Cancer pathogenesis and therapy最新文献

英文中文

Factors affecting the place of death in patients with liver cancer in China, 2013–2020: A population-based study 2013-2020年影响中国肝癌患者死亡地点的因素：基于人口的研究

Cancer pathogenesis and therapy

Pub Date : 2024-04-01 DOI: 10.1016/j.cpt.2024.04.001

Xiaosheng Ding, Weiwei Shi, Jinlei Qi, Juan An, Weiran Xu, Hui Shi, Xixi Zheng, Xiaoyan Li

引用次数: 0

Cancer phylogenetic inference using copy number alterations detected from DNA sequencing data 利用 DNA 测序数据检测到的拷贝数改变进行癌症系统发育推断

Cancer pathogenesis and therapy

Pub Date : 2024-04-01 DOI: 10.1016/j.cpt.2024.04.003

B. Lu

引用次数: 0

Association between autoimmunity-related disorders and prostate cancer: A Mendelian randomization study 自身免疫相关疾病与前列腺癌之间的关系：孟德尔随机研究

Cancer pathogenesis and therapy

Pub Date : 2024-03-29 DOI: 10.1016/j.cpt.2024.03.002

Background

Although many epidemiological studies and meta-analyses have reported an association between autoimmune disorders and prostate cancer, none has reported a clear correlation or the direction of the association. The purpose of our study was to explore the potential relationship between autoimmunity-related disorders and prostate cancer using Mendelian randomization (MR).

Methods

We retrieved literature from PubMed using the keywords “autoimmune disorder” AND “prostate cancer” to find more clues on the correlation between prostate cancer and autoimmunity-related disorder. Based on this literature search, we selected 16 autoimmunity-related disorders that had genome-wide association study (GWAS) data and may be associated with prostate cancer. The inverse variance weighting (IVW) method was applied as our primary analysis for two-sample MR and multivariate MR analysis to estimate the odds ratio (OR) and 95% confidence interval (CI). We further verified the robustness of our conclusions using a series of sensitivity analyses.

Results

The autoimmunity-related diseases selected include rheumatoid arthritis, ankylosing spondylitis, coxarthrosis, gonarthrosis, Crohn's disease, ulcerative colitis, irritable bowel syndrome, celiac disease, primary sclerosing cholangitis, asthma, type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, autoimmune hyperthyroidism, psoriatic arthropathies, and polymyalgia rheumatica. The results of inverse variance weighting (IVW suggested that six diseases were associated with the development of prostate cancer. The three diseases that may increase the risk of prostate cancer are rheumatoid arthritis (P = 0.001), coxarthrosis (P < 0.001), and gonarthrosis (P = 0.008). The three possible protective factors against prostate cancer are primary sclerosing cholangitis (P = 0.001), autoimmune hyperthyroidism (P = 0.011), and psoriatic arthropathies (P = 0.001). Horizontal pleiotropy was not observed in the MR-Egger test.

Conclusions

Our findings provide predictive genetic evidence for an association between autoimmune disorders and prostate cancer. Further research is needed to explore the underlying mechanisms of comorbidities at the molecular level.

背景尽管许多流行病学研究和荟萃分析报告了自身免疫性疾病与前列腺癌之间的关系，但没有一项研究报告了两者之间的明确相关性或关系的方向。我们使用关键词 "自身免疫性疾病 "和 "前列腺癌 "在PubMed上检索文献，以寻找更多有关前列腺癌与自身免疫性疾病相关的线索。在文献检索的基础上，我们选择了16种有全基因组关联研究（GWAS）数据且可能与前列腺癌相关的自身免疫相关疾病。我们采用反方差加权法（IVW）作为主要分析方法，进行双样本 MR 分析和多变量 MR 分析，以估算几率比（OR）和 95% 置信区间（CI）。我们通过一系列敏感性分析进一步验证了结论的稳健性。结果所选的自身免疫相关疾病包括类风湿性关节炎、强直性脊柱炎、髋关节病、寰枢关节病、克罗恩病、溃疡性结肠炎、肠易激综合征、乳糜泻、原发性硬化性胆管炎、哮喘、1 型糖尿病、系统性红斑狼疮、多发性硬化症、自身免疫性甲状腺功能亢进症、银屑病关节病和多发性风湿痛。逆方差加权（IVW）的结果表明，有六种疾病与前列腺癌的发病有关。可能增加前列腺癌风险的三种疾病是类风湿性关节炎（P = 0.001）、髋关节病（P < 0.001）和膝关节病（P = 0.008）。原发性硬化性胆管炎（P = 0.001）、自身免疫性甲状腺功能亢进症（P = 0.011）和银屑病关节病（P = 0.001）可能是前列腺癌的三个保护因素。我们的研究结果为自身免疫性疾病与前列腺癌之间的关联提供了预测性遗传证据。我们的研究结果为自身免疫性疾病与前列腺癌之间的关联提供了预测性遗传证据。

