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Lensless fiber endomicroscopy in biomedicine 生物医学中的无镜头纤维内窥镜
Q1 OPTICS Pub Date : 2024-05-14 DOI: 10.1186/s43074-024-00133-8
Jiawei Sun, Robert Kuschmierz, Ori Katz, Nektarios Koukourakis, Juergen W. Czarske

Lensless fiber endomicroscopy, an emergent paradigm shift for minimally-invasive microscopic optical imaging and targeted light delivery, holds transformative potential, especially in biomedicine. Leveraging holographic detection and physical or computational wavefront correction, it enables three-dimensional imaging in an unprecedentedly small footprint, which is crucial for various applications such as brain surgery. This perspective reviews the recent breakthroughs, highlighting potential emerging applications, and pinpointing gaps between innovation and real-world applications. As the research in this realm accelerates, the novel breakthroughs and existing frontiers highlighted in this perspective can be used as guidelines for researchers joining this exciting domain.

无透镜光纤内窥镜是微创显微光学成像和定向光传输的新兴范式,具有变革性的潜力,尤其是在生物医学领域。利用全息检测和物理或计算波前校正,它能以前所未有的小尺寸实现三维成像,这对脑外科手术等各种应用至关重要。本视角回顾了最近取得的突破,强调了潜在的新兴应用,并指出了创新与实际应用之间的差距。随着这一领域研究的加速,本视角中强调的新突破和现有前沿领域可作为研究人员加入这一激动人心领域的指南。
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引用次数: 0
Cascaded chiral birefringent media enabled planar lens with programable chromatic aberration 具有可编程色差的级联手性双折射介质平面透镜
Q1 OPTICS Pub Date : 2024-05-06 DOI: 10.1186/s43074-024-00132-9
Dewei Zhang, Chun-Ting Xu, Quan-Ming Chen, Han Cao, Hong-Guan Yu, Qing-Gui Tan, Yan-qing Lu, Wei Hu

Wavefront control is the fundamental requirement in optical informatics. Planar optics have drawn intensive attention due to the merits of compactness and light weight. However, it remains a challenge to freely manipulate the dispersion, hindering practical applications, especially in imaging. Here, we propose the concept of frequency-synthesized phase engineering to solve this problem. A phasefront-frequency matrix is properly designed to encode different spatial phases to separate frequencies, thus makes arbitrary dispersion tailoring and even frequency-separated functionalization possible. The periodically rotated director endows cholesteric liquid crystal with a spin and frequency selective reflection. Moreover, via presetting the local initial orientation of liquid crystal, geometric phase is encoded to the reflected light. We verify the proposed strategy by cascading the chiral anisotropic optical media of specifically designed helical pitches and initial director orientations. By this means, planar lenses with RGB achromatic, enhanced chromatic aberration and color routing properties are demonstrated. Inch-sized and high-efficient lenses are fabricated with low crosstalk among colors. It releases the freedom of dispersion control of planar optics, and even enables frequency decoupled phase modulations. This work brings new insights to functional planar optics and may upgrade the performance of existing optical apparatuses.

波前控制是光学信息学的基本要求。平面光学因其结构紧凑、重量轻等优点而备受关注。然而,自由操纵色散仍然是一项挑战,阻碍了实际应用,尤其是成像应用。在此,我们提出了频率合成相位工程的概念来解决这一问题。相位前沿-频率矩阵经过适当设计,可将不同的空间相位编码为不同的频率,从而实现任意色散定制,甚至是频率分离功能化。周期性旋转的导向器使胆甾液晶具有自旋和频率选择性反射。此外,通过预设液晶的局部初始方向,几何相位被编码到反射光中。我们通过级联专门设计的螺旋间距和初始导向的手性各向异性光学介质,验证了所提出的策略。通过这种方法,我们展示了具有 RGB消色差、增强色差和色彩路由特性的平面透镜。英寸大小的高效透镜制造出来后,颜色之间的串扰很低。它释放了平面光学的色散控制自由度,甚至实现了频率解耦相位调制。这项工作为功能平面光学带来了新的见解,并可能提升现有光学设备的性能。
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引用次数: 0
Astronomical adaptive optics: a review 天文自适应光学:综述
Q1 OPTICS Pub Date : 2024-05-01 DOI: 10.1186/s43074-024-00118-7
Changhui Rao, Libo Zhong, Youming Guo, Min Li, Lanqiang Zhang, Kai Wei

Since the concept of adaptive optics(AO) was proposed in 1953, AO has become an indispensable technology for large aperture ground-based optical telescopes aimed at high resolution observations. This paper provides a comprehensive review of AO progress for large aperture astronomical optical telescopes including both night-time and day-time solar optical telescopes. The recent AO technological advances, such as Laser Guide Star, Deformable Secondary Mirror, Extreme AO, and Multi-Conjugate AO are focused.

