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Processes of Identification in Families Enrolled in a Childhood Obesity Intervention: A Qualitative Study of Identities and Roles 参与儿童肥胖干预的家庭认同过程:认同与角色的质性研究
Pub Date : 2022-09-30 DOI: 10.3390/obesities2040027
Christina Hoeiberg, Stine Anne Jensen, D. Grabowski
Family involvement is important in interventions targeting childhood obesity. However, family-based interventions have limited impact. Being labeled obese or overweight and/or perceiving oneself as overweight is associated with weight gain over time. The links between weight perception, labelling, as well as individual and familial identities need to be studied more closely. This paper examines how dynamics of identity and identification within the family impact how the intervention is implemented into daily practices. The dataset consists of 15 semi-structured family interviews with a total of 15 children and 21 parents. The study showed an intense focus on the children’s weight and weight loss. Identification as overweight or obese determined how the members of the enrolled families approached the intervention. Children and other family members who identified themselves as being overweight or obese took more responsibility for their own health behavior, but not necessarily in a positive manner. This often resulted in conflicts within the families. Healthcare professionals working with childhood obesity interventions need to consider how to deal with family identity dynamics to secure support as different identities within the family predicts whether the family members find the intervention relevant and whether the intervention was implemented positively into daily life.
家庭参与在针对儿童肥胖的干预措施中很重要。然而,以家庭为基础的干预措施影响有限。随着时间的推移,被贴上肥胖或超重的标签和/或认为自己超重与体重增加有关。体重感知、标签以及个人和家族身份之间的联系需要更密切地研究。本文考察了家庭内部身份和认同的动态如何影响干预措施如何实施到日常实践中。该数据集由15个半结构化家庭访谈组成,共有15名儿童和21名父母。这项研究显示了对儿童体重和减肥的高度关注。被认定为超重或肥胖决定了参与家庭成员如何进行干预。认为自己超重或肥胖的孩子和其他家庭成员对自己的健康行为负有更多的责任,但不一定是以积极的方式。这常常导致家庭内部的冲突。从事儿童肥胖干预的医疗保健专业人员需要考虑如何处理家庭身份动态以获得支持,因为家庭中的不同身份预示着家庭成员是否认为干预相关,以及干预是否在日常生活中得到积极实施。
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引用次数: 0
The Prevalence of Risk and Protective Factors for Noncommunicable Diseases (NCDs) among Brazilian Adults with Pre-obesity and Obesity 巴西肥胖前期和肥胖成人中非传染性疾病(NCDs)的风险和保护因素的流行
Pub Date : 2022-09-10 DOI: 10.3390/obesities2030026
T. C. M. Caldeira, M. M. Soares, T. M. Sousa, I. P. A. Veiga, L. E. S. Silva, R. Claro
The present study aimed to identify the prevalence of risk and protective factors for noncommunicable disease (NCDs) among Brazilian adults with pre-obesity and obesity and compare it to that of non-overweight adults in the country. Data from the National Health Survey (NHS) 2013 (n = 40,942) and 2019 (n = 87,678) were used. Nutritional status was described for 2013 and 2019 according to sociodemographic characteristics, health conditions, and risk and protective factors for NCDs. Poisson regression models were used to analyze the crude and adjusted prevalence of risk and protective factors for NCDs with nutritional status in both years. Adults with pre-obesity and obesity were more likely to perform risk factors related to sedentary behavior (prolonged screen time) and less leisure-time physical activity (among adults with obesity) and active commuting (among adults with pre-obesity and obesity) and alcohol abuse. However, among adults with pre-obesity and obesity, a lower prevalence was observed in relation to the regular consumption of sweets and smoking. The identified risk and protective factors had a similar prevalence between 2013 and 2019. Brazilian adults with pre-obesity and obesity presented worrisome scenarios regarding risk and protective factor for NCDs.
