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Paraparesis Secondary to Microscopic Polyangiitis Resistantto Corticosteroids. Report of a Case 耐糖皮质激素的显微镜下多血管炎继发的肺截瘫。个案报告
Pub Date : 2023-10-30 DOI: 10.58624/svoane.2023.04.0109
Ignacio Saguier Padilla, Cinthya Reznik, María Eugenia Conti, Flavio Mercado, Agustina Causillas, Micaela Blanco, Ricardo Barcia
Microscopic polyangiitis (MPA) is an ANCA-associated vasculitis. Almost half of the patients may present with involvement of the peripheral nervous system such as mononeuropathy or polyneuropathy. The initial treatment is with corticosteroids, and up to 30% are non-responders, where other treatments should be used. Rapidly progressive renal failure and intestinal ischemia are usually high-mortality complications.
显微多血管炎(MPA)是一种与anca相关的血管炎。几乎一半的患者可能表现为累及周围神经系统,如单神经病变或多神经病变。最初的治疗是使用皮质类固醇,高达30%的患者无反应,应使用其他治疗方法。快速进展性肾衰竭和肠缺血通常是高死亡率的并发症。
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引用次数: 0
Pain Management in Patients with Hepatorenal Syndrome: A Literature Review 肝肾综合征患者的疼痛管理:文献综述
Pub Date : 2023-10-30 DOI: 10.58624/svoane.2023.04.0108
Jeremy Eckes, Karla Romero-Chacon
Introduction: Patients with cirrhosis often present with pain as a common complaint. Pharmacological pain management safety depends on the excretion and metabolism of drugs by the kidney and the liver. The analgesic choice in cirrhotic patients can be tremendously challenging, especially in patients with hepatorenal syndrome, a potentially reversible renal impairment associated with an increased drug accumulation and a high risk of potential toxicity. Choice and dose of medications depend on various factors, including the severity of the condition, possible drug interactions, drug dependence, and liver transplant status. Ideally, medications should be titrated from the lowest effective dose to higher strength. This review aims to discuss the pharmacodynamic and pharmacokinetics of analgesics used in cirrhotic patients. The metabolism of each drug, route of administration, pathophysiology, and limitations of their use are discussed to better understand their implementation in patients with cirrhosis and HRS. For this purpose, we performed a systematic literature search in PubMed and Google Scholar. Articles were searched via search terms and keywords. Certain high potency opioids like Sufentanil, Fentanyl, Remifentanil, Oxymorphone, and Butorphanol can be used cautiously. Low potency opioids such as Pentazocine, Tramadol, Nalbuphine, and Tapentadol may also be considered with dose adjustments. Albeit less favorable, some other analgesic options include Gabapentin, Pregabalin, acetaminophen, Duloxetine, Venlafaxine, Fluoxetine, Topical Lidocaine, Capsaicin, and Clonidine. Methodology: A systematic literature search in PubMed and google scholar was conducted between March 5 and August 10, 2021. Articles were searched via search terms and keywords relating to International Classification of Diseases: hepatorenal syndrome, pain, opioids, metabolism, renal clearance. Results: One thousand three hundred eighty-seven articles were identified from database searching. After removal of duplicates, 924 studies were screened for eligibility. After review of titles and abstracts, 665 studies were rejected for relevance reasons. Most of these studies were rejected because they were not relevant, did not meet search criteria, case-control article, case series articles, no English translation, articles did not mention adjustments in patients with liver or kidney disease. One hundred forty-two articles were used for the synthesis.
