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La Sota Vaccination Does Not Offer Satisfactory Protection Against Velogenic Newcastle Disease Virus Infection In Chickens- A Review La Sota疫苗不能提供令人满意的预防鸡新城疫病毒感染的研究综述
Pub Date : 2019-01-01 DOI: 10.32392/BIOMED.38
J. Okoye, A. O. Igwe
La Sota vaccination is the major vaccine used in the control of Newcastle disease (ND) of chickens in most countries of Europe and United States of America where millions of chickens are kept in one farm at a time. La Sota vaccine is administered through drinking water and can be easily administered on millions of chickens in few hours. Furthermore, the predominant field ND virus pathotype in these countries is the mesogenic virus for which La Sota vaccination is effective in providing protection. But this same vaccine has been found to be ineffective against velogenic ND virus pathotype which is enzootic in Africa, Middle and Far East. This makes large scale poultry production difficult in these areas. The Komarov ND vaccine which is effective against the velogenic ND virus is administered intramuscularly and requires individual handling of the chickens which is not possible where millions of chickens are housed together. Copyright: © 2019 Science Publishing Group This open access article is distributed under the terms of the Creative Commons Attribution NonCommercial License. La Sota Vaccination Against Velogenic Newcastle Disease Virus Infection in Chicken. Science Publishing Group Copyright 2019 www.spg.ltd 3 DISCUSSION Newcastle disease (ND) is a major disease of poultry worldwide (Alexander and Senne, 2008). The virus infects a wide range of avian species including poultry, cage and wild birds (Kaleta and Baldauf, 1988). Chickens are most severely affected probably because it is only in this species that ND causes severe haemorrhagic and ulcerative lesions in the gastrointestinal tract (Okoroafor et al, 2018). The velogenic form of ND is the most severe form of the disease and usually causes mortalities of up to 70 to 100 % within seven days in susceptible chickens (Igwe et al. 2018). Okpe et al (2015) reported that dietary supplementation of vitamin A significantly reduced the mortality of velogenic ND (VND) in chickens. VND is enzootic in Africa, Middle and Far East (Echeonwu et al, 1993; Solomon et al, 2012 and Shittu et al, 2016) and it is a major factor militating against poultry production in these areas (Czegledi et al, 2006). The outbreaks cause huge economic losses to poultry producers because of heavy mortalities, loss of egg production, imposition of trade embargo by the international community and the stamping out control policy used to control the disease in those countries where VND is exotic. Control of ND is mainly by vaccination and biosecurity. Recently, researchers have discovered many inadequacies and problems in the control of VND with La Sota vaccination. Ezema et al (2009) challenged La Sota vaccinated and unvaccinated chickens with velogenic viscerotropic ND virus and reported that there was no clinical sign in the vaccinated chickens but the mortality in unvaccinated was 84.6 %. But the atrophy, necrosis and the depletion of the lymphocytes in the bursa, spleen and thymus were equally very severe in both vaccinated
