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Water-Salt Metabolism in Rats with Acute Renal Failure Following Using Electrochemically Active Water Solutions 电化学活性水溶液对急性肾衰竭大鼠水盐代谢的影响
Pub Date : 2019-08-29 DOI: 10.33552/aun.2019.01.000517
R. Aizman, Koroshchenko Ga, Anna Pavlovna Kozlova, Khachatryan Aa
The importance of the kidney in maintaining and regulating the body’s homeostasis can be understood when there is a violation of their functions due to pathology. One of the most serious complications of mechanical injury is impaired renal hemodynamics and necrotic changes in the nephrons, which cause acute renal failure (ARF), that leads to death in 58% of cases. In clinical practice, various methods and drugs are widely used to treat renal failure and its complications, however, the problem of developing and using new protectors occupies an important place in experimental and clinical nephrology [1].
肾脏在维持和调节人体稳态方面的重要性可以理解,当其功能因病理而受到破坏时。机械损伤最严重的并发症之一是肾血流动力学受损和肾单位坏死改变,可导致急性肾功能衰竭(ARF),在58%的病例中导致死亡。在临床实践中,各种方法和药物被广泛用于治疗肾衰竭及其并发症,然而,开发和使用新的保护剂问题在实验和临床肾脏病学中占有重要地位。
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引用次数: 0
Evaluation of the 29 MHz Micro-Ultrasound Imaging for Prostate Cancer Diagnosis and Treatment 29MHz超声微成像对前列腺癌症诊断和治疗的评价
Pub Date : 2019-06-27 DOI: 10.33552/aun.2019.01.000515
W. Stanton, E. Crawford, Paul Arangua, Gretchen Hoyer, P. Werahera
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引用次数: 4
Role of Retrograde Intrarenal Surgery in Management of Renal Stones: 3 Years Experience 逆行肾内手术在肾结石治疗中的作用:3年经验
Pub Date : 2019-06-25 DOI: 10.33552/aun.2019.01.000514
Yadav Rajinder
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引用次数: 0
Overweight May Have Some Positive Reproductive Benefits as Compared to Obese Represented by Higher Sperm Progressive Motility in Infertile Men 与肥胖相比,超重可能对不育男性的生殖有一些积极的好处,肥胖代表着更高的精子进行性运动
Pub Date : 2019-06-17 DOI: 10.33552/aun.2019.01.000513
I. Ciccone, Ivan Iori, Giovanna Milani, Gustavo de Aguiar Andrade, E. Costa, J. Hallak
1,6 have (BMI) between 25 and 30 classified as overweight, and a BMI classified as to as a leading or indirect of and driven by an increase in related life-threatening disorders, including dyslipidemia, hypertension, cancer, type 2 diabetes, metabolic disorders, reproductive and sexual health impairment [5]. Although both males and females are affected by this lifestyle disorder in Abstract Objective: The purpose of this study is to unfold the
1,6的(BMI)在25到30之间,被归类为超重,BMI被归类为相关危及生命的疾病的增加的主要或间接原因,包括血脂异常、高血压、癌症、2型糖尿病、代谢障碍、生殖和性健康障碍[5]。尽管男性和女性都受到这种生活方式障碍的影响摘要目的:本研究的目的是揭示
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引用次数: 0
Primary Osteosarcoma of Testis and Para-Testicular Tissues: A Review and Update of the Literature 原发性睾丸及睾丸旁组织骨肉瘤:文献回顾与更新
Pub Date : 2019-06-06 DOI: 10.33552/aun.2019.01.000512
A. Venyo
Osteosarcoma of the testis and para-testicular tissue is a terminology that refers to a malignant tumor that contains pure osteoid forming malignant cells with no skeletal origin that affect the testis or para-testicular tissues. These tumors tends to present as an intra-scrotal or testicular mass which is non-specific. It may also present in association with a hydrocele. Clinical examination may reveal a firm to hard mass in the testis or in the affected para-testicular tissue. The inguinal glands may be normal but on rare occasions there may be lymph node enlargement in advanced cases. If there is an associated hydrocele there may be clinical examination evidence of a hydrocele. The full blood count, serum urea and electrolytes and liver function tests would tend to normal unless there are un-related pathologies which would need to be investigated accordingly. Nevertheless, if there are multiple liver metastases the liver function test results may show derangement in one or more elements of the liver function tests. The serum Beta Human Chorionic gonadotrophin, alpha fetoprotein, and lactate dehydrogenase levels would tend to normal unless the osteosarcoma is associated with a synchronous Germ cell tumor which does happen occasionally. Radiology imaging could show evidence of a heterogeneous mass within the testis in the case of a testicular tumor or in an intra-scrotal area at the site of the lesion and the mass tends to be associated with calcification. Treatment tends to be radical orchidectomy for localized tumors involving the testis only, but para-testicular osteosarcomas tend to be treated by radical orchidectomy plus en bloc excision of the para-testicular tissue. If there is evidence of metastasis then adjuvant therapy can be given. Gross examination of specimens of an excised osteosarcoma of the testis would tend to show a well-circumscribed, firm, solid, whitish tan, expansile mass which had compressed the surrounding parenchyma of the testis. Microscopic examination of primary osteosarcoma of the testis specimen would tend to show sheets of pleomorphic round to spindle cells that contain prominent nucleoli, areas of osteoid and scattered areas of mineralization, high mitotic activity and atypical mitosis, osteoid and at times osteoclasts among the area of osteoid. Immunohistochemistry studies of osteosarcoma of the testis or any para-testicular structures would tend to show the tumor cells stain positively for vimentin, but the tumor cells would stain negatively for: smooth muscle actin, CD34, cytokeratin, desmin, inhibin, myo-D1, and S-100 proteins.
