Pub Date : 2022-10-14DOI: 10.3390/nutraceuticals2040022
S. Ivanova, A. Prosekov
The effect of UV-A irradiation (353 nm, 365 nm, and 400 nm) on the antioxidant properties of fresh vegetables (cucumbers, bell peppers, zucchinis) was investigated. This type of processing was found to increase the total content of phenolic compounds and flavonoids in vegetables. With a UV irradiation of 360 min at a wavelength of 365 nm, the greatest increase in antioxidant activity occurred in vegetable samples vs. untreated control samples. The total content of phenolic compounds increased by 34–58% and the content of flavonoids by 26–53% for various vegetable varieties. There was an increase in the activity of antioxidant enzymes (catalase up to 86%, peroxidase from 38%, polyphenol oxidase up to 74% depending on the variety of vegetables) after 360 min of exposure (p < 0.05). The results of the conducted studies indicate that post-harvest ultraviolet irradiation of vegetables has the potential to control the antioxidant characteristics of vegetables; however, additional research is needed to form a complete mechanism of this effect and create a technology for vegetable processing.
{"title":"Study of the Antioxidant Potential of UV-Treated Vegetables","authors":"S. Ivanova, A. Prosekov","doi":"10.3390/nutraceuticals2040022","DOIUrl":"https://doi.org/10.3390/nutraceuticals2040022","url":null,"abstract":"The effect of UV-A irradiation (353 nm, 365 nm, and 400 nm) on the antioxidant properties of fresh vegetables (cucumbers, bell peppers, zucchinis) was investigated. This type of processing was found to increase the total content of phenolic compounds and flavonoids in vegetables. With a UV irradiation of 360 min at a wavelength of 365 nm, the greatest increase in antioxidant activity occurred in vegetable samples vs. untreated control samples. The total content of phenolic compounds increased by 34–58% and the content of flavonoids by 26–53% for various vegetable varieties. There was an increase in the activity of antioxidant enzymes (catalase up to 86%, peroxidase from 38%, polyphenol oxidase up to 74% depending on the variety of vegetables) after 360 min of exposure (p < 0.05). The results of the conducted studies indicate that post-harvest ultraviolet irradiation of vegetables has the potential to control the antioxidant characteristics of vegetables; however, additional research is needed to form a complete mechanism of this effect and create a technology for vegetable processing.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46157468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-11DOI: 10.3390/nutraceuticals2040021
G. Carullo, U. G. Spizzirri, R. Malivindi, V. Rago, Marisa Francesca Motta, D. Lofaro, D. Restuccia, F. Aiello
A quercetin derivative with remarkable biological performance was successfully synthesized by chemical modification of the flavonoid with docosahexaenoic acid to synthesize 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate (3), deeply characterized by NMR spetroscopy. Modified quercetin and pectin were involved in a grafting process by an ecofriendly radical procedure able to preserve the biological features of the quercetin derivative. Antioxidant performances of the conjugate were evaluated both in term of total phenolic amount and scavenger activity in organic and aqueous environments. Additionally, in vitro acute oral toxicity was also tested against Caco-2 cells and 3T3 fibroblasts, confirming that pectin conjugate does not have any effect on cell viability at the dietary use concentrations. Finally, in vitro experiments highlighted the ability of the conjugate to counteract the migratory properties of Caco-2 and HepG2 cells, indicating its feature in the reduction of the migration of tumour cells. These data showed that the covalent binding of the quercetin derivative to the pectin chain represents a very interesting strategy to improve the bioavailability of the quercetin, representing an effective means of protecting and to transporting polyphenol molecules.