本研究旨在确定巴西肥胖前期和肥胖成年人中非传染性疾病(NCDs)的风险和保护因素的患病率,并将其与该国非超重成年人的患病率进行比较。使用了2013年(n=40942)和2019年(n=87678)的国家健康调查数据。根据社会人口学特征、健康状况以及非传染性疾病的风险和保护因素,描述了2013年和2019年的营养状况。泊松回归模型用于分析这两年营养状况下非传染性疾病的风险和保护因素的粗略和调整患病率。肥胖前期和肥胖的成年人更有可能表现出与久坐行为(屏幕时间延长)、休闲时间较少的体育活动(肥胖成年人)、积极通勤(肥胖前期和肥胖症成年人)和酗酒有关的风险因素。然而,在肥胖前期和肥胖的成年人中,观察到与经常食用糖果和吸烟有关的患病率较低。2013年至2019年间,已确定的风险和保护因素的患病率相似。患有肥胖症前期和肥胖症的巴西成年人在非传染性疾病的风险和保护因素方面出现了令人担忧的情况。
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引用次数: 0
Effects of High-Fat Diet on the Gut Microbiota of Renalase Gene Knockout Mice 高脂饮食对Renalase基因敲除小鼠肠道微生物群的影响
Pub Date : 2022-09-09 DOI: 10.3390/obesities2030025
Hui Fang, Kai Aoki, Katsuyuki Tokinoya, M. Yonamine, T. Sugasawa, Y. Kawakami, K. Takekoshi
Metabolic diseases caused by gene and unhealthy living habits are increasing, which seriously threaten the life of people worldwide. Moreover, the microbiome has been shown to play an active role in the prevention and treatment of metabolic diseases. However, reliable evidence on renalase gene (Rnls), as a common gene related to metabolic diseases, is still lacking with regard to the influence on the microbiome. Hence, we investigated the effect of a normal diet (ND) and a high-fat diet (HFD) on the gut microbiota of Rnls knockout (Rnls−/−) and wild-type (Rnls+/+) mice. At the end of the 8-week experiment, DNA samples were extracted from fresh feces, and the composition of microbiota was profiled. The species in Rnls+/+-ND group were Bifidobacterium pseudolongum and Lactobacillus reuteri. Conversely, the species in Rnls−/−-ND group belonged to the genera Lactobacillus and Turicibacter. The HFD changed the ratio of Firmicutes/Bacteroidetes; while the bacteria in the Rnls+/+-HFD and Rnls−/−-HFD groups were different. Overall, this study not only revealed the composition of microbiota in Rnls−/− mice, but also indicated that Rnls and the bacteria related to Rnls may be new candidates in the prevention and diagnosis of metabolic diseases at an early stage.
由基因和不健康的生活习惯引起的代谢性疾病日益增多,严重威胁着全世界人民的生活。此外,微生物组已被证明在代谢性疾病的预防和治疗中发挥着积极作用。然而,关于renalase基因(Rnls)作为一种常见的代谢性疾病相关基因对微生物组的影响,目前还缺乏可靠的证据。因此,我们研究了正常饮食(ND)和高脂肪饮食(HFD)对Rnls敲除(Rnls−/−)和野生型(Rnls+/+)小鼠肠道微生物群的影响。在为期8周的实验结束时,从新鲜粪便中提取DNA样本,并对微生物群的组成进行了分析。Rnls+/+-ND组的菌种为假长双歧杆菌和路氏乳杆菌。相反,Rnls−/-ND组中的物种属于乳酸杆菌属和Turicibacter属。HFD改变了厚壁菌门/拟杆菌门的比例;而Rnls+/+-HFD组和Rnls−/-HFD组的细菌不同。总的来说,这项研究不仅揭示了Rnls−/−小鼠的微生物群组成,而且表明Rnls和与Rnls相关的细菌可能是早期预防和诊断代谢性疾病的新候选者。
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引用次数: 2
Adjustment of Unrealistic Weight Loss Expectations on a Mobile CBT-Based Behavior-Change Program: Prospective One-Armed Study 在移动cbt行为改变项目中调整不现实的减肥预期:前瞻性单臂研究
Pub Date : 2022-09-07 DOI: 10.3390/obesities2030024
Heather Behr, Matthew Baldwin, A. Ho, Paige Blanco, Ellen Siobhan Mitchell, Meaghan McCallum, Christine N. May, Andreas Michealides
