Pub Date : 2024-01-29DOI: 10.58624/svoane.2024.05.0126
Samasuk Thammachantha, C. Teerapakpinyo
Background: H3 G34-mutant glioma was a new high-grade glioma, characterized by mutation of histone3.3 codon34. Currently, standard gene sequencing methods are helping in tumor diagnosis, but less expensive and faster H3 G34R/V staining method has not been studied yet in Thailand. Objectives: The purpose of this research is to find surrogate makers for diagnosing this tumor by uncomplicated immunohistochemical method. Methods: Formalin-fixed and paraffin-embedded tissue samples of 30 diffuse hemispheric gliomas were collected H3 G34R, H3 G34V, Olig2, p53 were evaluated using immunohistochemistry. Comparisons of immunohistochemical method and sequencing standard technique were made. Cost-effectiveness was analyzed. Results: Two cases of H3 G34-mutant gliomas were confirmed by mutation analysis. One case was positive for H3 G34V antibody (1/1) while another case was negative for H3 G34R (0/1). The cost-effectiveness showed that the sequencing technique prolonged turnaround time but gave a cost saving 23 USD (17%). Conclusions: G34R and G34V antibodies are not sensitive surrogate markers for diagnosing H3.3 G34-mutant gliomas. However, more samplings are yet to be tested in the future.
{"title":"Evaluation Of Surrogate Markers to Define H3 G34R/V-Mutant Gliomas","authors":"Samasuk Thammachantha, C. Teerapakpinyo","doi":"10.58624/svoane.2024.05.0126","DOIUrl":"https://doi.org/10.58624/svoane.2024.05.0126","url":null,"abstract":"Background: H3 G34-mutant glioma was a new high-grade glioma, characterized by mutation of histone3.3 codon34. Currently, standard gene sequencing methods are helping in tumor diagnosis, but less expensive and faster H3 G34R/V staining method has not been studied yet in Thailand. Objectives: The purpose of this research is to find surrogate makers for diagnosing this tumor by uncomplicated immunohistochemical method. Methods: Formalin-fixed and paraffin-embedded tissue samples of 30 diffuse hemispheric gliomas were collected H3 G34R, H3 G34V, Olig2, p53 were evaluated using immunohistochemistry. Comparisons of immunohistochemical method and sequencing standard technique were made. Cost-effectiveness was analyzed. Results: Two cases of H3 G34-mutant gliomas were confirmed by mutation analysis. One case was positive for H3 G34V antibody (1/1) while another case was negative for H3 G34R (0/1). The cost-effectiveness showed that the sequencing technique prolonged turnaround time but gave a cost saving 23 USD (17%). Conclusions: G34R and G34V antibodies are not sensitive surrogate markers for diagnosing H3.3 G34-mutant gliomas. However, more samplings are yet to be tested in the future.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":"188 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140490026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29DOI: 10.58624/svoane.2024.05.0127
Enrique Marcos Sierra Benitez
Tumors of the central nervous system (CNS) represent 2% of all neoplasms. Low-prevalence hereditary syndromes constitute only a small proportion of all cases of primary tumors of the central nervous system. Most of these syndromes have autosomal-dominant inheritance, except in the case of Turcot syndrome type 1 which has an autosomal recessive inheritance pattern. It is important in daily neurosurgical practice to be able to recognize these hereditary syndromes in order to apply the best therapeutic alternative in these patients.