{"title":"Development of Quercetin-DHA Ester-Based Pectin Conjugates as New Functional Supplement: Effects on Cell Viability and Migration","authors":"G. Carullo, U. G. Spizzirri, R. Malivindi, V. Rago, Marisa Francesca Motta, D. Lofaro, D. Restuccia, F. Aiello","doi":"10.3390/nutraceuticals2040021","DOIUrl":"https://doi.org/10.3390/nutraceuticals2040021","url":null,"abstract":"A quercetin derivative with remarkable biological performance was successfully synthesized by chemical modification of the flavonoid with docosahexaenoic acid to synthesize 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate (3), deeply characterized by NMR spetroscopy. Modified quercetin and pectin were involved in a grafting process by an ecofriendly radical procedure able to preserve the biological features of the quercetin derivative. Antioxidant performances of the conjugate were evaluated both in term of total phenolic amount and scavenger activity in organic and aqueous environments. Additionally, in vitro acute oral toxicity was also tested against Caco-2 cells and 3T3 fibroblasts, confirming that pectin conjugate does not have any effect on cell viability at the dietary use concentrations. Finally, in vitro experiments highlighted the ability of the conjugate to counteract the migratory properties of Caco-2 and HepG2 cells, indicating its feature in the reduction of the migration of tumour cells. These data showed that the covalent binding of the quercetin derivative to the pectin chain represents a very interesting strategy to improve the bioavailability of the quercetin, representing an effective means of protecting and to transporting polyphenol molecules.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46473978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-03DOI: 10.3390/nutraceuticals2040020
Roberto Cannataro, E. Cione
Lipedema is a pathology of the adipose tissue, in evident female prevalence, diagnosed clinically and still of not well-defined etiopathogenesis. Indeed, an estrogen-related component is present, and an inflammatory state and a condition of edema are present in most cases; even pain seems to be a recurring feature, and insulin resistance is also often associated with lipedema. The therapeutic approach is finally becoming holistic. Therefore, with surgery, physiotherapy, and elastic compression therapy, the nutritional aspect of food supplementation is gaining much value. The objective of the present work is to consider the nutritional supplements that could be useful to manage this condition, underlining that, at the moment, the specific literature is practically non-existent. The most promising supplements seem to be omega 3 fish oil, polyphenols, and vitamin C, but the need for studies in this sector is urgent.
{"title":"Nutritional Supplements and Lipedema: Scientific and Rational Use","authors":"Roberto Cannataro, E. Cione","doi":"10.3390/nutraceuticals2040020","DOIUrl":"https://doi.org/10.3390/nutraceuticals2040020","url":null,"abstract":"Lipedema is a pathology of the adipose tissue, in evident female prevalence, diagnosed clinically and still of not well-defined etiopathogenesis. Indeed, an estrogen-related component is present, and an inflammatory state and a condition of edema are present in most cases; even pain seems to be a recurring feature, and insulin resistance is also often associated with lipedema. The therapeutic approach is finally becoming holistic. Therefore, with surgery, physiotherapy, and elastic compression therapy, the nutritional aspect of food supplementation is gaining much value. The objective of the present work is to consider the nutritional supplements that could be useful to manage this condition, underlining that, at the moment, the specific literature is practically non-existent. The most promising supplements seem to be omega 3 fish oil, polyphenols, and vitamin C, but the need for studies in this sector is urgent.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48739875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-26DOI: 10.3390/nutraceuticals2040019
Matúš Kučka, K. Ražná, Ľubomír Harenčár, Terézia Kolarovičová
Some seeds of flowering plants can differentiate their seed coat epidermis into the specialized cell layer producing a hydrophilic mucilage with several ecological functions, such as seed hydration, protection, spatial fixation, stimulation of metabolic activity and development of seed. Due to the species- and genotype-dependent variabilities in the chemical composition of mucilage, mucilage does not display the same functional properties and its role depends on the respective species and environment. Mucilaginous substances, depending on their composition, exhibit many preventive and curative effects for human and animal health, which has significant potential in the agricultural, food, cosmetic and pharmaceutical industries. This paper summarizes the ecological, biological, and functional properties of mucilaginous plant substances and highlights their significant nutritional potential in terms of the development of functional foods, and nutraceuticals and dietary supplements. A paragraph describing the gene regulation of seed mucilage synthesis is included, and some recommendations for the direction of further research on mucilaginous substances are outlined.