Background: Moderate weight loss of 5–10% is considered a realistically achievable weight loss goal and is associated with decreased risk of obesity-related health complications. However, individuals tend to expect that they will lose as much as 20–30% of their body weight when they start a behavioral weight loss program. Current research is limited on how these expectations change over time during weight loss and the consequences of adjusting one’s expectations in a more realistic direction, particularly on a CBT-based program. Method: Therefore, this prospective cohort study evaluated whether individuals adjusted their weight loss expectations over time during real-world use of a mobile CBT-based behavior-change program (Noom Weight) and how this adjustment related to weight loss outcomes, as well as how the amount of adjustment depended on program engagement. Participants had recently signed up for Noom Weight and reported their weight, expectations for weight loss, and psychological well-being at baseline and six months. Engagement was automatically recorded by the program. Results: We found that after using Noom Weight for six months, participants’ expectations became more realistic (i.e., significantly decreased) compared to baseline (−5.77, s.e. = 0.57, p < 0.001), and this downward adjustment was associated with greater weight loss (b = 1.80, 95% CI 1.21–2.38, p < 0.001). Higher program engagement, particularly reading articles focused on CBT-based principles, was associated with greater decreases in expectations over time (b = −0.007, t = −2.22, p = 0.03). Conclusions: The results suggest that CBT-based principles may aid in adjusting weight loss expectations to more realistic levels and that such adjustment is associated with positive weight outcomes. Future research should build on these results by evaluating adjustment in weight loss expectations over time, rather than solely expectations at baseline.
背景:5-10%的适度减肥被认为是一个现实可行的减肥目标,并与降低肥胖相关健康并发症的风险有关。然而,当个人开始一项行为减肥计划时,他们往往预计自己会减掉多达20-30%的体重。目前的研究局限于减肥过程中这些期望如何随着时间的推移而变化,以及朝着更现实的方向调整期望的后果,特别是在基于CBT的项目中。方法:因此,这项前瞻性队列研究评估了在现实世界中使用基于移动CBT的行为改变计划(正午体重)期间,个体是否随着时间的推移调整了他们的减肥预期,以及这种调整与减肥结果的关系,以及调整量如何取决于计划参与度。参与者最近报名参加了正午减肥,并报告了他们的体重、对减肥的期望以及基线和六个月时的心理健康状况。程序自动记录参与情况。结果:我们发现,在使用正午体重六个月后,与基线(−5.77,s.e.=0.57,p<0.001)相比,参与者的期望值变得更加现实(即显著降低),这种向下调整与更大的体重减轻有关(b=1.80,95%CI 1.21-2.38,p<0.001),特别是阅读以CBT为基础的原则为重点的文章,随着时间的推移,期望值的下降幅度更大(b=-0.007,t=-2.22,p=0.03)。结论:研究结果表明,基于CBT的原则可能有助于将减肥期望值调整到更现实的水平,并且这种调整与积极的体重结果有关。未来的研究应该以这些结果为基础,评估随着时间的推移对减肥预期的调整,而不仅仅是基线时的预期。
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引用次数: 0
Pilot Associations between Adverse Childhood Experiences, Executive Function, and Brain-Derived Neurotrophic Factor (BDNF) among Adults with Excess Adiposity 儿童期不良经历、执行功能和脑源性神经营养因子(BDNF)在肥胖成人中的相关性研究
Pub Date : 2022-08-17 DOI: 10.3390/obesities2030022
Cindy E. Tsotsoros, Madison E. Stout, Austin R. Medlin, L. Wideman, D. Sanromán, Chibing Tan, T. Teague, Misty A. W. Hawkins