{"title":"Hereditary Syndromes Associated with Brain Tumors. Literature Review.","authors":"Enrique Marcos Sierra Benitez","doi":"10.58624/svoane.2024.05.0127","DOIUrl":"https://doi.org/10.58624/svoane.2024.05.0127","url":null,"abstract":"Tumors of the central nervous system (CNS) represent 2% of all neoplasms. Low-prevalence hereditary syndromes constitute only a small proportion of all cases of primary tumors of the central nervous system. Most of these syndromes have autosomal-dominant inheritance, except in the case of Turcot syndrome type 1 which has an autosomal recessive inheritance pattern. It is important in daily neurosurgical practice to be able to recognize these hereditary syndromes in order to apply the best therapeutic alternative in these patients.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140488518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-17DOI: 10.58624/svoane.2024.05.0125
Olabisi O. Ogunleye, B. S. Makama, Haruna U. Liman, Kefas J. Bwala, Oluchukwu B. Ogunleye
Introduction: Traumatic brain injury is one of the leading causes of hospital admissions with resulting morbidity and mortality. It has become a major health problem in our environment. Mortalities from TBI vary from 10-36 per 100,000 populations and 2% death rate has been reported. The aim of this study was to study the trend of traumatic brain injury deaths within one year in our hospital. Methodology: This was a retrospective study included all deaths from traumatic brain injuries recorded within a year (December 2021 –November 2022) at our facility. The exclusion criteria were deaths from TBI occurred outside our facility but were brought in dead. Results: Forty–two deaths were recorded over a year period following traumatic brain injury (TBI) where 1,045 patients were attended to on account of TBI. The mean age of those that died from TBI was 45±15 and male had more mortality than female with 3:1. Mortality was pronounced more in 4th and 5th decades of life representing 55% of all deaths. Conclusion: TBI related deaths occurred across all age groups and the maximum number of deaths occurred in 41-50 years with Road traffic accident as the leading causes of TBI related deaths. Road safety enforcement, provision of social infrastructure like good road and provision of well-equipped health facilities with neurosurgical services closer to rural communities will reduce the mortality rate from TBI.
{"title":"Traumatic Brain Injury Deaths in Bauchi, Nigeria: A Single Center One-year Experience","authors":"Olabisi O. Ogunleye, B. S. Makama, Haruna U. Liman, Kefas J. Bwala, Oluchukwu B. Ogunleye","doi":"10.58624/svoane.2024.05.0125","DOIUrl":"https://doi.org/10.58624/svoane.2024.05.0125","url":null,"abstract":"Introduction: Traumatic brain injury is one of the leading causes of hospital admissions with resulting morbidity and mortality. It has become a major health problem in our environment. Mortalities from TBI vary from 10-36 per 100,000 populations and 2% death rate has been reported. The aim of this study was to study the trend of traumatic brain injury deaths within one year in our hospital. Methodology: This was a retrospective study included all deaths from traumatic brain injuries recorded within a year (December 2021 –November 2022) at our facility. The exclusion criteria were deaths from TBI occurred outside our facility but were brought in dead. Results: Forty–two deaths were recorded over a year period following traumatic brain injury (TBI) where 1,045 patients were attended to on account of TBI. The mean age of those that died from TBI was 45±15 and male had more mortality than female with 3:1. Mortality was pronounced more in 4th and 5th decades of life representing 55% of all deaths. Conclusion: TBI related deaths occurred across all age groups and the maximum number of deaths occurred in 41-50 years with Road traffic accident as the leading causes of TBI related deaths. Road safety enforcement, provision of social infrastructure like good road and provision of well-equipped health facilities with neurosurgical services closer to rural communities will reduce the mortality rate from TBI.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":"151 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140505047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-10DOI: 10.58624/svoane.2024.05.0124
S. Manorenj, Rindha V Rao, Reshma Sultana Shaik
An apathy syndrome is defined as a syndrome of primary motivational loss, that is, loss of motivation not attributable to emotional distress, intellectual impairment, or a diminished level of consciousness. The main anatomical correlate of apathy is the medial frontal lobe. Here we report a case of a 49-year-old male who presented with a history of lack of interest for the past 10 months without any other neurological symptoms. He was diagnosed with depression and was receiving treatment from multiple psychiatrists. In view of his persistent symptoms, he approached us and was evaluated. Examination showed anosmia with apathy that paved the way to the orbitofrontal location of the lesion. Psychiatric symptoms may be an unusual presentation of a space-occupying lesion of brain. Strong suspicion and imaging the brain is indicated in all cases to prevent the unnecessary use of psychiatric medicines and their complications.