{"title":"Plant Seed Mucilage—Great Potential for Sticky Matter","authors":"Matúš Kučka, K. Ražná, Ľubomír Harenčár, Terézia Kolarovičová","doi":"10.3390/nutraceuticals2040019","DOIUrl":"https://doi.org/10.3390/nutraceuticals2040019","url":null,"abstract":"Some seeds of flowering plants can differentiate their seed coat epidermis into the specialized cell layer producing a hydrophilic mucilage with several ecological functions, such as seed hydration, protection, spatial fixation, stimulation of metabolic activity and development of seed. Due to the species- and genotype-dependent variabilities in the chemical composition of mucilage, mucilage does not display the same functional properties and its role depends on the respective species and environment. Mucilaginous substances, depending on their composition, exhibit many preventive and curative effects for human and animal health, which has significant potential in the agricultural, food, cosmetic and pharmaceutical industries. This paper summarizes the ecological, biological, and functional properties of mucilaginous plant substances and highlights their significant nutritional potential in terms of the development of functional foods, and nutraceuticals and dietary supplements. A paragraph describing the gene regulation of seed mucilage synthesis is included, and some recommendations for the direction of further research on mucilaginous substances are outlined.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42374724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-17DOI: 10.3390/nutraceuticals2030018
Valeria Consoli, V. Sorrenti, Ilaria Burò, M. Modica, L. Vanella
Several lines of evidence indicate that plant-derived antioxidant compounds can be used as anticancer agents to support conventional pharmacological therapy. In this context, heme-oxygenase-1 (HO-1) modulation has been proven to represent a valid approach for reducing cancer cells’ proliferation through the activation of apoptosis and ferroptosis. This study focused on three little studied HO-1 inducers (paeonol, rosolic acid and dimethoxy resveratrol) in order to evaluate their efficacy as antiproliferative compounds on breast cancer cells (MCF-7 and MDA-MB 231). Cell viability data showed an interesting selectivity of dimethoxy resveratrol (DMR) for MDA-MB 231 cells. The ineffectiveness of Ferrostatin-1 and Trolox treatment led to the exclusion of ferroptosis involvement; meanwhile, cell viability reduction was associated with caspase 3/7 activation and apoptosis. Taken together, our results suggest a potential role of DMR as an adjuvant in conventional chemotherapy for breast cancer treatment.
{"title":"Antiproliferative Effect of Plant-Derived Bioactive Compounds Endowed with Antioxidant Activity on Breast Cancer Cells","authors":"Valeria Consoli, V. Sorrenti, Ilaria Burò, M. Modica, L. Vanella","doi":"10.3390/nutraceuticals2030018","DOIUrl":"https://doi.org/10.3390/nutraceuticals2030018","url":null,"abstract":"Several lines of evidence indicate that plant-derived antioxidant compounds can be used as anticancer agents to support conventional pharmacological therapy. In this context, heme-oxygenase-1 (HO-1) modulation has been proven to represent a valid approach for reducing cancer cells’ proliferation through the activation of apoptosis and ferroptosis. This study focused on three little studied HO-1 inducers (paeonol, rosolic acid and dimethoxy resveratrol) in order to evaluate their efficacy as antiproliferative compounds on breast cancer cells (MCF-7 and MDA-MB 231). Cell viability data showed an interesting selectivity of dimethoxy resveratrol (DMR) for MDA-MB 231 cells. The ineffectiveness of Ferrostatin-1 and Trolox treatment led to the exclusion of ferroptosis involvement; meanwhile, cell viability reduction was associated with caspase 3/7 activation and apoptosis. Taken together, our results suggest a potential role of DMR as an adjuvant in conventional chemotherapy for breast cancer treatment.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47846504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-16DOI: 10.3390/nutraceuticals2030017
T. Mokgehle, D. Ndou, N. Madala, N. Tavengwa
Solanum lycopersicum and Moringa oleifera are two essential nutraceutical-containing plants from two different families, and are sources of abundant metabolites. They have a variety of applications in medicines, functional food additives and even water purification. This review aims to complement earlier reviews by comparing the metabolite profiles and modern-day pharmacological relevance of both plants. The metabolome of Moringa oleifera was compared to that of Solanum lycopersicum, to evaluate the common metabolites found within the two plants and how these compounds can be used for same pharmacological and nutritional benefits. While these plants contain similar metabolites, they also contain different compounds of the same class that differ in terms of their biological functions. In such instances, Moringa oleifera and Solanum lycopersicum may have similar applications, but remain distinguishable from each other in terms of pharmacological potential.
