potential regulatory networks in ESCA, laying a foundation for further study of the role of TFF1 in carcinogenesis.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49332545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-06DOI: 10.31031/nacs.2020.05.000601
B. Uysal
Coronaviruses are one of the human and animal pathogens. A new coronavirus type was identified after pneumonia cases in Wuhan which is a city of China at the last month of 2019. This novel type of coronavirus resulted an epidemic throughout China and increasing number of cases in other countries worldwide [1]. In February 2020, the WHO (World Health Organization) announced the disease COVID-19 that representing coronavirus disease 2019. Severe acute respiratory syndrome that required intensive care is the possible complication of COVID-19 and can be fatal.
{"title":"Radiotherapy Recommendations in Covid-19 Pandemia: Mini-Review","authors":"B. Uysal","doi":"10.31031/nacs.2020.05.000601","DOIUrl":"https://doi.org/10.31031/nacs.2020.05.000601","url":null,"abstract":"Coronaviruses are one of the human and animal pathogens. A new coronavirus type was identified after pneumonia cases in Wuhan which is a city of China at the last month of 2019. This novel type of coronavirus resulted an epidemic throughout China and increasing number of cases in other countries worldwide [1]. In February 2020, the WHO (World Health Organization) announced the disease COVID-19 that representing coronavirus disease 2019. Severe acute respiratory syndrome that required intensive care is the possible complication of COVID-19 and can be fatal.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48764118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-26DOI: 10.31031/nacs.2020.04.000600
M. Roy
Obesity related diseases are on the rise worldwide and obesity is an economic burden on the public health system in most developed and developing countries. The control of obesity is a major challenge that is hard to solve using medication and surgical procedures as those often have serious side effects. Our focus in this article is to highlight the extensive research literature on use of plant-derived chemicals or phytochemicals for control of obesity and obesity related diseases with a particular focus on several types of cancer. We discuss the genes, proteins and pathways involved in obesity and its control, and discuss how current research has revealed the beneficial effects of plant-derived chemicals or phytochemicals on these genes and pathways.
{"title":"Phytochemicals for Controlling Obesity-Related Cancers","authors":"M. Roy","doi":"10.31031/nacs.2020.04.000600","DOIUrl":"https://doi.org/10.31031/nacs.2020.04.000600","url":null,"abstract":"Obesity related diseases are on the rise worldwide and obesity is an economic burden on the public health system in most developed and developing countries. The control of obesity is a major challenge that is hard to solve using medication and surgical procedures as those often have serious side effects. Our focus in this article is to highlight the extensive research literature on use of plant-derived chemicals or phytochemicals for control of obesity and obesity related diseases with a particular focus on several types of cancer. We discuss the genes, proteins and pathways involved in obesity and its control, and discuss how current research has revealed the beneficial effects of plant-derived chemicals or phytochemicals on these genes and pathways.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47379474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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