Adverse childhood experiences (ACEs) may predict markers of neurocognitive performance (i.e., executive function; EF) and brain health/plasticity (i.e., brain-derived neurotrophic factor; BDNF). This pilot examined: (1) ACES history and current EF performance, (2) ACEs history and current BDNF levels, and (3) current EF performance and BDNF levels. We hypothesized that higher ACEs would be associated with lower EF scores and that these patterns would be associated with serum BDNF levels. Given the pilot nature of the study, emphasis was placed on effect size vs. significance. Participants were 37 middle-aged women. Higher ACEs were not directly associated with EF scores (β = 0.08, p = 0.635) but showed potentially meaningful negative beta coefficients with proBDNF levels (β = −0.22, p = 0.200) and positive coefficients with mature BDNF (β = 0.28, p = 0.094). EF scores and proBDNF showed a positive relationship that did not reach significance (r = 0.28, p = 0.100) similar to EF scores and mature BDNF (r = 0.14, p = 0.406). In a modest pilot sample of middle-aged women with excess weight, higher ACEs were potentially associated with lower proBDNF and higher mature BDNF. Larger follow-up studies are warranted given the size of the detected coefficients and theoretical implications of ACEs and obesity as neurocognitively toxic for brain health and performance.
不良童年经历(ace)可以预测神经认知表现(即执行功能;EF)和脑健康/可塑性(即脑源性神经营养因子;BDNF)。该试验检查了:(1)ace历史和当前EF表现,(2)ace历史和当前BDNF水平,(3)当前EF表现和BDNF水平。我们假设较高的ace与较低的EF评分相关,并且这些模式与血清BDNF水平相关。考虑到该研究的试点性质,重点放在效应大小与显著性上。参与者是37名中年女性。高ace与EF评分无直接关系(β = 0.08, p = 0.635),但与proBDNF水平呈负β系数(β = - 0.22, p = 0.200),与成熟BDNF呈正系数(β = 0.28, p = 0.094)。EF评分与proBDNF呈显著正相关(r = 0.28, p = 0.100), EF评分与成熟BDNF呈显著正相关(r = 0.14, p = 0.406)。在适度的中年女性超重试点样本中,较高的ace可能与较低的proBDNF和较高的成熟BDNF相关。考虑到检测到的系数的大小以及ace和肥胖对大脑健康和表现的神经认知毒性的理论含义,有必要进行更大规模的后续研究。
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引用次数: 1
Liraglutide and Exercise: A Possible Treatment for Obesity? 利拉鲁肽与运动:肥胖的可能治疗方法?
Pub Date : 2022-08-17 DOI: 10.3390/obesities2030023
A. P. A. Macêdo, R. F. Vieira, Guilherme Domingos Brisque, G. F. Abud, J. Pauli
(1) Background: Obesity has become an important public health problem worldwide, and its characterization as a chronic disease reflects the impact of a complex and multifactorial condition. The treatment for obesity is based on lifestyle interventions that induce a negative energy balance. However, adherence to a lifestyle intervention is a challenge for many overweight and obese people. Thus, pharmacotherapy in the management of obesity is used to increase patient adherence to lifestyle changes and overcome the biological adaptations that occur with weight loss. Among these drugs, liraglutide stands out. Liraglutide is an analog of human glucagon-like peptide-1 (GLP-1), a hormone that regulates glucose-dependent insulin secretion, and glucagon release. (2) Results: Liraglutide appears to be effective in weight reduction and glycemic control in diabetic and obese patients, and combination of liraglutide and exercise can also bring benefits in weight loss. Furthermore, the combination of liraglutide and physical exercise can prevent adverse effects observed in the administration of liraglutide. (3) Conclusions: liraglutide seems to contribute to cardiometabolic improvement in obese individuals with or without diabetes, and the combination of liraglutide and physical exercise can prevent adverse effects observed in the administration of liraglutide.