{"title":"An Interesting Case of Chronic Isolated Apathetic Syndrome","authors":"S. Manorenj, Rindha V Rao, Reshma Sultana Shaik","doi":"10.58624/svoane.2024.05.0124","DOIUrl":"https://doi.org/10.58624/svoane.2024.05.0124","url":null,"abstract":"An apathy syndrome is defined as a syndrome of primary motivational loss, that is, loss of motivation not attributable to emotional distress, intellectual impairment, or a diminished level of consciousness. The main anatomical correlate of apathy is the medial frontal lobe. Here we report a case of a 49-year-old male who presented with a history of lack of interest for the past 10 months without any other neurological symptoms. He was diagnosed with depression and was receiving treatment from multiple psychiatrists. In view of his persistent symptoms, he approached us and was evaluated. Examination showed anosmia with apathy that paved the way to the orbitofrontal location of the lesion. Psychiatric symptoms may be an unusual presentation of a space-occupying lesion of brain. Strong suspicion and imaging the brain is indicated in all cases to prevent the unnecessary use of psychiatric medicines and their complications.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":"21 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140510710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-10DOI: 10.58624/svoane.2024.05.0123
Thomas Bogale Megerssa, R. Mahesparan
Background: Intraventricular tumors (IVT) are rare clinical entities; surgical resection remains challenging for neurosurgeons. Knowledge about the surgical outcome of these tumors in resource-limited settings is scarce. The study aims to do quality control of surgical management of IVT in a single neurosurgical center in Ethiopia. Methods: This study employed a hospital-based retrospective review of 40 patients who underwent surgical treatment for intraventricular tumors (IVT) at Tikur Anbesa Specialized Hospital between January 2015 and December 2020. Descriptive statistics used to evaluate the clinical presentation, imaging, histology, surgical approach, complications, mortality, overall survival and risk factors for poor outcome. Results: The median age was 19 years (range: 1-52 years). Headache was the most common presenting symptom (95%), followed by visual disturbance (65%). Supratentorial tumors accounted for 52.5% of cases, with medulloblastomas being the most frequent subtype (n=11). The overall complication rate was 52.5%, with hydrocephalus (40%) and infections (25%) being the most common postoperative complications. The 30-day operative mortality rate was 27.5%. Risk factors for complications and mortality included infratentorial tumor location, subtotal resection, EVD insertion, and longer ICU stay. Postoperative hydrocephalus independently predicted operative mortality. Conclusion: This study reveals higher complication and mortality rates for Intraventricular tumor (IVT) surgeries, especially for infratentorial tumors. Limited resources and experience contribute to these concerning outcomes. Postoperative hydrocephalus is identified as an independent risk factor for 30-day mortality. The findings highlight the challenges of managing IVT surgically in resource-limited settings, emphasizing the need for serious consideration and proper management to achieve better outcomes.
{"title":"Surgical Outcome of Intraventricular Tumors; A Retrospective Single Center Study in Addis Ababa, Ethiopia","authors":"Thomas Bogale Megerssa, R. Mahesparan","doi":"10.58624/svoane.2024.05.0123","DOIUrl":"https://doi.org/10.58624/svoane.2024.05.0123","url":null,"abstract":"Background: Intraventricular tumors (IVT) are rare clinical entities; surgical resection remains challenging for neurosurgeons. Knowledge about the surgical outcome of these tumors in resource-limited settings is scarce. The study aims to do quality control of surgical management of IVT in a single neurosurgical center in Ethiopia. Methods: This study employed a hospital-based retrospective review of 40 patients who underwent surgical treatment for intraventricular tumors (IVT) at Tikur Anbesa Specialized Hospital between January 2015 and December 2020. Descriptive statistics used to evaluate the clinical presentation, imaging, histology, surgical approach, complications, mortality, overall survival and risk factors for poor outcome. Results: The median age was 19 years (range: 1-52 years). Headache was the most common presenting symptom (95%), followed by visual disturbance (65%). Supratentorial tumors accounted for 52.5% of cases, with medulloblastomas being the most frequent subtype (n=11). The overall complication rate was 52.5%, with hydrocephalus (40%) and infections (25%) being the most common postoperative complications. The 30-day operative mortality rate was 27.5%. Risk factors for complications and mortality included infratentorial tumor location, subtotal resection, EVD insertion, and longer ICU stay. Postoperative hydrocephalus independently predicted operative mortality. Conclusion: This study reveals higher complication and mortality rates for Intraventricular tumor (IVT) surgeries, especially for infratentorial tumors. Limited resources and experience contribute to these concerning outcomes. Postoperative hydrocephalus is identified as an independent risk factor for 30-day mortality. The findings highlight the challenges of managing IVT surgically in resource-limited settings, emphasizing the need for serious consideration and proper management to achieve better outcomes.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":"46 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140511202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.58624/svoane.2024.05.0122