{"title":"A Comprehensive and Comparative Metabolomic Study of Two Nutraceutical-Containing Plants; Moringa oleifera and Solanum lycopersicum: A Review","authors":"T. Mokgehle, D. Ndou, N. Madala, N. Tavengwa","doi":"10.3390/nutraceuticals2030017","DOIUrl":"https://doi.org/10.3390/nutraceuticals2030017","url":null,"abstract":"Solanum lycopersicum and Moringa oleifera are two essential nutraceutical-containing plants from two different families, and are sources of abundant metabolites. They have a variety of applications in medicines, functional food additives and even water purification. This review aims to complement earlier reviews by comparing the metabolite profiles and modern-day pharmacological relevance of both plants. The metabolome of Moringa oleifera was compared to that of Solanum lycopersicum, to evaluate the common metabolites found within the two plants and how these compounds can be used for same pharmacological and nutritional benefits. While these plants contain similar metabolites, they also contain different compounds of the same class that differ in terms of their biological functions. In such instances, Moringa oleifera and Solanum lycopersicum may have similar applications, but remain distinguishable from each other in terms of pharmacological potential.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48781116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-08DOI: 10.3390/nutraceuticals2030016
Jiao Zhang, Ariane Perez-Gavilan, A. C. Neves
Brewer’s spent grain is the residue left after the separation of wort during the beer-brewing process. Although this by-product has been reported to have a high protein content, it is normally treated as waste. This work aims to isolate bioactive hydrolysates from BSG, and then explore their bioactivities. Two groups (A and B) of BSG were subjected to protein extraction using the alkaline extraction method at pH 12, where group A was pre-treated with cellulase, while group B was not pre-treated and was directly extracted. The final isolate yielded 50.18 ± 1.22% recovery of the BSGP from group A and 66.41 ± 0.37% recovery from group B. RP-HPLC profiles showed that the extracted BSGPs are mainly hydrophilic proteins. The proteins extracted by the two methods were hydrolyzed enzymatically using Alcalase and α-chymotrypsin. The hydrolysates obtained displayed blood pressure regulation activity and antioxidant properties, when assayed with angiotensin-converting enzyme assay, 2,2-diphenyl-picryl-hydrazyl assay, and ferric antioxidant power assay. It can be concluded that it is possible to extract good quality proteins from BSG and this by-product presents potential as a source for the extraction of a variety of proteins that might be of interest to the food industries.