睾丸和睾丸旁组织骨肉瘤是一个术语,指的是含有影响睾丸或睾丸旁组织的纯类骨恶性细胞的恶性肿瘤。这些肿瘤往往表现为阴囊内或睾丸内的非特异性肿块。它也可能与鞘膜积液有关。临床检查可能发现睾丸或受影响的睾丸旁组织中有一个硬到硬的肿块。腹股沟腺可能正常,但在极少数情况下,晚期病例可能有淋巴结肿大。如果有相关的鞘膜积液,可能有鞘膜积液的临床检查证据。全血细胞计数、血清尿素和电解质以及肝功能测试将趋于正常,除非存在需要相应调查的非相关病理。然而,如果存在多个肝转移,肝功能测试结果可能显示肝功能测试的一个或多个元素出现紊乱。血清β-人绒毛膜促性腺激素、甲胎蛋白和乳酸脱氢酶水平将趋于正常,除非骨肉瘤与偶尔发生的同步生殖细胞肿瘤有关。在睾丸肿瘤的情况下,放射学成像可以显示睾丸内或病变部位阴囊内有不均匀肿块的证据,并且肿块往往与钙化有关。治疗倾向于仅涉及睾丸的局限性肿瘤的睾丸根治术,但睾丸旁骨肉瘤倾向于通过睾丸根治术加上睾丸旁组织的整体切除来治疗。如果有转移的证据,那么可以给予辅助治疗。对切除的睾丸骨肉瘤标本进行大体检查,往往会发现一个边界清晰、坚固、坚实、白褐色、膨胀性肿块,压迫了睾丸周围的薄壁组织。睾丸标本原发性骨肉瘤的显微镜检查往往显示多形性圆形至纺锤形细胞片,其中含有突出的核仁、类骨区和分散的矿化区、高有丝分裂活性和非典型有丝分裂、类骨区域中有时有破骨细胞。睾丸或任何睾丸旁结构的骨肉瘤的免疫组织化学研究倾向于显示肿瘤细胞对波形蛋白呈阳性染色,但肿瘤细胞对平滑肌肌动蛋白、CD34、细胞角蛋白、结蛋白、抑制素、myo-D1和S-100蛋白呈阴性染色。
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引用次数: 0
An Unusual Cause of Rhabdomyolysis with Acute Kidney Injury 急性肾损伤引起横纹肌溶解的不寻常原因
Pub Date : 2019-05-16 DOI: 10.36959/832/397
Gharge Ankita, Rao Shobhana Nayak, M. Shenoy
Rhabdomyolysis is a serious syndrome due to a direct or indirect muscle injury. It results from the death of muscle fibers and release of their contents into the bloodstream. It can result from a variety of etiologies which may include traumatic or non-traumatic causes. Rhabdomyolysis due to hanging is extremely uncommon and not described in literature. This case highlights rhabdomyolysis as a potential complication of hanging.
横纹肌溶解是一种严重的综合征,由于直接或间接的肌肉损伤。它是由肌肉纤维的死亡和释放到血液中的内容物引起的。它可以由多种病因引起,其中可能包括创伤性或非创伤性原因。悬吊引起的横纹肌溶解非常罕见,文献中没有描述。本病例强调横纹肌溶解是悬吊的潜在并发症。
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引用次数: 0
Peritoneal Dialysis in Emergency in Children:Mono Centric Study in a Service of Adult Nephrology of Eastern Algeria 急诊儿童腹膜透析:阿尔及利亚东部成人肾脏病的单中心研究
Pub Date : 2019-04-03 DOI: 10.33552/aun.2019.01.000510
M. S
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引用次数: 1
Tubeless Ureterorenoscopy. A Dangerous Adventure or “Fresh Wind” Relied on Skills, Technique and New Technology? 无内胎Ureterorenoscopy。危险的冒险还是依靠技能、技术和新技术的“清新之风”?
