Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-1-168-343-351
D. Kiriya
{"title":"THE ROLE OF EPITHELIAL-MESENCHYMAL TRANSFORMATION IN INFERTILITY CAUSED BY CHRONIC ENDOMETRITIS","authors":"D. Kiriya","doi":"10.29254/2077-4214-2023-1-168-343-351","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-1-168-343-351","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89106138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-2-169-402-409
А. V. Nesteruk, E. Legach
innervation
神经支配
{"title":"BIOLOGICAL EFFECTS OF THE LOW-MOLECULAR FRACTION OF THE DORSAL ROOT GANGLIA CRYOEXTRACT ON THE REPRODUCTIVE SYSTEM OF FEMALE RATS","authors":"А. V. Nesteruk, E. Legach","doi":"10.29254/2077-4214-2023-2-169-402-409","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-2-169-402-409","url":null,"abstract":"innervation","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88386567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-2-169-269-277
N. Lutsiv, V. Akimova, O. Labinska, M. P. Halkevich, N. R. Demyanchuk, M. Shchurko, L. P. Kostiuk
three research groups (79 patients) were analyzed: Group I - 28 patients with STEMI and normal body weight, Group II - 24 patients with STEMI and excess body weight, and Group III - 27 patients with STEMI and obesity of the I-III degrees. The diagnosis (acute coronary syndrome) of ACS was made based on a complex clinical, laboratory and instrumental examination. Blood was taken for the study when patients were admitted to the department. The total number of leukocytes and the leukocyte blood formula were determined by standardized methods; the type of non-specific adaptation reaction - according to the method of L.H. Harkavi; the ratio of the absolute content of neutrophils to the absolute content of lymphocytes (neutrophil to lymphocyte ratio, NLR), and the ratio of the absolute content of neutrophils to the absolute content of platelets (neutrophil to platelet ratio, NPR) was determined. The course of ACS occurs against the background of several non-specific adaptation reactions, where the stress reaction was dominant (42.8% - group I, 50% - group II, and 51.9% - group III), indicating the disease's severity. The highest level of NLR (p<0.05) was found in group III, relative to the NLR indicator in group I and group II, and the highest level of NPR was found in group III precisely in case of a stress reaction, which indicates an unfavourable prognosis for patients of this group. Determining the type of nonspecific adaptation reaction can serve as an additional indicator of the severity of the patient and allows us to assess the effectiveness of therapy in patients with STEMI. The indicators of NLR and NPR were useful and powerful indicators of adverse consequences during the hospitalization of patients with ACS. The type of adaptive response and the indicators of NLR and NPR are determined based on clinical blood analysis indicators, and they are economical biomarkers for predicting the severity of inflammation.
分析三个研究组(79例):I组- 28例STEMI伴正常体重，II组- 24例STEMI伴超重体重，III组- 27例STEMI伴I-III度肥胖。ACS的诊断(急性冠脉综合征)是基于复杂的临床、实验室和仪器检查。当病人被送进该部门时，研究人员为这项研究采血。采用标准化方法测定白细胞总数和白细胞血方;非特异性适应反应的类型——根据L.H. Harkavi的方法;测定中性粒细胞绝对含量与淋巴细胞绝对含量之比(neutrophil to lymphocyte ratio, NLR)和中性粒细胞绝对含量与血小板绝对含量之比(neutrophil to platelet ratio, NPR)。ACS的病程发生在几种非特异性适应反应的背景下，其中应激反应占主导地位(42.8% - I组，50% - II组，51.9% - III组)，表明疾病的严重程度。ⅲ组NLR相对于ⅰ组和ⅱ组NLR指标最高(p<0.05)，而ⅲ组正是在应激反应时才出现NPR的最高水平，提示该组患者预后不良。确定非特异性适应反应的类型可以作为患者严重程度的附加指标，并使我们能够评估STEMI患者治疗的有效性。NLR和NPR指标是ACS患者住院期间不良后果的有用且有力的指标。NLR和NPR是根据临床血液分析指标确定的适应性反应类型和指标，是预测炎症严重程度的经济生物标志物。
{"title":"NON-SPECIFIC ADAPTIVE REACTIONS IN PATIENTS WITH ACUTE CORONARY SYNDROME WITH ST-SEGMENT ELEVATION (STEMI) AT DIFFERENT BODY WEIGHTS","authors":"N. Lutsiv, V. Akimova, O. Labinska, M. P. Halkevich, N. R. Demyanchuk, M. Shchurko, L. P. Kostiuk","doi":"10.29254/2077-4214-2023-2-169-269-277","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-2-169-269-277","url":null,"abstract":"three research groups (79 patients) were analyzed: Group I - 28 patients with STEMI and normal body weight, Group II - 24 patients with STEMI and excess body weight, and Group III - 27 patients with STEMI and obesity of the I-III degrees. The diagnosis (acute coronary syndrome) of ACS was made based on a complex clinical, laboratory and instrumental examination. Blood was taken