肝硬化患者常以疼痛为常见主诉。药物疼痛管理的安全性取决于肾脏和肝脏对药物的排泄和代谢。肝硬化患者的镇痛选择可能非常具有挑战性,特别是患有肝肾综合征的患者,这是一种潜在可逆的肾脏损害,与药物积累增加和潜在毒性的高风险相关。药物的选择和剂量取决于多种因素,包括病情的严重程度、可能的药物相互作用、药物依赖和肝移植状态。理想情况下,药物应该从最低有效剂量滴定到更高的剂量。本综述旨在探讨肝硬化患者使用的镇痛药的药效学和药代动力学。讨论了每种药物的代谢、给药途径、病理生理学和使用局限性,以更好地了解它们在肝硬化和HRS患者中的应用。为此,我们在PubMed和Google Scholar中进行了系统的文献检索。文章通过搜索词和关键词进行搜索。某些高效阿片类药物,如舒芬太尼、芬太尼、瑞芬太尼、羟吗啡酮和布托啡诺,可以谨慎使用。低效阿片类药物如戊唑嗪、曲马多、纳布啡和他他多也可以考虑剂量调整。尽管效果不佳,但其他一些镇痛药物包括加巴喷丁、普瑞巴林、对乙酰氨基酚、度洛西汀、文拉法辛、氟西汀、局部利多卡因、辣椒素和可乐定。方法:于2021年3月5日至8月10日在PubMed和google scholar进行系统文献检索。文章通过与国际疾病分类相关的搜索词和关键词进行搜索:肝肾综合征、疼痛、阿片类药物、代谢、肾脏清除。结果:检索到文献1387篇。在剔除重复项后,924项研究被筛选为合格研究。在审查标题和摘要后,665项研究因相关性原因被拒绝。这些研究大多被拒绝,因为它们不相关,不符合检索标准,病例对照文章,病例系列文章,没有英文翻译,文章没有提到肝脏或肾脏疾病患者的调整。142种物质被用于合成。
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引用次数: 0
Revelation and Management of Distal Anterior Cerebral Artery Aneurysms 脑前远端动脉瘤的发现与治疗
Pub Date : 2023-10-25 DOI: 10.58624/svoane.2023.04.0107
Yacine FELISSI
Pericallosal aneurysms can affect any segment of the anterior cerebral artery distal to the anterior communicating artery. They represent relatively 9% of all intracranial aneurysms and are mainly revealed by a hemorrhagic stroke in different forms. This retrospective study reviewed all patients that received clipping for DACA aneurysms among all cases of brain aneurysms. 10 patients were included in this group and several parameters were evaluated. 60% of patients were female and their ages ranged from 44 to 78 years. 80% of candidates complained of headaches and 50% presented seizures clipping. 60% of patients presented an IPH at their first presentation while SAH was found in half of them. A good WFNS score was noticed and almost of patients (80 %) were graded I. Most of aneurysms (80%) were located at the pericallosal – callosomarginal junction. We had two cases (20%) with additional aneurysms in other localizations. All of them received microsurgical clipping. most of them had good short and long -term follow-ups. We had one death after several systemic complications. DACA aneurysms are revealed at a small size with the onset of cingular hematoma or SAH, especially in the interhemispheric cistern. This could affect the cognitive functions and is considered a determining factor in the patient’s quality of life. The surgical clipping is an effective and durable option for their management
胼胝体周围动脉瘤可影响前交通动脉远端的大脑前动脉的任何一段。它们约占所有颅内动脉瘤的9%,主要表现为不同形式的出血性中风。本回顾性研究回顾了所有脑动脉瘤病例中所有接受DACA动脉瘤夹持术的患者。本组纳入10例患者,对多项参数进行评估。60%的患者为女性,年龄44 ~ 78岁。80%的候选人抱怨头痛,50%的人出现癫痫发作。60%的患者在首次就诊时出现IPH,而其中一半的患者发现SAH。WFNS评分良好,约80%的患者为i级。大部分动脉瘤(80%)位于胼胝体周围-胼胝体边缘交界处。我们有2例(20%)在其他部位有额外的动脉瘤。所有患者均接受显微手术夹持。他们中的大多数都有良好的短期和长期随访。我们有一个死于几个系统性并发症。DACA动脉瘤以小尺寸出现,并伴有带状血肿或SAH,尤其是在半球间池。这可能会影响认知功能,并被认为是患者生活质量的决定性因素。手术夹是一种有效而持久的治疗方法
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引用次数: 0
Importance of the Implementation of a Stereotaxy System forNeurosurgical Activity in Botswana 博茨瓦纳神经外科活动立体定位系统实施的重要性
Pub Date : 2023-10-25 DOI: 10.58624/svoane.2023.04.0106
Enrique Marcos Sierra Benitez
In daily Neurosurgical practice in Botswana we can observe dissimilar pathologies located in deep brain structures where a conventional neurosurgical approach would cause irreversible damage. In these cases, exact localization methods with stereotaxy play a leading role. Unfortunately, the country does not have such a system and it is necessary to refer patients to other countries such as South Africa or India to provide them with these services, at an extremely considerable cost and in many cases these processes are delayed, which produces irreversible deterioration of the patients. We believe that with the implementation of a stereotactic system in Botswana, the costs of these types of procedures can be reduced and, in turn, greater effectiveness and safety can be achieved in the treatment of these diseases.
