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Estimating high-order brain functional network via signed random walk for mild cognitive impairment identification 基于签名随机漫步的高阶脑功能网络估计在轻度认知障碍识别中的应用
Pub Date : 2022-07-01 DOI: 10.4103/2773-2398.356522
Li-Mei Zhang, Xiao Wu, Hui Su, Ting-Ting Guo, Mingxia Liu
Brain functional network (BFN) has become an increasingly important tool to discover informative biomarkers for diagnosing neurodegenerative diseases, such as Alzheimer’s disease and its prodrome stage, namely mild cognitive impairment. Currently, the most popular BFN estimation methods include Pearson’s correlation and sparse representation. Despite their empirical success in some scenarios, such estimated BFNs only capture the low-order relationship (i.e., the direct connectivity strength between brain regions), ignoring the high-order information in the brain (e.g., the global network structure). Therefore, in this study, we proposed a novel method based on the signed random walk (SRW) to estimate high-order BFNs. Not only can SRW measure the global network structure, but it can also naturally deal with negative brain functional connectivity through the structural balance theory. To the best of our knowledge, this study was the first to use SRW in BFN estimation. Furthermore, considering the complex interaction among different brain regions, we developed a parameterized variant of SRW for improving the flexibility of the high-order BFN estimation model. To illustrate the effectiveness of the proposed method, we identified patients with mild cognitive impairment from normal controls based on the estimated high-order BFNs. Our experimental findings showed that the proposed scheme tended to achieve higher classification performance than baseline methods.
脑功能网络(Brain functional network, BFN)已成为一种越来越重要的工具,用于发现诊断神经退行性疾病的信息性生物标志物,如阿尔茨海默病及其前驱期,即轻度认知障碍。目前,最流行的BFN估计方法包括Pearson相关法和稀疏表示法。尽管它们在某些情况下取得了经验上的成功,但这种估计的bfn只捕获了低阶关系(即大脑区域之间的直接连接强度),而忽略了大脑中的高阶信息(例如,全球网络结构)。因此,在本研究中,我们提出了一种基于签名随机漫步(SRW)的新方法来估计高阶bfn。SRW不仅可以测量全局网络结构,还可以通过结构平衡理论自然地处理脑功能负连通性。据我们所知,这项研究是第一次在BFN估计中使用SRW。此外,考虑到不同脑区之间复杂的相互作用,我们开发了一种参数化的SRW变体,以提高高阶BFN估计模型的灵活性。为了说明所提出方法的有效性,我们根据估计的高阶bfn从正常对照中识别出轻度认知障碍患者。我们的实验结果表明,所提出的方案往往比基线方法获得更高的分类性能。
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引用次数: 1
Biomaterials as regenerative therapies for traumatic brain injury: a narrative review 生物材料作为创伤性脑损伤的再生疗法:综述
Pub Date : 2022-07-01 DOI: 10.4103/2773-2398.356521
Wang Hui, Su Zhi, Ling Ziao
Over recent years, the events associated with traumatic brain injury (TBI) have become critical health problems. TBI involves various functional deficits that are caused by neuronal loss and is a common feature in various neuropathologies. Patients with TBI have a very high degree of disability and impairment at both the physical and psychological levels, thus creating a significant burden on the quality of life. Although stem cell therapy has achieved some success in the reconstruction of neural circuits for TBI therapies, there are several limitations that need to be overcome, such as the stem cell transplantation pathways and time to transplantation are challenges for clinical application. Recently, bioactive materials from the tissue engineering field have become promising candidates for TBI therapies. Herein, we briefly summarize and discuss the advantages and disadvantages of TBI-related biomaterials (such as hydrogels, nanofibers, and nanomaterials) for the regeneration of neural tissue and functional recovery at the lesion sites of TBI. Finally, we describe the desirable characteristics of bioactive materials for neural repair in TBI. Because the development of therapeutic strategies with biomaterials is still in its infancy, biomaterials deserve high priority and further development as a treatment for TBI.