{"title":"Association between autoimmunity-related disorders and prostate cancer: A Mendelian randomization study","authors":"","doi":"10.1016/j.cpt.2024.03.002","DOIUrl":"10.1016/j.cpt.2024.03.002","url":null,"abstract":"<div><h3>Background</h3><div>Although many epidemiological studies and meta-analyses have reported an association between autoimmune disorders and prostate cancer, none has reported a clear correlation or the direction of the association. The purpose of our study was to explore the potential relationship between autoimmunity-related disorders and prostate cancer using Mendelian randomization (MR).</div></div><div><h3>Methods</h3><div>We retrieved literature from PubMed using the keywords “autoimmune disorder” AND “prostate cancer” to find more clues on the correlation between prostate cancer and autoimmunity-related disorder. Based on this literature search, we selected 16 autoimmunity-related disorders that had genome-wide association study (GWAS) data and may be associated with prostate cancer. The inverse variance weighting (IVW) method was applied as our primary analysis for two-sample MR and multivariate MR analysis to estimate the odds ratio (OR) and 95% confidence interval (CI). We further verified the robustness of our conclusions using a series of sensitivity analyses.</div></div><div><h3>Results</h3><div>The autoimmunity-related diseases selected include rheumatoid arthritis, ankylosing spondylitis, coxarthrosis, gonarthrosis, Crohn's disease, ulcerative colitis, irritable bowel syndrome, celiac disease, primary sclerosing cholangitis, asthma, type 1 diabetes, systemic lupus erythematosus, multiple sclerosis, autoimmune hyperthyroidism, psoriatic arthropathies, and polymyalgia rheumatica. The results of inverse variance weighting (IVW suggested that six diseases were associated with the development of prostate cancer. The three diseases that may increase the risk of prostate cancer are rheumatoid arthritis (<em>P</em> = 0.001), coxarthrosis (<em>P</em> < 0.001), and gonarthrosis (<em>P</em> = 0.008). The three possible protective factors against prostate cancer are primary sclerosing cholangitis (<em>P</em> = 0.001), autoimmune hyperthyroidism (<em>P</em> = 0.011), and psoriatic arthropathies (<em>P</em> = 0.001). Horizontal pleiotropy was not observed in the MR-Egger test.</div></div><div><h3>Conclusions</h3><div>Our findings provide predictive genetic evidence for an association between autoimmune disorders and prostate cancer. Further research is needed to explore the underlying mechanisms of comorbidities at the molecular level.</div></div>","PeriodicalId":93920,"journal":{"name":"Cancer pathogenesis and therapy","volume":"2 4","pages":"Pages 292-298"},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949713224000211/pdfft?md5=aadc6f8c5ef4020d01d627f2bf5d8edb&pid=1-s2.0-S2949713224000211-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140402676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover 封面

Cancer pathogenesis and therapy

Pub Date : 2024-03-26 DOI: 10.1016/S2949-7132(24)00006-5

引用次数: 0

Long-term adoptive immunotherapy achieves complete response and bone lesion repair in an elderly patient with macrofocal multiple myeloma 长期采用免疫疗法使一名老年大灶多发性骨髓瘤患者获得完全应答并修复骨病变

