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Obesity and Residents’ Perceptions of Their Neighborhood’s Urban Amenities and Ambient Environment 肥胖与居民对周边城市设施和环境的感知
Pub Date : 2023-05-18 DOI: 10.3390/obesities3020014
Rayman Mohamed, B. Arnetz
There is a lack of research on how perceptions about urban spaces are associated with obesity. We surveyed 347 residents in a rapidly changing area of Detroit, Michigan about their perceptions of urban amenities and the ambient environment. We use principal component analysis to reduce the urban amenity and ambient environment variables to a manageable number. We use a spatial error model to account for spatial autocorrelation. We find that more urban amenities are associated with decreased obesity. A one-percent increase in residents’ perceptions of the availability of urban amenities is associated with a 0.13 percent decrease in obesity. Adverse ambient environments are associated with increased obesity. A one-percent increase in residents’ perceptions of adverse ambient environment quality is associated with a 0.12-percent increase in obesity. Addressing residents’ perceptions about urban spaces can provide planners with an additional tool to tackle obesity.
关于人们对城市空间的看法与肥胖之间的关系,目前还缺乏研究。我们调查了密歇根州底特律瞬息万变地区的347名居民,了解他们对城市便利设施和环境的看法。我们使用主成分分析来减少城市舒适和环境变量到一个可管理的数字。我们使用空间误差模型来解释空间自相关。我们发现更多的城市设施与减少肥胖有关。居民对城市便利设施的认识每增加1%,肥胖率就会下降0.13%。不利的环境与肥胖增加有关。居民对环境质量不良的看法每增加1%,肥胖人数就会增加0.12%。解决居民对城市空间的看法可以为规划者提供解决肥胖问题的额外工具。
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引用次数: 0
Respiratory Muscle Strength in Brazilian Adolescents: Impact of Body Composition 巴西青少年呼吸肌力量:身体成分的影响
Pub Date : 2023-05-15 DOI: 10.3390/obesities3020013
Viviane Campos de Lima, M. Marquezi, Paulo Roberto Alcantara, Nayara Barbosa Lopes, C. S. Frientes, Thais Miriã da Silva Santos, Leonardo Ribeiro Miedes, Matheus Silva Fornel, Danielle Castro Oliveira, P. Rogeri, A. L. Lancha Junior, Nathalia Bernardes, J. M. Lino Aparecido
(1) Introduction: Studies on respiratory muscle strength (RMS) in adolescents are controversial. Few studies so far have investigated respiratory muscle strength in Brazilian adolescents and the impact of body composition on it. (2) Objective: to evaluate the respiratory muscle strength of Brazilian adolescents and compare this with nationally and internationally predicted normality values. (3) Method: A cross-sectional study (CAEE: 34634414.5.0000.5479) was carried out with 98 adolescents, where both sexes were divided into four groups: eutrophic (n = 44); overweight (n = 15), obese (n = 25), and severely obese (n = 14). All were submitted to an anthropometric assessment, body composition analysis and manovacuometry. To interpret the results, Analysis of Variance (ANOVA) with Turkey’s post hoc test was used. The Kruskal–Wallis test and Friedman’s post hoc test were used to compare the observed vs. proposed results. A p-value < 0.05 was considered statistically significant. (4) Results: There were no differences among the groups for maximal inspiratory (MIP) and expiratory (MEP) pressures. However, when considering the total sample, we could say that RMS was higher among boys, and there were no significant differences in RMS in relation to the maturational stage. The values obtained for MIP were lower than those suggested for the national equation and higher than those proposed for the international equation. Similarly, the values obtained for MEP were lower than those suggested for the national and international equation. (5) Conclusions: RMS was similar in adolescents with different body compositions and different maturation stages. Adiposity did not interfere with RMS in adolescents. Boys had higher MIP and MEP values compared to girls. Therefore, the reference values proposed by the equations do not consistently match RMS in the adolescents studied. This context reinforces the need for new studies that are related to RMS to establish normality values and propose equations that represent the youth population.