Morales Moreno Antonio Jesús, Castro Rey, Margarita del Carmen, De Felipe Pérez, Morales Albertos Laura, Uribe Reina María del Pilar, Romero del Hombrebueno Gómez del Pulgar Yara, Aldana Villamañán Ignacio, Fernández González Santiago, García Montero María, Alonso Ferrero Jair
Background and Aim: The classic definition of acute encephalitis consists of altered consciousness associated with fever, seizures or focal neurological alterations on neuroimaging or electroencephalography. However, there are particularities that may provide a glimpse of the probably autoimmune versus infectious etiology of the same neurological picture. Case presentation: A 19-month-old male starts with motor clumsiness and refusal to ambulation and leg claudication in the context of febrile pharyngotonsillitis. Simultaneously, first episode of forced gaze’s lateralization and cephalic deviation with right tonic movements and sucking. On examination: intense irritability with no contact, denial-type stereotypies, hemiparetic gait, pronation and adduction of the right arm and foot with frequent stumbling. Results: Neuroimaging tests, electroencephalogram, laboratory tests and antistreptolysin-O were normal, no pathological clinical exome and detection of antibodies in cerebrospinal fluid paired with serum. Such as diagnosis: acute autoimmune encephalitis due to anti-NMDA-R (N-methyl-D-aspartate Receptor) antibodies and movement disorder (choreoathetosis, hemidystonia). We initiate treatment with intramuscular penicillin and oral clobazam with erratic response. Fortunately, high doses of intravenous (iv) corticosteroids and immunoglobulins, oral corticotherapy and iv rituximab on our patient were used. Months later, clear improvement with autonomous ambulation without assistance, adequate manual opening and entire disappearance of dystonic-myoclonic movements. Conclusions: Choreoathetoid movements accompanied by irritability in an infectious context should lead us to think of Sydenham's chorea. However, new developments in the analysis of biological samples and a high index of suspicion may lead us to autoimmune pathology and the consequent early use of immunotherapy with optimal results.
{"title":"A 19-Month-Old Spanish Boy with Anti-NMDAR Encephalitis: Case Report and Review of Literature","authors":"Morales Moreno Antonio Jesús, Castro Rey, Margarita del Carmen, De Felipe Pérez, Morales Albertos Laura, Uribe Reina María del Pilar, Romero del Hombrebueno Gómez del Pulgar Yara, Aldana Villamañán Ignacio, Fernández González Santiago, García Montero María, Alonso Ferrero Jair","doi":"10.58624/svoane.2024.05.0122","DOIUrl":"https://doi.org/10.58624/svoane.2024.05.0122","url":null,"abstract":"Background and Aim: The classic definition of acute encephalitis consists of altered consciousness associated with fever, seizures or focal neurological alterations on neuroimaging or electroencephalography. However, there are particularities that may provide a glimpse of the probably autoimmune versus infectious etiology of the same neurological picture. Case presentation: A 19-month-old male starts with motor clumsiness and refusal to ambulation and leg claudication in the context of febrile pharyngotonsillitis. Simultaneously, first episode of forced gaze’s lateralization and cephalic deviation with right tonic movements and sucking. On examination: intense irritability with no contact, denial-type stereotypies, hemiparetic gait, pronation and adduction of the right arm and foot with frequent stumbling. Results: Neuroimaging tests, electroencephalogram, laboratory tests and antistreptolysin-O were normal, no pathological clinical exome and detection of antibodies in cerebrospinal fluid paired with serum. Such as diagnosis: acute autoimmune encephalitis due to anti-NMDA-R (N-methyl-D-aspartate Receptor) antibodies and movement disorder (choreoathetosis, hemidystonia). We initiate treatment with intramuscular penicillin and oral clobazam with erratic response. Fortunately, high doses of intravenous (iv) corticosteroids and immunoglobulins, oral corticotherapy and iv rituximab on our patient were used. Months later, clear improvement with autonomous ambulation without assistance, adequate manual opening and entire disappearance of dystonic-myoclonic movements. Conclusions: Choreoathetoid movements accompanied by irritability in an infectious context should lead us to think of Sydenham's chorea. However, new developments in the analysis of biological samples and a high index of suspicion may lead us to autoimmune pathology and the consequent early use of immunotherapy with optimal results.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":"28 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140512520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-02DOI: 10.58624/svoane.2024.05.0120
Alshimaa Asran
Poststroke fatigue (PSF) is a common complication affecting a wide range of stroke patients, yet it remains under-reported and underestimated. PSF's exact underlying cause has not yet been identified and it seems to be multifactorial, with several models developed to answer that question. Identifying the true nature of PSF and its risk factors would help improve the quality of life of stroke patients.