(1) 背景:肥胖已成为世界范围内一个重要的公共卫生问题,其作为一种慢性疾病的特征反映了一种复杂和多因素条件的影响。肥胖的治疗是基于生活方式干预,诱导负能量平衡。然而,对于许多超重和肥胖的人来说,坚持生活方式干预是一个挑战。因此,肥胖管理中的药物治疗被用于提高患者对生活方式改变的依从性,并克服减肥带来的生物适应。在这些药物中,利拉鲁肽脱颖而出。利拉鲁肽是人胰高血糖素样肽-1(GLP-1)的类似物,GLP-1是一种调节葡萄糖依赖性胰岛素分泌和胰高血糖蛋白释放的激素。(2) 结果:利拉鲁肽对糖尿病和肥胖患者的减肥和血糖控制似乎是有效的,利拉鲁苷和运动的结合也可以带来减肥的好处。此外,利拉鲁肽和体育锻炼的结合可以预防利拉鲁苷给药中观察到的不良反应。(3) 结论:利拉鲁肽似乎有助于改善患有或不患有糖尿病的肥胖患者的心脏代谢,利拉鲁素与体育锻炼的结合可以预防利拉鲁苷给药中观察到的不良反应。
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引用次数: 1
Food Security, Fruit and Vegetable Intake, and Chronic Conditions among Supplemental Nutrition Assistance Program Education Participants Attending Free Food and Produce Events 参加免费食品和农产品活动的补充营养援助计划教育参与者的食品安全、水果和蔬菜摄入以及慢性病
Pub Date : 2022-08-05 DOI: 10.3390/obesities2030021
Priyanka Saxena, Julia I. Caldwell, Amy L. Ramos, D. Flores, Dipa Shah, T. Kuo
Non-traditional settings, such as schools, early childhood education programs, and healthcare clinics, can play a critical role in preventing obesity by providing free and nutritious food outside of food pantries to households that are experiencing low or very low food security, particularly during emergency situations. This evaluation study describes a low-income population that attended free food and produce distribution events during the COVID-19 pandemic. In 2021, a cross-sectional survey was administered to this group (n = 1498) to assess their food security status, fruit and vegetable (F+V) consumption, and prevalence of chronic disease condition(s). Program and event assessments were carried out using descriptive, bivariate, and multivariable logistic regression analyses. More than a quarter (26%) of the participants attended the free food events for the first time. Approximately 70% reported some level of low food security, 57% to 64% did not meet F+V intake recommendations, and 37% had a diet-related chronic disease condition. In the adjusted models, households with very low food security had lower odds of meeting F+V recommendations (aOR, 0.41, 95% CI, 0.28, 0.58 and aOR, 0.27, 95% CI, 0.19, 0.39, respectively) and higher odds of having a chronic condition (aOR, 3.49, 95% CI, 2.34, 5.20) than those with high or marginal food security. Given these experiences, future research should examine how safety net food assistance programs can incorporate alternative service/distribution models to improve the nutritional value of the foods they offer.