近年来,与创伤性脑损伤(TBI)相关的事件已成为严重的健康问题。创伤性脑损伤涉及由神经元丢失引起的各种功能缺陷,是各种神经病理学的共同特征。TBI患者在生理和心理层面上都有非常高程度的残疾和损伤,从而对生活质量造成重大负担。尽管干细胞疗法在创伤性脑损伤治疗的神经回路重建方面取得了一些成功,但仍有一些限制需要克服,如干细胞移植途径和移植时间是临床应用的挑战。近年来,来自组织工程领域的生物活性材料已成为创伤性脑损伤治疗的有希望的候选材料。在此,我们简要总结和讨论了创伤性脑损伤相关生物材料(如水凝胶、纳米纤维和纳米材料)在创伤性脑损伤损伤部位神经组织再生和功能恢复方面的优缺点。最后,我们描述了生物活性材料在创伤性脑损伤神经修复中的理想特性。由于生物材料治疗策略的发展仍处于起步阶段,生物材料作为创伤性脑损伤的治疗方法值得高度重视和进一步发展。
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引用次数: 0
Paroxysmal sympathetic hyperexcitation syndrome caused by ventriculoperitoneal shunt pressure-regulation in post-traumatic hydrocephalus: a case report 外伤性脑积水脑室-腹膜分流压力调节引起阵发性交感神经亢进综合征1例
Pub Date : 2022-07-01 DOI: 10.4103/2773-2398.356524
Li-jun Yang, Xin-wei Tang, Hai-Qing Li, Wang-huan Dun, Wenke Fan, Hongyu Xie, Nianhong Wang, Junfa Wu, Yi Wu
Paroxysmal sympathetic hyperactivity (PSH) is a rare symptom, but is difficult to manage. Here, we report a case of post-trauma PSH in a young male patient. The main reason for the occurrence of PSH in trauma patients may be nonnoxious or noxious stimuli. In this case, the detection of positive sympathetic parameters and heart rate variability after pressure regulation provided strong evidence for the PSH attack, thus enhancing the accuracy and reliability of early diagnosis. Clinicians should be alert to the possibility of PSH caused by rapid decline of ventricular pressure. Moreover, the appropriate regulation of ventricular pressure combined with pharmacologic interventions, rehabilitation and nutritional support may reduce and control this symptom.
阵发性交感神经亢进(PSH)是一种罕见的症状,但很难控制。在这里,我们报告一例创伤后PSH在一个年轻的男性患者。创伤患者发生PSH的主要原因可能是无害或有害的刺激。在本例中,检测交感神经参数阳性和血压调节后心率变异性为PSH发作提供了有力证据,从而提高了早期诊断的准确性和可靠性。临床医生应警惕由心室压迅速下降引起PSH的可能性。适当调节心室压,结合药物干预、康复和营养支持可减轻和控制这种症状。
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引用次数: 0
Treatment-resistant obsessive-compulsive disorder and multimodal augmentation: a case study 难治性强迫症和多模态增强:一个案例研究
Pub Date : 2022-07-01 DOI: 10.4103/2773-2398.356526
Shreya Verma, Shubhajeet Roy, V. Singh, Ashutosh Kumar Singh, Sujita Kumar Kar
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引用次数: 0
A case report describing accidental swallowing of an intermittent oro-esophageal tube 意外吞咽间歇性口食管管的病例报告
Pub Date : 2022-07-01 DOI: 10.4103/2773-2398.356525
Haoyu Xu, Lin Yan, Yin Lei, Qin Shen, L. Ding, Linfan Gu
A 74-year-old man with dementia was undergoing rehabilitation following a recent cerebrovascular accident. A nasogastric tube was inserted owing to swallowing dysfunction. However, the patient often dislodged the tube. We decided to apply intermittent feeding via an oro-esophageal tube. One day, he accidentally swallowed the tube into his stomach. The intermittent oro-esophageal tube was successfully removed by gastroscopy. This case herein highlights the need to be aware of dysphagia in patients with dementia when inserting an intermittent oro-esophageal tube.