Cancer pathogenesis and therapy

Pub Date : 2024-03-16 DOI: 10.1016/j.cpt.2024.03.001

引用次数: 0

Efficacy and safety of anlotinib plus penpulimab as second-line treatment for small cell lung cancer: A multicenter, open-label, single-arm phase II trial 安罗替尼加培罗单抗作为小细胞肺癌二线治疗的有效性和安全性：多中心、开放标签、单臂II期试验

Cancer pathogenesis and therapy

Pub Date : 2024-02-07 DOI: 10.1016/j.cpt.2024.02.001

Background

Currently, the need for new therapeutic strategies involving programmed cell death protein-1 (PD-1) monoclonal antibodies in the second-line setting of small cell lung cancer (SCLC) is urgent. This study aimed to evaluate the efficacy and safety of anlotinib plus penpulimab as a second-line treatment for patients with SCLC who progressed after first-line platinum-based chemotherapy.

Methods

This study included the patients from Cohort 4 of a single-arm, open-label, multicenter, phase II clinical trial. A safety run-in phase was performed under anlotinib (10/12 mg quaque die [QD], days 1–14) plus penpulimab (200 mg intravenously [IV], day 1) in a 21-day cycle, followed by the formal trial in which the patients received anlotinib (12 mg QD, days 1–14) plus penpulimab (200 mg IV, day 1) in a 21-day cycle. The primary endpoint of the safety run-in phase was safety. The primary endpoint of the formal trial phase was the objective response rate (ORR).

Results

From April 28, 2020, to November 24, 2020, 21 patients were enrolled from 11 hospitals, including 2 in the safety run-in phase and 19 in the formal trial phase. In the formal trial phase, the ORR was 42.1% (8/19; 95% confidence interval [CI]: 17.7–66.6%). The median progression-free survival was 4.8 months (95% CI: 2.9–11.3 months), and the median overall survival was 13.0 months (95% CI: 4.6–not applicable [NA] months). The incidence of ≥grade 3 treatment-related adverse events (TRAEs) was 52.4% (11/21), and the incidence of treatment-related serious adverse events (AEs) was 28.6% (6/21). Two AE-related deaths occurred. The most common AEs were hypertension (57.1%, 12/21), hypothyroidism (42.9%, 9/21), and hypertriglyceridemia (38.1%, 8/21).

Conclusions

In patients with SCLC who progressed after first-line platinum-based chemotherapy, the second-line anlotinib plus penpulimab treatment demonstrates promising anti-cancer activity and a manageable safety profile, which warrants further investigation.

Trial registration

No. NCT04203719, https://clinicaltrials.gov/.

背景目前，小细胞肺癌（SCLC）二线治疗急需使用程序性细胞死亡蛋白-1（PD-1）单克隆抗体的新治疗策略。本研究旨在评估安罗替尼联合戊普利单抗作为一线铂类化疗后病情进展的SCLC患者二线治疗的有效性和安全性。在安罗替尼（10/12 毫克，第 1-14 天，quaque die [QD]）+ Penpulimab（200 毫克，第 1 天，静脉注射[IV]）的 21 天周期内，患者接受安罗替尼（12 毫克，第 1-14 天，quaque die [QD]）+ Penpulimab（200 毫克，第 1 天，静脉注射[IV]）的 21 天周期治疗。安全运行阶段的主要终点是安全性。结果从2020年4月28日到2020年11月24日，共有来自11家医院的21名患者入组，其中安全运行阶段2人，正式试验阶段19人。在正式试验阶段，ORR 为 42.1%（8/19；95% 置信区间 [CI]：17.7-66.6%）。中位无进展生存期为4.8个月（95% CI：2.9-11.3个月），中位总生存期为13.0个月（95% CI：4.6-不适用[NA]个月）。≥3级治疗相关不良事件（TRAEs）发生率为52.4%（11/21），治疗相关严重不良事件（AEs）发生率为28.6%（6/21）。有两例与不良反应相关的死亡病例。最常见的不良反应是高血压（57.1%，12/21）、甲状腺功能减退（42.9%，9/21）和高甘油三酯血症（38.1%，8/21）。结论在一线铂类化疗后病情进展的SCLC患者中，二线安罗替尼加培罗单抗治疗显示出良好的抗癌活性和可控的安全性，值得进一步研究。试验登记号：NCT04203719，https://clinicaltrials.gov/。