未接种疫苗的雏鸡胃肠道、雌性生殖器官和免疫组织化学标记的病理改变比接种疫苗的雏鸡更严重。Igwe等人(2018b)观察到,感染VNDV的蛋鸡产蛋量下降与血清磷水平下降呈强烈正相关。上述观察结果表明,La Sota疫苗接种:1 .不能保护鸡免受VND在淋巴器官的损害。结果是免疫抑制。不能保护鸡不受VNDV病毒的感染。环境污染是后果。不能保护蛋鸡免受因VND而导致的产蛋量下降。巨大的经济损失是后果。这些条件与盈利的家禽养殖不相容。在欧洲和美洲的发达国家,家禽生产已经转变为大型工业,在一个农场同时饲养数百万只鸡,现在的做法是在特定的时间间隔接种La Sota疫苗。科马罗夫疫苗是在6周龄的鸡的胸肌处接种的,由于不可能单独处理数百万只鸡,因此已被排除在外。Komarov是中源性新城疫病病毒,比La Sota是慢源性新城疫病病毒产生更强的保护作用。发达国家目前的做法可能不会使鸡暴露在很大的风险中,因为VND在这些国家是外来的,而且他们的生物安全措施非常强。但是,在发生流行性出血热的地区,只接种La Sota疫苗进行大规模家禽生产是有风险的。总的来说,非洲的生物安全实践很薄弱。解决办法可能是重新审视La Sota疫苗和疫苗接种计划,使其对控制VND有效。La Sota疫苗预防鸡新城疫病毒感染。科学出版集团版权所有2019 www.spg.ltdAlexander, D.J.和Senne, d.a., 2008。ND和其他禽副黏液病毒感染。见:家禽疾病12版,Y.M.赛义夫,H.J.巴恩斯,J.R.格里森,A.M.最后,L.R. McDougal, D.E. Swayne(编)。爱荷华州立大学出版社,爱荷华州艾姆斯。p . 75 - 100。2. Bwala, D. G., cliff, S., Duncan, N . M., bishop, S. P . r .和Oludayo, Fasina F 2012。免疫组织化学法测定SPF和商品母鸡输卵管中透镜性疫苗和新城疫病毒的分布。兽医研究。科学,1993,520 - 528。3.Cattoli, G, Susta, L, Terregino, C, and Brown, C, 2011。新城疫病:现场识别和现有实验室检测方法综述。兽医诊断研究杂志,23,637-656。Czegledi, A., Ujvari, D., Somogyi, E., Wehmann E., Werner, o .和Lomniczi, B., 2006。禽副粘病毒血清型1(新城疫病毒)的第三个基因组大小分类及其进化意义。病毒研究,120,36-48艾川武,g.o.n, Ireogbu, c.i.和Emeruwa, a.c., 1993。在尼日利亚从死亡和健康的自由漫游鸟类中恢复新城疫病毒。家禽病理学杂志,22,383- 383。Eze, d.c.(2017)。新城疫病毒感染鸡体内体液免疫抑制特性的评价。博士论文。尼日利亚大学兽医病理学与微生物学系,尼日利亚,恩苏卡Ezema, w.s., Okoye, J O A和Nwanta, J A. 2009。Lasota疫苗接种可能不能预防鸡的新城疫病变。热带动物卫生与生产,41,477 - 484。8. Ezema, w.s., Eze, d.c., Shoyinka, S.V.O.和Okoye, j.o.a. 2016。新城疫病毒感染引起鸡淋巴器官萎缩及抗体反应抑制。热带动物卫生与生产,48,1703-1709。9. 刘建军,刘建军,刘建军,刘建军,刘建军。2018a。免疫组织化学标记法研究了接种和未接种蛋鸡生殖系统中新城疫病毒的病理和分布。中国医学杂志,2009,31(2):444 - 444。Doi.org/10.1016/i.jcpa.2017.12.009 10。刘建军,刘建军,刘建军,等。2018。新城疫病毒感染后蛋鸡血清钙、磷水平的变化及其与产蛋量的关系应用动物研究学报,46,523-528,doi.org/10.1080/09712119.2017.1352506Kaleta, E F和Baldauf, C.1988。自由生活和宠物鸟的新城疫。见:亚历山大,D . J .(主编)。纽卡斯尔疾病。Kluwer学术出版社,波士顿,第197-246页。La Sota疫苗预防鸡的新城疫病毒感染。科学出版集团版权所有2019 www.spg.ltd 6 12。米勒,p.j.,金,d.j.,阿方索,c.l.和苏亚雷斯,d.l. 2007。 疫苗制剂中不同基因型新城疫病毒株的抗原差异影响病毒的脱落
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引用次数: 0
Acetabular Revision Of Paprosky Iii Defects With A New Concept Shell: A Preliminary Study On 34 Consecutive Cases 新概念壳髋臼修复papprosky Iii型缺损34例的初步研究
Pub Date : 2019-01-01 DOI: 10.32392/biomed.50
Ceretti Marco, P. Gabriele, F. Francesco
The increasing duration of life with total hip arthroplasties and trend toward indication for surgery at younger ages, will increase the amount and complexity of revision surgery. Cementless acetabular components have shown improved long term survival over cemented components. Sometimes peripheral acetabular circumference (RIM) and acetabular wall integrity aren’t enough preserved to guarantee a new implant good stability. Usually the treatment options for III A and III B Paprosky defects are: cage implant with cemented polyethylene liner, cementless implants with augmentation using, big revision shell implant with biological/metal augmentation or the stemmed cup implant. The LIMA acetabular revision system born to make possible the combination between cage benefit with all the primary implant shell advantages. This solution gives the same stability of a cage and more options than a primary cup to restore the hip rotation centre without
全髋关节置换术患者寿命的延长和手术指征的年轻化趋势,将增加翻修手术的数量和复杂性。无骨水泥髋臼假体比骨水泥假体的长期生存率更高。有时髋臼外周(RIM)和髋臼壁完整性不足以保证新植入物的良好稳定性。通常,III A和III B类帕普洛斯基缺陷的治疗选择有:带胶结聚乙烯衬垫的笼状种植体、带增强物的无水泥种植体、带生物/金属增强物的大翻修壳种植体或柄杯种植体。LIMA髋臼翻修系统的诞生,使固定笼的优点与原有假体外壳的所有优点的结合成为可能。该解决方案提供了与笼一样的稳定性和更多的选择,以恢复髋关节旋转中心,而不是初级杯
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引用次数: 1
Non-Tuberculous Mycobacteria: An Emerging Clinical Problem 非结核分枝杆菌:一个新出现的临床问题
Pub Date : 2019-01-01 DOI: 10.32392/biomed.67
J. Holton
Mycobacteria are aerobic organism that are non-sporulating, non-motile (M. marinum is an exception) and have a waxy, relatively impermeable cell wall consisting of arabinogalactan and mycolic acids. There are over 188 mycobacterial species. Mycobacteria have a high GC content (around 65%) and the ability to grow over a wide temperature range (25-53 C). They are largely environmental organisms (M. tuberculosis and M. leprae are exceptions) and are slowly growing bacteria (M. leprae cannot be cultured on artificial media) with a long generation time of approximately twenty hours.