(1)引言:青少年呼吸肌力量(RMS)的研究存在争议。迄今为止,很少有研究调查巴西青少年的呼吸肌力量以及身体成分对其的影响。(2)目的:评价巴西青少年的呼吸肌力量,并与国内外预测正常值进行比较。(3)方法:采用横断面研究(CAEE: 34634414.5.000 .5479)对98名青少年进行研究,将其男女分为富营养化组(n = 44);超重(n = 15),肥胖(n = 25),严重肥胖(n = 14)。所有患者均接受人体测量学评估、身体成分分析和压力测量。为了解释结果,方差分析(ANOVA)与土耳其的事后检验被使用。采用Kruskal-Wallis检验和Friedman事后检验比较观察结果和建议结果。p值< 0.05认为有统计学意义。(4)结果:两组患者最大吸气压(MIP)和最大呼气压(MEP)差异无统计学意义。然而,当考虑到总样本时,我们可以说RMS在男孩中更高,并且RMS在成熟阶段没有显着差异。获得的MIP值低于国家方程的建议值,高于国际方程的建议值。同样,MEP得到的值低于国内和国际方程的建议值。(5)结论:不同身体成分、不同成熟阶段的青少年RMS相似。肥胖不影响青少年的RMS。男孩的MIP和MEP值高于女孩。因此,方程提出的参考值与所研究的青少年的RMS并不一致。这种背景加强了对与均方根相关的新研究的需求,以建立正态性值并提出代表青年人口的方程。
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引用次数: 0
Trend in Hypertension Prevalence and Health Behaviors among the Brazilian Adult Population: 2006–2019 巴西成年人高血压患病率和健康行为趋势:2006-2019
Pub Date : 2023-04-06 DOI: 10.3390/obesities3020012
T. C. M. Caldeira, Ana Claudia R. A. Sereno, M. M. Soares, E. G. Maia, R. Claro
Our objective was to analyze temporal trends in the prevalence of self-reported hypertension among Brazilian adults and to investigate differences in health behaviors between individuals with and without hypertension between 2006 and 2019. Data from the Surveillance System for Risk Factors and Protection for Chronic Diseases by Telephone Survey were analyzed (n = 730,309). Prais–Winsten regression was used to identify linear trends in the prevalence of hypertension for the entire period (2006–2019) and for the past 5 years. Poisson regression models were used to investigate the differences in health behaviors among individuals with and without hypertension. The prevalence of hypertension (approximately 24.0%) remained stable from 2006 to 2019 and decreased from 25.1% to 24.6% from 2015 to 2019. In the adjusted analyses, individuals with hypertension showed a significant association with unhealthy lifestyle habits: lower recommended intake of fruits and vegetables (APR = 0.97; p = 0.022), lower regular intake of fruits (APR = 0.98; p < 0.001), lower regular intake of beans (APR = 0.97; p < 0.001), lower leisure-time exercising (APR = 0.89; p < 0.001), higher abusive consumption of alcoholic beverages (APR = 1.04; p = 0.004), higher prevalence of overweight (APR = 1.40; p < 0.001), and higher prevalence of obesity (APR = 2.17; p < 0.001). Hypertension prevalence has remained stable during the entire period and decreased in the most recent period. Individuals with hypertension reported unfavorable scenarios for healthy habits.