{"title":"Efficacy and safety of anlotinib plus penpulimab as second-line treatment for small cell lung cancer: A multicenter, open-label, single-arm phase II trial","authors":"","doi":"10.1016/j.cpt.2024.02.001","DOIUrl":"10.1016/j.cpt.2024.02.001","url":null,"abstract":"<div><h3>Background</h3><div>Currently, the need for new therapeutic strategies involving programmed cell death protein-1 (PD-1) monoclonal antibodies in the second-line setting of small cell lung cancer (SCLC) is urgent. This study aimed to evaluate the efficacy and safety of anlotinib plus penpulimab as a second-line treatment for patients with SCLC who progressed after first-line platinum-based chemotherapy.</div></div><div><h3>Methods</h3><div>This study included the patients from Cohort 4 of a single-arm, open-label, multicenter, phase II clinical trial. A safety run-in phase was performed under anlotinib (10/12 mg <em>quaque die</em> [QD], days 1–14) plus penpulimab (200 mg intravenously [IV], day 1) in a 21-day cycle, followed by the formal trial in which the patients received anlotinib (12 mg QD, days 1–14) plus penpulimab (200 mg IV, day 1) in a 21-day cycle. The primary endpoint of the safety run-in phase was safety. The primary endpoint of the formal trial phase was the objective response rate (ORR).</div></div><div><h3>Results</h3><div>From April 28, 2020, to November 24, 2020, 21 patients were enrolled from 11 hospitals, including 2 in the safety run-in phase and 19 in the formal trial phase. In the formal trial phase, the ORR was 42.1% (8/19; 95% confidence interval [CI]: 17.7–66.6%). The median progression-free survival was 4.8 months (95% CI: 2.9–11.3 months), and the median overall survival was 13.0 months (95% CI: 4.6–not applicable [NA] months). The incidence of ≥grade 3 treatment-related adverse events (TRAEs) was 52.4% (11/21), and the incidence of treatment-related serious adverse events (AEs) was 28.6% (6/21). Two AE-related deaths occurred. The most common AEs were hypertension (57.1%, 12/21), hypothyroidism (42.9%, 9/21), and hypertriglyceridemia (38.1%, 8/21).</div></div><div><h3>Conclusions</h3><div>In patients with SCLC who progressed after first-line platinum-based chemotherapy, the second-line anlotinib plus penpulimab treatment demonstrates promising anti-cancer activity and a manageable safety profile, which warrants further investigation.</div></div><div><h3>Trial registration</h3><div>No. <span><span>NCT04203719</span><svg><path></path></svg></span>, <span><span>https://clinicaltrials.gov/</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":93920,"journal":{"name":"Cancer pathogenesis and therapy","volume":"2 4","pages":"Pages 268-275"},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949713224000041/pdfft?md5=00ec1c474c71cd0b292b4f28a4c4d00e&pid=1-s2.0-S2949713224000041-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139883467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-healing hydrogels for enhancing chemotherapy drug efficacy: Advancements in anti-sarcoma and carcinoma therapies and clinical trial feasibility 用于提高化疗药物疗效的自愈合水凝胶：抗肉瘤和癌症疗法的进展与临床试验的可行性

Cancer pathogenesis and therapy

Pub Date : 2024-02-02 DOI: 10.1016/j.cpt.2024.01.003

Luc Taylor

引用次数: 0

Autophagy as a targeted therapeutic approach for skin cancer: Evaluating natural and synthetic molecular interventions 自噬作为皮肤癌的靶向治疗方法：评估天然和合成分子干预措施