一名74岁老年痴呆症患者在最近脑血管事故后正在接受康复治疗。因吞咽功能障碍插入鼻胃管。然而,病人经常拔管。我们决定通过口食管管进行间歇喂养。有一天,他不小心把管子吞进了胃里。通过胃镜成功拔除间歇口食管管。本病例强调了痴呆患者在插入间歇口食管管时注意吞咽困难的必要性。
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引用次数: 0
Possible replacement of augmenting medication in treatment-resistant depression by transcranial magnetic stimulation: a case report 经颅磁刺激可能替代增强型药物治疗难治性抑郁症:1例报告
Pub Date : 2022-07-01 DOI: 10.4103/2773-2398.356523
A. Vaishampayan, B. Saad, Daniel Amarasinghe, Brin Carly, R. Balon, Mischel Nicholas
Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression. As the left prefrontal cortex activity is linked to depression, rTMS induces blood flow in the left dorsolateral prefrontal cortex. We used rTMS in a middle-aged male patient with depression who had discontinued psychostimulant medication over a 12-month period. He had been consistently taking dextroamphetamine-amphetamine extended release 30 mg once daily prior to the onset of rTMS treatment. The patient achieved depression remission through 39 sessions of high-frequency left dorsolateral prefrontal cortex rTMS treatments. We assessed disease progression using the Quick Inventory of Depressive Symptomatology, and we measured blood pressure before each session of rTMS. After tapering the dextroamphetamine-amphetamine extended release from 30 mg to 10 mg, the patient’s score on the Quick Inventory of Depressive Symptomatology increased slightly to 7 and then dropped to 0. The results indicate that interval rTMS can lower blood pressure and may be an alternative to adjunctive psychostimulants.
重复经颅磁刺激(rTMS)是治疗抑郁症的有效方法。由于左前额叶皮层的活动与抑郁有关,rTMS诱导左背外侧前额叶皮层的血液流动。我们在一位中年男性抑郁症患者中使用了rTMS,他在12个月的时间里停止了精神兴奋剂的治疗。在rTMS治疗开始前,他一直服用右苯丙胺-安非他明缓释片30毫克,每日一次。通过39次高频左背外侧前额皮质rTMS治疗,患者达到抑郁缓解。我们使用抑郁症状快速量表评估疾病进展,并在每次rTMS治疗前测量血压。右安非他明-安非他明缓释量从30毫克逐渐减少到10毫克后,患者的抑郁症状快速量表得分略有上升至7分,然后下降到0分。结果表明,间歇rTMS可以降低血压,可能是辅助精神兴奋剂的一种替代方法。
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引用次数: 0
UTILIZATION OF EMPTY SPACE UNDER FLY OVER AS AN OPEN PUBLIC SPACE 利用空中的空地作为开放的公共空间
Pub Date : 2022-06-06 DOI: 10.14710/mdl.22.1.2022.36-41
R. F. Jamila, Retno Wijayaningsih
The development of transportation facilities is also important to accommodate the mobility of city residents both by private vehicles and by public transportation. One way to break up the transportation complications is to build an overpass or commonly known as a fly over, and this effort is usually quite successful. However, there is another side that often escapes the government's fly over planning, namely the creation of new spaces under the overpass that are not clearly utilized, so that spontaneously, the spaces that are formed are used "at will" by the community. The purpose of this study is to obtain a variety of shapes and dimensions, as well as where the location of residual space under the fly over, Obtaining community use of residual space under the fly over, Obtaining community behavior in utilizing the residual space under the fly overThis research is a basic research that has a Level of Technology 1 and has a target output in the form of national accredited national journals.