自 1953 年提出自适应光学(AO)概念以来,AO 已成为以高分辨率观测为目标的大口径地面光学望远镜不可或缺的技术。本文全面回顾了大口径天文光学望远镜(包括夜用和日用太阳光学望远镜)的自适应光学技术进展。重点介绍了激光导星、可变形二次反射镜、极端自动光学观测和多共轭自动光学观测等最新自动光学观测技术的进展。
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引用次数: 0
Large-scale optical switches by thermo-optic waveguide lens 利用热光学波导透镜实现大规模光学开关
Q1 OPTICS Pub Date : 2024-04-18 DOI: 10.1186/s43074-024-00131-w
Tao Chen, Zhangqi Dang, Zeyu Deng, Shijie Ke, Zhenming Ding, Ziyang Zhang
Optical switches are desired in telecom and datacom as an upgrade to electrical ones for lower power consumption and expenses while improving bandwidth and network transparency. Compact, integrated optical switches are attractive thanks to their scalability, readiness for mass production, and robustness against mechanical disturbances. The basic unit relies mostly on a microring resonator or a Mach–Zehnder interferometer for binary “bar” and “cross” switching. Such single-mode structures are often wavelength / polarization dependent, sensitive to phase errors and loss-prone. Furthermore, when they are cascaded to a network, the number of control units grows quickly with the port count, causing high complexity in electronic wiring and drive circuit integration. Herein, we propose a new switching method by thermo-optic waveguide lens. Essentially, this multimode waveguide forms a square law medium by a pair of heater electrodes and focuses light within a chip by robust 1 × 1 imaging. A 1 × 24 basic switch is demonstrated with 32 electrodes and only two are biased at a time for a chosen output. By two-level cascading, the switch expands to 576 ports and only four electrodes are needed for one path. The chips are fabricated on wafer scale in a low-budget laboratory without resorting to foundries. Yet, the performance goes beyond state of the art for low insertion loss, low wavelength dependence and low polarization dependence. This work provides an original, alternative, and practical route to construct large-scale optical switches, enabling broad applications in telecom, datacom and photonic computing.
在电信和数据通信领域,人们希望将光开关作为电气开关的升级产品,以降低功耗和费用,同时提高带宽和网络透明度。紧凑型集成光开关因其可扩展性、可批量生产性和抗机械干扰的坚固性而备受青睐。其基本单元主要依靠微波谐振器或马赫-泽恩德干涉仪来实现二进制 "条形 "和 "交叉 "开关。这种单模结构通常与波长/偏振有关,对相位误差敏感,而且容易产生损耗。此外,当它们级联成一个网络时,控制单元的数量会随着端口数的增加而迅速增长,从而导致电子布线和驱动电路集成的高度复杂性。在此,我们提出了一种利用热光学波导透镜的新型开关方法。从本质上讲,这种多模波导通过一对加热器电极形成一个平方律介质,并通过稳健的 1 × 1 成像在芯片内聚焦光线。演示的 1 × 24 基本开关有 32 个电极,每次只偏压两个电极以获得所选输出。通过两级级联,开关扩展到 576 个端口,一条路径只需四个电极。这些芯片在低成本实验室中以晶圆规模制造,无需借助代工厂。然而,其性能却超越了低插入损耗、低波长依赖性和低偏振依赖性等技术水平。这项工作为构建大规模光开关提供了一条独创的、可供选择的实用途径,可广泛应用于电信、数据通信和光子计算领域。
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引用次数: 0
High-dimensional Poincaré beams generated through cascaded metasurfaces for high-security optical encryption 通过级联元曲面生成的高维 Poincaré 光束用于高安全性光学加密
Q1 OPTICS Pub Date : 2024-04-17 DOI: 10.1186/s43074-024-00125-8
Jitao Ji, Chen Chen, Jiacheng Sun, Xin Ye, Zhizhang Wang, Jian Li, Junyi Wang, Wange Song, Chunyu Huang, Kai Qiu, Shining Zhu, Tao Li

Optical encryption plays an increasingly important role in the field of information security owing to its parallel processing capability and low power consumption. Employing the ultrathin metasurfaces in optical encryption has promoted the miniaturization and multifunctionality of encryption systems. Nevertheless, with the few number of degrees of freedom (DoFs) multiplexed by single metasurface, both key space and encoding space are limited. To address this issue, we propose a high-security and large-capacity optical encryption scheme based on perfect high-dimensional Poincaré beams with expanded DoFs. By cascading two arrayed metasurfaces, more beam properties can be independently engineered, which gives rise to the extensively expanded key and encoding spaces. Our work provides a promising strategy for optical encryption with high security level and large information capacity and might facilitate the applications of Poincaré beams in optical communications and quantum information.