非传统环境,如学校、幼儿教育项目和医疗诊所,可以在预防肥胖方面发挥关键作用,在食品储藏室之外为粮食安全水平低或非常低的家庭提供免费营养食品,特别是在紧急情况下。这项评估研究描述了在新冠肺炎大流行期间参加免费食品和农产品分发活动的低收入人群。2021年,对这一群体(n=1498)进行了一项横断面调查,以评估他们的粮食安全状况、水果和蔬菜(F+V)消费以及慢性病患病率。使用描述性、双变量和多变量逻辑回归分析进行项目和事件评估。超过四分之一(26%)的参与者是第一次参加免费食品活动。大约70%的人报告说食物安全性较低,57%至64%的人不符合F+V摄入建议,37%的人患有与饮食相关的慢性病。在调整后的模型中,与粮食安全程度高或边际较低的家庭相比,粮食安全程度极低的家庭符合F+V建议的几率较低(aOR,0.41,95%CI,0.28,0.58和aOR,0.27,95%CI,0.19,0.39),患慢性病的几率较高(aOR、3.49,95%CI、2.34,5.20)。鉴于这些经验,未来的研究应该研究安全网食品援助计划如何结合替代服务/分销模式,以提高其提供的食品的营养价值。
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引用次数: 1
Dieters in the Covid-19 Pandemic: Risk for Eating Disorders and Their Association with Food Cravings and Intuitive Eating Traits 新冠肺炎大流行中的节食者:饮食失调的风险及其与食物渴求和直觉饮食特征的关系
Pub Date : 2022-07-24 DOI: 10.3390/obesities2030020
J. Oliveira, Isis de Carvalho Stelmo, Mariana Bueno Netto Santaella, T. Cordás
Objectives: To characterize a group of university students in social isolation regarding their eating behaviors and to investigate whether dieters have a tendency to engage in binge-eating. Study Design: Cross-sectional study carried out during Brazil’s first months of social isolation. Methods: University students filled out the Eating Attitudes Test—EAT, the Binge-eating Scale—BES, and the Hay questionnaire. In addition, the current research also evaluated food cravings (FC) and intuitive eating. Student’s t-test was used to compare the effect sizes (Cohen’s d) between groups. Results: More than 90% of participants were isolated from academic activities, and 68% reported significant dietary change. Those who dieted (n = 57) were less confident in signs of hunger and satiety (d = −0.9, p < 0.001) and had higher binge-eating and FC levels than those who did not diet. Conclusions: Data reinforces the high prevalence of risk for eating disorders in university students, the impact of dieting on FC, and intuitive eating during social isolation.
目的:描述一组处于社会孤立状态的大学生的饮食行为,并调查节食者是否有暴饮的倾向。研究设计:在巴西社会隔离的头几个月进行的横断面研究。方法:采用大学生饮食态度测试(EAT)、Binge饮食量表(BES)和Hay问卷。此外,目前的研究还评估了食物渴望(FC)和直觉饮食。学生t检验用于比较各组之间的效应大小(Cohen’s d)。结果:超过90%的参与者与学术活动隔离,68%的参与者报告了显著的饮食变化。与不节食的人相比,节食的人(n=57)对饥饿和饱腹感的迹象不太自信(d=-0.9,p<0.001),并且暴饮和FC水平更高。结论:数据强化了大学生饮食失调风险的高患病率、节食对FC的影响以及社交隔离期间的直觉饮食。
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引用次数: 0
The Endocrine–Metabolic Axis Regulation in Offspring Exposed to Maternal Obesity—Cause or Consequence in Metabolic Disease Programming? 暴露于母体肥胖的后代的内分泌-代谢轴调节——代谢疾病规划的原因或后果?
