Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-2-169-269-277
N. Lutsiv, V. Akimova, O. Labinska, M. P. Halkevich, N. R. Demyanchuk, M. Shchurko, L. P. Kostiuk
three research groups (79 patients) were analyzed: Group I - 28 patients with STEMI and normal body weight, Group II - 24 patients with STEMI and excess body weight, and Group III - 27 patients with STEMI and obesity of the I-III degrees. The diagnosis (acute coronary syndrome) of ACS was made based on a complex clinical, laboratory and instrumental examination. Blood was taken for the study when patients were admitted to the department. The total number of leukocytes and the leukocyte blood formula were determined by standardized methods; the type of non-specific adaptation reaction - according to the method of L.H. Harkavi; the ratio of the absolute content of neutrophils to the absolute content of lymphocytes (neutrophil to lymphocyte ratio, NLR), and the ratio of the absolute content of neutrophils to the absolute content of platelets (neutrophil to platelet ratio, NPR) was determined. The course of ACS occurs against the background of several non-specific adaptation reactions, where the stress reaction was dominant (42.8% - group I, 50% - group II, and 51.9% - group III), indicating the disease's severity. The highest level of NLR (p<0.05) was found in group III, relative to the NLR indicator in group I and group II, and the highest level of NPR was found in group III precisely in case of a stress reaction, which indicates an unfavourable prognosis for patients of this group. Determining the type of nonspecific adaptation reaction can serve as an additional indicator of the severity of the patient and allows us to assess the effectiveness of therapy in patients with STEMI. The indicators of NLR and NPR were useful and powerful indicators of adverse consequences during the hospitalization of patients with ACS. The type of adaptive response and the indicators of NLR and NPR are determined based on clinical blood analysis indicators, and they are economical biomarkers for predicting the severity of inflammation.
分析三个研究组(79例):I组- 28例STEMI伴正常体重，II组- 24例STEMI伴超重体重，III组- 27例STEMI伴I-III度肥胖。ACS的诊断(急性冠脉综合征)是基于复杂的临床、实验室和仪器检查。当病人被送进该部门时，研究人员为这项研究采血。采用标准化方法测定白细胞总数和白细胞血方;非特异性适应反应的类型——根据L.H. Harkavi的方法;测定中性粒细胞绝对含量与淋巴细胞绝对含量之比(neutrophil to lymphocyte ratio, NLR)和中性粒细胞绝对含量与血小板绝对含量之比(neutrophil to platelet ratio, NPR)。ACS的病程发生在几种非特异性适应反应的背景下，其中应激反应占主导地位(42.8% - I组，50% - II组，51.9% - III组)，表明疾病的严重程度。ⅲ组NLR相对于ⅰ组和ⅱ组NLR指标最高(p<0.05)，而ⅲ组正是在应激反应时才出现NPR的最高水平，提示该组患者预后不良。确定非特异性适应反应的类型可以作为患者严重程度的附加指标，并使我们能够评估STEMI患者治疗的有效性。NLR和NPR指标是ACS患者住院期间不良后果的有用且有力的指标。NLR和NPR是根据临床血液分析指标确定的适应性反应类型和指标，是预测炎症严重程度的经济生物标志物。
{"title":"NON-SPECIFIC ADAPTIVE REACTIONS IN PATIENTS WITH ACUTE CORONARY SYNDROME WITH ST-SEGMENT ELEVATION (STEMI) AT DIFFERENT BODY WEIGHTS","authors":"N. Lutsiv, V. Akimova, O. Labinska, M. P. Halkevich, N. R. Demyanchuk, M. Shchurko, L. P. Kostiuk","doi":"10.29254/2077-4214-2023-2-169-269-277","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-2-169-269-277","url":null,"abstract":"three research groups (79 patients) were analyzed: Group I - 28 patients with STEMI and normal body weight, Group II - 24 patients with STEMI and excess body weight, and Group III - 27 patients with STEMI and obesity of the I-III degrees. The diagnosis (acute coronary syndrome) of ACS was made based on a complex clinical, laboratory and instrumental examination. Blood was taken for the study when patients were admitted to the department. The total number of leukocytes and the leukocyte blood formula were determined by standardized methods; the type of non-specific adaptation reaction - according to the method of L.H. Harkavi; the ratio of the absolute content of neutrophils to the absolute content of lymphocytes (neutrophil to lymphocyte ratio, NLR), and the ratio of the absolute content of neutrophils to the absolute content of platelets (neutrophil to platelet ratio, NPR) was determined. The course of ACS occurs against the background of several non-specific adaptation reactions, where the stress reaction was dominant (42.8% - group I, 50% - group II, and 51.9% - group III), indicating the disease's severity. The highest level of NLR (p<0.05) was found in group III, relative to the NLR indicator in group I and group II, and the highest level of NPR was found in group III precisely in case of a stress reaction, which indicates an unfavourable prognosis for patients of this group. Determining the type of nonspecific adaptation reaction can serve as an additional indicator of the severity of the patient and allows us to assess the effectiveness of therapy in patients with STEMI. The indicators of NLR and NPR were useful and powerful indicators of adverse consequences during the hospitalization of patients with ACS. The type of adaptive response and the indicators of NLR and NPR are determined based on clinical blood analysis indicators, and they are economical biomarkers for predicting the severity of inflammation.","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88387091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2022-4-167-251-254
V. P. Bilash, N. Svintsytska, S. Bilash, O. Pronina, O. Bilanov, Ya. O. Oliinichenko, O. T. Tkachenko
{"title":"USE OF HEALTH-PRESERVING FEATURES OF LEARNING IN THE CONTEXT OF OPTIMIZATION AND IMPROVEMENT OF PEDAGOGICAL MANAGEMENT IN HIGHER MEDICAL EDUCATION","authors":"V. P. Bilash, N. Svintsytska, S. Bilash, O. Pronina, O. Bilanov, Ya. O. Oliinichenko, O. T. Tkachenko","doi":"10.29254/2077-4214-2022-4-167-251-254","DOIUrl":"https://doi.org/10.29254/2077-4214-2022-4-167-251-254","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82075581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-2-169-381-386
S. Donchenko, S. Bilash
sodium
钠
{"title":"STRUCTURAL ORGANIZATION OF THE ADRENAL GLANDS MEDULLA OF RATS IN NORMAL AND AFTER INFLUENCE OF FOOD ADDITIVE COMPLEX","authors":"S. Donchenko, S. Bilash","doi":"10.29254/2077-4214-2023-2-169-381-386","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-2-169-381-386","url":null,"abstract":"sodium","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78219477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-2-169-178-185
A. Hromova, N. Mitiunina, V. M. Shafarchuk, V. B. Martynenko, N. O. Prylutska, T. Liakhovska
{"title":"FEATURES OF THE FUNCTIONAL MORPHOLOGY OF THE PLACENTA IN CASE OF PREMATURE AMNIOTIC FLUID DISCHARGE","authors":"A. Hromova, N. Mitiunina, V. M. Shafarchuk, V. B. Martynenko, N. O. Prylutska, T. Liakhovska","doi":"10.29254/2077-4214-2023-2-169-178-185","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-2-169-178-185","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85205269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2523-4110-2023-2-169/addition-14
З. З. Масна, І. В. Челпанова, Є. В. Пальтов, О. П. Адамович
{"title":"ПОРІВНЯЛЬНИЙ АНАЛІЗ ПЕРЕБІГУ РЕПАРАТИВНОЇ РЕГЕНЕРАЦІЇ КІСТКОВОЇ ТКАНИНИ РІЗНИХ ДІЛЯНОК НИЖНЬОЇ ЩЕЛЕПИ","authors":"З. З. Масна, І. В. Челпанова, Є. В. Пальтов, О. П. Адамович","doi":"10.29254/2523-4110-2023-2-169/addition-14","DOIUrl":"https://doi.org/10.29254/2523-4110-2023-2-169/addition-14","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82780506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2022-4-167-307-315
Yulia Onashko
{"title":"CRANIOMETRIC CHARACTERISTICS OF THE OPENINGS POSITION OF THE FACIAL SKULL DIVISION DEPENDING ON THE GENDER OF A MATURE PERSON","authors":"Yulia Onashko","doi":"10.29254/2077-4214-2022-4-167-307-315","DOIUrl":"https://doi.org/10.29254/2077-4214-2022-4-167-307-315","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82687422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2023-1-168-207-211
V. Pshychenko, V. Cherno, L. Chebotar, O. Yulevich, O. I. Petrova
{"title":"PROOXIDANT-ANTIOXIDANT STATUS OF THE HEART OF RATS UNDER THE ACTION OF MONOSODIUM GLUTAMAT AND CORRECTION WITH MELATONIN","authors":"V. Pshychenko, V. Cherno, L. Chebotar, O. Yulevich, O. I. Petrova","doi":"10.29254/2077-4214-2023-1-168-207-211","DOIUrl":"https://doi.org/10.29254/2077-4214-2023-1-168-207-211","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84325905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2022-4-167-223-236