{"title":"Evaluation of the In Vitro Bioactivities’ Profiles of Brewers’ Spent Grain Protein and Hydrolysates with and without Cellulase Pretreatment","authors":"Jiao Zhang, Ariane Perez-Gavilan, A. C. Neves","doi":"10.3390/nutraceuticals2030016","DOIUrl":"https://doi.org/10.3390/nutraceuticals2030016","url":null,"abstract":"Brewer’s spent grain is the residue left after the separation of wort during the beer-brewing process. Although this by-product has been reported to have a high protein content, it is normally treated as waste. This work aims to isolate bioactive hydrolysates from BSG, and then explore their bioactivities. Two groups (A and B) of BSG were subjected to protein extraction using the alkaline extraction method at pH 12, where group A was pre-treated with cellulase, while group B was not pre-treated and was directly extracted. The final isolate yielded 50.18 ± 1.22% recovery of the BSGP from group A and 66.41 ± 0.37% recovery from group B. RP-HPLC profiles showed that the extracted BSGPs are mainly hydrophilic proteins. The proteins extracted by the two methods were hydrolyzed enzymatically using Alcalase and α-chymotrypsin. The hydrolysates obtained displayed blood pressure regulation activity and antioxidant properties, when assayed with angiotensin-converting enzyme assay, 2,2-diphenyl-picryl-hydrazyl assay, and ferric antioxidant power assay. It can be concluded that it is possible to extract good quality proteins from BSG and this by-product presents potential as a source for the extraction of a variety of proteins that might be of interest to the food industries.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47791182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-22DOI: 10.3390/nutraceuticals2030015
Kirsty M. Reynolds, Loris A. Juett, James Cobb, C. Hulston, S. Mears, L. James
Carbohydrate consumption during exercise enhances endurance performance. A food-focused approach may offer an alternative, ‘healthier’ approach given the potential health concerns associated with artificial fructose sources, but food-based carbohydrate sources may increase gastrointestinal (GI) symptoms. This study compared the cycling performance and GI comfort of two different fructose sources (fruit and artificial) ingested during exercise. Nine trained male cyclists (age 24 ± 7 years; VO2peak 65 ± 6 mL/kg/min) completed a familiarisation and two experimental trials (60 g/h carbohydrate, 120 min at 55% Wmax and ~15 min time trial). In the two experimental trials, carbohydrate was ingested in a 2:1 glucose-to-fructose ratio, with fructose provided as artificial crystalline fructose (GLU/FRU) or natural apple puree (APPLE PUREE) and maltodextrin added to provide sufficient glucose. Time trial (TT) performance was not different between trials (GLU/FRU 792 ± 68 s, APPLE PUREE 800 ± 65 s; p = 0.313). No GI symptoms were significantly different between trials (p ≥ 0.085). Heart rate, blood glucose/lactate concentrations, and RPE were not different between trials, but all, excluding blood glucose concentration, increased from rest to exercise and further increased post-TT. Apple puree as a natural fructose source provides an alternative to artificial fructose sources without influencing cycling performance or GI symptoms.
{"title":"Apple Puree as a Natural Fructose Source Provides an Effective Alternative to Artificial Fructose Sources for Fuelling Endurance Cycling Performance in Males","authors":"Kirsty M. Reynolds, Loris A. Juett, James Cobb, C. Hulston, S. Mears, L. James","doi":"10.3390/nutraceuticals2030015","DOIUrl":"https://doi.org/10.3390/nutraceuticals2030015","url":null,"abstract":"Carbohydrate consumption during exercise enhances endurance performance. A food-focused approach may offer an alternative, ‘healthier’ approach given the potential health concerns associated with artificial fructose sources, but food-based carbohydrate sources may increase gastrointestinal (GI) symptoms. This study compared the cycling performance and GI comfort of two different fructose sources (fruit and artificial) ingested during exercise. Nine trained male cyclists (age 24 ± 7 years; VO2peak 65 ± 6 mL/kg/min) completed a familiarisation and two experimental trials (60 g/h carbohydrate, 120 min at 55% Wmax and ~15 min time trial). In the two experimental trials, carbohydrate was ingested in a 2:1 glucose-to-fructose ratio, with fructose provided as artificial crystalline fructose (GLU/FRU) or natural apple puree (APPLE PUREE) and maltodextrin added to provide sufficient glucose. Time trial (TT) performance was not different between trials (GLU/FRU 792 ± 68 s, APPLE PUREE 800 ± 65 s; p = 0.313). No GI symptoms were significantly different between trials (p ≥ 0.085). Heart rate, blood glucose/lactate concentrations, and RPE were not different between trials, but all, excluding blood glucose concentration, increased from rest to exercise and further increased post-TT. Apple puree as a natural fructose source provides an alternative to artificial fructose sources without influencing cycling performance or GI symptoms.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43177540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-03DOI: 10.3390/nutraceuticals2030014
Taiki Miyazawa, Chizumi Abe, G. Burdeos, Akira Matsumoto, Masako Toda
The concept of food and aging is of great concern to humans. So far, more than 300 theories of aging have been suggested, and approaches based on these principles have been investigated. It has been reported that antioxidants in foods might play a role in human aging. To clarify the current recognition and positioning of the relationship between these food antioxidants and aging, this review is presented in the following order: (1) aging theories, (2) food and aging, and (3) individual food antioxidants and aging. Clarifying the significance of food antioxidants in the field of aging will lead to the development of strategies to achieve healthy human aging.