Cancer pathogenesis and therapy

Pub Date : 2024-02-01 DOI: 10.1016/j.cpt.2024.01.002

Md. Liakot Ali , Amdad Hossain Roky , S.M. Asadul Karim Azad , Abdul Halim Shaikat , Jannatul Naima Meem , Emtiajul Hoque , Abu Mohammed Fuad Ahasan , Mohammed Murshedul Islam , Md. Saifur Rahaman Arif , Md. Saqline Mostaq , Md. Zihad Mahmud , Mohammad Nurul Amin , Md. Ashiq Mahmud

Skin cancer, a prevalent malignancy worldwide, poses significant health concerns owing to its increasing incidence. Autophagy, a natural cellular process, is a pivotal event in skin cancer and has advantageous and detrimental effects. This duality has prompted extensive investigations into medical interventions targeting autophagy modulation for their substantial therapeutic potential. This systematic review aimed to investigate the relationship between skin cancer and autophagy and the contribution and mechanism of autophagy modulators in skin cancer. We outlined the effectiveness and safety of targeting autophagy as a promising therapeutic strategy for the treatment of skin cancer. This comprehensive review identified a diverse array of autophagy modulators with promising potential for the treatment of skin cancer. Each of these compounds demonstrates efficacy through distinct physiological mechanisms that have been elucidated in detail. Interestingly, findings from a literature search indicated that none of the natural, synthetic, or semisynthetic compounds exhibited notable adverse effects in either human or animal models. Consequently, this review offers novel mechanistic and therapeutic perspectives on the targeted modulation of autophagy in skin cancer.

皮肤癌是一种全球流行的恶性肿瘤，由于其发病率不断上升，对人们的健康造成了极大的威胁。自噬是一种自然的细胞过程，在皮肤癌中起着关键作用，有利有弊。这种双重性促使人们广泛研究针对自噬调节的医疗干预措施，以挖掘其巨大的治疗潜力。本系统综述旨在研究皮肤癌与自噬之间的关系，以及自噬调节剂在皮肤癌中的作用和机制。我们概述了以自噬为靶点作为皮肤癌治疗策略的有效性和安全性。这篇综合综述发现了一系列具有治疗皮肤癌潜力的自噬调节剂。这些化合物中的每一种都通过已详细阐明的不同生理机制显示出疗效。有趣的是，文献检索结果表明，这些天然、合成或半合成化合物均未在人体或动物模型中表现出明显的不良反应。因此，本综述为有针对性地调节皮肤癌自噬提供了新的机制和治疗视角。

{"title":"Autophagy as a targeted therapeutic approach for skin cancer: Evaluating natural and synthetic molecular interventions","authors":"Md. Liakot Ali , Amdad Hossain Roky , S.M. Asadul Karim Azad , Abdul Halim Shaikat , Jannatul Naima Meem , Emtiajul Hoque , Abu Mohammed Fuad Ahasan , Mohammed Murshedul Islam , Md. Saifur Rahaman Arif , Md. Saqline Mostaq , Md. Zihad Mahmud , Mohammad Nurul Amin , Md. Ashiq Mahmud","doi":"10.1016/j.cpt.2024.01.002","DOIUrl":"10.1016/j.cpt.2024.01.002","url":null,"abstract":"<div><div>Skin cancer, a prevalent malignancy worldwide, poses significant health concerns owing to its increasing incidence. Autophagy, a natural cellular process, is a pivotal event in skin cancer and has advantageous and detrimental effects. This duality has prompted extensive investigations into medical interventions targeting autophagy modulation for their substantial therapeutic potential. This systematic review aimed to investigate the relationship between skin cancer and autophagy and the contribution and mechanism of autophagy modulators in skin cancer. We outlined the effectiveness and safety of targeting autophagy as a promising therapeutic strategy for the treatment of skin cancer. This comprehensive review identified a diverse array of autophagy modulators with promising potential for the treatment of skin cancer. Each of these compounds demonstrates efficacy through distinct physiological mechanisms that have been elucidated in detail. Interestingly, findings from a literature search indicated that none of the natural, synthetic, or semisynthetic compounds exhibited notable adverse effects in either human or animal models. Consequently, this review offers novel mechanistic and therapeutic perspectives on the targeted modulation of autophagy in skin cancer.</div></div>","PeriodicalId":93920,"journal":{"name":"Cancer pathogenesis and therapy","volume":"2 4","pages":"Pages 231-245"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949713224000028/pdfft?md5=49e34dccae0c252025870fda72f8c316&pid=1-s2.0-S2949713224000028-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inetetamab combined with pyrotinib and oral vinorelbine for patients with human epidermal growth factor receptor 2 positive advanced breast cancer: A single-arm phase 2 clinical trial 伊奈他单抗联合吡罗替尼和口服长春瑞滨治疗人类表皮生长因子受体 2 阳性晚期乳腺癌患者：单臂 2 期临床试验