M. Y. Stroev, M. Berezka, V. Grigoruk, M. Karpinsky, A. Yaresko, I. Subbota
.9% of disabilities. The goal was to conduct a comparative analysis of the stress-strain state of models of the tibia with its fracture in the middle third with different options of osteosynthesis under the influence of bending load depending on the patient's weight. The model simulated a tibial fracture in the middle third and three types of osteosynthesis using an external fixation device (EFD), a bone plate, and an intramedullary rod. The models were studied at 700 N and 1200 N bending loads. Usually, under a bending load, the maximum stress magnitude is determined in the distal part of the tibia. When using EFD osteosynthesis, the maximum stress level is observed in the distal fragment of the tibia. The maximum stresses are determined in the fracture zone during osteosynthesis with a bone plate. Osteosynthesis with an intramedullary rod provides the lowest stress level in the fracture zone. An increase in the load value to 1200 N leads to a rise in the stress values in all model elements. The worst stress level indicators in the fracture zone and the metal structure were determined using a bone plate. With the help of EFD, osteosynthesis ensures a relatively low stress level in the fracture zone; it is worth noting the lowest stress level on the device itself. The lowest stress indicators in the fracture zone and the proximal fragment of the tibia are determined when using osteosynthesis with an intramedullary rod.
{"title":"ANALYSIS OF THE STRESS-STRAIN STATE OF THE TIBIAL MODEL IN CASE OF ITS FRACTURE IN THE MIDDLE THIRD WITH VARIOUS TYPES OF OSTEOSYNTHESIS UNDER CONDITIONS OF INCREASING BENDING LOAD","authors":"M. Y. Stroev, M. Berezka, V. Grigoruk, M. Karpinsky, A. Yaresko, I. Subbota","doi":"10.29254/2077-4214-2022-4-167-223-236","DOIUrl":"https://doi.org/10.29254/2077-4214-2022-4-167-223-236","url":null,"abstract":".9% of disabilities. The goal was to conduct a comparative analysis of the stress-strain state of models of the tibia with its fracture in the middle third with different options of osteosynthesis under the influence of bending load depending on the patient's weight. The model simulated a tibial fracture in the middle third and three types of osteosynthesis using an external fixation device (EFD), a bone plate, and an intramedullary rod. The models were studied at 700 N and 1200 N bending loads. Usually, under a bending load, the maximum stress magnitude is determined in the distal part of the tibia. When using EFD osteosynthesis, the maximum stress level is observed in the distal fragment of the tibia. The maximum stresses are determined in the fracture zone during osteosynthesis with a bone plate. Osteosynthesis with an intramedullary rod provides the lowest stress level in the fracture zone. An increase in the load value to 1200 N leads to a rise in the stress values in all model elements. The worst stress level indicators in the fracture zone and the metal structure were determined using a bone plate. With the help of EFD, osteosynthesis ensures a relatively low stress level in the fracture zone; it is worth noting the lowest stress level on the device itself. The lowest stress indicators in the fracture zone and the proximal fragment of the tibia are determined when using osteosynthesis with an intramedullary rod.","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82301340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.29254/2077-4214-2022-4-167-316-321
О. О. Sodomora
{"title":"THE EFFECT OF MONOSODIUM GLUTAMATE CONSUMPTION ON CAROTID SINUS MORPHOLOGY: AN ELECTRON MICROSCOPY EXPERIMENTAL STUDY","authors":"О. О. Sodomora","doi":"10.29254/2077-4214-2022-4-167-316-321","DOIUrl":"https://doi.org/10.29254/2077-4214-2022-4-167-316-321","url":null,"abstract":"","PeriodicalId":9360,"journal":{"name":"Bulletin of Problems Biology and Medicine","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88947072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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