我们的目标是分析巴西成年人自我报告的高血压患病率的时间趋势,并调查2006年至2019年间高血压患者和非高血压患者健康行为的差异。通过电话调查分析来自慢性疾病危险因素和防护监测系统的数据(n = 730,309)。Prais-Winsten回归用于确定整个时期(2006-2019年)和过去5年高血压患病率的线性趋势。采用泊松回归模型研究高血压患者和非高血压患者健康行为的差异。高血压患病率从2006年到2019年保持稳定(约24.0%),从2015年到2019年从25.1%下降到24.6%。在调整后的分析中,高血压患者与不健康的生活习惯有显著关联:水果和蔬菜的推荐摄入量较低(APR = 0.97;p = 0.022),较低的水果摄入量(APR = 0.98;p < 0.001),定期摄入豆类较低(APR = 0.97;p < 0.001),较低的休闲时间运动(APR = 0.89;p < 0.001),酒精饮料滥用率较高(APR = 1.04;p = 0.004),超重患病率较高(APR = 1.40;p < 0.001),肥胖患病率较高(APR = 2.17;P < 0.001)。高血压患病率在整个期间保持稳定,并在最近期间有所下降。高血压患者报告了健康习惯的不利情况。
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引用次数: 0
Co-Designing and Refining a Home-Based Exercise Programme for Adults Living with Overweight and Obesity: Insight from People with Lived Experience 为超重和肥胖成年人共同设计和完善家庭锻炼计划:有生活经验的人的见解
Pub Date : 2023-04-01 DOI: 10.3390/obesities3020011
Sofie Power, Nikita Rowley, M. Duncan, D. Broom
Undertaking a home-based exercise programme should be a positive, health-enhancing lifestyle behaviour, particularly for adults living with overweight and obesity. However, exercise programmes are seldom designed in collaboration with people with lived experience, limiting adherence, efficacy, and effectiveness. Two focus groups (in-person n = 6 and virtual n = 7) were undertaken in the United Kingdom, to glean feedback and further refine a home-based exercise programme, developed from previously conducted semi-structured interviews with adults living with overweight and obesity. Both focus groups provided an opportunity for participants to discuss the proposed programme, highlighting strengths and areas for further improvement. Three key priorities were identified for consideration throughout the design process, specifically for adults living with overweight and obesity: (1) individualisation—a person-centred programme was non-negotiable; (2) motivation—integration of motivational features affected adherence and engagement; (3) more than just weight loss—consideration of other outcomes aside from solely numerical weight loss. These priorities provide direction for further refinement of the proposed home-based exercise programme, in an effort to ensure the final intervention is truly population-specific and needs-sensitive. Following completion, the programme will be assessed using a feasibility randomised controlled trial design.
开展以家庭为基础的锻炼方案应该是一种积极的、增进健康的生活方式行为,对超重和肥胖的成年人来说尤其如此。然而,运动计划很少与有生活经验的人合作设计,限制了依从性、疗效和有效性。在英国进行了两个焦点小组(面对面n = 6和虚拟n = 7),以收集反馈并进一步完善基于家庭的锻炼计划,该计划是从先前对超重和肥胖成年人进行的半结构化访谈中发展而来的。两个焦点小组都为与会者提供了讨论拟议方案的机会,突出了优点和需要进一步改进的领域。在整个设计过程中确定了三个关键的优先事项,特别是对于超重和肥胖的成年人:(1)个性化-以人为本的计划是不可协商的;(2)动机特征的动机整合影响依从性和敬业度;(3)不仅仅是减肥——考虑除数字减肥之外的其他结果。这些优先事项为进一步改进拟议的以家庭为基础的锻炼方案提供了方向,以确保最后的干预措施真正针对具体人口和顾及需要。完成后,将采用可行性随机对照试验设计对该方案进行评估。
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引用次数: 0
Temporal Trend of Severe Obesity in Brazilian State Capitals (2006–2021) 巴西各州首府严重肥胖的时间趋势(2006-2021)
Pub Date : 2023-04-01 DOI: 10.3390/obesities3020010
F. B. Dias, Tiago Feitosa da Silva, Yara de Moura Magalhães Lima, Luana Silva de Farias, Jhonatan Gomes Gadelha, A. A. Ramalho
The aim of this study was to analyze the trend of severe obesity in the capitals of the Brazilian states and the Federal District, from 2006 to 2021. For this purpose, a time-series, population-based, observational study was designed using data from the VIGITEL Survey. The dependent variable of this study was the prevalence of severe obesity, which was defined as a body mass index ≥ 40 kg/m2. Time series analysis was conducted using Joinpoint Regression Analysis Software v.4.9.1.0. In this study, a normal distribution was assumed, and the average annual percentage change (AAPC) and 95% confidence intervals (95% CIs) were presented. In total, 778,445 individuals participated in the study (38.2% were male and 61.8% were female). The prevalence of severe obesity has increased from 1.1% in 2006 to 1.9% in 2021. The average annual percentage change indicates an upward trend for the period (AAPC: 4.7; 95% CI: 3.8; 5.7). When stratifying the trend of severe obesity by sex, a significant upward trend was observed for females (AAPC: 4.3; 95% CI: 1.9; 6.8). There was a significant upward trend for all age groups, skin colors, and education levels. However, the older age groups and those with less education had lower AAPC.