分枝杆菌是需氧生物,不产孢,不运动(海洋分枝杆菌是个例外),有蜡质,相对不渗透的细胞壁,由阿拉伯半乳聚糖和霉菌酸组成。有超过188种分枝杆菌。分枝杆菌具有高GC含量(约65%)和在宽温度范围内(25-53℃)生长的能力。它们主要是环境生物(结核分枝杆菌和麻风分枝杆菌除外),并且是生长缓慢的细菌(麻风分枝杆菌不能在人工培养基上培养),生长时间长,约为20小时。
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引用次数: 1
Innovations to Improve Neonatal Mortality in low and Middle-Income Countries 提高低收入和中等收入国家新生儿死亡率的创新
Pub Date : 2019-01-01 DOI: 10.32392/BIOMED.70
K. Azad, S. Akhter, Shareen Khan
Evidence-based interventions are available which, if scaled-up, can prevent roughly half of neonatal deaths; these include tetanus toxoid immunization to mothers, clean and skilled care at delivery, newborn resuscitation, exclusive breastfeeding, clean umbilical cord care, and/or management of infections. Apart from these conventional approaches, few innovative approaches have been developed to reduce neonatal mortality.
现有以证据为基础的干预措施,如果加以推广,可以预防大约一半的新生儿死亡;这些措施包括对母亲进行破伤风类毒素免疫、分娩时的清洁和熟练护理、新生儿复苏、纯母乳喂养、清洁脐带护理和/或感染管理。除了这些传统方法外,很少有创新的方法来降低新生儿死亡率。
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引用次数: 0
Neurophysiology of transformation through transcending 神经生理学的转化通过超越
Pub Date : 2019-01-01 DOI: 10.32392/BIOMED.39.2
F. Travis, R. Wallace, A. Arenander, Ted Wallace
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引用次数: 0
How Côte d’Ivoire avoided the 2014 Ebola Virus Disease (EVD) outbreak Côte科特迪瓦是如何避免2014年埃博拉病毒病(EVD)爆发的
Pub Date : 2019-01-01 DOI: 10.32392/BIOMED.57
D. Coulibaly, E. Adjogoua, D. Chérif, Y. Traoré, A. K. N’gattia, J. Bénié, Bm Dosso, S. Dagnan
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引用次数: 1
Alcohol consumption reduction using opioid receptor antagonists 使用阿片受体拮抗剂减少酒精消耗
Pub Date : 2019-01-01 DOI: 10.32392/biomed.40
J. Guardia-Serecigni
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引用次数: 1
“Polyphenolic-food” Effects on Brain Health (Human Data review) “多酚类食物”对大脑健康的影响(人类数据综述)
Pub Date : 2019-01-01 DOI: 10.32392/BIOMED.65.3
D’Angelo Stefania
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引用次数: 1
Meal Frequency and Time - Restricted Feeding as Strategies for Reducing Metabolic Risk : a Review 进餐频率和时间限制是降低代谢风险的策略:综述
Pub Date : 2019-01-01 DOI: 10.32392/BIOMED.56
R. Oke, A. Khadilkar, S. Chiplonkar
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引用次数: 2
Virtual Reality in Psychiatry 精神病学中的虚拟现实
Pub Date : 2019-01-01 DOI: 10.32392/biomed.55.1
E. Jung, Sung-Jung Eun, Seong-Jin Cho, H. Kim, Dong-Kyun Park
Virtual Reality in the field of medicine is making a considerable progress in psychiatry. Virtual reality exposure therapy (VRET) in particular can serve as a preferable solution for PTSD (Post-Traumatic Stress disorder) patients who avoids or finds retrieving image difficult. Relevant studies were reviewed to identify the pros and cons of virtual reality technology applied to psychiatry and to determine its medical effect.
虚拟现实在医学领域的应用正在精神病学领域取得相当大的进展。特别是虚拟现实暴露疗法(VRET)可以作为创伤后应激障碍(PTSD)患者避免或发现检索图像困难的首选解决方案。本文回顾了相关研究,以确定虚拟现实技术应用于精神病学的利弊,并确定其医疗效果。
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