{"title":"Fatigue Models and Poststroke Fatigue: A Literature Review","authors":"Alshimaa Asran","doi":"10.58624/svoane.2024.05.0120","DOIUrl":"https://doi.org/10.58624/svoane.2024.05.0120","url":null,"abstract":"Poststroke fatigue (PSF) is a common complication affecting a wide range of stroke patients, yet it remains under-reported and underestimated. PSF's exact underlying cause has not yet been identified and it seems to be multifactorial, with several models developed to answer that question. Identifying the true nature of PSF and its risk factors would help improve the quality of life of stroke patients.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":"63 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139390101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-02DOI: 10.58624/svoane.2024.05.0121
S. Bahrami
Neurologic music therapy (NMT) has proven instrumental in aiding recovery from complications in patients with a diverse range of neurologic diseases. Integrating music and virtual reality with standard rehabilitation therapies enhances patient compliance and makes therapy more enjoyable. The act of listening to music not only reduces epileptiform discharges but also amplifies brain plasticity. Moreover, music induces discernible variations in brain anatomy between musicians and non-musicians. As a cost-effective intervention, music therapy significantly contributes to the accelerated and efficient recovery of post-stroke patients, particularly when applied promptly after the event. Substantial evidence supports the integration of music into rehabilitation programs, facilitating the recovery of hand function, dexterity, spatial movement, cognitive function, mood, coordination, stride length, and memory. Techniques such as learning words as lyrics, melodic intonation therapy, and singing play crucial roles in expediting recovery for aphasic patients. Recognized by the World Rehabilitation Federation, NMT therapists are valuable members of the rehabilitation team. The approval of NMT as an effective, evidence-based treatment method underscores its significance in enhancing patient outcomes.
{"title":"Utilizing Music Therapy for Enhanced Recovery from Neurologic Disease Complications","authors":"S. Bahrami","doi":"10.58624/svoane.2024.05.0121","DOIUrl":"https://doi.org/10.58624/svoane.2024.05.0121","url":null,"abstract":"Neurologic music therapy (NMT) has proven instrumental in aiding recovery from complications in patients with a diverse range of neurologic diseases. Integrating music and virtual reality with standard rehabilitation therapies enhances patient compliance and makes therapy more enjoyable. The act of listening to music not only reduces epileptiform discharges but also amplifies brain plasticity. Moreover, music induces discernible variations in brain anatomy between musicians and non-musicians. As a cost-effective intervention, music therapy significantly contributes to the accelerated and efficient recovery of post-stroke patients, particularly when applied promptly after the event. Substantial evidence supports the integration of music into rehabilitation programs, facilitating the recovery of hand function, dexterity, spatial movement, cognitive function, mood, coordination, stride length, and memory. Techniques such as learning words as lyrics, melodic intonation therapy, and singing play crucial roles in expediting recovery for aphasic patients. Recognized by the World Rehabilitation Federation, NMT therapists are valuable members of the rehabilitation team. The approval of NMT as an effective, evidence-based treatment method underscores its significance in enhancing patient outcomes.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":"34 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140515584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-08DOI: 10.58624/svoane.2023.04.0115
Erika Juliani, Matthew Calestino
We report a case of Creutzfeldt-Jakob disease with acute onset of symptoms with EEG negative for PSWC, resembling a cerebrovascular accident. The patient was diagnosed with sporadic CJD by positive RT-QUIC, positive 14-3-3 protein, T-Tau protein of 14560 pg/mL, brain magnetic resonance imaging (MRI) demonstrating restricted diffusion on DWI in bilateral frontal, temporal, occipital cortex, caudate and putaminal nuclei, as well as T2 FLAIR hyperintensities in the bilateral cerebral cortex and basal ganglia. The entire course of the disease from onset to death was 52 days.