光学加密因其并行处理能力和低功耗,在信息安全领域发挥着越来越重要的作用。在光加密中采用超薄元表面促进了加密系统的小型化和多功能化。然而,由于单个元表面复用的自由度(DoF)数量较少,密钥空间和编码空间都受到了限制。为了解决这个问题,我们提出了一种高安全性和大容量的光学加密方案,该方案基于具有扩展自由度的完美高维庞加莱光束。通过级联两个阵列元面,可以独立设计更多光束属性,从而广泛扩展密钥和编码空间。我们的工作为具有高安全等级和大信息容量的光学加密提供了一种前景广阔的策略,并可能促进波形光束在光通信和量子信息领域的应用。
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引用次数: 0
Three-dimensional dipole orientation mapping with high temporal-spatial resolution using polarization modulation 利用偏振调制实现高时空分辨率的三维偶极子方位制图
Q1 OPTICS Pub Date : 2024-04-16 DOI: 10.1186/s43074-024-00127-6
Suyi Zhong, Liang Qiao, Xichuan Ge, Xinzhu Xu, Yuzhe Fu, Shu Gao, Karl Zhanghao, Huiwen Hao, Wenyi Wang, Meiqi Li, Peng Xi
Fluorescence polarization microscopy is widely used in biology for molecular orientation properties. However, due to the limited temporal resolution of single-molecule orientation localization microscopy and the limited orientation dimension of polarization modulation techniques, achieving simultaneous high temporal-spatial resolution mapping of the three-dimensional (3D) orientation of fluorescent dipoles remains an outstanding problem. Here, we present a super-resolution 3D orientation mapping (3DOM) microscope that resolves 3D orientation by extracting phase information of the six polarization modulation components in reciprocal space. 3DOM achieves an azimuthal precision of 2° and a polar precision of 3° with spatial resolution of up to 128 nm in the experiments. We validate that 3DOM not only reveals the heterogeneity of the milk fat globule membrane, but also elucidates the 3D structure of biological filaments, including the 3D spatial conformation of λ-DNA and the structural disorder of actin filaments. Furthermore, 3DOM images the dipole dynamics of microtubules labeled with green fluorescent protein in live U2OS cells, reporting dynamic 3D orientation variations. Given its easy integration into existing wide-field microscopes, we expect the 3DOM microscope to provide a multi-view versatile strategy for investigating molecular structure and dynamics in biological macromolecules across multiple spatial and temporal scales.
荧光偏振显微镜在生物学中被广泛应用于分子定向特性的研究。然而,由于单分子取向定位显微镜的时间分辨率有限,偏振调制技术的取向维度也有限,因此实现荧光偶极子三维(3D)取向的同步高时空分辨率绘图仍是一个突出问题。在这里,我们提出了一种超分辨率三维方位映射(3DOM)显微镜,它通过提取倒易空间中六个偏振调制分量的相位信息来解析三维方位。在实验中,3DOM 实现了 2° 的方位精度和 3° 的极性精度,空间分辨率高达 128 nm。我们验证了3DOM不仅能揭示牛奶脂肪球膜的异质性,还能阐明生物丝的三维结构,包括λ-DNA的三维空间构象和肌动蛋白丝的结构紊乱。此外,3DOM 还能对活体 U2OS 细胞中用绿色荧光蛋白标记的微管的偶极动态进行成像,报告动态三维方向变化。鉴于3DOM显微镜易于集成到现有的宽视场显微镜中,我们希望它能为研究生物大分子的分子结构和动力学提供一种跨时空尺度的多视角多功能策略。
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引用次数: 0
Multiplexing near- and far-field functionalities with high-efficiency bi-channel metasurfaces 利用高效双通道元表面复用近场和远场功能
Q1 OPTICS Pub Date : 2024-04-15 DOI: 10.1186/s43074-024-00128-5
Changhong Dai, Tong Liu, Dongyi Wang, Lei Zhou
Propagating waves and surface waves are two distinct types of light-transporting modes, the free control of which are both highly desired in integration photonics. However, previously realized devices are bulky in sizes, inefficient, and/or can only achieve one type of light-manipulation functionality with a single device. Here, we propose a generic approach to design bi-channel meta-devices, constructed by carefully selected meta-atoms possessing reflection phases of both structural-resonance and geometric origins, which can exhibit two distinct light-manipulation functionalities in near-field (NF) and far-field (FF) channels, respectively. After characterizing the scattering properties of basic meta-atoms and briefly stating the theoretical strategy, we design/fabricate three different meta-devices and experimentally characterize their bi-channel wave-control functionalities in the telecom regime. Our experiments show that the first two devices can multiplex the generations of NF and FF optical vortices with different topological charges, while the third one exhibits anomalous surface plasmon polariton focusing in the NF and hologram formation in the FF simultaneously. Our results expand the wave-control functionalities of metasurfaces to all wave-transporting channels, which may inspire many exciting applications in integration optics.
传播波和表面波是两种截然不同的光传输模式,对它们的自由控制都是集成光子学所亟需的。然而,以前实现的器件体积庞大、效率低下,并且/或者只能通过单个器件实现一种光操纵功能。在此,我们提出了一种设计双通道元器件的通用方法,该方法由精心挑选的元原子构建而成,具有结构共振和几何来源的反射相位,可分别在近场(NF)和远场(FF)通道中实现两种不同的光操纵功能。在描述了基本元原子的散射特性并简要说明了理论策略之后,我们设计/制造了三种不同的元器件,并通过实验描述了它们在电信系统中的双通道波控制功能。实验结果表明,前两个器件可以复用具有不同拓扑电荷的 NF 和 FF 光学漩涡,而第三个器件则可以同时在 NF 中显示异常表面等离子体极化子聚焦和在 FF 中显示全息图形成。我们的研究结果将超表面的波控制功能扩展到了所有波传输通道,这可能会激发集成光学中许多激动人心的应用。
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引用次数: 0
Ultra-wideband terahertz fingerprint enhancement sensing and inversion model supported by single-pixel reconfigurable graphene metasurface 单像素可重构石墨烯元表面支持的超宽带太赫兹指纹增强传感和反转模型
Q1 OPTICS Pub Date : 2024-04-15 DOI: 10.1186/s43074-024-00129-4
Bingwei Liu, Yan Peng, YuFan Hao, Yiming Zhu, Shengjiang Chang, Songlin Zhuang