Cancer pathogenesis and therapy

Pub Date : 2024-01-01 DOI: 10.1016/j.cpt.2023.10.004

Nan Jin , Yi Xu , Siqi Wang , Chunxiao Sun , Xueqi Yan , Fan Yang , Yan Liang , Weiwei Chen , Xiang Huang

Background

Human epidermal growth factor receptor 2 (HER2)-targeted agents have significantly improved the outcomes of patients with HER2-positive breast cancer; however, a large proportion of patients still develop resistance to trastuzumab. In this study, we investigated the efficacy and safety of inetetamab, another anti-HER2 antibody, combined with pyrotinib and oral vinorelbine in patients with HER2-positive advanced breast cancer so as to provide new ideas for the treatment.

Methods

In this prospective, single-arm, phase 2 trial, patients with HER2-positive advanced breast cancer with disease progression after trastuzumab were recruited. Patients received a combination of inetetamab (loading dose of 8 mg/kg and subsequent doses of 6 mg/kg intravenously once every 3 weeks), pyrotinib (400 mg orally once daily), and vinorelbine (60 mg/m² orally once weekly) until disease progression or intolerable toxicity. The primary endpoint was progression-free survival (PFS). The secondary endpoints included objective response rate (ORR), overall survival (OS), disease control rate (DCR), and safety.

Results

Between February 13, 2022 and December 25, 2022, 30 patients were screened and enrolled in this study. The median age of the patients at enrollment was 54 years, 12 patients (40.0 %) had hormone-receptor-positive disease and 23 patients (76.7 %) had visceral metastasis. The median PFS was 8.63 months (95 % confidence interval [CI] 4.15–13.12 months). The median OS was not reached. The ORR was 53.3 % (16/30) and the DCR was 96.7 % (29/30). The most common Grade III/IV adverse events were leukopenia (n = 5, 16.7 %), neutropenia (n = 4, 13.3 %), and diarrhea (n = 3, 10 %). No treatment-related serious adverse events or deaths occurred.

Conclusions

The combination regimen of inetetamab, pyrotinib, and oral vinorelbine showed encouraging efficacy and favorable safety in patients with HER2-positive advanced breast cancer and could be considered as an alternative treatment option for the patients.

Trial registration

No.NCT05823623; https://www.clinicaltrials.gov/.

背景人类表皮生长因子受体2（HER2）靶向药物已显著改善了HER2阳性乳腺癌患者的预后；然而，仍有很大一部分患者对曲妥珠单抗产生了耐药性。本研究探讨了伊奈他单抗（另一种抗HER2抗体）联合吡罗替尼和口服长春瑞滨治疗HER2阳性晚期乳腺癌患者的疗效和安全性，以期为治疗提供新思路。方法在这项前瞻性、单臂、2期试验中，招募了曲妥珠单抗治疗后疾病进展的HER2阳性晚期乳腺癌患者。患者接受伊奈他单抗（负荷剂量为8毫克/千克，随后每3周静脉注射一次，剂量为6毫克/千克）、吡罗替尼（400毫克，口服，每天一次）和长春瑞滨（60毫克/平方米，口服，每周一次）的联合治疗，直至疾病进展或出现不可耐受的毒性反应。主要终点是无进展生存期（PFS）。次要终点包括客观反应率（ORR）、总生存率（OS）、疾病控制率（DCR）和安全性。结果2022年2月13日至2022年12月25日期间，本研究共筛选并招募了30名患者。入组患者的中位年龄为54岁，12名患者（40.0%）激素受体阳性，23名患者（76.7%）有内脏转移。中位生存期为8.63个月（95%置信区间[CI] 4.15-13.12个月）。未达到中位OS。ORR为53.3%（16/30），DCR为96.7%（29/30）。最常见的III/IV级不良事件为白细胞减少（5例，16.7%）、中性粒细胞减少（4例，13.3%）和腹泻（3例，10%）。结论伊奈他单抗、吡罗替尼和口服长春瑞滨的联合治疗方案在HER2阳性晚期乳腺癌患者中显示出令人鼓舞的疗效和良好的安全性，可作为患者的另一种治疗选择。试验登记号：NCT05823623；https://www.clinicaltrials.gov/。