交通设施的发展也很重要,以适应城市居民乘坐私人车辆和公共交通的流动性。解决交通问题的一种方法是建造一个立交桥,或者通常被称为天桥,这种努力通常是相当成功的。然而,还有另一面往往逃不过政府的飞越式规划,即在立交桥下创造新的空间,这些空间没有得到明确的利用,从而自发地,形成的空间被社区“随意”使用。本研究的目的是获取蝇下剩余空间的各种形状和维度,以及所在位置,获取蝇下剩余空间的社区利用,获取蝇下剩余空间的社区利用行为。本研究是一项技术水平为1级的基础研究,目标以国家认可的国家级期刊的形式输出。
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引用次数: 0
THE EFFECT OF STARCHITECT’S DESIGN ON HOUSING IMAGE ACCORDING TO RESIDENTS' PERCEPTION 根据居民的感知,明星建筑师的设计对住房形象的影响
Pub Date : 2022-06-06 DOI: 10.14710/mdl.22.1.2022.31-35
G. P. Putra, R. F. Jamila
The development of residential real estate in Indonesia continues to grow. Although it cannot be denied that the current global economic recession affect the property business, housing development must continue to grow in order to accommodate the population demand. The recent economic conditions make housing developers have to make various innovations for convincing the public to buy their housing units. One of the innovations carried out is to recruit famous architects to collaborate in designing their housing. There are those who collaborate to design housing units in their housing clusters, but there are also those who collaborate since the creation of masterpaln to housing units. Of course, with the hope of cooperating with famous architects will be able to make their housing more pretentious, preferred by consumers, and ultimately bought by consumers.While on the community side, what do they expect by buying a house in housing designed by a well-known architect? Is it because of prestige, is it because of other things? This phenomenon is what makes researchers interested in finding out what the influence of a famous architect on the image of a housing in the eyes of the public.The purpose of this study was to determine the effect of the design of starchitect.
印度尼西亚住宅房地产的发展持续增长。虽然不可否认,目前的全球经济衰退影响了房地产业,但房屋发展必须继续增长,以适应人口的需求。最近的经济状况使得房地产开发商不得不采取各种创新措施来说服公众购买他们的住房。其中一项创新是聘请著名建筑师合作设计他们的房屋。有些人在他们的住房集群中合作设计住房单元,但也有一些人在住房单元的总体规划创建后合作。当然,希望通过与著名建筑师的合作,可以让自己的房子更加矫情,受到消费者的青睐,最终被消费者购买。而在社区方面,他们希望买一个由知名建筑师设计的房子吗?是因为声望,还是因为其他原因?这种现象使得研究人员有兴趣找出一个著名的建筑师对公众眼中的住房形象的影响。本研究的目的是确定明星建筑师的设计效果。
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引用次数: 0
TRANSFORMASI FISIK DAN BUDAYA KAWASAN PULO BRAYAN, KOTA MEDAN
Pub Date : 2022-05-26 DOI: 10.14710/mdl.22.1.2022.1-12
A. Widya, Muhammad Abdul Soleh, Widi Dwi Satria
Perkembangan kota di Indonesia sangat dipengaruhi oleh perkembangan sosial, ekonomi, dan politik, tak terkecuali Medan sebagai salah satu kota terbesar. Awal perkembangan Kota Medan dipengaruhi oleh keputusan politik Belanda. Ekspansi terhadap lahan perkebunan oleh Belanda berpengaruh besar pada bentuk struktur kota dan perkampungan warga, salah satunya yaitu Pulo Brayan. Penelitian empiris ini bertujuan untuk mengungkap transformasi fisik dan budaya pada kawasan bersejarah Pulo Brayan, Kota Medan. transformasi major arteries (jalan utama), roads (jalan), dan buildings elements (elemen bangunan). Analisis dilakukan secara kualitatif berbasis pada kajian literatur, survei lapangan, dan penelusuran melalui citra satelit. Peneliti menemukan bahwa transformasi jaringan jalan yang terdiri atas “major arteries” dan “roads” dilakukan untuk mengakomodasi pertumbuhan kawasan yang dinamis seperti kemacetan lalu lintas dan kebutuhan perumahan. Sementara itu, transformasi bangunan bergantung pada status kepemilikkan (milik pribadi atau perusahaan). Minimnya regulasi yang mengatur tentang perlindungan bangunan juga diyakini sebagai faktor keterawatan bangunan tersebut. Hasil penelitian dapat digunakan pengembangan kawasan Pulo Brayan sebagai kawasan cagar budaya Kota Medan dengan memahami sejarah dan perkembangan kawasan dari masa ke masa.