The molecular fingerprint sensing technology based on metasurface has unique attraction in the biomedical field. However, in the terahertz (THz) band, existing metasurface designs based on multi-pixel or angle multiplexing usually require more analyte amount or possess a narrower tuning bandwidth. Here, we propose a novel single-pixel graphene metasurface. Based on the synchronous voltage tuning, this metasurface enables ultra-wideband ((sim) 1.5 THz) fingerprint enhancement sensing of trace analytes, including chiral optical isomers, with a limit of detection (LoD) ≤ 0.64 μg/mm2. The enhancement of the fingerprint signal ((sim) 17.4 dB) originates from the electromagnetically induced transparency (EIT) effect excited by the metasurface, and the ideal overlap between the light field constrained by single-layer graphene (SLG) and ultra-thin analyte. Meanwhile, due to the unique nonlinear enhancement mechanism in graphene tuning, the absorption envelope distortion is inevitable. To solve this problem, a universal fingerprint spectrum inversion model is developed for the first time, and the restoration of standard fingerprints reaches Rmax2 ≥ 0.99. In addition, the asynchronous voltage tuning of the metasurface provides an opportunity for realizing the dynamic reconfiguration of EIT resonance and the slow light modulation in the broadband range. This work builds a bridge for ultra-wideband THz fingerprint sensing of trace analytes, and has potential applications in active spatial light modulators, slow light devices and dynamic imaging equipments.