Pub Date : 2022-07-19 DOI: 10.3390/obesities2030019
L. Grilo, Mariana S. Diniz, Carolina Tocantins, A. Areia, Susana P. Pereira
Obesity incidence is rising worldwide, including women of reproductive age, contributing to increased gestations in which Maternal Obesity (MO) occurs. Offspring born to obese mothers present an increased predisposition to develop metabolic (e.g., obesity, diabetes) and cardiovascular disease (CVD). The developmental programming of the metabolic dysfunction in MO offspring can initiate in utero. The different availability of metabolic substrates, namely glucose, can modulate cellular growth, proliferation, and differentiation, resulting in different levels of tissue maturation and function. We defined the remodelling of these early processes as the first hit of metabolic disease programming. Among these, adipocyte early differentiation and gut dysbiosis are initial repercussions occurring in MO offspring, contributing to -tissue-specific dysfunction. The second hit of disease programming can be related to the endocrine–metabolic axis dysregulation. The endocrine–metabolic axis consists of multi-organ communication through the release of factors that are able to regulate the metabolic fate of cells of organs involved in physiological metabolic homeostasis. Upon adipose tissue and gut early dysregulation, these organs’ endocrine function can be programmed to the disrupted release of multiple factors (e.g., adiponectin, leptin, glucagon-like peptide). This can be perceived as a natural mechanism to overcome metabolic frailty in an attempt to prevent or postpone organ-specific disease. However, the action of these hormones on other tissues may potentiate metabolic dysfunction or even trigger disease in organs (liver, pancreas, heart) that were also programmed in utero for early disease. A second phase of the endocrine–metabolic dysregulation happens when the affected organs (e.g., liver and pancreas) self-produce an endocrine response, affecting all of the involved tissues and resulting in a new balance of the endocrine–metabolic axis. Altogether, the second hit exacerbates the organ-specific susceptibility to disease due to the new metabolic environment. The developmental programming of the endocrine–metabolic axis can start a vicious cycle of metabolic adaptations due to the release of factors, leading to an endocrine response that can jeopardize the organism’s function. Diseases programmed by MO can be boosted by endocrine dysregulation, namely Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Fatty Pancreas Disease, and the aggravation of the adipose tissue and gut dysfunction. Chronic metabolic dysregulation can also predispose MO offspring to CVD through the modulation of the endocrine environment and/or the metabolic status. To cease the vicious cycle of MO disease transmission among generations and-provide preventive and specialized prenatal and postnatal care to MO offspring, it is necessary to understand the molecular mechanisms underlying the MO-related disease development. In this review, we summarize most of the developmental programming
