Pub Date : 2023-05-02DOI: 10.58624/svoane.2023.04.090
Damian Lastra Copello
Objective: Gliomas are the most common primary malignant tumors of the central nervous system (CNS) and, from them, 45.6 % corresponds to glioblastomas (GB). This work aims to determine the results of treatment for patients with glioblastomas treated at the “Hermanos Ameijeiras” Hospital, Cuba, in the period from January 2015 to December 2020. Method: An observational, descriptive, retrospective cohort assessment was carried out in a population of 45 patients treated at the “Hermanos Ameijeiras” Hospital, Cuba, with a diagnosis of glioblastoma. Results: Male patients aged 40 to 59 years (57.7 %) with white color skin (82 %) were predominant with clinical symptoms of motor deficit syndrome. The survival rate was greater than 12 months in 18 patients (40 %), while for 21 patients (46.7 %) it was between 6 and 12 months. Conclusions: Glioblastoma is a challenge for the multidisciplinary medical team. The best therapeutic results and survival rates are related to the strategies of a multimodal treatment that begins with maximum safe resection of the lesion, followed by radiotherapy, chemotherapy and immunotherapy oncological treatments.
{"title":"Glioblastoma, Treatment Strategies at the \"Hermanos Ameijeiras\" Hospital.","authors":"Damian Lastra Copello","doi":"10.58624/svoane.2023.04.090","DOIUrl":"https://doi.org/10.58624/svoane.2023.04.090","url":null,"abstract":"Objective: Gliomas are the most common primary malignant tumors of the central nervous system (CNS) and, from them, 45.6 % corresponds to glioblastomas (GB). This work aims to determine the results of treatment for patients with glioblastomas treated at the “Hermanos Ameijeiras” Hospital, Cuba, in the period from January 2015 to December 2020. Method: An observational, descriptive, retrospective cohort assessment was carried out in a population of 45 patients treated at the “Hermanos Ameijeiras” Hospital, Cuba, with a diagnosis of glioblastoma. Results: Male patients aged 40 to 59 years (57.7 %) with white color skin (82 %) were predominant with clinical symptoms of motor deficit syndrome. The survival rate was greater than 12 months in 18 patients (40 %), while for 21 patients (46.7 %) it was between 6 and 12 months. Conclusions: Glioblastoma is a challenge for the multidisciplinary medical team. The best therapeutic results and survival rates are related to the strategies of a multimodal treatment that begins with maximum safe resection of the lesion, followed by radiotherapy, chemotherapy and immunotherapy oncological treatments.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47089534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-20DOI: 10.58624/svoane.2023.04.088
Ignacio Saguier Padilla, Juan Cao, Santiago Cutillier, Carolina E. Siracusa, D. Gestro, M. Figuerola, Lidia Saroto
The pathogenesis of Adie's pupil would be postganglionic parasympathetic dysfunction, with no defined cause. There are some case reports of its association with migraine. Few cases of anisocoria secondary to non-aneurysmal neurovascular conflict of the III pair due to preganglionic deficit with response to pilocarpine 0.125% have also been reported. We present the case of a patient with anisocoria, migraine without aura and neurovascular conflict, diagnosed with Adie's pupil.