在博茨瓦纳的日常神经外科实践中,我们可以观察到位于脑深部结构的不同病理,传统的神经外科方法会造成不可逆转的损伤。在这些情况下,具有立体定位的精确定位方法起着主导作用。不幸的是,该国没有这样一个系统,必须将患者转介到其他国家,如南非或印度,向他们提供这些服务,费用极其可观,在许多情况下,这些过程被推迟,这导致患者的病情不可逆转地恶化。我们认为,在博茨瓦纳实施立体定向系统后,可以减少这类程序的费用,从而可以在治疗这些疾病方面取得更大的效力和安全性。
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引用次数: 0
Diagnosis and Surgical Management of Chiari Malformation Type I I型Chiari畸形的诊断与外科治疗
Pub Date : 2023-10-18 DOI: 10.58624/svoane.2023.04.0105
Yacine FELISSI
Introduction: Chiari malformation type I (CM I) is an abnormality of the craniovertebral junction affecting both adults and children. Its genesis is not clear however a reduced volume of the posterior fossa looks to play a significant role. We aim to report our experience in the diagnosis and the surgical management of CM I. Methods: A prospective study was conducted in our department over three years. We have included 50 patients diagnosed with CM I and surgically managed. We reviewed different criteria; epidemiological, clinical, and radiological before and after surgery to evaluate the efficiency of surgery in our patients. The data were analyzed using the Epidata software. Results: The most encountered preoperative symptoms were headaches majored by Valsalva in 100 ℅ and sensitive disorders (suspended sensory disorders in 32℅ and thermo-algesic dissociation in 32 ℅). Preoperative imaging showed that 66% have Chiari type I, 28% have Chiari type 1.5, and 06% have Chiari type 0. The bony and dural opening was performed in all patients. In 70% of patients, cerebellar tonsils were coagulated in 58% and resected in 12% of cases unilaterally. The thenar and hypothenar amyotrophies improved only in 10% of cases, and thermo-algesic dissociation improved in 63%. Conclusion: Surgical management for CM I is a safe and efficient procedure to relieve preoperative symptoms. Bony and dural is considered a good surgical technique. Additional maneuvers on tonsils should be added according to the preoperative finding after arachnoidal opening.