本研究的目的是分析2006年至2021年巴西各州首府和联邦区严重肥胖的趋势。为此,使用VIGITEL调查的数据设计了一项时间序列、基于人群的观察性研究。本研究的因变量是严重肥胖的患病率,其定义为体重指数≥40 kg/m2。使用Joinpoint回归分析软件4.9.1.0版进行时间序列分析。在本研究中,假设了正态分布,并给出了平均年百分比变化(AAPC)和95%置信区间(95%CI)。总共有778445人参与了这项研究(38.2%为男性,61.8%为女性)。严重肥胖的患病率从2006年的1.1%上升到2021年的1.9%。平均年百分比变化表明这一时期有上升趋势(AAPC:4.7;95%CI:3.8;5.7)。当按性别对严重肥胖的趋势进行分层时,女性有显著的上升趋势(APC:4.3;95%CI:1.9;6.8)。所有年龄组、肤色和教育水平都有显著的增长趋势。然而,年龄较大的人群和受教育程度较低的人群AAPC较低。
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引用次数: 0
The Role of Women’s and Men’s Body Shapes in Explicit and Implicit Fat Stigma 女性和男性的体型在显性和隐性肥胖污名中的作用
Pub Date : 2023-03-31 DOI: 10.3390/obesities3020009
J. Krems, Jarrod E. Bock
Beyond being painful, fat stigma might facilitate pernicious consequences; over and above one’s weight, fat stigma is associated with lesser wellbeing, poorer health, greater all-cause mortality, and weight gains that perpetuate the weight-stigma cycle. To combat fat stigma effectively requires an understanding of the perceptual calculus underlying it. Here, we seized upon new work asserting that importance of a previously overlooked variable in this calculus—fat deposition location (body shape)—and we examine basic but fundamental open questions about the role of body shape in fat stigma via two experiments (one pre-registered). We replicate and extend work investigating how body shape—over and above body size—drives stigma toward women, using a figure set created specifically to test predictions about the role of body shape as well as size. We asked: (1) Are findings of greater explicit stigma toward adult women with abdominal (gut) versus gluteofemoral fat depositions (hips, thighs, buttocks) replicated—and (2) does this same finding hold for implicit stigma?; (3) Are male targets similarly stigmatized as a function of shape? (4) Do individual difference factors known to predict anti-fat stigma, e.g., Protestant Work Ethic, play a role here? We examined these questions by presenting American participants with women and men targets varying in both body size and shape—assessing participants’ explicit stigma (via self-report) and implicit stigma (via the Attitude Misattribution Procedure; AMP). We replicated the pattern that explicit fat stigma toward women is shape-sensitive and extend that to implicit stigma—finding, for example, that, of two women with the same exact heights and higher weights, the woman with abdominal fat deposition is more stigmatized than the woman with gluteofemoral fat deposition. We found no consistent results regarding the role of body shape in driving fat stigma toward men. We also found that some individual difference factors predicting anti-fat stigma were also attuned to body shape as well as body size. The results underscore the importance of integrating body shape into future work on fat stigma (toward women).