for the study when patients were admitted to the department. The total number of leukocytes and the leukocyte blood formula were determined by standardized methods; the type of non-specific adaptation reaction - according to the method of L.H. Harkavi; the ratio of the absolute content of neutrophils to the absolute content of lymphocytes (neutrophil to lymphocyte ratio, NLR), and the ratio of the absolute content of neutrophils to the absolute content of platelets (neutrophil to platelet ratio, NPR) was determined. The course of ACS occurs against the background of several non-specific adaptation reactions, where the stress reaction was dominant (42.8% - group I, 50% - group II, and 51.9% - group III), indicating the disease's severity. The highest level of NLR (p<0.05) was found in group III, relative to the NLR indicator in group I and group II, and the highest level of NPR was found in group III precisely in case of a stress reaction, which indicates an unfavourable prognosis for patients of this group. Determining the type of nonspecific adaptation reaction can serve as an additional indicator of the severity of the patient and allows us to assess the effectiveness of therapy in patients with STEMI. The indicators of NLR and NPR were useful and powerful indicators of adverse consequences during the hospitalization of patients with ACS. The type of adaptive response and the indicators of NLR and NPR are determined based on clinical blood analysis indicators, and they are economical biomarkers for predicting the severity of inflammation.","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88387091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-1-168-429-434
D. Dychko, O. Dychko, O. Nekhanevich, I. V. Kushakova, O. Zinoviev, V. Dychko, O. Shayda
{"title":"THE EFFECTIVENESS OF THE INFLUENCE OF A COMPLEX OF PHYSICAL EXERCISES ON THE RESULTS AND EVALUATION OF PHYSICAL WORKABILITY IN CHILDREN WITH SCOLIOSIS","authors":"D. Dychko, O. Dychko, O. Nekhanevich, I. V. Kushakova, O. Zinoviev, V. Dychko, O. Shayda","doi":"10.29254/2077-4214-2023-1-168-429-434","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-1-168-429-434","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"128 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88146992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-1-168-120-130
O. Voronkova, O. Pavlova, O. Starishko, O. M. Prykhodko, A. V. Narbiekova, O. M. Simonova
{"title":"CHANGES IN HEMATOLOGICAL INDICATORS IN PATIENTS WITH CORONAVIRUS DISEASE","authors":"O. Voronkova, O. Pavlova, O. Starishko, O. M. Prykhodko, A. V. Narbiekova, O. M. Simonova","doi":"10.29254/2077-4214-2023-1-168-120-130","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-1-168-120-130","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86574167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A paired t-test (paired-samples t-test) was performed to compare the respondents' indicators during the first and second measurements a year later. Statistical analysis of the obtained data was carried out using the licensed program RStudio. When testing the hypothesis that the average value of the length of the right thigh significantly increased, a significant increase in the length of the right thigh was found between the first (M=53.870, SD=4.098) and the second (M=54.319, SD=4.118) measurements; t(68)= -6.704, p<0.001. The average value of the length of the left thigh also increased significantly, and there was a significant increase in the length of the left thigh between the first (M=53.855, SD=4.237) and the second (M=54.478, SD=4.161) measurements; t(68)= -5.328, p<0.001. A comparison of the length of the thigh in the dynamics after a year; in student-athletes of the main group showed a difference in the increase of the length of the thigh in 2022 compared to 2021 (±0.48-0.62 cm). According to the comparison of the left and right thigh during the second measurement of student-athletes, no significant difference in the average length of the right and left thigh was found (right – 54.31±2.04 cm, left – 54.47±2.04 cm). A significant predictor of thigh length is height. A model was derived for predicting the length of the right thigh Lr = 0.308 h and the left Ll = 0.309 h, where L is the length of the thigh, h is height. The coefficient of determination is 99.8%.