印度尼西亚城市的发展受到社会、经济和政治发展的高度影响,棉兰是世界上最大的城市之一。棉田城市的早期发展受到荷兰政治决策的影响。荷兰对种植园的扩张对城市和社区的结构产生了深远的影响,其中之一是普罗布拉扬(Pulo Brayan)。这种实证研究的目的是揭示在历史悠久的棉兰市巴洛布拉扬的身体和文化转变。主要街道、道路和建筑元素的改变。基于文献研究、实地调查和卫星图像搜索的定性分析。研究人员发现,由“主要动脉”和“道路”组成的道路网络的转变是为了适应交通堵塞和住房需求等动态区域的增长。与此同时,建筑的转变取决于所有权地位(个人或企业)。建筑保护缺乏监管也被认为是效率低下的一个因素。研究结果可以通过了解该地区的历史和历史发展,将其作为棉兰区的开发。
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引用次数: 0
POSITIVISME DAN POST POSITIVISME: REFLEKSI ATAS PERKEMBANGAN ILMU PENGETAHUAN DAN PERENCANAAN KOTA DALAM TINJAUAN FILSAFAT ILMU DAN METODOLOGI PENELITIAN 积极主义和后积极主义:反映科学发展和城市规划在研究哲学和方法论审查
Pub Date : 2022-05-26 DOI: 10.14710/mdl.22.1.2022.21-30
Hendrianto Sundaro
Sebagai paradigma ilmu pengetahuan, Positivisme dan Post positivisme telah memberikan pengaruh yang besar bagi perkembangan ilmu pengetahuan dan kemajuan peradaban manusia termasuk didalamnya adalah perkembangan kota yang menjadi pusat peradaban manusia. Dalam proses tersebut, filsafat dan metodologi penelitian memiliki peran penting bukan hanya dalam membentuk ilmu pengetahuan tetapi juga meninjau eksistensi ilmu pengetahuan. Meninjau eksistensi ilmu pengetahuan melalu kacamata filsafat dan bukan oleh ilmu itu sendiri adalah agar dapat menempatkan ilmu pengetahuan secara jujur dan obyektif.  Artikel ini bertujuan untuk : 1) Mendeskripsikan sejarah perkembangan filsafat dan ilmu pengetahuan, 2) Mengetahu esensi dari filsafat ilmu dan kedudukannya dalam konstelasi ilmu pengetahuan (science),  3) Mengetahui keterkaitan filsafat ilmu dengan paradigma positivisme dan post-positivisme dalam metodologi penelitian serta 4) Mengetahui kontribusi positivisme dan post positivisme terhadap perkembangan kota. Metode yang digunakan dalam penulisan artikel ini adalah  studi literatur dengan pendekatan deskriptif-kualitatif. Data yang digunakan adalah data sekunder berupa hasil-hasil pemikiran yang dituangkan di dalam buku dan jurnal baik nasional maupun yang terakreditasi yang memuat topik tentang filsafat, positivisme dan post positivisme, metodologi penelitian dan perkembangan kota / perencanaan wilayah dan kota.  
作为一种科学范例,积极主义和后积极主义对人类科学的发展和文明的进步产生了巨大的影响,包括城市成为人类文明的中心。在这个过程中,研究的哲学和方法论不仅在塑造科学,而且在审查科学的存在方面发挥着重要作用。通过哲学的角度而不是科学本身来审视科学的存在,是为了诚实和客观地看待科学。这篇文章的目的:1)描述历史发展哲学和科学,2)知道如何科学和哲学的本质中地位科学(science), 3)知道星座中的实证科学的哲学范式和post-positivisme联系实证研究方法以及4)知道贡献和实证post)对城市的发展。本文采用的方法是专业化的文献研究。所使用的数据是国家书籍和期刊中所产生的思想产生的次要数据,以及被认可的思想结果,主题是哲学、积极主义和后积极主义、研究方法和城市发展/地区规划。
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引用次数: 2
期刊
Brain network and modulation
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