I型Chiari畸形(CM I)是一种影响成人和儿童的颅椎交界处异常。其成因尚不清楚,但后窝体积缩小似乎起了重要作用。我们的目的是报告我们在CM i的诊断和手术治疗方面的经验。方法:在我科进行了为期三年的前瞻性研究。我们纳入了50例诊断为CM I并进行手术治疗的患者。我们审查了不同的标准;术前、术后流行病学、临床及影像学资料评价手术疗效。使用Epidata软件对数据进行分析。结果:术前最常见的症状是100℅Valsalva致头痛和敏感障碍(32℅悬吊感觉障碍和32℅热痛分离)。术前影像学显示66%为Chiari I型,28%为Chiari 1.5型,06%为Chiari 0型。所有患者均行骨及硬脑膜切开。在70%的患者中,58%的患者小脑扁桃体凝固,12%的患者单侧切除。大鱼际和下鱼际肌损伤仅在10%的病例中得到改善,而热痛觉解离在63%的病例中得到改善。结论:手术治疗CM I是一种安全有效的方法,可缓解术前症状。骨和硬脑膜被认为是一种很好的手术技术。蛛网膜打开后,应根据术前发现,在扁桃体上增加额外的操作。
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引用次数: 0
Acute Infarction in the Artery of Percheron Territory During Cerebral Angiography: A Case Report 脑血管造影中Percheron动脉急性梗死1例
Pub Date : 2023-10-08 DOI: 10.58624/svoane.2023.04.0104
Yacine FELISSI
We present a case of a 51-year-old man with a history of hypertension and diabetes who underwent cerebral angiography for evaluation of spontaneous subarachnoid hemorrhage. The procedure was unremarkable, but the patient did not wake up and remained minimally responsive afterward. Imaging studies showed bilateral medial thalamic and midbrain infarctions consistent with an artery of Percheron infarction. The patient received antiplatelet therapy and had minimal improvement in his cognitive function. He was discharged to a rehab center after one week of hospitalization. We shortly discuss this rare complication including the risk factor, clinical presentation, and the management.
我们报告了一例51岁的高血压和糖尿病病史的患者,他接受了脑血管造影来评估自发性蛛网膜下腔出血。手术过程平淡无奇,但患者没有醒来,并保持最低限度的反应。影像学检查显示双侧内侧丘脑和中脑梗死与Percheron动脉梗死一致。患者接受抗血小板治疗,认知功能改善甚微。他住院一周后出院到康复中心。我们将简要讨论这种罕见的并发症,包括危险因素、临床表现和治疗。
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引用次数: 0
Occipital Cavernous Malformation. Case Report and Literature Review 枕海绵状血管瘤。病例报告及文献复习
Pub Date : 2023-09-25 DOI: 10.58624/svoane.2023.04.0103
Enrique Marcos Sierra Benitez, Mairianny Quianella León Pérez, Yohanny Pérez González, Javier Martínez Gómez, Odaliza Casañola Chávez, Esteban Cabrales Manrique
We present a 47-year-old female patient with a personal pathological history of squamous cell carcinoma of the cervix treated with multimodal therapy. She is rushed to our hospital because of a generalized tonic-clonic seizure. After performing computed axial tomography and magnetic resonance imaging studies of the skull, an occipital lesion was evident that was located above the tentorium cerebellum in relation to her right transverse sinus. An occipital approach is performed where said lesion is completely
我们报告一位47岁的女性患者,其个人病理史为宫颈鳞状细胞癌,并接受多模式治疗。她因全身性强直阵挛发作而被紧急送往我院。在对颅骨进行计算机轴位断层扫描和磁共振成像研究后,枕骨病变明显位于小脑幕上方,与右横窦相关。枕骨入路在病变完全的地方进行
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引用次数: 0
Surgical Results in Neurotraumatology in a Hospital in Botswana 博茨瓦纳一家医院的神经创伤外科手术结果
Pub Date : 2023-09-07 DOI: 10.58624/svoane.2023.04.0102
Enrique Marcos Sierra Benitez
Objective: To describe the surgical results in patients operated on for traumatic brain injury in a hospital in Botswana. Methods: Observational, descriptive, cross-sectional study, in the period from January 2023 to August 2023, at the Nyangabgwe Referal Hospital in Botswana. The sample under study consisted of 50 patients. General and specific variables of the traumatic Brain injury were analyzed. Results: The average age was 40.8 years, with a predominance of males (86%), the most frequent cause of head trauma was aggression (50%), chronic subdural hematoma predominated (36%), with intrahospital pneumonia being the complication more frequent (10%), mortality was 12%. Conclusions: Traumatic brain injury is a health problem in Botswana, it behaves with an incidence and prevalence that rises despite the small population of the country. Surgical results of a heterogeneous group of pathologies secondary to TBI were described.