{"title":"DYNAMIC COMPARISON THE THIGH LENGTH IN STUDENTS OF BUKOVYNA","authors":"Karatieieva Svitlana, Yuriyivna Каратєєва, Світлана Юріївна","doi":"10.29254/2077-4214-2023-2-169-424-431","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-2-169-424-431","url":null,"abstract":"A paired t-test (paired-samples t-test) was performed to compare the respondents' indicators during the first and second measurements a year later. Statistical analysis of the obtained data was carried out using the licensed program RStudio. When testing the hypothesis that the average value of the length of the right thigh significantly increased, a significant increase in the length of the right thigh was found between the first (M=53.870, SD=4.098) and the second (M=54.319, SD=4.118) measurements; t(68)= -6.704, p<0.001. The average value of the length of the left thigh also increased significantly, and there was a significant increase in the length of the left thigh between the first (M=53.855, SD=4.237) and the second (M=54.478, SD=4.161) measurements; t(68)= -5.328, p<0.001. A comparison of the length of the thigh in the dynamics after a year; in student-athletes of the main group showed a difference in the increase of the length of the thigh in 2022 compared to 2021 (±0.48-0.62 cm). According to the comparison of the left and right thigh during the second measurement of student-athletes, no significant difference in the average length of the right and left thigh was found (right – 54.31±2.04 cm, left – 54.47±2.04 cm). A significant predictor of thigh length is height. A model was derived for predicting the length of the right thigh Lr = 0.308 h and the left Ll = 0.309 h, where L is the length of the thigh, h is height. The coefficient of determination is 99.8%.","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86608844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-1-168-224-232
O. Bieliaieva, S. Bilash, O. Pronina, Y. Lysanets, V. P. Bilash, K. Havrylieva, Z. Taran
{"title":"THE BIOGRAPHICAL METHOD AS A MEANS OF FORMING THE PROFESSIONAL PERSONALITY AND PROFESSIONAL IDENTITY OF THE FUTURE DOCTOR (as exemplified by the integration of the study of human anatomy and the disciplines of the foreign language training cycle)","authors":"O. Bieliaieva, S. Bilash, O. Pronina, Y. Lysanets, V. P. Bilash, K. Havrylieva, Z. Taran","doi":"10.29254/2077-4214-2023-1-168-224-232","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-1-168-224-232","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86195778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2022-4-167-251-254
V. P. Bilash, N. Svintsytska, S. Bilash, O. Pronina, O. Bilanov, Ya. O. Oliinichenko, O. T. Tkachenko
{"title":"USE OF HEALTH-PRESERVING FEATURES OF LEARNING IN THE CONTEXT OF OPTIMIZATION AND IMPROVEMENT OF PEDAGOGICAL MANAGEMENT IN HIGHER MEDICAL EDUCATION","authors":"V. P. Bilash, N. Svintsytska, S. Bilash, O. Pronina, O. Bilanov, Ya. O. Oliinichenko, O. T. Tkachenko","doi":"10.29254/2077-4214-2022-4-167-251-254","DOIUrl":"https://doi.org/10.29254/2077-4214-2022-4-167-251-254","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82075581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-2-169-277-281
Lutsiv Natalia, Zbyslavivna, Луців Наталія, Збиславівна, I. Horbachevsky
Obesity was simulated using a high-calorie diet. On the 1st day, the level of NOx metabolites in the blood serum of the group of animals with AGP on the background of obesity was 9 % significantly higher than that of the group of animals with isolated GPP, on the 3rd day – by 8 %, and on the 7th day – by 7 %, respectively (р<0,05). Comparing the indicators of NO-synthase activity in the liver of the rats of the main group and the comparison group, we obtained higher indicators in the animals of the AGP group and the background of obesity during all periods of the experiment: on the 1st day – by 16 %, on the 3rd day – by 14 %, and on the 7th day – by 13 % (р<0,05). The mechanisms of nitrooxidative stress are significantly increased in animals with AGP against the background of obesity during all periods of the experiment, which is confirmed by statistically significantly higher levels of NO-synthase in the liver and the content of nitrates and nitrites in blood serum compared to animals with isolated obe - sity or animals with AGP.
{"title":"THE CONCEPT OF NITRO-OXIDATIVE STRESS IN ACUTE GENERALIZED PERITONITIS ON THE BACKGROUND OF OBESITY IN EXPERIMENT","authors":"Lutsiv Natalia, Zbyslavivna, Луців Наталія, Збиславівна, I. Horbachevsky","doi":"10.29254/2077-4214-2023-2-169-277-281","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-2-169-277-281","url":null,"abstract":"Obesity was simulated using a high-calorie diet. On the 1st day, the level of NOx metabolites in the blood serum of the group of animals with AGP on the background of obesity was 9 % significantly higher than that of the group of animals with isolated GPP, on the 3rd day – by 8 %, and on the 7th day – by 7 %, respectively (р<0,05). Comparing the indicators of NO-synthase activity in the liver of the rats of the main group and the comparison group, we obtained higher indicators in the animals of the AGP group and the background of obesity during all periods of the experiment: on the 1st day – by 16 %, on the 3rd day – by 14 %, and on the 7th day – by 13 % (р<0,05). The mechanisms of nitrooxidative stress are significantly increased in animals with AGP against the background of obesity during all periods of the experiment, which is confirmed by statistically significantly higher levels of NO-synthase in the liver and the content of nitrates and nitrites in blood serum compared to animals with isolated obe - sity or animals with AGP.","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82492583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2523-4110-2023-2-169/addition-20
Давид Соломонович Аветіков, В. В. Хатту, Ігор Олексійович Іваницький, О. С. Іваницька, Ольга Петрівна Буханченко
{"title":"МОЖЛИВОСТІ ВИКОРИСТАННЯ КРІОЕКСТРАКТУ ПЛАЦЕНТИ ДЛЯ ОПТИМІЗАЦІЇ РЕПАРАТИВНОЇ РЕГЕНЕРАЦІЇ КІСТКОВОЇ ТКАНИНИ ПІСЛЯ ОПЕРАЦІЇ ВИДАЛЕННЯ ЗУБА","authors":"Давид Соломонович Аветіков, В. В. Хатту, Ігор Олексійович Іваницький, О. С. Іваницька, Ольга Петрівна Буханченко","doi":"10.29254/2523-4110-2023-2-169/addition-20","DOIUrl":"https://doi.org/10.29254/2523-4110-2023-2-169/addition-20","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79718583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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