除了痛苦之外,肥胖的耻辱可能会导致有害的后果;除了一个人的体重,肥胖耻辱感还与较差的幸福感、较差的健康状况、更高的全因死亡率和体重增加有关,从而使体重耻辱感的循环永久化。要有效地对抗肥胖耻辱感,需要了解其背后的感知微积分。在这里,我们抓住了新的工作,断言在这种结石中以前被忽视的变量——脂肪沉积位置(身体形状)的重要性,我们通过两个实验(一个预先注册的)来检查关于身体形状在脂肪柱头中的作用的基本但基本的开放问题。我们复制并扩展了研究身体形状(除了身体大小之外)如何导致女性被污名化的工作,使用专门创建的一组数字来测试关于身体形状和尺寸的作用的预测。我们的问题是:(1)与臀股脂肪沉积(臀部、大腿、臀部)相比,成年女性腹部(肠道)脂肪沉积更明显的耻耻感是否被复制?(2)同样的发现是否也适用于隐性耻耻感?(3)男性目标是否同样因外形而受到歧视?(4)预测反肥胖污名的个体差异因素,如新教工作伦理,是否在这里发挥作用?我们通过向美国参与者展示不同体型和体型的女性和男性目标来检验这些问题——评估参与者的显性耻辱(通过自我报告)和隐性耻辱(通过态度错误归因程序);AMP)。我们复制了这种模式,即对女性的显性肥胖歧视是对身材敏感的,并将其扩展到隐性歧视的发现,例如,在两个身高和体重完全相同的女性中,腹部脂肪沉积的女性比臀股脂肪沉积的女性更容易受到歧视。我们没有发现一致的结果,关于身体形状的作用,推动肥胖对男性的耻辱。我们还发现,一些预测抗脂肪耻辱感的个体差异因素也与体型和体型有关。研究结果强调了将体型纳入未来(对女性)肥胖污名研究的重要性。
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引用次数: 0
Physical Activity, Sedentary Behaviour and Cardiovascular Risk Factors in Overweight Low-Income Schoolchildren: A Complex System Perspective 身体活动,久坐行为和心血管危险因素超重低收入学童:一个复杂系统的观点
Pub Date : 2023-03-22 DOI: 10.3390/obesities3010008
Thaynã Bezerra, Anastácio Souza Filho, Natália Quirino, Paulo Bandeira, Luciana Cabral, Cézane Reuter, Clarice Martins, Ferdinando Carvalho
Background: This study analysed through the perspective of networks the association between physical activity (PA), sedentary behaviour (SB), and cardiovascular risk factors in overweight low-income schoolchildren from the perspective of complex systems. Methods: The sample consisted of 41 overweight children between 6 and 10 years old (56% girls). PA and SB were analysed by accelerometer, and the measures of cardiovascular factor risk were: anthropometric and hemodynamic measurements, body fat, lipid profile and glucose, cardiorespiratory fitness (CRF), left ventricular mass (LVM), and Sokolow–Lyon. Network analysis with Bootstrap-1000 was performed to analyse the association between PA, SB and the cardiovascular risk factors. Results: Moderate-to-vigorous PA was positive related to waist circumference (WC; 0.499), HDL-C (0.307), and CRF (0.276), and negatively associated with BMI (−0.251) and Fat (−0.341). For SB, positive associations were seen with WC (0.326), CRF (0.296), LVM (0.250) and Sokolow (0.215). In addition, the centrality indicators highlighted WC as the most important variable in the network. Conclusion: Interventions that aim to mitigate the harmful effects of obesity on cardiovascular risk factors in overweight children should consider WC as an important variable in the system.