基于元表面的分子指纹传感技术在生物医学领域具有独特的吸引力。然而,在太赫兹(THz)波段,现有的基于多像素或角度复用的元表面设计通常需要更多的分析物量或更窄的调谐带宽。在此,我们提出了一种新型单像素石墨烯元表面。基于同步电压调谐,该元表面可实现包括手性光学异构体在内的痕量分析物的超宽带(1.5 THz)指纹增强传感,其检测限(LoD)≤ 0.64 μg/mm2。指纹信号的增强(17.4 dB)源于元表面激发的电磁诱导透明(EIT)效应,以及单层石墨烯(SLG)和超薄分析物所限制的光场之间的理想重叠。同时,由于石墨烯调谐中独特的非线性增强机制,吸收包络畸变不可避免。为解决这一问题,首次建立了通用的指纹谱反演模型,标准指纹的还原度达到 Rmax2 ≥ 0.99。此外,元表面的异步电压调谐为实现 EIT 共振的动态重构和宽带范围内的慢光调制提供了机会。这项研究为痕量分析物的超宽带太赫兹指纹传感搭建了一座桥梁,并有望应用于有源空间光调制器、慢光器件和动态成像设备。
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引用次数: 0
Brillouin microscopy monitors rapid responses in subcellular compartments 布里渊显微镜监测亚细胞区的快速反应
Q1 OPTICS Pub Date : 2024-04-10 DOI: 10.1186/s43074-024-00123-w
Zachary N. Coker, Maria Troyanova-Wood, Zachary A. Steelman, Bennett L. Ibey, Joel N. Bixler, Marlan O. Scully, Vladislav V. Yakovlev
Measurements and imaging of the mechanical response of biological cells are critical for understanding the mechanisms of many diseases, and for fundamental studies of energy, signal and force transduction. The recent emergence of Brillouin microscopy as a powerful non-contact, label-free way to non-invasively and non-destructively assess local viscoelastic properties provides an opportunity to expand the scope of biomechanical research to the sub-cellular level. Brillouin spectroscopy has recently been validated through static measurements of cell viscoelastic properties, however, fast (sub-second) measurements of sub-cellular cytomechanical changes have yet to be reported. In this report, we utilize a custom multimodal spectroscopy system to monitor for the very first time the rapid viscoelastic response of cells and subcellular structures to a short-duration electrical impulse. The cytomechanical response of three subcellular structures - cytoplasm, nucleoplasm, and nucleoli - were monitored, showing distinct mechanical changes despite an identical stimulus. Through this pioneering transformative study, we demonstrate the capability of Brillouin spectroscopy to measure rapid, real-time biomechanical changes within distinct subcellular compartments. Our results support the promising future of Brillouin spectroscopy within the broad scope of cellular biomechanics.
生物细胞机械响应的测量和成像对于了解许多疾病的机理以及能量、信号和力传导的基础研究至关重要。最近出现的布里渊显微镜是一种功能强大的非接触、无标记方法,可对局部粘弹性进行非侵入、非破坏性评估,为将生物力学研究范围扩展到亚细胞水平提供了机会。最近,布里渊光谱法通过静态测量细胞粘弹性特性得到了验证,然而,亚细胞细胞力学变化的快速(亚秒级)测量尚未见报道。在本报告中,我们利用定制的多模态光谱系统首次监测了细胞和亚细胞结构对短时电脉冲的快速粘弹性响应。我们监测了三种亚细胞结构--细胞质、核质和核小体--的细胞机械响应,结果显示,尽管受到相同的刺激,它们还是发生了明显的机械变化。通过这项开创性的变革研究,我们展示了布里渊光谱法测量不同亚细胞区室内快速、实时生物力学变化的能力。我们的研究结果支持了布里渊光谱学在细胞生物力学领域的广阔前景。
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引用次数: 0
Three-channel robust optical encryption via engineering coherence Stokes vector of partially coherent light 通过部分相干光的工程相干斯托克斯矢量实现三信道稳健光学加密
Q1 OPTICS Pub Date : 2024-04-03 DOI: 10.1186/s43074-024-00126-7
Yonglei Liu, Zhen Dong, Yimeng Zhu, Haiyun Wang, Fei Wang, Yahong Chen, Yangjian Cai
Optical encryption strategies utilizing fully coherent light have been widely explored but often face challenges such as speckle noise and beam instabilities. In this work, we introduce a novel protocol for multi-channel optical information encoding and encryption using vectorial spatial coherence engineering of a partially coherent light beam. By characterizing the beam’s spatial coherence structure with a $$2 times 2$$ coherence matrix, we demonstrate independent control over the three components of the coherence Stokes vector. This allows for three-channel optical information encoding and encryption, with applications in color image representation. Unlike existing methods based on fully coherent light modulations, our approach utilizes a two-point dependent coherence Stokes vector, proving resilient to random noise in experimental scenarios. Our findings provide a robust foundation for higher-dimensional optical encoding and encryption, addressing limitations associated with partially coherent light in complex environments.
利用全相干光的光学加密策略已被广泛探索,但往往面临斑点噪声和光束不稳定性等挑战。在这项工作中,我们介绍了一种利用部分相干光束的矢量空间相干工程进行多通道光信息编码和加密的新型协议。通过用 2 次 2 元相干矩阵描述光束的空间相干结构,我们展示了对相干斯托克斯矢量三个分量的独立控制。这使得三通道光学信息编码和加密成为可能,并可应用于彩色图像表示。与基于全相干光调制的现有方法不同,我们的方法利用了两点相关相干斯托克斯矢量,在实验中证明了对随机噪声的适应能力。我们的研究成果为更高维度的光学编码和加密奠定了坚实的基础,解决了复杂环境中部分相干光的局限性。
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引用次数: 0
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PhotoniX
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