{"title":"Acute Onset of Creutzfeldt-Jakob Disease Resembling Stroke in Absence of Diagnostic EEG Findings","authors":"Erika Juliani, Matthew Calestino","doi":"10.58624/svoane.2023.04.0115","DOIUrl":"https://doi.org/10.58624/svoane.2023.04.0115","url":null,"abstract":"We report a case of Creutzfeldt-Jakob disease with acute onset of symptoms with EEG negative for PSWC, resembling a cerebrovascular accident. The patient was diagnosed with sporadic CJD by positive RT-QUIC, positive 14-3-3 protein, T-Tau protein of 14560 pg/mL, brain magnetic resonance imaging (MRI) demonstrating restricted diffusion on DWI in bilateral frontal, temporal, occipital cortex, caudate and putaminal nuclei, as well as T2 FLAIR hyperintensities in the bilateral cerebral cortex and basal ganglia. The entire course of the disease from onset to death was 52 days.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":"44 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139010904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.58624/svoane.2023.04.0114
César Chong Loor, Andrea Chong Zambrano
Male patient, 38 years old, with a history of previous surgical intervention in another center for brain lesion in the left fronto-parietal region, who had undergone a biopsy, with a result of failed pathological anatomy (he had no diagnosis). In the neurological examination, the patient was conscious, oriented in the three spheres, without neurological deficit, Glasgow 15/15. In the cranial MRI was observed in the left fronto-parietal subcortical region a hypointense lesion on T1, and an irregular hyperintense image in relation to the midline on T2, which did not uptake the contrast medium. Surgical intervention was performed, with a biopsy guided by the neuronavigation system (Brain Lab Curve) using a trephine less than 1 cm and the target planned by fusion of PET scan choline (Positron Emission Tomography) and contrasted cranial MRI, the most representative sample of the lesion was taken where observed the maximum affinity of the lesion for radioactive choline. The Pathological Anatomy result was low grade Astrocytoma, establishing a diagnosis. Control cranial CT scan 6 hours post-operatively, which determined the planned biopsy sample site. The post-surgical evolution was satisfactory, Glasgow 15/15, without neurological deficit. It has been proposed to continue treatment for these cases. In cases of complex lesions where CT and MRI cannot offer adequate resolution through imaging of the lesion, PET scan choline can offer an option to plan an appropriate biopsy of the lesion and obtain representativeness and obtain the best diagnosis. We recommend the use of PET scan in these cases.
{"title":"Positron Emission Tomography (PET Scan) in NeuronavigationGuided Biopsy of Complex Brain Tumors","authors":"César Chong Loor, Andrea Chong Zambrano","doi":"10.58624/svoane.2023.04.0114","DOIUrl":"https://doi.org/10.58624/svoane.2023.04.0114","url":null,"abstract":"Male patient, 38 years old, with a history of previous surgical intervention in another center for brain lesion in the left fronto-parietal region, who had undergone a biopsy, with a result of failed pathological anatomy (he had no diagnosis). In the neurological examination, the patient was conscious, oriented in the three spheres, without neurological deficit, Glasgow 15/15. In the cranial MRI was observed in the left fronto-parietal subcortical region a hypointense lesion on T1, and an irregular hyperintense image in relation to the midline on T2, which did not uptake the contrast medium. Surgical intervention was performed, with a biopsy guided by the neuronavigation system (Brain Lab Curve) using a trephine less than 1 cm and the target planned by fusion of PET scan choline (Positron Emission Tomography) and contrasted cranial MRI, the most representative sample of the lesion was taken where observed the maximum affinity of the lesion for radioactive choline. The Pathological Anatomy result was low grade Astrocytoma, establishing a diagnosis. Control cranial CT scan 6 hours post-operatively, which determined the planned biopsy sample site. The post-surgical evolution was satisfactory, Glasgow 15/15, without neurological deficit. It has been proposed to continue treatment for these cases. In cases of complex lesions where CT and MRI cannot offer adequate resolution through imaging of the lesion, PET scan choline can offer an option to plan an appropriate biopsy of the lesion and obtain representativeness and obtain the best diagnosis. We recommend the use of PET scan in these cases.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138610162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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