{"title":"Adie's Pupil, Migraine, and Neurovascular Conflict of the III Nerve in a Young Patient. Case Report","authors":"Ignacio Saguier Padilla, Juan Cao, Santiago Cutillier, Carolina E. Siracusa, D. Gestro, M. Figuerola, Lidia Saroto","doi":"10.58624/svoane.2023.04.088","DOIUrl":"https://doi.org/10.58624/svoane.2023.04.088","url":null,"abstract":"The pathogenesis of Adie's pupil would be postganglionic parasympathetic dysfunction, with no defined cause. There are some case reports of its association with migraine. Few cases of anisocoria secondary to non-aneurysmal neurovascular conflict of the III pair due to preganglionic deficit with response to pilocarpine 0.125% have also been reported. We present the case of a patient with anisocoria, migraine without aura and neurovascular conflict, diagnosed with Adie's pupil.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43169044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.58624/svoane.2023.04.087
F. Palavra, Ana Moura Figueiredo, Laura Correia, J. Ribeiro, Cristina Pereira
Introduction: “Alice In Wonderland Syndrome” (AIWS) is characterized by episodes of distorted perceptions or temporal/spatial changes. The pathophysiological mechanism is not well defined. However, some authors argue that it is a rare perceptive disturbance, which affects mainly associative sensorial cortex integration mechanisms, involved in internal-external relationship development. It was initially described in migraine and/or epilepsy patients. Infections are considered the main cause of AIWS in children, and it can occur before, during or after the contact with the microorganism. COVID-19 is the disease caused by the SARS-CoV-2 virus, which can be linked with neurological manifestations. Clinical case reports: Three children, between 6 and 11 years of age, previously healthy and without personal or familiar history of migraine and/or epilepsy, were observed in Neuropediatrics consultations because of visual changes, described as corresponding to macropsia, micropsia, teleopsia and pelopsia. In two of the cases, symptoms began during SARS-CoV-2 infection and, in the other one, a week after the disease. Every episode lasted a few minutes and resolved spontaneously in a few days. Discussion: No complementary exams are needed to diagnose AIWS. Nevertheless, when paroxysmic visual changes are present, other aetiologies frequently need to be excluded. Generally, episodes are self-limited, and symptoms completely resolve, with a long-term good prognosis. Until this moment, AIWS has not been linked to COVID-19. However, in this case reports, SARS-CoV-2 was the only identified trigger. Similarly to other viruses, like EBV or H1N1, cerebral hypoperfusion by hypoxemia and/or by pro-inflammatory cytokines action in response to SARS-CoV-2 are possible underlying pathophysiological mechanisms.
{"title":"Alice in Wonderland Syndrome and Covid-19: A Report of Three Cases","authors":"F. Palavra, Ana Moura Figueiredo, Laura Correia, J. Ribeiro, Cristina Pereira","doi":"10.58624/svoane.2023.04.087","DOIUrl":"https://doi.org/10.58624/svoane.2023.04.087","url":null,"abstract":"Introduction: “Alice In Wonderland Syndrome” (AIWS) is characterized by episodes of distorted perceptions or temporal/spatial changes. The pathophysiological mechanism is not well defined. However, some authors argue that it is a rare perceptive disturbance, which affects mainly associative sensorial cortex integration mechanisms, involved in internal-external relationship development. It was initially described in migraine and/or epilepsy patients. Infections are considered the main cause of AIWS in children, and it can occur before, during or after the contact with the microorganism. COVID-19 is the disease caused by the SARS-CoV-2 virus, which can be linked with neurological manifestations. Clinical case reports: Three children, between 6 and 11 years of age, previously healthy and without personal or familiar history of migraine and/or epilepsy, were observed in Neuropediatrics consultations because of visual changes, described as corresponding to macropsia, micropsia, teleopsia and pelopsia. In two of the cases, symptoms began during SARS-CoV-2 infection and, in the other one, a week after the disease. Every episode lasted a few minutes and resolved spontaneously in a few days. Discussion: No complementary exams are needed to diagnose AIWS. Nevertheless, when paroxysmic visual changes are present, other aetiologies frequently need to be excluded. Generally, episodes are self-limited, and symptoms completely resolve, with a long-term good prognosis. Until this moment, AIWS has not been linked to COVID-19. However, in this case reports, SARS-CoV-2 was the only identified trigger. Similarly to other viruses, like EBV or H1N1, cerebral hypoperfusion by hypoxemia and/or by pro-inflammatory cytokines action in response to SARS-CoV-2 are possible underlying pathophysiological mechanisms.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43836527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.58624/svoane.2023.04.086
Yurledys Jhohana Linares Benavides, D. Casas, Orestes Ramón López Piloto, Bianchy González Pérez, Moises Banks Díaz, Gustavo Guerrero Guerrero, Oscar Estrada Camacho, Claudia La O Cruz, Abdul-Aziz Mahama
The tuberculum sellae meningiomas represent between 5-10% of intracranial meningiomas, most frequently between the 5th and 6th decade of life. Bitemporal hemianopia, associated with optic atrophy, represents the most frequently found clinic symptoms. Treatment is usually surgical resection of the tumor either by transcranial or endoscopic endonasal approach. A case of a 44-year-old female patient who presented with a clinical symptoms of 5 months duration, characterized by progressive visual disorder caused by blurred vision on the left eye, associated with low-grade frontal headache, with simple cranial MRI study with evidence of T1 hyperintense lesion in the sellar region with an apparent dural tail that sits at the level of the sellar tubercle, and moves towards the posterior pituitary gland and pituitary stalk.