背景:本研究从复杂系统的角度,通过网络的视角分析了低收入超重学童身体活动(PA)、久坐行为(SB)与心血管危险因素之间的关系。方法:41例6 ~ 10岁超重儿童(56%为女孩)。通过加速度计分析PA和SB,并测量心血管因素风险:人体测量和血流动力学测量、体脂、血脂和血糖、心肺适能(CRF)、左心室质量(LVM)和Sokolow-Lyon。采用Bootstrap-1000进行网络分析,分析PA、SB与心血管危险因素之间的关系。结果:中高强度PA与腰围(WC;0.499)、HDL-C(0.307)和CRF(0.276),且与BMI(- 0.251)和Fat(- 0.341)呈负相关。对于SB,与WC(0.326)、CRF(0.296)、LVM(0.250)和Sokolow(0.215)呈正相关。此外,中心性指标强调WC是网络中最重要的变量。结论:旨在减轻肥胖对超重儿童心血管危险因素的有害影响的干预措施应将腰围作为系统中的一个重要变量。
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引用次数: 0
Temporal Trend of Multimorbidity of Noncommunicable Diseases among Brazilian Adults, 2006–2021 2006-2021年巴西成年人非传染性疾病多发病率的时间趋势
Pub Date : 2023-03-14 DOI: 10.3390/obesities3010007
T. C. M. Caldeira, T. M. Sousa, M. M. Soares, I. P. A. Veiga, L. E. S. Silva, R. Claro
We aimed to identify the temporal trend of multimorbidity of noncommunicable disease (NCDs) among Brazilian adults (n = 784,479) over a 16-year period of time. This is a time series of cross-sectional studies based on data from the Surveillance System of Risk and Protective Factors for Chronic Diseases by Telephone Survey (Vigitel) from 2006 to 2021. The presence of multimorbidity was assessed from the co-occurrence of (1) obesity and diabetes; (2) obesity and hypertension; and (3) obesity and diabetes and/or hypertension. Linear regression models (Prais–Winsten) were used to identify significant trends for the complete period (2006–2021) and the most recent quinquennium (2017–2021). Multimorbidity of obesity and diabetes and/or hypertension increased in the complete period (5.5% to 9.6%; 0.22 pp/year) and the most recent period (8.3% to 9.6%; 0.40 pp/year) studied. The highest increase occurred especially among men, older adults, and those with fewer years of education. Additionally, there was a high prevalence and an intense increase in multimorbidity among adults with poor self-rated health. These results reinforce the need for expanding and strengthening public health actions focused on individuals with multimorbidity especially with obesity.
我们的目的是确定巴西成年人(n = 784,479)在16年期间非传染性疾病(NCDs)多重发病率的时间趋势。这是一个时间序列的横断面研究,基于2006年至2021年通过电话调查的慢性病风险和保护因素监测系统(Vigitel)的数据。多重疾病的存在是通过以下两种情况来评估的:(1)肥胖和糖尿病的共同发生;(2)肥胖和高血压;(3)肥胖、糖尿病和/或高血压。线性回归模型(Prais-Winsten)用于确定整个时期(2006-2021年)和最近五年期(2017-2021年)的显著趋势。在整个研究期间,肥胖、糖尿病和/或高血压的多重发病率增加了(5.5%至9.6%;0.22 pp/年)和最近一段时期(8.3%至9.6%;0.40 pp/年)研究。增幅最大的群体是男性、老年人和受教育年限较短的人。此外,在自评健康状况较差的成年人中,患病率很高,多重发病率急剧增加。这些结果表明,有必要扩大和加强针对多病人群,特别是肥胖人群的公共卫生行动。
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引用次数: 0
Disrupting the Mood and Obesity Cycle: The Potential Role of Metformin 破坏情绪和肥胖周期:二甲双胍的潜在作用
Pub Date : 2023-02-27 DOI: 10.3390/obesities3010006
S. Doan, Sunita K. Patel, Bin Xie, R. Nelson, Lisa D. Yee
Mounting evidence links obesity, metabolic dysfunction, mood, and cognition. Compromised metabolic health and psychological functioning worsen clinical outcomes, diminish quality of life, and contribute to comorbid conditions. As a medication with both insulin-sensitizing and anti-inflammatory effects, metformin affords the exciting opportunity to abrogate the bidirectional relationship between poor metabolic health and psychological function. In the current paper, we review the literature linking metformin to mood and cognitive function, examine potential underlying mechanisms, and suggest new directions for investigating the role of metformin in increasing adherence to health behavior recommendations.