目的:描述博茨瓦纳某医院外伤性脑损伤患者的手术效果。方法:观察性、描述性、横断面研究,研究时间为2023年1月至2023年8月,地点为博茨瓦纳Nyangabgwe转诊医院。研究的样本包括50名患者。分析外伤性脑损伤的一般变量和特殊变量。结果:平均年龄40.8岁,男性居多(86%),颅脑外伤以攻击性为主(50%),慢性硬膜下血肿为主(36%),院内肺炎为常见并发症(10%),病死率为12%。结论:创伤性脑损伤是博茨瓦纳的一个健康问题,尽管该国人口不多,但其发病率和流行率仍在上升。描述了一组不同病理继发于TBI的手术结果。
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引用次数: 0
Neurosarcoidosis: Review and Update of the Mimic Disease 神经结节病:模拟疾病的回顾和最新进展
Pub Date : 2023-08-28 DOI: 10.58624/svoane.2023.04.0101
David Enrique Barbero Jimenez, Judit Villamor Rodríguez, Maria de la Cruz Barbero Jiménez, Diego Domingo Merino
Sarcoidosis is a systemic inflammatory disorder characterized by non-caseating granulomas with variable involvement of the lungs, central nervous system (CNS), skin, liver, bone, and eye. Neurosarcoidosis is similarly heterogeneous with diverse anatomical manifestations and response to therapy. The diagnosis of neurosarcoidosis is established by the clinical syndrome, imaging and histopathological findings, and exclusion of other causes. In this narrative review, we summarize recent advances in the diagnosis and treatment of neurosarcoidosis.
结节病是一种全身性炎症性疾病,以非干酪化肉芽肿为特征,累及肺、中枢神经系统、皮肤、肝脏、骨骼和眼睛。神经结节病同样具有异质性,具有不同的解剖表现和对治疗的反应。神经结节病的诊断是建立在临床症状,影像学和组织病理学的结果,并排除其他原因。在这篇叙述性的回顾中,我们总结了神经结节病的诊断和治疗的最新进展。
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引用次数: 0
Trigeminal Neuralgia as An Atypical Manifestation of Intracranial Hypertension. Case Report and Literature Review 三叉神经痛是颅内高压的一种不典型表现。病例报告及文献复习
Pub Date : 2023-07-27 DOI: 10.58624/svoane.2023.04.096
M. Rivera, Enrique Aguilar
Trigeminal neuralgia, a chronic neuropathic pain, is characterized by frequent episodes of stabbing facial pain, in the territory of the trigeminal nerve, which can severely impair patient’s quality of life. It is primarily caused by vascular compression of the trigeminal nerve root, but it is sometimes secondary to other identifiable neurological conditions, such as multiple sclerosis or a cerebellopontine angle tumor. Uncommonly, it may be caused by the presence of idiopathic intracranial hypertension, a condition most likely identified by headache, visual disturbances, and sixth nerve palsy, among other manifestations. Secondary causes of trigeminal neuralgia are usually detected after an atypical clinical manifestation, such as ophthalmic rather than maxillary or mandibular nerve involvement, more than one branch affected, or bilateral symptoms. We present a patient who presented with trigeminal neuralgia as a primary manifestation, and after thorough evaluation she was diagnosed with intracranial hypertension as the underlying mechanism responsible of the trigeminal neuralgia.
三叉神经痛是一种慢性神经性疼痛,其特点是在三叉神经范围内经常发作刺痛性面部疼痛,严重影响患者的生活质量。它主要由血管压迫三叉神经根引起,但有时继发于其他可识别的神经系统疾病,如多发性硬化症或桥小脑角肿瘤。罕见的是,它可能是由特发性颅内高压引起的,这种情况最可能由头痛、视觉障碍和第六神经麻痹等表现来确定。三叉神经痛的继发原因通常在临床表现不典型后才被发现,如累及眼神经而不是上颌或下颌神经,多个分支受累,或双侧症状。我们报告了一位以三叉神经痛为主要表现的患者,经过全面的评估,她被诊断为颅内高压,这是导致三叉神经痛的潜在机制。
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引用次数: 0
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SVOA neurology
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