{"title":"Pterional Approach for A Tuberculum Sellae Meningioma: A Case Report","authors":"Yurledys Jhohana Linares Benavides, D. Casas, Orestes Ramón López Piloto, Bianchy González Pérez, Moises Banks Díaz, Gustavo Guerrero Guerrero, Oscar Estrada Camacho, Claudia La O Cruz, Abdul-Aziz Mahama","doi":"10.58624/svoane.2023.04.086","DOIUrl":"https://doi.org/10.58624/svoane.2023.04.086","url":null,"abstract":"The tuberculum sellae meningiomas represent between 5-10% of intracranial meningiomas, most frequently between the 5th and 6th decade of life. Bitemporal hemianopia, associated with optic atrophy, represents the most frequently found clinic symptoms. Treatment is usually surgical resection of the tumor either by transcranial or endoscopic endonasal approach. A case of a 44-year-old female patient who presented with a clinical symptoms of 5 months duration, characterized by progressive visual disorder caused by blurred vision on the left eye, associated with low-grade frontal headache, with simple cranial MRI study with evidence of T1 hyperintense lesion in the sellar region with an apparent dural tail that sits at the level of the sellar tubercle, and moves towards the posterior pituitary gland and pituitary stalk.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42480831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-14DOI: 10.58624/svoane.2023.04.085
H. N, B. K, D. M
We report the case of a 37 year old female patient who had got high-dose irradiation after subtotal removal of an ependymoma in posterior cerebral fossa. 16 years later a temporal meningioma is diagnosed and removed surgically. In this case the following meningioma fulfills the criteria for a radiation-induced tumor. There exist many reports about tumors of the central nervous system which have developed after radiotherapy in the irradiated field after a latency period. But after a thorough review of the international literature about radiation-induced tumors of the CNS is this the five cases in which a benign meningioma has followed a radiotherapy for an ependymoma.
{"title":"Radio Induced Temporal Meningioma: A Rare Case Report and Literature Review","authors":"H. N, B. K, D. M","doi":"10.58624/svoane.2023.04.085","DOIUrl":"https://doi.org/10.58624/svoane.2023.04.085","url":null,"abstract":"We report the case of a 37 year old female patient who had got high-dose irradiation after subtotal removal of an ependymoma in posterior cerebral fossa. 16 years later a temporal meningioma is diagnosed and removed surgically. In this case the following meningioma fulfills the criteria for a radiation-induced tumor. There exist many reports about tumors of the central nervous system which have developed after radiotherapy in the irradiated field after a latency period. But after a thorough review of the international literature about radiation-induced tumors of the CNS is this the five cases in which a benign meningioma has followed a radiotherapy for an ependymoma.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46312379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-10DOI: 10.58624/svoane.2023.04.084
Panagiotis Gklinos
Hyperosmolar hyperglycemic state (HHS), a life-threatening complication of diabetes mellitus, may initially manifest with a broad spectrum of neurological symptoms. These include encephalopathy, coma, chorea-hemiballismus and epileptic activity. Focal motor seizures are among the most common manifestations whilst aphasia has rarely been described so far. Based on a recent experience from our hospital, we herein report a rare case of a patient with nonketotic hyperglycemia-induced global aphasia, followed by focal motor seizures and attempt a comprehensive review of the literature with regards to the various neurological syndromes through which, undiagnosed diabetes and HHS may present. Neurological aspects of HHS are not so well-documented and are certainly under-represented in the literature.