{"title":"Inetetamab combined with pyrotinib and oral vinorelbine for patients with human epidermal growth factor receptor 2 positive advanced breast cancer: A single-arm phase 2 clinical trial","authors":"Nan Jin , Yi Xu , Siqi Wang , Chunxiao Sun , Xueqi Yan , Fan Yang , Yan Liang , Weiwei Chen , Xiang Huang","doi":"10.1016/j.cpt.2023.10.004","DOIUrl":"10.1016/j.cpt.2023.10.004","url":null,"abstract":"<div><h3>Background</h3><p>Human epidermal growth factor receptor 2 (HER2)-targeted agents have significantly improved the outcomes of patients with HER2-positive breast cancer; however, a large proportion of patients still develop resistance to trastuzumab. In this study, we investigated the efficacy and safety of inetetamab, another anti-HER2 antibody, combined with pyrotinib and oral vinorelbine in patients with HER2-positive advanced breast cancer so as to provide new ideas for the treatment.</p></div><div><h3>Methods</h3><p>In this prospective, single-arm, phase 2 trial, patients with HER2-positive advanced breast cancer with disease progression after trastuzumab were recruited. Patients received a combination of inetetamab (loading dose of 8 mg/kg and subsequent doses of 6 mg/kg intravenously once every 3 weeks), pyrotinib (400 mg orally once daily), and vinorelbine (60 mg/m<sup>2</sup> orally once weekly) until disease progression or intolerable toxicity. The primary endpoint was progression-free survival (PFS). The secondary endpoints included objective response rate (ORR), overall survival (OS), disease control rate (DCR), and safety.</p></div><div><h3>Results</h3><p>Between February 13, 2022 and December 25, 2022, 30 patients were screened and enrolled in this study. The median age of the patients at enrollment was 54 years, 12 patients (40.0 %) had hormone-receptor-positive disease and 23 patients (76.7 %) had visceral metastasis. The median PFS was 8.63 months (95 % confidence interval [CI] 4.15–13.12 months). The median OS was not reached. The ORR was 53.3 % (16/30) and the DCR was 96.7 % (29/30). The most common Grade III/IV adverse events were leukopenia (<em>n</em> = 5, 16.7 %), neutropenia (<em>n</em> = 4, 13.3 %), and diarrhea (<em>n</em> = 3, 10 %). No treatment-related serious adverse events or deaths occurred.</p></div><div><h3>Conclusions</h3><p>The combination regimen of inetetamab, pyrotinib, and oral vinorelbine showed encouraging efficacy and favorable safety in patients with HER2-positive advanced breast cancer and could be considered as an alternative treatment option for the patients.</p></div><div><h3>Trial registration</h3><p>No.NCT05823623; <span>https://www.clinicaltrials.gov/</span><svg><path></path></svg>.</p></div>","PeriodicalId":93920,"journal":{"name":"Cancer pathogenesis and therapy","volume":"2 1","pages":"Pages 31-37"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949713223000861/pdfft?md5=dc961df2356f92d5808448e7ca98f6ad&pid=1-s2.0-S2949713223000861-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136128019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover 封面

Cancer pathogenesis and therapy

Pub Date : 2024-01-01 DOI: 10.1016/S2949-7132(23)00099-X

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Cancer pathogenesis and therapy

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