{"title":"Food Antioxidants and Aging: Theory, Current Evidence and Perspectives","authors":"Taiki Miyazawa, Chizumi Abe, G. Burdeos, Akira Matsumoto, Masako Toda","doi":"10.3390/nutraceuticals2030014","DOIUrl":"https://doi.org/10.3390/nutraceuticals2030014","url":null,"abstract":"The concept of food and aging is of great concern to humans. So far, more than 300 theories of aging have been suggested, and approaches based on these principles have been investigated. It has been reported that antioxidants in foods might play a role in human aging. To clarify the current recognition and positioning of the relationship between these food antioxidants and aging, this review is presented in the following order: (1) aging theories, (2) food and aging, and (3) individual food antioxidants and aging. Clarifying the significance of food antioxidants in the field of aging will lead to the development of strategies to achieve healthy human aging.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49444778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-26DOI: 10.3390/nutraceuticals2030013
Yurika Kitamura, K. Nishi, M. Ishida, S. Nishimoto, T. Sugahara
Coriander (Coriandrum sativum L.) is classified in the Apiaceae family and used as an herb. Coriander leaf has been reported to possess various health functions. Here, we report the anti-allergic effect of aqueous coriander leaf extract (ACLE). ACLE with 1.0 mg/mL or higher concentration significantly inhibited degranulation of RBL-2H3 cells in a concentration-dependent manner with no cytotoxicity. ACLE suppressed the increase in the intracellular Ca2+ concentration in response to antigen-specific stimulation. Immunoblot analysis demonstrated that ACLE significantly downregulates phosphorylation of phosphatidylinositol 3-kinase and tends to downregulate phosphorylation of Syk kinase in the signaling pathways activated by antigen-mediated stimulation. Oral administration of ACLE did not alter the sneezing frequency of pollinosis model mice stimulated with cedar pollen, but significantly reduced the serum IgE level. Our data show anti-allergic effects of coriander leaf in both cultured cells and pollinosis mice. These results suggest that coriander leaf has the potential to be a functional foodstuff with anti-allergy effects.
{"title":"Anti-Allergic Effect of Aqueous Extract of Coriander (Coriandrum sativum L.) Leaf in RBL-2H3 Cells and Cedar Pollinosis Model Mice","authors":"Yurika Kitamura, K. Nishi, M. Ishida, S. Nishimoto, T. Sugahara","doi":"10.3390/nutraceuticals2030013","DOIUrl":"https://doi.org/10.3390/nutraceuticals2030013","url":null,"abstract":"Coriander (Coriandrum sativum L.) is classified in the Apiaceae family and used as an herb. Coriander leaf has been reported to possess various health functions. Here, we report the anti-allergic effect of aqueous coriander leaf extract (ACLE). ACLE with 1.0 mg/mL or higher concentration significantly inhibited degranulation of RBL-2H3 cells in a concentration-dependent manner with no cytotoxicity. ACLE suppressed the increase in the intracellular Ca2+ concentration in response to antigen-specific stimulation. Immunoblot analysis demonstrated that ACLE significantly downregulates phosphorylation of phosphatidylinositol 3-kinase and tends to downregulate phosphorylation of Syk kinase in the signaling pathways activated by antigen-mediated stimulation. Oral administration of ACLE did not alter the sneezing frequency of pollinosis model mice stimulated with cedar pollen, but significantly reduced the serum IgE level. Our data show anti-allergic effects of coriander leaf in both cultured cells and pollinosis mice. These results suggest that coriander leaf has the potential to be a functional foodstuff with anti-allergy effects.","PeriodicalId":93800,"journal":{"name":"Nutraceuticals","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47808310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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