Pub Date : 2019-04-03 DOI: 10.33552/aun.2019.01.000511
Itay M Sabler
Upper urinary tract endoscopic stone treatment includes intracorporeal lithotripsy, usually using Holmium laser fiber, and temporary drainage of the upper urinary tract postoperatively. Almost absolute endourologic routine is to leave Double-J stent (DJS) for several weeks or ureteral catheter attached to urethral catheter for 24–72 hours. The reason for that is to prevent postoperative pain and infection due to local edema at the ureteral orifice, and upper urinary tract obstruction. On the other hand, postoperative tubing is known to cause lower urinary tract symptoms (LUTS), abdominal and flank pain. Postoperative tubing may cause additional emergency department visits, analgesics use, preliminary interventions and in case of DJS, usually demands invasive procedure, sometimes under general anesthesia in order to retrieve the stent after predetermined period of carriage. At the end of Tubeless Ureterorenoscopy (URS) for treatment of kidney and ureteral stones – no drainage left. Patient comfort advantages of tubeless approach are obvious, but fear of obstruction precluded urologist all over the world from leaving upper tracts undrained for decades. These days, technological achievements enable endourologists to use miniaturized flexible or semirigid ureteroscopes and novel high-power laser machines, minimizing upper urinary tract damage during the procedure and promoting a very effective stone dusting never seen before. These factors permit, in selected cases, to avoid postoperative tubing, reduce LUTS, and shorten hospitalization period facilitating ambulatory nature of the procedure with overall decreasing costs. A tubeless approach is safe in properly selected uncomplicated cases. The postoperative period is at least the same as in drained patients, avoiding long term postoperative stent related symptoms. More RCT are needed to point the place for safe tubeless endourologic procedures.
上尿路内窥镜结石治疗包括通常使用钬激光纤维的体内碎石术,以及术后对上尿路进行暂时引流。几乎绝对的尿内常规是双j支架(DJS)留置数周或输尿管导管附着在尿道导管上24-72小时。这样做的原因是为了防止输尿管口局部水肿和上尿路梗阻引起的术后疼痛和感染。另一方面,术后插管已知会引起下尿路症状(LUTS),腹部和侧腹疼痛。术后插管可能会导致额外的急诊科就诊,使用止痛药,进行初步干预,并且在DJS的情况下,通常需要进行侵入性手术,有时在全身麻醉下,以便在预定的支架放置时间后收回支架。无管输尿管镜(URS)治疗肾结石和输尿管结石结束时-无引流液。无管入路的患者舒适优势是显而易见的,但由于担心梗阻,几十年来全世界的泌尿科医生都不允许上尿路不排水。如今,技术成就使泌尿科医生能够使用小型柔性或半刚性输尿管镜和新型高功率激光设备,最大限度地减少了手术过程中的上尿路损伤,并促进了前所未有的非常有效的结石除尘。这些因素允许,在选定的情况下,避免术后插管,减少LUTS,缩短住院时间,促进手术的流动性质,整体降低成本。在适当选择的简单病例中,无管入路是安全的。术后时间至少与引流患者相同,避免了长期的术后支架相关症状。需要更多的随机对照试验来为安全的无管泌尿外科手术指明方向。
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引用次数: 0
Serotonin Syndrome: Fairly Common but Frequently Forgotten 血清素综合征:相当普遍但经常被遗忘
Pub Date : 2019-03-11 DOI: 10.36959/832/396
Magbri Awad, El-Magbri Mariam, Suljuki Kamran, Rose Darcy
The authors presented a case of serotonin syndrome cause by drug interaction. The patient is presented with classical features of the syndrome with hyper-excitability, tremor, change in mental status, and low grade fever. The patient made uneventful recovery after the stoppage of the offending drugs. This case calls for the clinicians to be vigilant of the drug interaction that can cause unintended side effects to the patient under their care.
作者报告了一例由药物相互作用引起的血清素综合征。患者表现为典型的亢奋、震颤、精神状态改变和低烧。病人停止服用令人讨厌的药物后平静地康复了。这种情况要求临床医生警惕药物相互作用,可能导致意想不到的副作用,在他们的照顾下的病人。
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引用次数: 0
Keeping a Brave Front 保持勇敢的前线
Pub Date : 2019-02-25 DOI: 10.36959/832/395
M. Laico
The burden of end stage renal disease often seems insurmountable. This is especially true for patients who are on renal replacement therapy, whose lives and whose family's lives have been changed by this dreaded illness. As nephrologists taking care of dialysis patients, we are witnesses to the effect chronic kidney disease has to the patient and their family. Often, aside from managing the patient during regular dialysis sessions, we take the time to converse with the patient and with the patient's family.
终末期肾病的负担往往似乎无法克服。对于接受肾脏替代疗法的患者来说尤其如此,他们的生活和家庭的生活已经被这种可怕的疾病改变了。作为照顾透析患者的肾病学家,我们目睹了慢性肾病对患者及其家人的影响。通常,除了在常规透析期间管理患者外,我们还会花时间与患者及其家属交谈。
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引用次数: 0
期刊
Annals of urology & nephrology
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