越来越多的证据表明肥胖、代谢障碍、情绪和认知有关。代谢健康和心理功能受损会使临床结果恶化,降低生活质量,并导致合并症。作为一种同时具有胰岛素增敏和抗炎作用的药物,二甲双胍为消除代谢不良与心理功能之间的双向关系提供了令人兴奋的机会。在本文中,我们回顾了二甲双胍与情绪和认知功能之间的联系,研究了潜在的潜在机制,并为研究二甲双胍在提高健康行为建议依从性方面的作用提出了新的方向。
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引用次数: 1
Why Are Obese People Predisposed to Severe Disease in Viral Respiratory Infections? 为什么肥胖的人易患严重的病毒性呼吸道感染?
Pub Date : 2023-02-13 DOI: 10.3390/obesities3010005
R. Aziz, A. Sherwani, Saeed Al Mahri, S. Malik, S. Mohammad
Obesity is one of the most pressing healthcare concerns of the twenty-first century. Obesity prevalence has risen dramatically in recent decades, and in 2016, more than 1.9 billion adults were overweight (BMI ≥ 25 kg/m2) and 650 million were obese (BMI ≥ 30 kg/m2). About 50% of the world’s population is anticipated to be obese/overweight within the next decade. Obesity is a major risk factor for a variety of non-communicable diseases, including type 2 diabetes mellitus, cardiovascular disease, non-alcoholic fatty liver disease, and a variety of malignancies. Obesity has emerged as a substantial risk factor for hospitalization and death from viral respiratory infections such as influenza A and the ongoing pandemic SARS-CoV-2. Several independent studies have indicated that obese/overweight patients are at a higher risk of severe disease and death from these respiratory diseases. Excess fat, particularly visceral fat, contributes to the development of a variety of metabolic disorders, including persistent systemic inflammation and decreased immunological function. As a result, the immunological response to infectious pathogens is weakened, resulting in poorer outcomes post-infection. Additionally, the poor lung mechanics associated with obesity may increase the risk of more serious respiratory infections. In this review, we address the likely mechanism(s) that predispose obese people to severe diseases caused by viral respiratory infections.
肥胖是二十一世纪最紧迫的医疗保健问题之一。近几十年来,肥胖率急剧上升,2016年,超过19亿成年人超重(BMI≥25 kg/m2),6.5亿人肥胖(BMI≥30 kg/m2)。预计在未来十年内,世界上大约50%的人口将肥胖/超重。肥胖是多种非传染性疾病的主要风险因素,包括2型糖尿病、心血管疾病、非酒精性脂肪肝和各种恶性肿瘤。肥胖已成为因甲型流感和持续的严重急性呼吸系统综合征冠状病毒2型等病毒性呼吸道感染住院和死亡的一个重要风险因素。几项独立研究表明,肥胖/超重患者患严重疾病和死于这些呼吸道疾病的风险更高。过量的脂肪,特别是内脏脂肪,会导致各种代谢紊乱,包括持续的全身炎症和免疫功能下降。因此,对传染性病原体的免疫反应减弱,导致感染后的结果较差。此外,与肥胖相关的肺力学不良可能会增加更严重的呼吸道感染的风险。在这篇综述中,我们讨论了肥胖者易患病毒性呼吸道感染引起的严重疾病的可能机制。
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引用次数: 2
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Obesities
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