{"title":"Neurological Manifestations of Hyperosmolar Hyperglycemic State: A Case Report and A Review of the Literature","authors":"Panagiotis Gklinos","doi":"10.58624/svoane.2023.04.084","DOIUrl":"https://doi.org/10.58624/svoane.2023.04.084","url":null,"abstract":"Hyperosmolar hyperglycemic state (HHS), a life-threatening complication of diabetes mellitus, may initially manifest with a broad spectrum of neurological symptoms. These include encephalopathy, coma, chorea-hemiballismus and epileptic activity. Focal motor seizures are among the most common manifestations whilst aphasia has rarely been described so far. Based on a recent experience from our hospital, we herein report a rare case of a patient with nonketotic hyperglycemia-induced global aphasia, followed by focal motor seizures and attempt a comprehensive review of the literature with regards to the various neurological syndromes through which, undiagnosed diabetes and HHS may present. Neurological aspects of HHS are not so well-documented and are certainly under-represented in the literature.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46924144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-07DOI: 10.58624/svoane.2023.04.083
Y. Felissi
Apoplexy is relatively a rare clinical expression or revelation of pituitary adenoma. Necrotic apoplexy is a subgroup with unique findings in its different aspects. Early surgical resection through the transsphenoidal route is the main modality for their management. We report three cases of patients with necrotic apoplexy. we reviewed the circumstances of revelation, the imaging features, surgical findings, and the results of histological analysis. The age of patients ranged between 22 and 53 years old. All patients complained of headaches and visual disorders. At the MRI evaluation, they had the same radiological features of necrotic apoplexy. They received endoscopic endonasal surgery for the resection and the histological analysis confirmed the presence of necrosis areas in the sampled tissues. Necrotic apoplexy is a rare and unique clinical entity. At the imaging, it appears as a solid sellar mass, iso to hyperintense in both sequences T1 and T2. during the surgical removal, the lesion is yellowish and poorly bleeding without hemorrhagic contents. The histological studies reveal large areas of necrosis in similar lesions.
{"title":"Necrotic Apoplexy of Pituitary Adenoma; A Report of Three Cases","authors":"Y. Felissi","doi":"10.58624/svoane.2023.04.083","DOIUrl":"https://doi.org/10.58624/svoane.2023.04.083","url":null,"abstract":"Apoplexy is relatively a rare clinical expression or revelation of pituitary adenoma. Necrotic apoplexy is a subgroup with unique findings in its different aspects. Early surgical resection through the transsphenoidal route is the main modality for their management. We report three cases of patients with necrotic apoplexy. we reviewed the circumstances of revelation, the imaging features, surgical findings, and the results of histological analysis. The age of patients ranged between 22 and 53 years old. All patients complained of headaches and visual disorders. At the MRI evaluation, they had the same radiological features of necrotic apoplexy. They received endoscopic endonasal surgery for the resection and the histological analysis confirmed the presence of necrosis areas in the sampled tissues. Necrotic apoplexy is a rare and unique clinical entity. At the imaging, it appears as a solid sellar mass, iso to hyperintense in both sequences T1 and T2. during the surgical removal, the lesion is yellowish and poorly bleeding without hemorrhagic contents. The histological studies reveal large areas of necrosis in similar lesions.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45498757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-12DOI: 10.58624/svoane.2022.03.065
Abbasi Hina Naz
We present a rare case of acute anti NMDAR encephalitis after COVID - 19 vaccination (Sinopharm). On literature review only 1 such case has been reported so far. Our patient initially presented with flu like symptoms and generalized weakness which started 1 day after COVID - 19 vaccine. 3 weeks later she received second dose of vaccine which led to worsening of her symptoms including progressive cognitive decline. She eventually deteriorated and required ICU management for 2 months due to depressed level of consciousness, respiratory and hemodynamic instability requiring intubation and ventilation support. During course of disease, she had clinical features consistent with NMDA encephalitis including constitutional symptoms, memory disturbance, confusion, fish mouthing movement and seizures requiring treatment with anti - epileptic medications. Diagnosis was confirmed after CSF NMDA testing as blood NMDA test was negative. The patient was treated with high dose steroids, IVIg, TPLEX and finally Rituximab. She responded very well to the complex treatment.