全球范围内,包括育龄妇女在内的肥胖发病率正在上升,导致妊娠期增加,其中母亲肥胖(MO)发生。肥胖母亲所生的后代更容易发生代谢(如肥胖、糖尿病)和心血管疾病(CVD)。MO子代代谢功能障碍的发育程序可以在子宫内启动。代谢底物(即葡萄糖)的不同可用性可以调节细胞生长、增殖和分化,导致不同水平的组织成熟和功能。我们将这些早期过程的重塑定义为代谢疾病编程的第一次冲击。其中,脂肪细胞早期分化和肠道微生态失调是MO后代发生的最初影响,导致组织特异性功能障碍。疾病规划的第二次打击可能与内分泌代谢轴失调有关。内分泌-代谢轴包括通过释放能够调节参与生理代谢稳态的器官细胞代谢命运的因子进行的多器官交流。在脂肪组织和肠道早期失调时,这些器官的内分泌功能可以被编程为多种因素(如脂联素、瘦素、胰高血糖素样肽)的释放被破坏。这可以被视为一种克服代谢脆弱的自然机制,试图预防或推迟器官特异性疾病。然而,这些激素对其他组织的作用可能会增强代谢功能障碍,甚至引发器官(肝脏、胰腺、心脏)的疾病,而这些器官也在子宫内被编程用于早期疾病。内分泌-代谢失调的第二阶段发生在受影响的器官(如肝脏和胰腺)自我产生内分泌反应时,影响所有相关组织,并导致内分泌-代谢轴的新平衡。总之,由于新的代谢环境,第二次打击加剧了器官对疾病的特异性易感性。内分泌-代谢轴的发育程序可能会由于因子的释放而引发代谢适应的恶性循环,导致内分泌反应,从而危及生物体的功能。MO编程的疾病可以通过内分泌失调来促进,即非酒精性脂肪肝、非酒精性胰腺脂肪病,以及脂肪组织和肠道功能障碍的加重。慢性代谢失调也可通过调节内分泌环境和/或代谢状态使MO后代易患CVD。为了停止MO疾病在代际之间传播的恶性循环,并为MO后代提供预防性和专门的产前和产后护理,有必要了解MO相关疾病发展的分子机制。在这篇综述中,我们总结了在暴露于MO的后代身上描述的内分泌-代谢轴的大多数发育规划分子事件,简要概述了使MO后代易患代谢疾病的潜在机制,并讨论内分泌-代谢轴的编程作为MO后代代谢疾病易感性的可能机制。
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引用次数: 6
Training Mode Comparisons on Cardiorespiratory, Body Composition and Metabolic Profile Adaptations in Reproductive Age Women: A Systemic Review and Meta-Analysis 育龄妇女心肺、身体组成和代谢特征适应的训练模式比较:系统回顾和荟萃分析
Pub Date : 2022-06-13 DOI: 10.3390/obesities2020018
J. M. L. Aparecido, C. S. Frientes, G. L. Martins, G. C. Santos, Jennyfer D. Alves Silva, P. Rogeri, R. S. Pires, T. S. Amorim, T. O. D. da Silva, Thayná Espírito Santo, N. Boisseau, A. Lancha, M. Marquezi
Purpose: This study aimed to compare the effects of high-intensity interval training (HIT), sprint interval training (SIT) and moderate-intensity continuous training (MICT) on cardiorespiratory fitness (CRF), weight (kg), body fat mass (%), plasma glucose (fasting) and lipid levels in reproductive-age women. Method: The search was conducted in Pubmed, Cochrane Library, Virtual Health Library and Scielo. The meta-analyses were conducted using Review Manager software for random-effects models. The results were presented as standardized mean differences and 95%CI, which were calculated to determine the effect size of HIT/SIT and MICT interventions. Results: Eleven articles meet the inclusion criteria. The analyses demonstrated that all exercise modes improved body composition and metabolic profile, but nevertheless, MICT was significantly better at improving CRF (mL·min−1·kg−1) compared with HIT (2.45 mL·min−1·kg−1 (95% CI: 1.15 to 3.75 mL·min−1·kg−1); p < 0.05; I2 = 0%) and with SIT (0.98 mL·min−1·kg−1 (95% CI: −0.98 to 2.93 mL·min−1·kg−1); p = 0.33; I2 = 53%). Conclusion: Both HIT and SIT have the potential to be used as a training modality in reproductive-age women, with similar effects to MICT on body composition/metabolic markers but inferior effects on CRF, suggesting that HIT/SIT may be considered a “time-efficient component″ of weight management programs. However, the variability in the secondary outcome measures, coupled with the small sample sizes in studies, limits this finding.
目的:本研究旨在比较高强度间歇训练(HIT)、短跑间歇训练(SIT)和中等强度连续训练(MICT)对育龄妇女心肺功能(CRF)、体重(kg)、体脂质量(%)、血糖(禁食)和脂质水平的影响。方法:在Pubmed、Cochrane图书馆、虚拟健康图书馆和Scielo进行检索。使用Review Manager软件对随机效应模型进行荟萃分析。结果以标准化平均差异和95%置信区间表示,计算这些差异以确定HIT/SIT和MICT干预的效果大小。结果:11篇文章符合入选标准。分析表明,所有运动模式都能改善身体成分和代谢状况,但与HIT(2.45 mL·min−1·kg−1)相比,MICT在改善CRF方面显著更好(95%CI:1.15至3.75 mL·min-1·kg−);p<0.05;I2=0%)和SIT(0.98 mL·min−1·kg−1(95%置信区间:−0.98至2.93 mL·min-1·kg−);p=0.33;I2=53%)。结论:HIT和SIT都有潜力作为育龄妇女的训练模式,对身体成分/代谢标志物的影响与MICT相似,但对CRF的影响较差,这表明HIT/SIT可能被认为是体重管理计划的“时效性组成部分”。然而,次要结果测量的可变性,加上研究中的小样本量,限制了这一发现。
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引用次数: 3
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Obesities
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