{"title":"Acute Anti-N-Methyl D-Aspartate Receptor Encephalitis Following Covid-19 Vaccination","authors":"Abbasi Hina Naz","doi":"10.58624/svoane.2022.03.065","DOIUrl":"https://doi.org/10.58624/svoane.2022.03.065","url":null,"abstract":"We present a rare case of acute anti NMDAR encephalitis after COVID - 19 vaccination (Sinopharm). On literature review only 1 such case has been reported so far. Our patient initially presented with flu like symptoms and generalized weakness which started 1 day after COVID - 19 vaccine. 3 weeks later she received second dose of vaccine which led to worsening of her symptoms including progressive cognitive decline. She eventually deteriorated and required ICU management for 2 months due to depressed level of consciousness, respiratory and hemodynamic instability requiring intubation and ventilation support. During course of disease, she had clinical features consistent with NMDA encephalitis including constitutional symptoms, memory disturbance, confusion, fish mouthing movement and seizures requiring treatment with anti - epileptic medications. Diagnosis was confirmed after CSF NMDA testing as blood NMDA test was negative. The patient was treated with high dose steroids, IVIg, TPLEX and finally Rituximab. She responded very well to the complex treatment.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49140484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-24DOI: 10.58624/svoane.2022.02.026
Rolando Lovaton
Amebic encephalitis is a rare and devastating disease. Mortality rate is almost 90% of cases. Here is described a very rare case of bacterial brain abscess in a patient with recent diagnosis of granulomatous amebic encephalitis. Case Description: A 29 - year - old woman presented with headache, right hemiparesis and tonic - clonic seizure. Patient was diagnosed with granulomatous amebic encephalitis due to Acanthamoeba spp.; although, there was no improvement of symptoms in spite of stablished treatment. Three months after initial diagnosis, a brain MRI showed a ring - enhancing lesion in the left frontal lobe compatible with brain abscess. Patient was scheduled for surgical evacuation and brain abscess was confirmed intraoperatively. However, Gram staining of the purulent content showed gram - positive cocci. Patient improved headache and focal deficit after surgery. Conclusion: It is the first reported case of a patient with central nervous system infection secondary to Acanthamoeba spp. who presented a bacterial brain abscess in a short time.
{"title":"Bacterial Brain Abscess in a Patient with Granulomatous Amebic Encephalitis. A Misdiagnosis or Free-Living Amoeba Acting as Trojan Horse?","authors":"Rolando Lovaton","doi":"10.58624/svoane.2022.02.026","DOIUrl":"https://doi.org/10.58624/svoane.2022.02.026","url":null,"abstract":"Amebic encephalitis is a rare and devastating disease. Mortality rate is almost 90% of cases. Here is described a very rare case of bacterial brain abscess in a patient with recent diagnosis of granulomatous amebic encephalitis. Case Description: A 29 - year - old woman presented with headache, right hemiparesis and tonic - clonic seizure. Patient was diagnosed with granulomatous amebic encephalitis due to Acanthamoeba spp.; although, there was no improvement of symptoms in spite of stablished treatment. Three months after initial diagnosis, a brain MRI showed a ring - enhancing lesion in the left frontal lobe compatible with brain abscess. Patient was scheduled for surgical evacuation and brain abscess was confirmed intraoperatively. However, Gram staining of the purulent content showed gram - positive cocci. Patient improved headache and focal deficit after surgery. Conclusion: It is the first reported case of a patient with central nervous system infection secondary to Acanthamoeba spp. who presented a bacterial brain abscess in a short time.","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47423948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amro Saad Aldine, Amy Ogilvie, John Wemmie, James Kent, Jordan Schultz, Jeffrey D Long, John Kamholz, Hassan Sajjad, Joel Kline, Emily Shaw, Michelle Voss, Jane S Paulsen, Vincent A Magnotta
Background: While it has been shown that aerobic exercise interventions are well tolerated in participants with the Huntington disease (HD) gene mutation, no study to date has tested whether an aerobic exercise intervention benefits brain structure and function in pre-manifest HD.
Objective: In this study we utilized magnetic resonance (MR) imaging techniques to assess the efficacy of moderate-to-vigorous exercise treatment relative to active stretching and toning control.
Methods: Forty pre-manifest participants with confirmed HD gene expansion were recruited into a two-arm intervention study that included a moderate-to-vigorous intensity home-based walking exercise intervention (N=34) and an active stretching and toning control intervention (N=6). Participants were assessed at baseline and after 26 weeks in one of the two study arms.
Results: 25 of the 34 (74%) participants assigned to the moderate-to-vigorous intensity group completed the intervention while 4 of the 6 (67%) participants in the stretching and toning intervention completed the study. The primary analyses compared the two arms of the study and found no statistical differences between the groups. Both groups were found to have improved their cardiorespiratory fitness as assessed by maximal oxygen uptake (VO2max). A secondary analysis combined the two arms of the study and there was a significant relationship (p<0.05) between change in VO2max and change in brain structure.
Conclusions: Though this study did not show efficacy for the exercise intervention, secondary results suggest that aerobic exercise interventions increasing cardiorespiratory fitness may be a potential way to slow progression in pre-manifest HD.
{"title":"Moderate Intensity Exercise in Pre-manifest Huntington's Disease: Results of a 6 months Trial.","authors":"Amro Saad Aldine, Amy Ogilvie, John Wemmie, James Kent, Jordan Schultz, Jeffrey D Long, John Kamholz, Hassan Sajjad, Joel Kline, Emily Shaw, Michelle Voss, Jane S Paulsen, Vincent A Magnotta","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>While it has been shown that aerobic exercise interventions are well tolerated in participants with the Huntington disease (HD) gene mutation, no study to date has tested whether an aerobic exercise intervention benefits brain structure and function in pre-manifest HD.</p><p><strong>Objective: </strong>In this study we utilized magnetic resonance (MR) imaging techniques to assess the efficacy of moderate-to-vigorous exercise treatment relative to active stretching and toning control.</p><p><strong>Methods: </strong>Forty pre-manifest participants with confirmed HD gene expansion were recruited into a two-arm intervention study that included a moderate-to-vigorous intensity home-based walking exercise intervention (N=34) and an active stretching and toning control intervention (N=6). Participants were assessed at baseline and after 26 weeks in one of the two study arms.</p><p><strong>Results: </strong>25 of the 34 (74%) participants assigned to the moderate-to-vigorous intensity group completed the intervention while 4 of the 6 (67%) participants in the stretching and toning intervention completed the study. The primary analyses compared the two arms of the study and found no statistical differences between the groups. Both groups were found to have improved their cardiorespiratory fitness as assessed by maximal oxygen uptake (VO<sub>2</sub>max). A secondary analysis combined the two arms of the study and there was a significant relationship (p<0.05) between change in VO<sub>2</sub>max and change in brain structure.</p><p><strong>Conclusions: </strong>Though this study did not show efficacy for the exercise intervention, secondary results suggest that aerobic exercise interventions increasing cardiorespiratory fitness may be a potential way to slow progression in pre-manifest HD.</p>","PeriodicalId":93502,"journal":{"name":"SVOA neurology","volume":"2 1","pages":"6-36"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39895898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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